You have accessJournal of Urology1 Apr 2009HIGH RESOLUTION MAPPING OF THE ALPHA-1A-ADRENERGIC RECEPTOR SUBTYPE IN MALE MOUSE UROGENITAL ORGANS Chihiro Hosoda, Bat-Erdene Myagmar, Philip M Swigart, Brian C Jensen, and Paul C Simpson Chihiro HosodaChihiro Hosoda More articles by this author , Bat-Erdene MyagmarBat-Erdene Myagmar More articles by this author , Philip M SwigartPhilip M Swigart More articles by this author , Brian C JensenBrian C Jensen More articles by this author , and Paul C SimpsonPaul C Simpson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60425-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "HIGH RESOLUTION MAPPING OF THE ALPHA-1A-ADRENERGIC RECEPTOR SUBTYPE IN MALE MOUSE UROGENITAL ORGANS." The Journal of Urology, 181(4S), pp. 147–148 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 147-148 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Chihiro Hosoda More articles by this author Bat-Erdene Myagmar More articles by this author Philip M Swigart More articles by this author Brian C Jensen More articles by this author Paul C Simpson More articles by this author Expand All Advertisement PDF downloadLoading ...

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10.1016/s0022-5347(09)60425-0

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A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart

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Randell C. Thomas Abhishek Singh Patrick M. Cowley Bat‐Erdene Myagmar Megan D. Montgomery

The authors used 52 nonfailing and failing human hearts to develop a simple, high throughput left ventricular myocardial slice model that is stable by ATP and viability assays for at least 3 days. The model supports studies of signaling, contraction, and viral transduction. They use the model to show for the first time that the alpha-1A-adrenergic receptor, which is present at very low abundance in the human myocardium, activates cardioprotective ERK with nanomolar EC50 in failing heart slices and stimulates a positive inotropic effect. This model should be useful for translational studies, to test whether molecules discovered in basic experiments are functional in the human heart.

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10.1016/j.jacbts.2016.03.005

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