Dahu Qi

Henan Provincial People's Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Jun Xiao

Tongji Hospital

Hao Zhu

Huazhong University of Science and Technology

Chuankun Zhou

Huazhong University of Science and Technology

Xi Yuan

Jilin Normal University

Hui Liu

Yulin Normal University

Tenghui Tao

Huazhong University of Science and Technology

Xuying Sun

Tongji Hospital

Yusheng Shi

Huazhong University of Science and Technology

Shuai‐Bin Hua

Huazhong University of Science and Technology

Meipeng Zhu

Huazhong University of Science and Technology

Cooperative Institutions

Huazhong University of Science and Technology

Tongji Hospital

Sun Yat-sen University

Wuhan University

Ministry of Education of the People's Republic of China

Guangzhou Medical University

The First Affiliated Hospital, Sun Yat-sen University

Henan Provincial People's Hospital

Zhengzhou University

Central South University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Variable Reduction in Particle Least Squares (PLS) Analysis through Variation Projection Method

Lasers, Sources, and Related Photonic Devices (2012)

Dahu Qi

A variation projection method is proposed to 1) remove the redundant variables in spectrum, and improve the measurement accuracy in partial least squares (PLS) prediction. The algorithm was tested on urine Raman spectra taken on a liquid core optical fiber Raman spectroscopy system. The variables were effectively removed without affecting the final prediction accuracy.

Least-squares function approximation

Projection method

10.1364/lacsea.2012.lt6b.4

Cite

Citations (0)

Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss

Frontiers in Pharmacology (2021)

Dahu Qi Hui Liu Xuying Sun Danni Luo Meipeng Zhu

Osteoporosis is characterized by bone loss and destruction of trabecular architecture, which greatly increases the burden on the healthcare system. Excessive activation of osteoclasts is an important cause of osteoporosis, and suppression of osteoclastogenesis is helpful for the treatment of osteoporosis. Pristimerin, a natural compound, possesses numerous pharmacological effects via inactivating the NF-κB and MAPK pathways, which are closely related to osteoclastogenesis process. However, the relationship between Pristimerin and osteoclastogenesis requires further investigation. In this research, we examined the effect of Pristimerin on osteoclastogenesis and investigated the related mechanisms. Our results showed Pristimerin inhibited RANKL-induced osteoclast differentiation and osteoclastic bone resorption in vitro , with decreased expression of osteoclastogenesis-related markers including c-Fos, NFATc1, TRAP, Cathepsin K, and MMP-9 at both mRNA and protein levels. Furthermore, Pristimerin suppressed NF-κB and MAPK signaling pathways, reduced reactive oxygen species (ROS) production and activated the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) signaling during osteoclastogenesis. Our in vivo experiments showed that Pristimerin remarkably ameliorated ovariectomy-induced bone loss, reduced serum levels of TNF-α, IL-1β, IL-6, and RANKL, and increased serum level of osteoprotegerin (OPG). Therefore, our research indicated that Pristimerin is a potential chemical for the treatment of osteoporosis.

Cathepsin K

10.3389/fphar.2020.621110

Cite

Citations (8)

3D printed tricalcium phosphate-bioglass scaffold with gyroid structure enhance bone ingrowth in challenging bone defect treatment

Applied Materials Today (2021)

Hao Zhu Meng Li Xiaolong Huang Dahu Qi Liebert Parreiras Nogueira

Gyroid

10.1016/j.apmt.2021.101166

Cite

Citations (44)