Samir Acherar

Laboratoire de Chimie Physique

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Céline Frochot

Université de Lorraine

Régis Vanderesse

Université de Lorraine

Philippe Arnoux

Université de Lorraine

Brigitte Jamart‐Grégoire

Université de Lorraine

Eugénie Romero

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Ludovic Colombeau

Institut Curie

Ralph‐Olivier Moussodia

Université de Lorraine

Francis Baros

Centre National de la Recherche Scientifique

Jérôme Babin

Centre National de la Recherche Scientifique

Habib Nasri

University of Monastir

Cooperative Institutions

Centre National de la Recherche Scientifique

147

Université de Lorraine

119

Inserm

Laboratoire Réactions et Génie des Procédés

Laboratoire de Chimie Physique

Centre de Recherche en Automatique de Nancy

Laboratoire de Chimie-Physique Macromoléculaire

Columbia University

University of Pisa

University of Pavia

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Use of lipase-catalyzed kinetic resolution for the enantioselective approach toward sesquiterpenes containing quaternary centers: the cuparane family

Tetrahedron Asymmetry (2003)

Samir Acherar Gérard Audran Nicolas Vanthuyne Honoré Monti

Kinetic resolution

Absolute Configuration

Vinyl acetate

Stereoisomerism

10.1016/s0957-4166(03)00445-2

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Citations (17)

Targeted porphyrins ans nanoparticles for both detection and photodynamic therapy

Céline Frochot Samir Acherar Henri Azaïs Muriel Barberi‐Heyob Serge Mordon

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Citations (0)

Use of Cyclodextrins in Anticancer Photodynamic Therapy Treatment

Molecules (2018)

Amina Ben Mihoub Ludivine Larue Albert Moussaron Zahraa Youssef Ludovic Colombeau

Photodynamic therapy (PDT) is mainly used to destroy cancerous cells; it combines the action of three components: a photoactivatable molecule or photosensitizer (PS), the light of an appropriate wavelength, and naturally occurring molecular oxygen. After light excitation of the PS, the excited PS then reacts with molecular oxygen to produce reactive oxygen species (ROS), leading to cellular damage. One of the drawbacks of PSs is their lack of solubility in water and body tissue fluids, thereby causing low bioavailability, drug-delivery efficiency, therapeutic efficacy, and ROS production. To improve the water-solubility and/or drug delivery of PSs, using cyclodextrins (CDs) is an interesting strategy. This review describes the in vitro or/and in vivo use of natural and derived CDs to improve antitumoral PDT efficiency in aqueous media. To achieve these goals, three types of binding modes of PSs with CDs are developed: non-covalent CD–PS inclusion complexes, covalent CD–PS conjugates, and CD–PS nanoassemblies. This review is divided into three parts: (1) non-covalent CD-PS inclusion complexes, covalent CD–PS conjugates, and CD–PS nanoassemblies, (2) incorporating CD–PS systems into hybrid nanoparticles (NPs) using up-converting or other types of NPs, and (3) CDs with fullerenes as PSs.

Conjugate

10.3390/molecules23081936

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Citations (48)

Targeted Photodynamic Therapy using a Vectorized Photosensitizer coupled to Folic Acid Analog induces Ovarian Tumor Cell Death and inhibits IL-6-mediated Inflammation

Journal of Controlled Release (2024)

Léa Boidin Morgane Moinard Albert Moussaron Margaux Merlier Olivier Moralès

Ovarian cancer (OC) is one of the most lethal cancers among women. Frequent recurrence in the peritoneum due to the presence of microscopic tumor residues justifies the development of new therapies. Indeed, our main objective is to develop a targeted photodynamic therapy (PDT) treatment of peritoneal carcinomatosis from OC to improve the life expectancy of cancer patients. Herein, we propose a targeted-PDT using a vectorized photosensitizer (PS) coupled with a newly folic acid analog (FAA), named PSFAA, in order to target folate receptor alpha (FRα) overexpressed on peritoneal metastasis. This PSFAA was the result of the coupling of pyropheophorbide-a (Pyro-a), as the PS, to a newly synthesized FAA via a polyethylene glycol (PEG) spacer. The selectivity and the PDT efficacy of PSFAA was evaluated on two human OC cell lines overexpressing FRα compared to fibrosarcoma cells underexpressing FRα. Final PSFAA, including the synthesis of a newly FAA and its conjugation to Pyro-a, was obtained after 10 synthesis steps, with an overall yield of 19%. Photophysical properties of PSFAA in EtOH were performed and showed similarity with those of free Pyro-a, such as the fluorescence and singlet oxygen quantum yields (Φf = 0.39 and ΦΔ = 0.53 for free Pyro-a, and Φf = 0.26 and ΦΔ = 0.41 for PSFAA). Any toxicity of PSFAA was noticed. After light illumination, a dose-dependent effect on PS concentration and light dose was shown. Furthermore, a PDT efficacy of PSFAA on OC cell secretome was detected inducing a decrease of a pro-inflammatory cytokine secretion (IL-6). This new PSFAA has shown promising biological properties highlighting the selectivity of the therapy opening new perspectives in the treatment of a cancer in a therapeutic impasse.

Folate receptor

HeLa

10.1016/j.jconrel.2024.05.033

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Citations (1)

Vascular targeting for the treatment of glioblastoma by PDT

HAL (Le Centre pour la Communication Scientifique Directe) (2017)

Céline Frochot Ludovic Colombeau Eloïse Thomas Régis Vanderesse Magali Toussaint

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Synthesis, X-ray molecular structure and QTAIM and NCI-RDG theoretic studies of a new cadmium (II) (4′4 diaminodiphenylmethane) (meso-arylporphyrin) coordination compound

Inorganic Chemistry Communications (2021)

Chadlia Mchiri Bouzid Gassoumi Samir Acherar Marwa A.M.Sh. El‐Sharief Habib Nasri

Atoms in molecules

Monoclinic crystal system

Non-covalent interactions

10.1016/j.inoche.2021.108924

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Citations (9)

Using X-rays in photodynamic therapy: an overview

Photochemical & Photobiological Sciences (2018)

Lionel Larue Amina Ben Mihoub Zahraa Youssef Ludovic Colombeau Samir Acherar

Photon Upconversion

Treatment modality

Modality (human–computer interaction)

10.1039/c8pp00112j

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Citations (106)

New Crystal Form of Human Neuropilin-1 b1 Fragment with Six Electrostatic Mutations Complexed with KDKPPR Peptide Ligand

Molecules (2023)

Ibrahima Goudiaby Thérèse E. Malliavin Eva Mocchetti Sandrine Mathiot Samir Acherar

Neuropilin 1 (NRP1), a cell-surface co-receptor of a number of growth factors and other signaling molecules, has long been the focus of attention due to its association with the development and the progression of several types of cancer. For example, the KDKPPR peptide has recently been combined with a photosensitizer and a contrast agent to bind NRP1 for the detection and treatment by photodynamic therapy of glioblastoma, an aggressive brain cancer. The main therapeutic target is a pocket of the fragment b1 of NRP1 (NRP1-b1), in which vascular endothelial growth factors (VEGFs) bind. In the crystal packing of native human NRP1-b1, the VEGF-binding site is obstructed by a crystallographic symmetry neighbor protein, which prevents the binding of ligands. Six charged amino acids located at the protein surface were mutated to allow the protein to form a new crystal packing. The structure of the mutated fragment b1 complexed with the KDKPPR peptide was determined by X-ray crystallography. The variant crystallized in a new crystal form with the VEGF-binding cleft exposed to the solvent and, as expected, filled by the C-terminal moiety of the peptide. The atomic interactions were analyzed using new approaches based on a multipolar electron density model. Among other things, these methods indicated the role played by Asp320 and Glu348 in the electrostatic steering of the ligand in its binding site. Molecular dynamics simulations were carried out to further analyze the peptide binding and motion of the wild-type and mutant proteins. The simulations revealed that specific loops interacting with the peptide exhibited mobility in both the unbound and bound forms.

10.3390/molecules28145603

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Citations (3)

Spontaneous self-assembly

HAL (Le Centre pour la Communication Scientifique Directe) (2015)

E Romero Ralph‐Olivier Moussodia Samir Acherar Brigitte Jamart‐Grégoire

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New cadmium(II) porphyrin-based coordination dimer: Experimental and theoretic studies

Journal of Solid State Chemistry (2022)

Chadlia Mchiri Bouzid Gassoumi Houcine Ghalla Samir Acherar Ilona Turowska-Tyrke

Bridging ligand

10.1016/j.jssc.2022.123364

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Citations (6)