Andrew Sharff

Global Phasing (United Kingdom)

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G. Bricogne

Global Phasing (United Kingdom)

Claus Flensburg

Global Phasing (United Kingdom)

Clemens Vonrhein

Global Phasing (United Kingdom)

Ian J. Tickle

Global Phasing (United Kingdom)

W. A. Paciorek

Global Phasing (United Kingdom)

Tina Izard

Scripps Research Institute

Harren Jhoti

Napp Pharmaceuticals (United Kingdom)

Ben F. Luisi

University of Cambridge

Florante A. Quiocho

Baylor College of Medicine

Oliver S. Smart

European Bioinformatics Institute

Cooperative Institutions

Centre National de la Recherche Scientifique

Global Phasing (United Kingdom)

Aix-Marseille Université

Inserm

Architecture et Fonction des Macromolécules Biologiques

University of Cambridge

KU Leuven

Romax Technology (United Kingdom)

Institute of Cancer Research

Janssen (Belgium)

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High throughput protein crystallography: Developments in crystallisation, data collection and data processing

Drug Discovery Today Technologies (2006)

Marc O’Reilly M. Vinković Andrew Sharff Harren Jhoti

Protein crystallization

Structural genomics

10.1016/j.ddtec.2006.11.001

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Citations (6)

automated NCS and target-structure restraints in

In Buster Oliver S. Smart Andrew Sharff See Profile Oliver S. Smart

Source

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Citations (0)

Structure of MELK in complex with inhibitors

Chalmers Johnson Valério Berdini Lijs Beke Peter‐Helmut Bonnet Dirk Brehmer

10.2210/pdb4d2p/pdb

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Refined Structures of Two Insertion/Deletion Mutants Probe Function of the Maltodextrin Binding Protein

Journal of Molecular Biology (1995)

Andrew Sharff Lynn E. Rodseth S Szmelcman Maurice Hoffnung Florante A. Quiocho

Maltodextrin

10.1006/jmbi.1994.0059

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Citations (22)

Human vinculin head domain Vh1 (residues 1-252) in complex with murine talin (VBS33; residues 1512-1546)

S.D. Yogesha Andrew Sharff G. Bricogne Tina Izard

Vinculin

Residue (chemistry)

10.2210/pdb3s90/pdb

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Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase

ACS Medicinal Chemistry Letters (2014)

Christopher N. Johnson Valério Berdini Lijs Beke Pascal Bonnet Dirk Brehmer

Fragment-based drug design was successfully applied to maternal embryonic leucine zipper kinase (MELK). A low affinity (160 μM) fragment hit was identified, which bound to the hinge region with an atypical binding mode, and this was optimized using structure-based design into a low-nanomolar and cell-penetrant inhibitor, with a good selectivity profile, suitable for use as a chemical probe for elucidation of MELK biology.

Zipper

Fragment (logic)

10.1021/ml5001245

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Citations (29)

Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export

Nature (2000)

Vassilis Koronakis Andrew Sharff Eva Koronakis Ben F. Luisi Colin Hughes

Efflux

Inner membrane

Transport protein

Structural Biology