Andréa Arantes Braga

Unité de Recherche Pluridisciplinaire Sport, Santé, Société

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Danielle Leite Cunha de Queiroz

Universidade de Fortaleza

Fabiana Cardoso Pereira Valera

Universidade de Ribeirão Preto

Alexandre Rambaud

Hôpital de la Tour

MÂ

Miguel Ângelo Hyppolito

Universidade de São Paulo

Rosário Dominguez Crespo Hirata

Universidade de São Paulo

Mário Hiroyuki Hirata

Universidade de São Paulo

Marisa Santos

Instituto Nacional de Cardiologia

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Álan Luiz Éckeli

Universidade de São Paulo

Eduardo Tanaka Massuda

Universidade de São Paulo

Marcelo Ferraz Sampaio

Beneficência Portuguesa de São Paulo

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Universidade de São Paulo

Clinics Hospital of Ribeirão Preto

Universidade de Ribeirão Preto

Fundação de Medicina Tropical

Universidade Estadual de Campinas (UNICAMP)

Instituto Dante Pazzanese de Cardiologia

Universidade Federal da Bahia

Universidad de La Frontera

Weatherford College

Universidade do Estado do Amazonas

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Adherence of obstructive sleep apnea syndrome patients to continuous positive airway pressure in a public service,

Figshare (2021)

Danielle Leite Cunha de Queiroz Mariane Sayuri Yui Andréa Arantes Braga Mariana L. Coelho Daniel S. Küpper

Introduction: The standard therapy for obstructive sleep apnea syndrome (OSAS) is continuous positive airway pressure (CPAP), but its correct and frequent use is essential to control the disease. Purpose: To analyze adherence to CPAP among patients with OSAS treated in a multidisciplinary outpatient clinic of a public tertiary hospital. Methods: This was a retrospective study evaluating 156 patients with OSAS who underwent polysomnography for CPAP titration from 2008 to 2011. The patients were divided into two groups, those with good adherence to CPAP (a mean use of four or more hours per night) and those with poor adherence. The groups were compared regarding the following data: gender, age, body mass index, associated diseases, AHI at diagnostic polysomnography, and pressure (cmH2O) suggested by titration polysomnography. Results: 125 patients were analyzed, and it was observed that 82 of the patients (65%) had good adherence, whereas 43 (35%) showed poor adherence. Comparison between groups revealed that patients with a higher apnea-hypopnea index (AHI) were those who better adhered to treatment with CPAP. Conclusions: the rate of adherence to CPAP among OSAS patients undergoing clinical monitoring at a public service was 65%. Patients with a higher AHI were those who adhered better to treatment with CPAP.

Sleep

10.6084/m9.figshare.14289095

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O benefício da gelatina hemostática absorvível em pó (Spongostan powder) comparada ao Gelfoam em timpanoplastias

Revista Brasileira de Otorrinolaringologia (2013)

Carlos Henrique Simões Matheus Cecília de Oliveira Bruni Carvalho Danielle Leite Cunha de Queiroz Andréa Arantes Braga Adriano H. Braga

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NOC-9, a selective nitric oxide donor, induces flight reactions in the dorsolateral periaqueductal gray of rats by activating soluble guanylate cyclase

Neuroscience Letters (2009)

Andréa Arantes Braga Daniele C. Aguiar Francisco Silveira Guimarães

Previous studies have showed that SIN-1, a nitric oxide (NO) donor, injected into the dorsolateral column of the periaqueductal gray (dlPAG) induces flight reactions. This drug, however, can also produce peroxynitrite, which may interfere in this effect. In addition, it is also unknown if this effect is mediated by local activation of soluble guanylate cyclase (sGC). The aims of this study, therefore, were (1) to investigate if NOC-9 (6-(2-Hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-hexanamine), a NO donor that does not produce peroxynitrite, would produce flight reactions after intra-dlPAG administration similar to those induced by SIN-1; (2) to verify if these responses could be prevented by local injection of a selective guanylate cyclase inhibitor (ODQ). Male Wistar rats (n=5-12) with cannulae aimed at the dlPAG received injections of TRIS (pH 10.0, 0.5 microl), NOC-9 (75 and 150 nmol), saline or SIN-1 (200 nmol) and were placed in an open arena for 10 min. In a subsequent experiment animals (n=7-8) were pretreated with ODQ (1 nmol/0.5 microl) before receiving NOC-9 150 nmol. NOC-9 induced a significant dose-dependent increase in flight reactions in the first minute after injection (% of animals displaying flight: vehicle=0%, NOC 75=67%, NOC 150=75%). SIN-1 had a similar effect (100% of animals showing flight) but the effects lasted longer (10 min) than those of NOC-9. The effect of NOC-9 (150 nmol) was prevented by pretreatment with ODQ (% of animals displaying flight: vehicle+NOC 150=71%, ODQ+NOC 150=37%). The results suggest that NO donors injected into the dlPAG induce defensive responses that are not mediated by secondary peroxynitrite production. Moreover, they also indicate that these defensive responses depend on activation of local sGC. The data strengthen the proposal that NO can modulate defensive reactions in the dlPAG.

Periaqueductal gray

Soluble guanylyl cyclase

10.1016/j.neulet.2009.05.009

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An Experimental Model of Eosinophilic Chronic Rhinosinusitis Induced by Bacterial Toxins in Rabbits

American Journal of Rhinology and Allergy (2019)

Andréa Arantes Braga Fabiana Cardoso Pereira Valera Francesca Maia Faria Maria Rossato Adriana Andrade Batista Murashima

Background The pathophysiology of chronic rhinosinusitis (CRS) is still not well known due to the multifactorial etiologies involved. Bacteria play a role in the pathogenesis of CRS by various means, including biofilm adhesion, intracellular persistence, or inducing inflammation secondary to toxins. Endotoxins and exotoxins, especially Staphylococcus aureus superantigens, can produce significant immune responses in the host and are implicated in patients with CRS. The majority of animal models described for CRS revalidates the pathophysiology of acute sinusitis, ostium occlusion, or foreign body associated infection. Objectives To evaluate an experimental model of eosinophilic CRS using prolonged exposure to bacterial toxins. The histological changes in rabbits exposed to S. aureus enterotoxin B (SEB), lipopolysaccharide (LPS), or lipoteichoic acid (LTA) were compared. Methods After induction with ovalbumin (OVA) sensitization with subcutaneous injection for 2 weeks, rabbits underwent surgery to insert an indwelling catheter into the maxillary sinus. The sinus was irrigated with OVA 3 times weekly for 2 weeks, followed by sinus irrigation with bacterial toxin (SEB: 1 µg/mL, LPS: 100 ng/mL, or LTA: 100 ng/mL) 3 times weekly for 4 weeks. The histological changes in the treated sinus were compared with control rabbits. Results Sinuses exposed to bacterial toxins (SEB, LPS, and LTA) produced significant mucosal thickening with infiltration of inflammatory cells, notably eosinophils. SEB was the only toxin that promoted a mixed pattern of inflammation, including eosinophilic and neutrophilic infiltration. Conclusion Our experimental model of eosinophilic CRS in rabbits produced significant mucosal thickening and inflammation in the sinuses exposed to bacterial toxins, with histological changes analogous to what is observed in patients with CRS with nasal polyps. This model may serve as a basis for future investigation of the pathogenesis of eosinophilic CRS in relation to bacterial toxins or as a model for testing new therapeutic modalities for this disease.

Pathophysiology

Cellular infiltration

10.1177/1945892419865642

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Évaluation et entraînement avec électromyogramme de surface (sEMG) des muscles intrinsèques du pied

Journal de Traumatologie du Sport (2024)

Andréa Arantes Braga Florian Forelli Jean Mazeas Alexandre Rambaud

10.1016/j.jts.2024.09.001

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Acute coronary syndrome and gene polymorphisms influence leukocyte mRNA expression of adhesion molecules and inflammatory proteins