Ali Alahmari

King Faisal Specialist Hospital & Research Centre

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Mouhab Ayas

King Faisal Specialist Hospital & Research Centre

Mahmoud Aljurf

King Faisal Specialist Hospital & Research Centre

Abdullah Al‐Jefri

King Faisal Specialist Hospital & Research Centre

Riad El Fakih

King Faisal Specialist Hospital & Research Centre

Amal Al-Seraihy

King Faisal Specialist Hospital & Research Centre

Hassan El‐Solh

King Faisal Specialist Hospital & Research Centre

Naeem Chaudhri

King Faisal Specialist Hospital & Research Centre

Walid Rasheed

King Faisal Specialist Hospital & Research Centre

Saud Alhayli

King Faisal Specialist Hospital & Research Centre

Syed Osman Ahmed

King Faisal Specialist Hospital & Research Centre

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King Faisal Specialist Hospital & Research Centre

386

Alfaisal University

King Saud University

University of Toronto

King Saud bin Abdulaziz University for Health Sciences

King Fahd Medical City

The University of Texas MD Anderson Cancer Center

Inserm

King Abdulaziz Medical City

King Fahd Security College

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Hematopoietic stem cell transplantation in Saudi Arabia between 1984 and 2016: Experience from four leading tertiary care hematopoietic stem cell transplantation centers

Hematology/Oncology and Stem Cell Therapy (2020)

Marwan Shaheen Fahad Almohareb Naif I. AlJohani Mouhab Ayas Naeem Chaudhri

Saudi Arabia is the largest of the Arabian Gulf countries with a total population of 33.41 million as of 2017. This report summarizes the experience from four leading tertiary care hematopoietic stem cell transplantation (HSCT) centers in Saudi Arabia representing more than 90% of all HSCTs performed in the country. Between 1984 and 2016, a total of 6,184 HSCTs were performed. Of these, 3,586 HSCTs were performed in adults and 2,598 HSCTs were performed in pediatric patients. Malignancy was the main indication for transplantation (47%). While most transplants were performed from an identical sibling donor, HSCTs from cord blood, unrelated and, more recently, haploidentical donors have also been performed. Relative shortage of HSCT bed capacity is perceived to be a limiting factor in Saudi Arabia. Lately, more HSCT centers are emerging with rapid growth, which may significantly improve the access to HSCT in the country in the near future.

Cord blood

Economic shortage

10.1016/j.hemonc.2020.07.008

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Citations (16)

Hemopoietic stem cell transplantation in thalassemia: a report from the European Society for Blood and Bone Marrow Transplantation Hemoglobinopathy Registry, 2000–2010

Bone Marrow Transplantation (2016)

D Baronciani Emanuele Angelucci Ulrike Pötschger Javid Gaziev Akif Yeşilipek

Hemoglobinopathy

Beta thalassemia

10.1038/bmt.2015.293

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Citations (190)

Human herpesvirus 7 in pediatric hematopoietic stem cell transplantation

Pediatric Blood & Cancer (2006)

Muhammad Faisal Khanani Ali Alahmari Raymond Tellier Upton Allen Susan E. Richardson

Little is known about the significance of human herpesvirus 7 (HHV-7) in pediatric hematopoietic stem cell transplantation (HSCT).To evaluate children post autologous and allogeneic HSCT, with a positive PCR or immunohistochemistry for HHV-7 either from blood, cerebrospinal fluid (CSF) or any other pathology specimen. Clinical data for these patients were collected examining symptoms and signs, engraftment, acute infectious complications, graft versus host disease (GVHD) where applicable, and survival.Between June 1999 and June 2003, 265 HSCT were performed in The Hospital for Sick Children, Toronto, allogeneic (n = 163) and autologous (n = 102). Nine children were positive for HHV-7 at a median of 21 days (range 16-27 days) post-HSCT. All had allogeneic transplantation. The most common underlying diagnosis was acute leukemia and 7 had matched unrelated donor (MUD) transplantation. Eight of the nine patients had grade II-IV acute GVHD and all of them had multiple infectious episodes with fungal, bacterial and other viral pathogens. Although not fully attributed to HHV-7, the clinical syndrome varied from fever, vomiting and diarrhea to septic shock. Four patients died due to GVHD and sepsis.HHV-7 was uncommon post-HSCT. It was associated with severe GVHD and sepsis secondary to severe immunosuppression.

Immunosuppression

Pediatric cancer

Human herpesvirus 6

10.1002/pbc.20829

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Citations (16)

Graft Versus Host Disease Following HLA-Matched Sibling Donor Compared with Matched Related Donor for Hematopoietic Stem Cell Transplantation for the Treatment of Severe Combined Immunodeficiency Disease

Journal of Clinical Immunology (2019)

Bandar Al‐Saud Alhanouf AlSaleem Bashayer Al Rasheed Abdulaziz Al‐Ghonaium Ali Alahmari

Cumulative incidence

10.1007/s10875-019-00634-3

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Citations (0)

A comparative evaluation of 4% articaine and 2% lidocaine in mandibular buccal infiltration anesthesia: A clinical study

Journal of International Society of Preventive and Community Dentistry (2015)

Sunith Maruthingal Dennis Mohan Ramesh Kumar Maroli Ali Alahmari Ahmed Shaher Alqahtani

To compare 4% articaine and 2% lidocaine local anesthetics in achieving pulpal anesthesia of the lower first permanent molar teeth objectively, and to assess and compare lip and lingual mucosa numbness subjectively.All subjects received 1.7 ml of any one anesthetic in the mucobuccal fold adjacent to mandibular first molar teeth; the same individuals received the second infiltration at least 1 week after the first. Later, comparisons for pulpal anesthesia, lip and lingual mucosa numbness between these two anesthetics solutions were made.Articaine showed significant results with P = 0.006 in achieving pulpal anesthesia objectively, when compared with lidocaine. Articaine also showed very high significant results subjectively with P = 0.0006 in achieving lip numbness, when compared with lidocaine. But the results in achieving lingual mucosa numbness with articaine subjectively was not significant with P = 0.01, when compared with lidocaine.Endodontic and operative treatments are one of the most common oral non-surgical procedures done under local anesthesia. The diversity of anesthetic substances currently available on the market requires dental professionals to assess the drug both by its pharmacokinetic and also by its clinical characteristics during dental treatments. Our study used 4% articaine, which is available in the market, for comparison with 2% lidocaine. Further studies are required to use an equal concentration of solutions to achieve more accurate results.

Articaine

10.4103/2231-0762.167717

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Citations (19)

CD11b Expression Is An Independent Adverse Prognostic Factor in Pediatric Acute Myeloid Leukemia Treated with Allogeneic Stem Cell Transplantation,

Blood (2011)

Maher Albitar Amal Al-Seraihy Mouhab Ayas Abdullah Al‐Jefri Ali Alahmari

Immunophenotyping

Clinical Significance

10.1182/blood.v118.21.4092.4092

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Citations (1)

Outcomes of blood and marrow transplantation in children less than 2-years of age

International Journal of Pediatrics and Adolescent Medicine (2022)

Saadiya Khan Khawar Siddiqui H El-Solh Abdullah Al‐Jefri Ali Alahmari

Allogeneic hematopoietic cell transplantation (Allo-HCT) is a curative option for children with various malignant and non-malignant diseases. Most reports studied all age groups amongst children. Herein we analyzed our data in children transplanted at or less than 2-years of age.We reviewed medical charts of 618 patients who underwent 666 transplantation at our center between 1993 and 2015. There were 340 boys and 278 girls. Median age was 0.7 years (range 0.04-2). Stem cell source was bone marrow (BM) in 492 (73.9%), unrelated umbilical cord blood (UCB) in 161 (24.2%) followed by peripheral blood stem cell (PBSC) in 13 (2%) patients. Matched siblings were the most common donors (n = 356, 53.5%), followed by unrelated (n = 161, 24.2%) with haploidentical family member donors in 29 (4.4%) transplants. Disease groups were categorized as benign hematology (Thalassemia, Fanconi, Aplastic anemia etc.), benign neoplasm (Langerhans cell histiocytosis, Hemophagocytic Lymphohistiocytosis etc.), non-neoplasms (metabolic disorders, immunodeficiency disorders etc.) and Leukemia/lymphomas (myeloid and lymphoid malignancies etc.).Cumulative incidence of acute GvHD (I-IV) was 31.5% (n = 210) and grade III-IV GvHD was 8.7% (n = 58). At median follow-up of 115.1 months, the cumulative probability of overall survival (OS) at 5 years was 70.0% ± 1.9%. Our mortality rate was 31.2% (n = 193). The five-year OS was significantly better in patients transplanted for benign hematological disorders (P = .001). Patients transplanted using BM/PBSC as source of stem cells fared significantly better compared to those in which CB was used (P<.001). Post-transplant graft failure remains the leading cause requiring further transplants in this age group. In conclusion, the cumulative probability of OS at 5 years was about 70.0% for all with an OS of 61% in our haploidentical recipients.Analyzing our institutional data over time has enabled us to develop tentative strategies to minimize transplant related toxicities in very young children who are candidates for allo-HCT.

Cumulative incidence

Hematology

Aplastic anemia

10.1016/j.ijpam.2022.09.002

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Citations (3)

Prognostic Impact of CD19 Status Pre-Lymphodepletion in Anti-CD19 CAR-T Therapy for B-Acute Lymphoblastic Leukemia

Blood (2024)

Nourah Alzaidy Mostafa Saleh Ahmed Kotb Abdrabou Reem Alasbali Amer Bugnah

Blinatumomab

Acute lymphocytic leukemia

10.1182/blood-2024-207988