David A. Gerber

University of North Carolina at Chapel Hill

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Jeffrey H. Fair

The University of Texas Health Science Center at Houston

Mark W. Johnson

University of Michigan–Ann Arbor

Chirag S. Desai

University of North Carolina at Chapel Hill

A. Sidney Barritt

University of North Carolina at Chapel Hill

Lola M. Reid

University of North Carolina at Chapel Hill

Alan M. Kraut

American University

George Mazariegos

University of Pittsburgh

Kenneth A. Andreoni

Thomas Jefferson University

Andrew M. Moon

University of North Carolina at Chapel Hill

Lisa Samuelson

University of North Carolina at Chapel Hill

Cooperative Institutions

University of North Carolina at Chapel Hill

274

Park Plaza Hospital

150

Level (Czechia)

132

University of North Carolina Health Care

University of Pittsburgh

Johns Hopkins University

Duke University

University of Michigan–Ann Arbor

University of Pittsburgh Medical Center

University of North Carolina Hospitals

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Primary Gianturco Stent Placement for Inferior Vena Cava Abnormalities following Liver Transplantation

Journal of Vascular and Interventional Radiology (2000)

Susan Mace Weeks David A. Gerber Paul F. Jaques Jeet Sandhu Mark W. Johnson

10.1016/s1051-0443(07)61462-6

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Citations (69)

Impact of kidney transplant on post‐operative morbidity and mortality in patients with pre‐operative cardiac dysfunction

Clinical Transplantation (2022)

Aman Kumar Caroline Naso Daniel R. Bacon Chris B. Agala David A. Gerber

Several studies show an increase in complications, both cardiac and non-cardiac, and a higher mortality in patients with preexisting cardiac disease when they undergo elective surgery. Due to the high incidence of cardiac dysfunction in patients with concomitant chronic kidney disease, we wanted to determine if the same negative impact is demonstrated in patients undergoing kidney transplantation.A retrospective analysis was done on 582 patients who underwent kidney transplant from a single transplant center between 2014 and 2019. Participants for this study were divided into two groups based on cardiac ejection fraction: normal EF (≥40%) (n = 540) and low EF (<40%) (n = 33); exclusion criteria included patients undergoing multi-organ transplants (n = 9). Characteristics and outcomes of patients were compared before and after transplant using chi-square tests for categorical measures, and either Kruskal-Wallis or paired Student's t tests for continuous measures. Overall survival (OS) between groups was assessed using the Kaplan-Meier test. We compared outcomes between the normal EF and low EF groups using logistic regression in raw data, and propensity score matched sample and inverse-probability-weighting to mitigate selection bias.There was no significant difference in survival between patients in the low EF and normal EF groups (p = .33). Among patients with low EF, mean EF after transplant significantly improved (mean: 55.83% ± 5.75%) compared to mean EF before transplant (38.28% ± 7.35%), (p = < .0001). Of the patients with a low EF before transplant, 1 in 5 had a history of CAD, compared to only 1 in 10 among those patients with a normal EF, p = .0657. Post-transplant complications were comparable between the groups.Patients undergoing kidney transplantation with a low ejection fraction do not demonstrate an increased incidence of morbidity or mortality in the peri- and post-transplant follow-up compared with patients with a normal ejection fraction. Cardiac events post-transplantation is also comparable between the two groups. Of note, patients with a low EF have a significantly improved EF after kidney transplant which is likely a function of improvement in their physiologic state after the kidney transplant.

Concomitant

10.1111/ctr.14878

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Citations (4)

Liver transplantation in Ellis–van Creveld syndrome: A case report

Pediatric Transplantation (2002)

Dalliah Black Jason C. Reutter Mark W. Johnson Jeffrey H. Fair John T. Woosley

Abstract: This case represents a rare association of Ellis–van Creveld (EvC) syndrome, a chondroectodermal disorder, with congenital paucity of bile ducts. Sequential liver biopsies during the patient's childhood demonstrated progressive fibrosis that can occur in other chondrodysplastic malformations. However, this EvC case is the first report to demonstrate paucity of intra‐hepatic bile ducts progressing to cirrhosis and subsequently requiring transplant.

Congenital hepatic fibrosis

Congenital disorder

10.1034/j.1399-3046.2002.01085.x

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Citations (6)

Histo-morphology of the Uterus and Early Placenta of the African Buffalo (Syncerus caffer) and Comparative Placentome Morphology of the African Buffalo and Cattle (Bos taurus)

Placenta (2005)

Susanne Schmidt David A. Gerber John T. Soley T. A. Aire Alois Boos

Bubalus

Trophoblast

Conceptus

10.1016/j.placenta.2005.09.008

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Citations (26)

Safely expanding surgical resection for patients with hepatocellular carcinoma and cirrhosis

Digestive Medicine Research (2020)

David A. Gerber

Surgical resection

10.21037/dmr-20-42

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Citations (0)

Technique of Right Laparoscopic Donor Nephrectomy: A Single Center Experience

American Journal of Transplantation (2001)

Mark W. Johnson Kenneth A. Andreoni Lynn McCoy Lisa Scott Beverly Rodegast

The majority of laparoscopic donor nephrectomies (LDNs) are limited to the left side due to technical and allograft concerns in using the right. We review our experience with right LDNs. Since June 1997, 15 right LDNs were performed and the records retrospectively reviewed for demographics, operative time, transfusions, complications, and length of stay. Recipient records were also reviewed for delayed graft function, complications, and serum creatinine levels. Overall donor, recipient and graft survivals at 6 months are 100%. Mean operative time was 317 +/- 11.0 min, length of stay was 4.2 +/- 0.2 d, and mean serum creatinine levels at discharge, 1, 3, and 6 months were 1.74 +/- 0.19, 1.59 +/- 0.13, 1.72 +/- 0.13, and 1.68 +/- 0.13 mg/dL, respectively. No transfusions were required. There were no operative or hospital complications. Two recipients (13.3%) experienced delayed graft function, defined as requiring hemodialysis post-transplantation. With hand-assisted laparoscopy, the right laparoscopic donor nephrectomy is safe and allows excellent allograft function.

Single Center

Demographics

10.1034/j.1600-6143.2001.001003293.x

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Citations (21)

359 Neo-Kidney Augment (NKA): Phase II Study of Percutaneous Renal Injection of Autologous Homologous NKA in Subjects with Type 2 Diabetes and CKD

American Journal of Kidney Diseases (2020)

Joseph Stavas Tim Bertram Ashely Johns Deepak Jain David A. Gerber

Augment

10.1053/j.ajkd.2020.02.361

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Towards the creation of decellularized organ constructs using irreversible electroporation and active mechanical perfusion

BioMedical Engineering OnLine (2010)

Michael B. Sano Robert E. Neal Paulo A. Garcia David A. Gerber John L. Robertson

Abstract Background Despite advances in transplant surgery and general medicine, the number of patients awaiting transplant organs continues to grow, while the supply of organs does not. This work outlines a method of organ decellularization using non-thermal irreversible electroporation (N-TIRE) which, in combination with reseeding, may help supplement the supply of organs for transplant. Methods In our study, brief but intense electric pulses were applied to porcine livers while under active low temperature cardio-emulation perfusion. Histological analysis and lesion measurements were used to determine the effects of the pulses in decellularizing the livers as a first step towards the development of extracellular scaffolds that may be used with stem cell reseeding. A dynamic conductivity numerical model was developed to simulate the treatment parameters used and determine an irreversible electroporation threshold. Results Ninety-nine individual 1000 V/cm 100-μs square pulses with repetition rates between 0.25 and 4 Hz were found to produce a lesion within 24 hours post-treatment. The livers maintained intact bile ducts and vascular structures while demonstrating hepatocytic cord disruption and cell delamination from cord basal laminae after 24 hours of perfusion. A numerical model found an electric field threshold of 423 V/cm under specific experimental conditions, which may be used in the future to plan treatments for the decellularization of entire organs. Analysis of the pulse repetition rate shows that the largest treated area and the lowest interstitial density score was achieved for a pulse frequency of 1 Hz. After 24 hours of perfusion, a maximum density score reduction of 58.5 percent had been achieved. Conclusions This method is the first effort towards creating decellularized tissue scaffolds that could be used for organ transplantation using N-TIRE. In addition, it provides a versatile platform to study the effects of pulse parameters such as pulse length, repetition rate, and field strength on whole organ structures.

Decellularization

Irreversible Electroporation

10.1186/1475-925x-9-83

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Citations (111)

Anti-Semitism in American History

Journal for the Scientific Study of Religion (1987)

Michael Kent Curtis David A. Gerber

10.2307/1385806

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Citations (94)

Listening to Disabled People: The Problem of Voice and Authority in Robert B. Edgerton's the Cloak of Competence

Disability Handicap & Society (1990)

David A. Gerber

ABSTRACT Using anthropological methods and a theoretical perspective derived from the sociology of Erving Goffman, Robert B. Edgerton's The Cloak of Competence: stigma in the lives of the mentally retarded (1967) brought an unusual degree of empathy to attempts to understand the lives of those labeled 'mentally retarded'. Yet the book was conceived prior to the time when mental retardation began to be widely formulated as a social construction rather than a clinical syndrome. This essay analyzes the consequences for Edgerton's understanding of the lives of recently deinstitutionalized people of this uneasy combination of empathy and acceptance of mental retardation as an unalterable condition. Particular attention is paid to the ways in which Edgerton's conceptualization of mental retardation served to deny to members of his sample a voice with which to speak authoritatively about their own situation. Edgerton's revisionist follow-up research, which called into question some aspects of his earlier conceptualization of mental retardation, is also discussed.

Mentally retarded

10.1080/02674649066780011

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Citations (35)