Keiko Fujiwara

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Differences in characteristics of raters who use the visual estimation method in hospitals based on their training experiences

Clinical Nutrition (2018)

Yui Kawasaki Yuki Tamaura Rie Akamatsu Masashi Sakai Keiko Fujiwara

10.1016/j.clnu.2018.01.026

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Citations (4)

Synthesis of a Misfit-layered Magnesium Manganese Hydroxide Oxide

Chemistry Letters (2005)

Yaohua Xu Noriaki Nakayama Keiko Fujiwara Tadato Mizota Seishi Goto

Abstract A new magnesium manganese hydroxide oxide, [Mg(OH)2]10[MnO1.86(OH)0.07]14·2.34H2O, which has a novel incommensurate misfit-layered structure built from two pseudohexagonal MnO2 and Mg(OH)2 sheets, has been hydrothermally synthesized by using the layered birnessite as the precursor. This compound has been investigated by TEM, XRD, TG-DTA. The lattice parameters are a1 = 0.496(2), b1 = 0.292(5), c1 = 0.957(2) nm, and β1 = 94.1(9)° for manganese oxide sublattice, and a2 = 0.534(6), b2 = 0.313(6), c2 = 0.958(1) nm, and β2 = 94.8(4)° for magnesium hydroxide sublattice.

Birnessite

10.1246/cl.2005.448

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Citations (3)

Effect of ciclosporin on clinical signs of degenerative mucinotic mural folliculitis in a young cat

Veterinary Record Case Reports (2023)

T Mizoguchi Keiko Fujiwara Maiko Sekiguchi Toshiroh Iwasaki

Abstract A 1.5‐year‐old, spayed, female, mixed‐breed cat that had been housed completely indoors presented with a chief complaint of facial hair loss. Alopecia extended from the face to the outside of the auricle, and was accompanied by thickening of the dorsal eyelid and scales on the dorsal chest. Histopathological examination revealed infiltration of lymphocytes targeting the hair follicle wall and deposition of mucin in the isthmus of hair follicles. A diagnosis of degenerative mucinotic mural folliculitis was obtained based on the clinical and histological findings. The cat was treated with ciclosporin (9.3 mg/kg) administered once daily. The alopecia and thickening resolved, and the general condition improved. The cat was clinically well for 10 months. The cat has survived 14 months since treatment was started. This case demonstrates the efficacy of high‐dose ciclosporin in treating degenerative mucinotic mural folliculitis.

Ciclosporin

Folliculitis

Auricle

10.1002/vrc2.710

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Transfer of Tellurium and Cesium from Nutrient Solution to Radish (Raphanus sativus var. sativus) and Their Distribution in the Plant

Japanese Journal of Health Physics (2015)

Keiko Fujiwara Tomoyuki Takahashi Tadatoshi Kinouchi Satoshi Fukutani Yuki Hattori

Various radionuclides, including radioactive tellurium (Te), were released to the environment by the Fukushima nuclear power plant accident. The total amount of Te-127m released from the power plant was estimated to be 1.1 × 1015 Bq. The radioactive Te may have contributed to the internal radiation dose at the initial stage of the accident. However, data on the environmental behavior of radioactive Te are limited. In this study, therefore, the uptake of Te in plants was investigated. Radishes (Raphanus sativus var. sativus) were cultivated into a nutrient solution, grown for 20-30 days, and then their fine roots (taproots in the plant anatomy) and a part of fleshy roots (hypocotyls in the plant anatomy) were immersed for two hours into nutrient solutions with different Te and Cs concentrations. After soaking, plants were returned to the initial Te- and Cs-free nutrient solution for further maturation. ICP-MS measurements were made to assess concentrations of Te and Cs in the plants' leaves and fleshy roots (the fine roots were removed). Resulting differences among the individual plants were large. The leaf/fleshy root ratios of the concentration of Te and Cs were 0.09-1.14 and 1.59-5.00 on a fresh-matter basis, respectively. Both Te and Cs were absorbed by the radishes through the fine roots. There was a general tendency for Te to be retained in the fleshy roots, whereas Cs was mainly absorbed by the fine roots and then transferred to the leaves.

Raphanus

Taproot

10.5453/jhps.50.189

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Citations (1)

A case of chronic graft-versus-host-disease(GVHD)with multiple oral squamoous cell cartinomas in a patient

Japanese Society of Oral and Maxillofacial Surgeons (2019)

Keiko Fujiwara

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Congenital acantholytic dyskeratotic epidermal naevus following Blaschko's lines versus segmental Darier's disease.

PubMed (2007)

W. Huh Keiko Fujiwara Hidenori Takahashi Jean Kanitakis

A Japanese newborn male with an unremarkable family history presented at birth with verrucous papules on the left side of the trunk and limbs, distributed along Blaschko's lines. Histological examination showed mild acantholytic dyskeratosis, consistent with Darier's disease; however, search for mutations of the SERCA gene, performed on DNA extracted from cells from involved and uninvolved skin and peripheral blood proved negative. The absence of detectable SERCA mutations did not allow confirmation of the diagnosis of (segmental) Darier's disease, and a tentative diagnosis of congenital acantholytic dyskeratotic epidermal nevus was considered. The relationship between the two conditions is briefly discussed.

Darier's disease

Dyskeratosis

Dyskeratosis congenita

Darier Disease

10.1684/ejd.2007.0124

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Citations (18)

Development of a Zinc/Chlorine Battery for Electric Energy Storage Applications

H. Horie Keiko Fujiwara Y. Watakabe Toshiaki Yabumoto K. Ashizawa

Zinc compounds

10.2514/6.1987-9266

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Structure Refinement of the Partially Dehydrated Natural Chabazite Cal.57Na0.49Al3.39Si8.55O24·11.53H2O

Transactions of the Materials Research Society of Japan (2008)

Akihiko Nakatsuka Hironao Okada Keiko Fujiwara Noriaki Nakayama Tadato Mizota

Structure analysis of a slightly partially-dehydrated natural chabazite was carried out using single crystal X-ray diffraction. The presences of the five water sites and four exchangeable-cation sites, found in the fully hydrated sample investigated by our recent study (Nakatsuka et al., 2007), were also confirmed in the present partially dehydrated sample. The final structure refinement converged to R = 0.0280 and Rw = 0.0284 for 926 reflections. The occupancy of the water site located at the center of the 8-ring window in the [412 62 86]-cavity decreases significantly compared with that in the fully hydrated sample.

Chabazite

10.14723/tmrsj.33.907

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Decontamination technology of designated wastes as specified in act on special measures concerning the handling of radioactive pollution. Procedures of the on-site test

Yoko Fujikawa Keiko Fujiwara Hiroaki Ozaki Hiroshi Tsuno Aiichiro Fujinaga

Human decontamination

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Sensitive enzyme immunoassay for the quantification of bleomycin using beta-D-galactosidase as a label.

PubMed (1983)

Keiko Fujiwara Midori Isobe Hitoshi Saikusa Hideki Nakamura T. Kitagawa

A sensitive and specific enzyme immunoassay (EIA) for an anticancer drug, bleomycin (BLM), has been developed, which allows measurement of as little as 25 pg of the antibiotic/tube. An antibody to BLM was obtained by immunizing rabbits with an antigen prepared by conjugating BLM with mercaptosuccinylated bovine serum albumin via N-(gamma-maleimidobutyryloxy)succinimide as a coupling agent. Enzyme labeling of BLM was performed using beta-D-galactosidase (beta-Gal; EC 3.2.1.23) via N-(m-maleimidobenzoyloxy)succinimide. Free and antibody-bound BLM-beta-Gal conjugates were separated by precipitation of the antibody-bound fraction with a second antibody (anti-rabbit IgG). Displacement of BLM-beta-Gal by unlabeled BLM when plotted as a logit-log function was linear over a concentration range of 10 pg-1 ng. The antibody distinguished alterations in the terminal structure of BLM, showing 277% cross-reaction with BLM B2, 4.6% with A2, 0.42% with A2'-b, 0.13% with A5, and 0.07% with the second-generation analog peplomycin. The EIA is free from interference by other anticancer drugs. Using this assay, drug levels were easily determined in tissues of rats following sc administration at a dose of 500 micrograms/kg. The sensitivity and specificity of the EIA should provide a useful tool for developing pharmacokinetic and toxicity studies of BLM.

Succinimides

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Citations (10)