Marc Pagès

United States Department of Agriculture

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Emilio del Cacho

Universidad de Zaragoza

L. V. Monteagudo

Centro de Investigación y Tecnología Agroalimentaria de Aragón

Margarita Gallego

Universidad de Zaragoza

Caridad Sánchez-Acedo

Universidad de Zaragoza

Martina Dardi

Bärbel Ruttkowski

University of Veterinary Medicine Vienna

Anja Joachim

University of Veterinary Medicine Vienna

Ahmed Abdelfattah

Graz University of Technology

Aruna Shrestha

Applied Technical Services (United States)

Andrea Ladinig

University of Veterinary Medicine Vienna

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Acciona (Spain)

Universitat Politècnica de Catalunya

Agricultural Research Service

Inserm

United States Department of Agriculture

University of Veterinary Medicine Vienna

Institut National de la Recherche Agronomique

Universidade do Porto

Beltsville Agricultural Research Center

Centro de Excelência em Bioinformática

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Pathogenesis ofEimeria praecoxin chickens: virulence of field strains compared with laboratory strains ofE. praecoxandEimeria acervulina

Avian Pathology (2009)

R. B. Williams R. N. Marshall Marc Pagès Martina Dardi Emilio del Cacho

The pathogenesis in chickens of the apicomplexan Eimeria praecox was compared with that of Eimeria acervulina, using intestinal lesions, mucosal integrity, body weight gain (BWG) and the feed conversion ratio (FCR) as criteria. Characteristics of each species were described by combinations of polymerase chain reaction assays and classic parasitological signs. There were considerable overlaps in lengths, breadths, shape indices and volumes of the oocysts of each species. Both species caused statistically significant reductions in BWG at the lowest inocula tested (500,000 sporulated oocysts per bird of E. praecox and 250,000 of E. acervulina). E. praecox was observed for the first time to cause actual body weight loss and marked increases in FCR, as did E. acervulina. E. acervulina caused gross, white pathognomonic lesions, but E. praecox caused micro-lesions, visible in fresh tissue only with a dissecting microscope. Occasionally, lesions of the Houghton strain of E. acervulina were observed to be rounded, rather than typically "ladder-like". Both species caused villous erosion and atrophy. No mortality occurred in birds receiving up to 1 million sporulated oocysts of either species. Using BWG and FCR as criteria, the virulence of recent field strains of E. praecox from Wales (Tynygongl) and the USA (Raleigh) was compared with English laboratory strains of E. praecox (Houghton) and E. acervulina (Houghton). E. praecox (Tynygongl) was markedly more virulent than E. acervulina (Houghton), which was more virulent than E. praecox (Raleigh) and E. praecox (Houghton).

Eimeria acervulina

10.1080/03079450903186028

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Citations (49)

Antineutrophil cytoplasmic antibodies and antibodies to myeloperoxidase in rheumatoid arthritis

Arthritis & Rheumatism (1991)

S Lassoued L Sixou Françoise Oksman Marc Pagès A Fournié

10.1002/art.1780340821

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Efficacy of an attenuated vaccine against avian coccidiosis in combination with feed additives based on organic acids and essential oils on production performance and intestinal lesions in broilers experimentally challenged with necrotic enteritis

Poultry Science (2022)

E. van Eerden Regiane R. Santos Francesc Molist Martina Dardi Luis Augusto Pantoja-Millas

Several factors predisposing to necrotic enteritis (NE) have been identified, including diet and Eimeria spp. infestations. Coccidiosis vaccines are indicated to decrease the intestinal lesions caused by specific Eimeria species that are a known predisposing factor to NE and, consequently, these vaccines could be a holistic approach to the control of NE disease and an alternative solution to coccidiostats. Besides, feed additives have also gained special attention from the poultry industry as an alternative solution to antibiotics to prevent NE as well as other bacterial enteritis. Then, the combination of vaccination against coccidiosis and the supplementation of the diet with feed additives could be a composite approach to the control of NE problems triggered by Eimeria spp. infestation. The objective of this study was to test the efficacy of an attenuated coccidiosis vaccine (EVANT) in combination with different feed additives to prevent the loss of production performance and intestinal lesions in broilers challenged with NE. Healthy day-old broilers (n = 960) were randomly allocated to 6 groups (8 cages/group). Groups 1–2 were left unvaccinated. Groups 3–6 were vaccinated following the manufacturer's instructions. Chickens were grown using a diet favoring the intestinal proliferation of Clostridium perfringens. Moreover, the diets of groups 4–6 were supplemented with medium chain fatty acids (MCFA), butyric acid or phytogenic feed additives (PFA), respectively. A NE infection model was used to challenge groups 2–6; chickens were orally infected with Eimeria maxima (4,500 oocysts) and then C. perfringens (108 CFU) at 15 and 20 d, respectively. Birds were monitored and productive parameters recorded until 42 d; intestinal lesions were scored. Results showed that coccidiosis vaccination, with or without the addition of feed additives, decreased intestinal lesions associated with NE and improved the performance of the birds. Besides, the addition of MCFA to the diet decreased intestinal lesions associated to NE in vaccinated animals compared to all treatment groups. Moreover, the same additive improved the feed conversion rate. Therefore, vaccination with a live attenuated coccidiosis vaccine together with in-feed inclusion of MCFA might be a solution to reduce NE in broilers raised antimicrobial- and coccidiostat-free.

Eimeria maxima

Clostridium perfringens

Coccidiostats

Feed additive

10.1016/j.psj.2022.101848

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Citations (9)

Additional file 1: of Antibody and cytokine response to Cystoisospora suis infections in immune-competent young pigs

Figshare (2018)

Barbara Freudenschuss Bärbel Ruttkowski Aruna Shrestha Ahmed Abdelfattah Marc Pagès

Table S1. Hematological parameters and white blood cell counts determined on study days 1 and 29. Abbreviations: MCV, mean cell volume; MCH, mean cellular hemoglobin; MCHC, mean cellular hemoglobin concentration. Table S2. Differences in hematological parameters and white blood cell counts between groups and over time. Values of SD 1 and SD 29 were compared between uninfected animals and infected animals altogether. Additionally, differences over time were calculated for both groups. Abbreviations: x ¯ $$ \overline{\mathrm{x}} $$ , mean; σ, standard deviation. Table S3. Serum titer development over time within groups. In brackets: test statistic χ2 and degrees of freedom df according to the Friedman rank sum test. Abbreviations: SD, study day; x ¯ $$ \overline{\mathrm{x}} $$ , mean titer; σ, standard deviation. Table S4. Results (as P-values) of antibody titer comparisons between groups on each study day. Significant differences (P ≤ 0.05) are indicated in bold. Abbreviations: SD, study day; SL, Single Low; SH, Single High; TL, Trickle Low; TH, Trickle High; C, Control. Table S5. Change of cytokine mRNA expression of white blood cells over time within groups. Expression levels of study days 8, 15 and 29 of each group were compared to those of study day 1. Significant differences (P ≤ 0.05) are indicated in bold. Abbreviations: SD, study day; SL, Single Low; SH, Single High; TL, Trickle Low TH, Trickle High; C, Control. Table S6. Cytokine mRNA expression of white blood cells before infection. Expression values of study day 1 were compared between groups and resulting P-values are shown. Significant differences (P ≤ 0.05) are indicated in bold. Abbreviations: SL, Single Low; SH, Single High; TL, Trickle Low; TH, Trickle High; C, Control. (XLSX 34 kb)

Antibody response

10.6084/m9.figshare.6742838

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Effect of the quinolone coccidiostat decoquinate on the rearrangement of chromosomes of Eimeria tenella

International Journal for Parasitology (2006)

Emilio del Cacho Margarita Gallego Marc Pagès L. V. Monteagudo Caridad Sánchez-Acedo

Synaptonemal complex

10.1016/j.ijpara.2006.08.004

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Citations (2)

Can a pig adapted to the Label Rouge production be created by using local races ?