Kevin Y. Chen

University of California, Los Angeles

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Kimberly Nixon

The University of Texas at Austin

Justin A. McClain

University of Kentucky

Dayna M. Hayes

Radford University

Hui Peng

University of Science and Technology of China

Chelsea R. Geil Nickell

University of Kentucky

Kaitlyn Buhlinger

University of North Carolina at Chapel Hill

J. Ryan Shaw

University of North Carolina at Chapel Hill

Kelly M. Brunk

University of North Carolina at Chapel Hill

Wesley R. Armstrong

Molecular Theranostics (United States)

Bianka Patel

UNC Lineberger Comprehensive Cancer Center

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University of North Carolina at Chapel Hill

University of North Carolina Health Care

University of Kentucky

University of North Carolina Hospitals

University of California, Los Angeles

UNC Lineberger Comprehensive Cancer Center

Virginia Commonwealth University

The University of Texas at Austin

Universitat Autònoma de Barcelona

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Type 2 Neural Progenitor Cell Activation Drives Reactive Neurogenesis after Binge-Like Alcohol Exposure in Adolescent Male Rats

Frontiers in Psychiatry (2017)

Chelsea R. Geil Nickell Hui Peng Dayna M. Hayes Kevin Y. Chen Justin A. McClain

Excessive alcohol consumption during adolescence remains a significant health concern as alcohol drinking during adolescence increases the likelihood of an alcohol use disorder in adulthood by fourfold. Binge drinking in adolescence is a particular problem as binge-pattern consumption is the biggest predictor of neurodegeneration from alcohol and adolescents are particularly susceptible to the damaging effects of alcohol. The adolescent hippocampus, in particular, is highly susceptible to alcohol-induced structural and functional effects, including volume and neuron loss. However, hippocampal structure and function may recover with abstinence and, like in adults, a reactive burst in hippocampal neurogenesis in abstinence may contribute to that recovery. As the mechanism of this reactive neurogenesis is not known, the current study investigated potential mechanisms of reactive neurogenesis in binge alcohol exposure in adolescent, male rats. In a screen for cell cycle perturbation, a dramatic increase in the number of cells in all phases of the cycle was observed at 7 days following binge ethanol exposure as compared to controls. However, the proportion of cells in each phase was not different between ethanol-exposed rats and controls, indicating that cell cycle dynamics are not responsible for the reactive burst in neurogenesis. Instead, the marked increase in hippocampal proliferation was shown to be due to a twofold increase in proliferating progenitor cells, specifically an increase in cells colabeled with the progenitor cell marker Sox2 and S-phase (proliferation) marker, BrdU, in ethanol-exposed rats. To further characterize the individual subtypes of neural progenitor cells (NPCs) affected by adolescent binge ethanol exposure, a fluorescent quadruple labeling technique was utilized to differentiate type 1, 2a, 2b, and 3 progenitor cells simultaneously. At one week into abstinence, animals in the ethanol exposure groups had an increase in proliferating type 2 (intermediate progenitors) and type 3 (neuroblast) progenitors but not type 1 neural stem cells. These results together suggest that activation of type 2 NPCs out of quiescence is likely the primary mechanism for reactive hippocampal neurogenesis following adolescent alcohol exposure.

Binge drinking

10.3389/fpsyt.2017.00283

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Citations (11)

Testing of a Program to Automatically Analyze Students’ Concept Maps

Pharmacy (2020)

Robert Hubal Laura J. Bobbitt Sarah Garfinkle Suzanne C. Harris Brandon Powell

Concept maps are graphical representations of how various concepts relate to one another. Assessment of concept maps developed by students in the pharmacy curriculum helps to evaluate student understanding of course material. However, providing feedback on concept maps can be time-consuming and often requires the grader to be a content expert. The purpose of this study was to develop and validate a software program to provide students with feedback on their concept map performance. Student maps for four different disease states were compared against expert concept maps. The analysis of the program compared favorably to a manual assessment of student maps for the maps' complexity and content but did not correlate for their organization. The value of using a software program to quickly and efficiently analyze concept maps is discussed.

Concept map

10.3390/pharmacy8040209

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Citations (2)

Increased expression of M1 and M2 phenotypic markers in isolated microglia after four-day binge alcohol exposure in male rats

Alcohol (2017)

Hui Peng Chelsea R. Geil Nickell Kevin Y. Chen Justin A. McClain Kimberly Nixon

CD86

Entorhinal cortex

10.1016/j.alcohol.2017.02.175

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Citations (90)

Activation of neural stem cells from quiescence drives reactive hippocampal neurogenesis after alcohol dependence

Neuropharmacology (2018)

Dayna M. Hayes Chelsea G. Nickell Kevin Y. Chen Justin A. McClain Megan M. Heath

10.1016/j.neuropharm.2018.01.032

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Citations (13)

Plerixafor strategies for autologous hematopoietic cell transplant mobilization: A comparison of efficacy and cost

Transfusion and Apheresis Science (2021)

Kevin Y. Chen Tyler G. Bucci J. Ryan Shaw Maurice Alexander Tatjana Grgic

Plerixafor

Mobilization

Leukapheresis

10.1016/j.transci.2021.103303

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Citations (5)

Alcohol and adult hippocampal neurogenesis: Promiscuous drug, wanton effects

Progress in Neuro-Psychopharmacology and Biological Psychiatry (2014)

Chelsea Geil Dayna M. Hayes Justin A. McClain Daniel J. Liput S. Alex Marshall

Neuropathology

10.1016/j.pnpbp.2014.05.003

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Citations (87)

Fam-Trastuzumab-Deruxtecan and Osimertinib Combination to Target HER2 Driven Resistance in a NSCLC Patient Following Osimertinib Progression: Case Report

JTO Clinical and Research Reports (2025)

Hirokazu Hirata Carrie B. Lee Kevin Y. Chen

Osimertinib

Acquired resistance

10.1016/j.jtocrr.2025.100787

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Pharmacists’ Role in Managing Patients with Chronic Lymphocytic Leukemia

Pharmacy (2020)

Kevin Y. Chen Kelly M. Brunk Bianka Patel K. Stöcker Jessica Auten

Chronic lymphocytic leukemia (CLL) is a hematologic malignancy that has seen significant advances in care over the last 5 years with the approval of oral agents such as ibrutinib and venetoclax for the treatment of this disease. As such, there has been a substantial shift away from the traditional chemotherapy infusions which have allowed patients greater autonomy with oral cancer therapies. This paradigm shift poses new challenges for the medical team, including drug–drug interactions, adherence counseling, and financial toxicity. Pharmacists are uniquely trained and equipped to help to manage the changing landscape of CLL care. From identifying common medications which may impair ibrutinib clearance to ensuring patients are on the appropriate anti-infective prophylaxis while receiving obinutuzumab, pharmacists can play a vital role in ensuring the highest quality of patient care. Furthermore, additional credentialing of clinical pharmacists in select states allows for independent visits with the pharmacists, allowing for greater involvement, particularly for initiation of venetoclax and management of ibrutinib-induced toxicities. Pharmacists are essential to both expanding and enhancing the care of patients with CLL and should be leveraged to improve patient outcomes whenever possible.

Venetoclax

Credentialing

Obinutuzumab

10.3390/pharmacy8020052

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Citations (8)

ASO Visual Abstract: Larger Tumor Size and Elevated Serum Chromogranin A Levels Predict Metastatic Disease on DOTATATE Imaging in Patients with Gastroenteropancreatic Neuroendocrine Tumors

Annals of Surgical Oncology (2024)

Amanda Labora Takayuki Shimizu Alexandra Moore Alykhan Premji Wesley R. Armstrong

Chromogranin A

Surgical oncology

10.1245/s10434-024-15740-9

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Citations (0)