Gerlândia N. Pontes

Hospital Israelita Albert Einstein

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Magda Carneiro‐Sampaio

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Margareth Afonso Torres

Hospital Israelita Albert Einstein

Patrícia Palmeira

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Juliana Emilia Prior Carnavalli

Fleury S.A. (Brazil)

Regina Célia Mingroni‐Netto

Universidade de São Paulo

M. E. Moraes

Universidade de São Paulo

Lilian Kimura

Universidade de São Paulo

Diogo Meyer

Universidade de São Paulo

Kelly Nunes

Universidade de São Paulo

Bruno Zagonel Piovezan

Hospital de Clínicas Universidade Federal do Paraná

Cooperative Institutions

Universidade de São Paulo

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Universidade Brasil

Hospital Universitário da Universidade de São Paulo

Universidade Federal de São Paulo

Instituto Butantan

Brazilian Biosciences National Laboratory

Hospital Israelita Albert Einstein

Universidade Cidade de São Paulo

Universidade Federal do Paraná

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Pineal melatonin and the innate immune response: the TNF‐α increase after cesarean section suppresses nocturnal melatonin production

Journal of Pineal Research (2007)

Gerlândia N. Pontes Elaine Cristina Cardoso Magda Carneiro‐Sampaio Regina P. Markus

Abstract: The nocturnal surge of melatonin is the endocrine expression of the circadian system and is essential for organizing the timing of various endogenous processes. Previous works suggest that, in the beginning of a defense response, the increase in circulating tumor necrosis factor‐α (TNF‐α) leads to a transient block of nocturnal melatonin production and promotes a disruption of internal time organization. In the present paper, the concentration of melatonin and cytokines [TNF‐α, interferon‐γ (IFN‐γ), interleukin (IL)‐2, IL‐4, IL‐5, IL‐10, IL‐12] in the colostrum (postdelivery day 3) and in the milk (postdelivery days 10, 15, 20 and 30) obtained at midday and midnight from mothers who gave birth by vaginal or cesarean section were compared. The nocturnal melatonin surge observed 3 days after vaginal delivery was absent after cesarean section. IL‐12 presented no daily variation in either case, while daily variations in IFN‐γ, IL‐10, IL‐4 and IL‐5 were observed after vaginal delivery and cesarean section. On the other hand, the increase in TNF‐α after cesarean section resulted in suppression of the nocturnal melatonin surge. Daily variation of IL‐2 was only observed after recovery of the nocturnal melatonin surge, 30 days after cesarean section. The present paper supports the hypothesis of a cross‐talk between the pineal gland and the immune system, which could represent a putative immune–pineal axis.

10.1111/j.1600-079x.2007.00487.x

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Citations (110)

Preterm and term neonates transplacentally acquire IgG antibodies specific to LPS fromKlebsiella pneumoniae, Escherichia coliandPseudomonas aeruginosa

FEMS Immunology & Medical Microbiology (2011)

Ana Lúcia Silveira Lessa Vera Lúcia Jornada Krebs Tatiana Braga Brasil Gerlândia N. Pontes Magda Carneiro‐Sampaio

High incidences of Gram-negative bacteria are found in neonatal nosocomial infections. Our aim was to investigate placental transmission of immunoglobulin G (IgG) reactive with lipopolysaccharide from Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli O111, O6 and O26. The total and lipopolysaccharide-specific IgM and IgG were determined in 11 maternal/umbilical-cord sera aged ≤33 weeks (GI); 21 aged >33 and <37 weeks (GII); and 32 term newborns (GIII). The total and lipopolysaccharide-specific IgM concentrations were equivalent in maternal sera. The total IgG concentrations were equivalent in maternal and newborn sera, with the exception of GIII newborns as compared with their mothers (P<0.0001) and with neonates from GI and GII (P<0.05). Lipopolysaccharide-specific IgG concentrations were lower in GI neonates than in their mothers (P<0.01) and lower in GII (P<0.05). Lower lipopolysaccharide-specific IgG levels were observed among neonates only for O111 in GI (P<0.05) and for O26 and Pseudomonas in GII, both as compared with GIII (P<0.05). The anti-lipopolysaccharide IgG transfer ratios were lower in GI (except for O26) and in GII (except for Klebsiella and O111) as compared with GIII (P<0.05). Our results suggest that the greater susceptibility to infections in preterm infants is influenced (besides the humoral response) by factors intrinsic and extrinsic to the condition of prematurity.

Klebsiella

Immunoglobulin M

10.1111/j.1574-695x.2011.00807.x

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Citations (27)

Salivary lysozyme levels in patients with primary immunodeficiencies

Allergologia et Immunopathologia (2005)

Mariana Acenjo Kmiliauskis Patrícia Palmeira C. Arslanian Gerlândia N. Pontes B.T. Costa-Carvalho

Primary Immunodeficiency

10.1157/13072915

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Citations (16)

Protective of the antibodies of colostrum from human mothers in animals challemged with viable escherichia coli 06:K2AC

Clinics (2010)

G Comenale Sílvia Maria Gomes Massironi D L Friedlander Del-Nero Magda Carneiro‐Sampaio Gerlândia N. Pontes

Source

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HLA imputation in an admixed population: An assessment of the 1000 Genomes data as a training set

Human Immunology (2015)

Kelly Nunes Xiuwen Zheng Margareth Afonso Torres M. E. Moraes Bruno Zagonel Piovezan

Imputation (statistics)

1000 Genomes Project

Genome-wide Association Study

SNP

Training set

10.1016/j.humimm.2015.11.004

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Citations (29)

Transfer of antibodies across the placenta and in breast milk from mothers on intravenous immunoglobulin

Pediatric Allergy and Immunology (2009)

Patrícia Palmeira Beatriz Tavares Costa‐Carvalho Christina Arslanian Gerlândia N. Pontes Aparecida Tiemi Nagao

We studied the levels of immunoglobulins in colostrum, milk and sera from two common variable immunodeficiency (CVID) mothers (M1 and M2), and in sera from their newborn infants. During pregnancy they continued intravenous immunoglobulin therapy (IVIG). Antibody levels from maternal and cord blood collected at delivery and colostrum and milk, collected on the 3rd and 7th post-partum days, respectively, were analyzed. Although cord/maternal blood ratios of total immunoglobulins and subclasses, as well as specific antibodies differed between M1 and M2, both showed good placental transfer of anti-protein and anti-polysaccharide antibodies, despite lower cord/maternal blood ratios in M2. Anti-Streptococcus pneumoniae antibody avidity indexes were similar between paired maternal and cord serum. Both mothers' colostrum and milk samples showed only traces of IgA, and IgM and IgG levels in colostrum were within normal range in M1, whereas M2 presented elevated IgG and low IgM levels, when compared with healthy mothers. The study of colostrum and milk activity showed that they strongly inhibited enteropathogenic Escherichia coli adhesion in vitro. CVID patients must be informed about the relevance of regular IVIG administration during pregnancy, not only for their own health but also for their immune immature offspring. Breast-feeding should be encouraged as colostra from these CVID patients strongly inhibited E. coli adhesion to human epithelial cells thus providing immunological protection plus nutritional and psychological benefits for the infant.

10.1111/j.1399-3038.2008.00828.x

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Citations (73)

Population variation of HLA genes in rural communities in Brazil, the Quilombos from the Vale do Ribeira, São Paulo – Brazil

Human Immunology (2016)

Kelly Nunes Bruno Zagonel Piovezan Margareth Afonso Torres Gerlândia N. Pontes Lilian Kimura

Rural population

10.1016/j.humimm.2016.04.007

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Citations (9)

A new HLA-C∗02 null allele described in quilombo remnants samples from southern brazil

Human Immunology (2015)

Kelly Nunes Margareth Afonso Torres Bruno Zagonel Piovezan Gerlândia N. Pontes Lilian Kimura

Null allele

10.1016/j.humimm.2015.07.194

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Citations (0)

Minimal concentration of human IgM and IgG antibodies necessary to protect mice from challenges with live O6 Escherichia coli

FEMS Immunology & Medical Microbiology (2011)

Sílvia Maria Gomes Massironi Christina Arslanian Magda Carneiro‐Sampaio Gerlândia N. Pontes

This work evaluated the ability of human anti-lipopolysaccharide O6 IgM and IgG antibodies to protect mice challenged with Escherichia coli serotype O6 : K2ac. Purified IgM-effluent, purified IgG, pools of normal human serum (NHS), or control group were injected into mice 18 h before challenges with O6 E. coli. Interleukin 6 and tumor necrosis factor alpha were quantified in the sera of test and control groups. All mice receiving purified IgM-effluent (66.6 mg L(-1) of anti-lipopolysaccharide O6 IgM antibodies) and NHS survived. Purified IgG (1.1 mg L(-1) of anti-lipopolysaccharide O6 IgG antibodies) protected 87.5% of the animals. The control group showed no protective ability. The minimal concentration of anti-lipopolysaccharide O6 IgM antibodies, able to protect 50% of the animals was 33.3 mg L(-1) of purified IgM-effluent, whereas purified IgG was able to protect 50% of the animals with only 1.1 mg L(-1) of anti-lipopolysaccharide O6 IgG antibodies. Serum from animals pretreated with purified IgM-effluent and purified IgG before challenges with lipopolysaccharide O6 did not have detectable pro-inflammatory cytokines. Hepatocytes of the control group were completely invaded by bacteria, whereas none was found in animals pretreated with purified IgM-effluent and purified IgG. Higher concentrations of anti-lipopolysaccharide O6 IgM antibodies as compared to anti-lipopolysaccharide O6 IgG antibodies were needed to protect mice from challenges with E. coli O6 serotype.

Immunoglobulin M

10.1111/j.1574-695x.2011.00841.x

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Citations (1)

92-P

Human Immunology (2013)

Maria Elisabete de Moraes Matilde Romero Maria I. Hue Gerlândia N. Pontes Margareth Afonso Torres

10.1016/j.humimm.2013.08.167

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Citations (0)