Eliahu Bishburg

Newark Beth Israel Medical Center

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Sandhya Nagarakanti

Mayo Clinic in Florida

Sagy Grinberg

Newark Beth Israel Medical Center

Alexis K. Okoh

Emory University

Madhu Suryadevara

Newark Beth Israel Medical Center

Sandhya Nalmas

Newark Beth Israel Medical Center

Anita Bapat

Jehangir Hospital

Trini Chan

Newark Beth Israel Medical Center

Christian Engell

Newark Beth Israel Medical Center

Monica Shah

Memorial Sloan Kettering Cancer Center

David A. Baran

Cleveland Clinic Florida

Cooperative Institutions

Baxter (United States)

Baxter (India)

Newark Beth Israel Medical Center

RELX Group (United States)

New York Proton Center

Lindsay Unified School District

Communities In Schools of Orange County

Oregon Medical Research Center

Rutgers, The State University of New Jersey

University of Pittsburgh

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Gram-Negative Ventricular Assist Device Infections Experience in a Tertiary Care Hospital

Open Forum Infectious Diseases (2015)

Ami Patel Eliahu Bishburg Sandhya Nagarakanti Melinda Brown

Tertiary care

Gram

10.1093/ofid/ofv133.117

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Gram negative bacillary catheter related blood stream infection in the era of increased resistance

International Journal of Infectious Diseases (2010)

Vikas Kapoor Christian Engell Eliahu Bishburg

Background: Gram negative bacilli (GN) are recognized as an important cause of catheter related blood stream infections (CRBSI). CRBSI caused by resistant GN (RGN) is less well described. Our objective was to 1) evaluate whether cases with discharge diagnosis of GNCRBSI were diagnosed appropriately based on predetermined criteria, and whether correct diagnosis had an effect on outcome 2) describe the epidemiology of GN-CRBSI and its impact on patient outcomes. Methods: A retrospective chart review in a 670 bed tertiary care hospital from 1/2002- 11/2008. Patients with discharge diagnosis of CRBSI and GN bacteremia were included. Definite GN-CRBSI was defined as positive cultures (PC) from peripheral blood and either positive central venous catheter (CVC) or CVC tip cultures without another source of GN bacteremia. Probable GN-CRBSI was defined as positive CVC blood cultures or CVC tip cultures and no other source of infection. Data was collected for demographics, diagnoses, type and site of CVC, bacterial isolates, length of stay, and outcomes. Results: Ninety two patients were included: 25 met criteria for definite GN-CRBSI and 24 met criteria for probable GN-CRBSI. 43(47%) patients did not meet our criteria for CRBSI: 23 had another source of bacteremia, 19 had PC from peripheral blood only. Comparison between patients with definite and probable GN CRBSI and patients without these diagnoses did not show a difference in mortality (12% vs 7%, p = 0.39) or median time to discharge (13 days vs 10days: p = 0.92). Of all the GN isolated, Klebsiella spp. (59%) and Enterobacter spp. (25%) predominated. Twenty percent (10/49) of all GN isolates from definite and probable CRBSI were RGN including extended spectrum $ lactamase producing isolates and multidrug resistant isolates. Twenty-four percent (12/49) of patients received inappropriate initial antibiotics and 83% (10/12) of these were patients who had RGN. Mortality trended higher in patients with RGN infection compared to other GN bacilli (3/10, 30% vs. 3/39, 7.7%; p = 0.06). Conclusion: Most patients diagnosed with GN-CRBSI did not meet our strict criteria for diagnosis, a fact that suggests that GN-CRBSI is misdiagnosed. However, the true diagnosis of GN-CRBSI does not clearly impact mortality or median length of stay. There was a nonsignificant trend towards increased mortality in patients with RGN infection. Antibiotics active against RGN should be considered as part of initial empiric coverage. Abstracts for SupplementInternational Journal of Infectious DiseasesVol. 14Preview Full-Text PDF Open Archive

Bacteremia

Blood stream

Blood Culture

Bloodstream infection

Central venous catheter

10.1016/j.ijid.2010.02.2064

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Staphylococcus capitis prosthetic valve endocarditis: Report of two rare cases and review of literature

Heart & Lung (2008)

Sandhya Nalmas Eliahu Bishburg Jeremias Meurillio Sargis Khoobiar Marc Cohen

10.1016/j.hrtlng.2007.09.005

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Clinical outcomes of patients with COVID‐19 and HIV coinfection

Journal of Medical Virology (2020)

Sandhya Nagarakanti Alexis K. Okoh Sagy Grinberg Eliahu Bishburg

Patients with human immunodeficiency virus (HIV) infection may be at an increased risk for morbidity and mortality from the coronavirus disease 2019 (COVID-19). We present the clinical outcomes of HIV patients hospitalized for COVID-19 in a matched comparison with historical controls.We conducted a retrospective cohort study of HIV patients admitted for COVID-19 between March 2020 and April 2020 to Newark Beth Israel Medical Center. Data on baseline clinical characteristics and hospital course were documented and compared with that of a matched control group of COVID-19 patients who had no history of HIV. Kaplan-Meier survival curves and the log-rank tests were used to estimate and compare in-hospital survival between both unmatched and matched groups.Twenty-three patients with HIV were hospitalized with COVID-19. The median age was 59 years. The rates of in-hospital death, the need for mechanical ventilation, and intensive care unit (ICU) admission were 13% (n = 3), 9% (n = 2), and 9% (n = 2), respectively. The HIV infection was well-controlled in all patients except for three patients presented with acquired immune deficiency syndrome (AIDS). All AIDS patients were discharged home uneventfully. A one-to-one propensity matching identified 23 COVID-19 patients who served as a control group. In both pre- and post-match cohorts, survival between HIV and control groups were comparable.In our cohort of HIV-infected patients hospitalized for COVID-19, there was no difference in mortality, ICU admission, and the need for mechanical ventilation when compared with a matched control of COVID-19 patients with HIV.

10.1002/jmv.26533

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ICE volume 29 issue 1 Cover and Front matter

Infection Control and Hospital Epidemiology (2008)

Paul A. Carling Parry Von Beheren Mark E. Rupp Teresa Fitzgerald

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Front cover

10.1017/s0195941700047445

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Empiric Acyclovir Use for Suspected Herpes Simplex Meningoencephalitis: How Are We Doing?

Open Forum Infectious Diseases (2016)

Daniel Assefa Sagy Grinberg Emmanuel Achu Sandhya Nagarakanti Eliahu Bishburg

Aciclovir

10.1093/ofid/ofw172.884

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Influenza Vaccination Among Medical Residents in a Teaching Hospital

Infection Control and Hospital Epidemiology (2007)

Eliahu Bishburg Monica Shah A. Scott Mathis

We assessed the rates of influenza vaccine acceptance and the reasons for acceptance or refusal among medical residents in different disciplines during the 2004-2005 influenza season. Rates varied among disciplines; emergency department residents had the lowest acceptance rate (24%). The perception of a low risk of contracting influenza was the most common reason reported for vaccine refusal.

Influenza season

10.1086/524322

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Is Minocycline an Antiviral Agent? A Review of Current Literature

Basic & Clinical Pharmacology & Toxicology (2015)

Sandhya Nagarakanti Eliahu Bishburg

Minocycline is a second-generation semi-synthetic derivative of tetracycline and has well-known anti-bacterial effects. The drug possesses anti-inflammatory, anti-oxidant, anti-apoptotic and immunomodulatory effects. The drug is widely used in bacterial infections and non-infectious conditions such as acne, dermatitis, periodontitis and neurodegenerative conditions. Minocycline was shown to have antiviral activity in vitro and also against different viruses in some animal models. Some studies have been done on human patients infected with Human Immunodeficiency Virus. We have review the available data regarding minocycline activity as an antiviral agent.

Minocycline

10.1111/bcpt.12444

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Cumulative AIDS Incidence And Altered Mortality from Bacterial Infections

AIDS Research and Human Retroviruses (1990)

Daniel Fife Giles L. Crane Eliahu Bishburg

To determine whether populations with high cumulative incidence of acquired immunodeficiency syndrome (AIDS) experienced increased deaths from sepsis, central nervous system abscess, or endocarditis, New Jersey AIDS patients were grouped according to their age, sex, race, and residence-specific cumulative incidence of AIDS since the onset of the AIDS epidemic. Between 1980 and 1986, among 25-44 year olds in the highest cumulative incidence group for AIDS, sepsis mortality increased from 3.3 to 15.2 deaths/100,000/year, an increase of 11.9 deaths/100,000/year (95% confidence interval (6.9, 17.0) deaths/100,000/year); mortality from central nervous system abscesses increased from zero to 1.7 (0.1, 3.2) deaths/100,000/year; and mortality from endocarditis increased from 0.8 deaths/100,000/year to 2.4 deaths/100,000/year, an increase of 1.6 (-0.5, 3.7) deaths/100,000/year. Age-matched New Jersey patient populations with low cumulative incidence of AIDS did not sustain a similar increase. The HIV disease-associated increase in sepsis mortality among young populations represents a new component of the substantial increase in U.S. sepsis mortality that occurred over the last two decades, but was previously limited to older populations.

Cumulative incidence

10.1089/aid.1990.6.1203

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1383. Malaria Prophylaxis Use In a Travel Clinic, How Are We Doing?

Open Forum Infectious Diseases (2023)

Dennis Hogan Eliahu Bishburg Madhu Suryadevara

Abstract Background Malaria chemoprophylaxis is indicated for travelers going to geographic areas designated as endemic for malaria. Often persons traveling to their native countries where malaria is present consider themselves immune and decline chemoprophylaxis. This study aimed to evaluate malaria chemoprophylaxis utilization in a travel clinic and whether it is correlated with the patient’s native place. Methods A retrospective study of patients attending a travel clinic between 2021 to 2023. Data were extracted on demographics, trip destinations, trip duration, and, malaria chemoprophylaxis prescribed. Pharmacies were contacted to verify prescription filling. Patients admitted with malaria were analyzed at the same time period. Comparison between groups was made using a chi-square test. p < 0.05 is considered significant. Results One hundred patients were included. Median age 55.5 years (21-80). 62 % (62) were females while 38% were males. There were ninety-four 94 travelers to Africa, 6 to South America, and 1 to Asia. Of the travelers, 44 were US natives while 56 were non-US natives. The median trip duration was 14 and 15 days among US and non-US natives respectively. All 100 patients received prescriptions for malaria prophylaxis: Atovaquone/Proguanil was prescribed to 94, while 6 were given mefloquine. Of the 100 prescriptions, 58 were filled. Of the 44 travelers who were US natives,33/44 (75 %) filled their prescriptions. Among the 56 non-US natives, 25/56 (44 %) filled prescriptions, p -0.002. During the study period, 10 patients (6 females and 4 males) were admitted with a diagnosis of malaria in returning travelers, median age of 54.5 years. The median trip duration was 19 days. All were non-US natives returning from Africa (Nigeria, Ghana, Guinea, and Mali). Only 1/10 patients took mefloquine chemoprophylaxis. All the patients were treated successfully without sequelae. Conclusion In our travel clinic malaria chemoprophylaxis was prescribed to all patients as indicated, US native patients filled their prescriptions significantly more than nonnative patients. Malaria in returning travelers was diagnosed exclusively in non-US natives who did not take malaria chemoprophylaxis. Disclosures All Authors: No reported disclosures

Chemoprophylaxis

Malaria prophylaxis

Travel medicine

Proguanil

10.1093/ofid/ofad500.1220

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