Pravin Popatrao Kale

Shri Vile Parle Kelavani Mandal

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i-10 index

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Co-Authors

Gaurav Doshi

Shri Vile Parle Kelavani Mandal

Veeranjaneyulu Addepalli

Dr. D. Y. Patil Medical College, Hospital and Research Centre

Pramod Kadu

Shri Vile Parle Kelavani Mandal

Kedar S. Prabhavalkar

Shri Vile Parle Kelavani Mandal

Nirav Bhatia

Shri Vile Parle Kelavani Mandal

Jay Savai

Narsee Monjee Institute of Management Studies

Angel Godad

Shri Vile Parle Kelavani Mandal

Amrita Sarkar

Children's Hospital of Philadelphia

Janhavi Naik

Vishwakarma University

P. S. Rodrigues

Shri Vile Parle Kelavani Mandal

Cooperative Institutions

Shri Vile Parle Kelavani Mandal

Narsee Monjee Institute of Management Studies

University of Mumbai

Savitribai Phule Pune University

King Edward Memorial Hospital and Seth G.S. Medical College

Dr. D.Y. Patil Vidyapeeth, Pune

Bharati Vidyapeeth Deemed University

Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College

Equinox (United States)

Tata Memorial Hospital

Author Statistics

Papers

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Finite element analysis of LPG cylinder

AIP conference proceedings (2022)

Hitesh Shinde Pravin Popatrao Kale Swapnil More

This paper study deals with selection of different material used for construction of Liquified Petroleum Gas cylinder which is used in our day-to-day life. Solidwork-2020 is used for modelling of LPG Cylinder. finite element analysis (FEA) of LPG cylinders made of Low carbon Steel and E-Glass Epoxy composites has been carried out. They are subjected to internal pressure. ANSYS (version 2021) has been used to Analyze the LPG cylinder. Both Static structural Analysis and Dynamic analysis is done. The Ansys results of deformation and stresses for Low Carbon steel & composite cylinders are compared which are built of Low carbon steel (LCS) and E-Glass Epoxy are studied.

Carbon fibers

Liquefied petroleum gas

Internal pressure

10.1063/5.0111486

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Citations (0)

Importance of glucose and its metabolism in neurodegenerative disorder, as well as the combination of multiple therapeutic strategies targeting α-synuclein and neuroprotection in the treatment of Parkinson's disease

Revue Neurologique (2023)

Azeem Siddique Pravin Popatrao Kale

Phosphoglycerate kinase

Trimetazidine

10.1016/j.neurol.2023.08.011

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Citations (0)

Batch distillation for separating the acetone and n-heptane binary azeotrope mixture: Optimization and simulation

Journal of the Indian Chemical Society (2022)

Pravin Popatrao Kale Siddhesh Pujari Jotiram Gujar Renuka Sontakke Ejaz I. Haddadi

Batch distillation

UNIFAC

Azeotrope

Heptane

Azeotropic distillation

Continuous distillation

Extractive distillation

10.1016/j.jics.2022.100795

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Citations (11)

Potentiation of Antidepressant Effects of Agomelatine and Bupropion by Hesperidin in Mice

Neurology Research International (2018)

Jegan Sakthivel Nadar Pravin Popatrao Kale Pramod Kadu Kedar S. Prabhavalkar Ruchita Ravindra Dhangar

Hesperidin, a well-known flavanone glycoside mostly found in citrus fruits, showed neuroprotective and antidepressant activity. Agomelatine, a melatonergic MT 1 /MT2 agonist and 5-HT2C receptor antagonist, exhibits good antidepressant efficacy. Bupropion has been widely used for the treatment of depression because of its dopamine and norepinephrine reuptake inhibition. The objective of present study was to assess the antidepressant effects of hesperidin combination with agomelatine or bupropion. Male Swiss Albino mice received treatment of saline, vehicle, ‘hesperidin alone’, ‘agomelatine alone’, hesperidin+agomelatine, ‘bupropion alone’, hesperidin+bupropion, and agomelatine+bupropion for 14 days. The immobility period was analysed 30 min after the treatment in forced swim and tail suspension tests. Dopamine and serotonin levels were analysed in hippocampus, cerebral cortex, and whole brain using HPLC with fluorescence detector. Hesperidin plus agomelatine treated group was better in terms of decrease in immobility period and increase in dopamine and serotonin levels when compared to their respective monotherapy treated groups.

Bupropion

Agomelatine

10.1155/2018/9828639

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Citations (14)

Isolation, Screening, Characterization and Maintenance of Amylase Producing Bacteria from Soil

International Journal for Research in Applied Science and Engineering Technology (2022)

Avinash Gadhave Mahesh S Wagh Pravin Popatrao Kale Sagar Bhakare

Abstract: Amylases are amongst most widely used enzymes in industries such as food, fermentation, starch processing, textile, and paper. In the present investigation, bacteria were isolated from soil samples of different areas of Padmashri Vikhe Patil College, Pravaranagar, Maharashtra, India screened for the production of amylase. Soil samples were serially diluted in normal saline and plated on sterile nutrient agar plates. The colonies obtained from higher dilutions were subjected to Gram staining, biochemical reactions, and starch hydrolysis test. Bacterial colony yielding positive starch hydrolysis test were subjected to Amylase activity test by DNSA method. Characteristic feature of the strain indicates that it belongs to the genus Bacillus and will be later used for further characterization. Maximum yield of amylase was obtained after 48hrs of incubation. The isolated amylase producing organism was maintain by using agar slant & glycerol stock method.

Nutrient agar

Serial dilution

10.22214/ijraset.2022.46121

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Citations (1)

Enhancement of nootropic effect of duloxetine and bupropion by caffeine in mice

Indian Journal of Pharmacology (2015)

Veeranjaneyulu Addepalli Pravin Popatrao Kale

Objective: The existing evidence suggests an association between depression and memory impairment. The objective of present study was to assess the effect of low dose caffeine with duloxetine and bupropion on memory.
Materials and Methods: Mice were divided randomly into seven groups. Intra-peritoneal treatment of normal saline (10 ml/kg), caffeine (10 mg/kg), duloxetine (10 mg/kg), bupropion alone (10 mg/kg), caffeine + duloxetine (5 mg/kg, each), caffeine + bupropion (5 mg/kg, each), and bupropion + duloxetine (5 mg/kg, each) were given to groups I-VII, respectively. Elevated plus maze was used to evaluate transfer latency (TL) and Morris water maze was used to estimate the time spent in target quadrant.
Results: Caffeine with duloxetine treated group was better than other combination treated groups in terms of a significant decrease in TL and increase in the time spent in target quadrant recorded.
Conclusion: Combining lower dose of caffeine with duloxetine may enhance cognitive benefits than respective monotherapies.

Bupropion

Nootropic

10.4103/0253-7613.153430

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Citations (3)

Combinational Approaches Targeting Neurodegeneration, Oxidative Stress, and Inflammation in the Treatment of Diabetic Retinopathy

Current Drug Targets (2021)

Siddhi Dilip Chalke Pravin Popatrao Kale

Diabetic Retinopathy (DR) is one of the most severe ocular problems of diabetes. It is a microvascular complication that impairs the vision of diabetic individuals and can cause acquired blindness. Currently, available treatment options like laser therapy, vitrectomy, intravitreal anti-vascular endothelial growth factor (VEGF) agents, and glucocorticoids help to reduce vision loss at advanced stages. In spite of the available therapies, patients with severe vision loss face difficulty in achieving the normal vision. There is a need for the development of newer treatment strategies to address the condition from the early stages. Multiple factors owing to complex pathophysiological events are responsible for this long-term complication. Neurodegeneration, inflammation, and oxidative stress are the three important factors associated with the development of DR. Oxidative stress is a major contributor to the onset and progression of DR. Pathological events like retinal neurodegeneration and inflammation damage the retina in the early stages of DR. Different combinations of treatments targeting these pathological events are discussed in the present review. The first combination discussed is citicoline and resveratrol and the second combination is duloxetine and N-acetyl cysteine (NAC). These combinations may help in the early stages of DR. CD5-2, and angiopoietin-2 inhibitors is the third combination and this combination may help to manage diabetic macular edema. The main purpose of this article is to discuss the link between these pathologies and the three combinational approaches with the objective of considerating newer therapeutic approaches in research related to DR treatment.

PEDF

10.2174/1389450122666210319113136

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Citations (25)

Mini review–vanadium-induced neurotoxicity and possible targets

Neurological Sciences (2019)

Madhuri Ramji Jaiswal Pravin Popatrao Kale

Neurotoxicity

10.1007/s10072-019-04188-5

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Citations (24)

Assessment of antidiabetic activity of combination of Murraya koenigii leaves extract and Vitis vinifera seeds extract in alloxan-induced diabetic rats

Journal of Reports in Pharmaceutical Sciences (2020)

Pravin Popatrao Kale ShreyaM Palwankar Pramod Kadu Kedar S. Prabhavalkar

Background: Murraya koenigii is a well-known curry leaf tree. Its leaves are used as a spice in food recipe in India. Its related antidiabetic activity is attributed to alpha glucosidase activity of carbazole alkaloids. The proanthocyanidins present in Vitis vinifera contribute to its hyperglycemic activity through antioxidant effect and preservation of β-cell function. Aims and Objective: The aim of this study was to assess antidiabetic effect of the combination of M. koenigii leaves extract and V. vinifera seeds extract. Materials and Methods: A total of 36 animals were randomly selected for the study and were divided in six different groups: control group, alloxan (130 mg/kg; intraperitoneal [i.p.]) treated group, alloxan (130 mg/kg) treatment + M. koenigii leaves extract (300 mg/kg; per oral [p.o.]) treated group, alloxan (130 mg/kg) i.p. treatment + V. vinifera seeds extract (200 mg/kg; p.o.) treated group, alloxan (130 mg/kg) + M. koenigii leaves extract (150 mg/kg; p.o.) treatment + V. vinifera seeds extract (100 mg/kg; p.o.) treated group, and alloxan (130 mg/kg) treatment + glibenclamide (5 mg/kg; i.p.) treated group. Treatment was given for 21 days after induction of diabetes. Result: The combination treated group showed a significant reduction in serum glucose levels when compared to individual test extracts. It also attenuated the elevated activity of alkaline phosphatase enzyme in diabetic rats as compared with the healthy controls. The combination treatment showed reversal of the serum glutamic oxaloacetic transaminase (P < 0.001) and serum glutamic pyruvic transaminase (P < 0.001) levels. It also significantly decreased cholesterol level to near normalcy (P < 0.001). Conclusion: The findings of this study suggest additive antidiabetic effect of the combination of M. koenigii leaves extract and V. vinifera seeds extract.

Alloxan

Murraya

Transaminase

Phytotherapy

10.4103/jrptps.jrptps_50_19

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Citations (6)

Caffeine-induced Augmentation of Antidepressant Therapy

Journal of Experimental & Clinical Medicine (2010)

Pravin Popatrao Kale Veeranjaneyulu Addepalli Pallavi Bafna Kedar S. Prabhavalkar

Stimulant

Depression

Clomipramine

10.1016/j.jecm.2010.09.001

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Citations (11)