John F. Coffey

Leicester Royal Infirmary

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David L. Carr‐Locke

New York Hospital Queens

Graham L. Cullingford

University of Western Australia

Hiroshi Teraoka

National Institute for Materials Science

L. Fullwood

University of Nottingham

R. Ebert

University of Göttingen

A.J. Cowley

South East Coast Ambulance Service NHS Foundation Trust

A.F. Mutter

Anna Suk Fong Lok

Michael A. Nauck

University of Adelaide

Caterina Cellerino

Università Cattolica del Sacro Cuore

Cooperative Institutions

National Hospital Organization Kyushu Cancer Center

Tokyo Metropolitan Institute of Gerontology

Hammersmith Hospital

Casa Sollievo della Sofferenza

Istituti di Ricovero e Cura a Carattere Scientifico

McGill University

Kyoto University

University of Göttingen

Diabeteszentrum Bad Lauterberg

Università Cattolica del Sacro Cuore

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Irritable Bowel Syndrome: Can the Patient’s Response to Colonoscopy Help with Diagnosis?

Digestion (1992)

Graham L. Cullingford John F. Coffey David L. Carr‐Locke

The irritable bowel syndrome (IBS) is a common disorder estimated to affect up to 20% of adult Causasians, with only a small percentage requiring investigation. This prospective study was performed to substantiate the impression that patients with IBS experience more pain during endoscopic examination of the colon than do patients with other conditions. Patients with IBS were observed to experience significantly more pain during colonoscopy than did patients without IBS (median observed pain scores 46 and 9, respectively), p < 0.001. The intensity of the pain perceived during examination was significantly higher for patients with IBS than for those without IBS (median 52.5 and 23.5, respectively), p < 0.001. Within the groups, there was no significant difference between flexible sigmoidoscopy and colonoscopy in observed or perceived pain. 64% of the patients with IBS said that the pain experienced at colonoscopy was identical to their presenting pain. This study supports the hypothesis of a lower colonic pain threshold with colonic hyperalgesia in patients with IBS. We have found that hypersensitivity to the endoscopic examination of the colon is a useful clinical adjunct in the diagnosis of the IBS in those selected to undergo colonoscopy.

Colonic Diseases

10.1159/000200955

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Citations (16)

Does a Palliative Care Clinic Have a Role in Improving End-of-Life Care? Results of a Pilot Program

Journal of Palliative Medicine (2002)

David Casarett Karen B. Hirschman John F. Coffey Lucy Pierre

Objective: To assess the efficacy of a palliative care clinic (PCC), which provided some of the interdisciplinary services and expertise of an inpatient consult service to outpatients, in traditional clinic sessions. Design: Chart review. Setting: A large urban Veterans Administration Medical Center. Patients: One hundred patients referred to clinic. Interventions: Palliative care clinic. Outcome Measures: Patients' reported needs, Global Distress Index (GDI) subscale, hospice eligibility, and time to death. Results: The most common diagnosis was cancer (n = 85). Most patients (n = 89) had at least one need for services that the team provided (median, 2; range, 0-4), the most common of which was a desire for information about prognosis (n = 84). In a Cox proportional hazards model, predictors of enrollment in hospice included white ethnicity (hazard ratio, 3.42; p < 0.001), a need for help around the home (hazard ratio, 3.26; p = 0.002), and insufficient money left at the end of the month (hazard ratio, 2.39; p = 0.014). Conclusions: The experience of the PCC described here offers a unique approach to improving end-of-life care for those outpatients who may not be well served by existing structures of care such as palliative care consult services and who have not yet enrolled in hospice.

End-of-Life Care

10.1089/109662102320135270

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Citations (43)

Subject Index, Vol. 52, 1992

Digestion (1992)

Hung‐Shang Tang Oliver Yoa-Pu Hu Juha Grönroos Timo J. Nevalainen Akihiro Funakoshi

10.1159/000200960

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Citations (0)

Contents, Vol. 52, 1992

Digestion (1992)

Hung‐Shang Tang Oliver Yoa-Pu Hu Juha Grönroos Timo J. Nevalainen Akihiro Funakoshi

10.1159/000200945

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Citations (0)

Serum middle molecule levels in uremia during long term intermittent hemoperfusions with the acac (coated charcoal) microcapsule artificial kidney.

PubMed (1974)

Tsu‐Yuan Chang Margriet Migchelsen John F. Coffey A. M. Stark

Uremia

Charcoal

Artificial kidney

Activated Charcoal

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Citations (27)

ENDOSCOPIC MANAGEMENT OF INTRAGASTRIC MIGRATION OF AN ANGELCHIK PROSTHESIS

Australian and New Zealand Journal of Surgery (1990)

Graham L. Cullingford John F. Coffey David L. Carr‐Locke

The Angelchik prosthesis was devised as a simple surgical solution for reflux oesophagitis. since 1983 there have been increasing reports of complications attributed to the prosthesis, the more seriuos being transmural erosion through the oesophageal or gastric wall. The majority of these have required repeat surgery, which is not without risks. A case report of an Angelchik prosthesis incompletely eroding into the stomach is presented. The prosthesis was tethered by a 1 cm‐thick mucosal bridge which precluded simple extraction. using an endoscopic sphincterotome, the bridge was divided and the prosthesis removed. Endoscopic methods of extracting intragastric Angelchik prostheses should be considered before surgery is undertaken for this complication.

Bridge (graph theory)

10.1111/j.1445-2197.1990.tb07500.x

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Citations (5)

Race Education/Training: The State of the Art; Issues and Dilemmas.

John F. Coffey Mark A. Chesler

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Microcapsule artificial kidney: treatment of patients with acute drug intoxication.

PubMed (1973)

T. M. S. Chang John F. Coffey Paul E. Barré A. Gonda John H. Dirks

The microcapsule artificial kidney was used in the treatment of three patients with acute drug intoxication. The apparatus contains 300 g. of microencapsulated activated charcoal with a total membrane area available for diffusion of more than 2m.(2) The membrane thickness is only 500 A. These properties make possible a compact artificial kidney whose efficiency for the removal of uremic metabolites and drugs is much higher than standard hemodialysis apparatus. The microcapsules are made blood-compatible by coating with human albumin. A roller pump was used to propel the blood through the microcapsule artificial kidney at a flow rate of 300 ml./min. for two to three hours. The clearance values for glutethimide, methyprylon and methaqualone were much higher than those achieved by standard hemodialysis. Hemoperfusion quickly lowered the drug level in the blood with resulting clinical improvement.

Hemoperfusion

Artificial kidney

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Citations (60)

ACAC MICROCAPSULE ARTIFICIAL KIDNEY FOR THE LONG TERM AND SHORT TERM MANAGEMENT OF ELEVEN PATIENTS WITH CHRONIC RENAL FAILURE

ASAIO Journal (1972)

T. M. S. Chang A. Gonda John H. Dirks John F. Coffey Tracy Lee-Burns

Artificial kidney

Chronic renal failure

10.1097/00002480-197201000-00114

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