Maria Júlia Sousa Fonseca

Universidade Estadual do Ceará

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Nilberto Robson Falcão do Nascimento

Universidade Estadual do Ceará

Otília Deusdênia Loiola Pessoa

Hospital Geral de Fortaleza

Kirley Marques Canuto

Brazilian Agricultural Research Corporation

Taynara Simão Matos

Universidade Estadual de Campinas (UNICAMP)

Matheus Carlos Matos Silva

Universidade Estadual do Ceará

Ana Karine O. Silva

Universidade Federal do Ceará

Herbert S. Magalhães

Universidade Federal do Ceará

Cláudia Ferreira Santos

Universidade Estadual do Ceará

Ariana Gomes da Silva

Universidade Estadual do Ceará

Luis Gustavo Farias de Sousa

Faculdade de Ciências Médicas de Minas Gerais

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Universidade Federal do Ceará

Universidade Estadual do Ceará

Universidade de Fortaleza

State University of Vale do Acaraú

Brazilian Agricultural Research Corporation

University of Virginia

Universidade Estadual de Campinas (UNICAMP)

National Cancer Institute

Universidade Federal do Cariri

Universidade do Estado do Rio Grande do Norte

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Eficacia do conservante methyldibromo glutaronitrile (and) phenoxyethanol em formulacoes cosmeticas contendo vitamina a e acido glicolus

Anais (1996)

Francesca Furlan Maria Júlia Sousa Fonseca Patrícia Maria Berardo G. Maia-Campos

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Lipoic Acid Prevents Renal Dysfunction in Experimental Diabetes

The FASEB Journal (2019)

Manassés Claudino Fonteles Ariana Gomes da Silva Maria Júlia Sousa Fonseca Cláudia Ferreira Santos Davi Elisiário Lima lopes

Introduction Diabetic nephropathy affects approximately 30–40% of patients with type 1 diabetes mellitus and 8% to 10% of patients with type 2 diabetes, and is the main cause of end‐stage renal disease, requiring hemodialysis or renal transplantation. Objective The study evaluated the effect of lipoic acid for 60 days in the prevention of experimental diabetic nephropathy in diabetic rats. Male Wistar rats were divided into three groups: euglycemic (eugly; n = 12), untreated diabetic (Diab; n = 6), and diabetic treated with lipoic acid (AL) 20mg/kg every 12 hours Orally (Diab + AL; n = 12) for 60 days. The animals were induced to diabetes with intraperitoneal injection of streptozotocin (STZ) (65 mg/kg, i.p), diluted in citrate buffer (pH 4.5). The control group received only citrate buffer (0.1mL/100g; i.p). Renal function was evaluated in metabolic cages on days 0, 15, 30, 45 and 60, with collection of urine and blood. After 60 days, all the animals were assigned to functional studies of renal hemodynamics and pressure natriuresis, in addition to molecular marker studies of diabetic nephropathy. Results The animals studied presented classic diabetes characteristics such as hyperglycemia, maintained throughout the experimental protocol, polyuria, polydipsia and glycosuria, whose treatment with lipoic acid, was able to improve all these alterations. After 60 days, they presented albuminuria, which was attenuated with AL treatment. The excreted fraction of sodium, was increased 4‐fold in the Diab group and was attenuated in the AL‐treated group. The natriuresis increased about 7‐fold in the Eugli group during the period of increased renal perfusion pressure, however, it was impaired by 65% in the control non‐treated diabetic animals. The AL treated group, however, had normal pressure natriuresis. The renal concentration of gluthatione (GSH) decreased by 48% in the diabetic group when compared to the Eugli group, and the AL treatment restored the GSH levels to control values. The lipoperoxidation marker, malondialdehyde, was increased in the Diab group (68%) but was normal in the AL‐treated diabetic group. Conclusion Treatment with lipoic acid is able to prevent the great majority of changes caused during the course of experimental diabetes, and could be an alternative to the composition of a primary prevention treatment in conjunction with metabolic control drugs. Support or Funding Information FUNCAP, CAPES and CNPq This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .

Polyuria

Glycosuria

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Albuminuria

10.1096/fasebj.2019.33.1_supplement.678.13

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Neuroinhibitory meroterpenoid compounds from Cordia oncocalyx

Fitoterapia (2017)

Taynara Simão Matos Ana Karine O. Silva Amanda Lemos Quintela L. Francisco das Chagas Pinto Kirley Marques Canuto

10.1016/j.fitote.2017.09.021

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