Sarah Schalekamp‐Timmermans

Erasmus MC

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Eric A.P. Steegers

Erasmus MC - Sophia Children’s Hospital

Vincent W. V. Jaddoe

Erasmus MC

Jeanine E. Roeters van Lennep

Erasmus MC

Laura Benschop

Erasmus University Rotterdam

Maria C. Adank

Erasmus University Rotterdam

Albert Hofman

Harvard University

Henning Tiemeier

Erasmus University Rotterdam

Tim I.M. Korevaar

Erasmus MC

M. Kamran Ikram

Erasmus MC

Yolanda B. de Rijke

Erasmus MC

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Erasmus MC

Erasmus University Rotterdam

Erasmus MC - Sophia Children’s Hospital

Harvard University

Rotterdam University of Applied Sciences

University Medical Center

University of Pittsburgh

University Medical Center Utrecht

Radboud University Nijmegen

Magee-Womens Research Institute

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Validation of a Semi-Quantitative Food-Frequency Questionnaire for Dutch Pregnant Women from the General Population Using the Method or Triads

Nutrients (2020)

Trudy Voortman Régine P.M. Steegers‐Theunissen Nienke E. Bergen Vincent W. V. Jaddoe Caspar W. N. Looman

Objective: We aimed to validate a food-frequency questionnaire (FFQ) for Dutch pregnant women, against three 24 h-recalls and blood concentrations of B-vitamins and fatty acids, using the method of triads. Methods: We included 83 pregnant women from the general population of Rotterdam, the Netherlands, at a median gestational age of 15.6 weeks. Participants completed three non-consecutive 24 h-recalls, and subsequently filled out the 293-item FFQ. Participants provided blood samples from which we analyzed serum folate and vitamin B12, as well as red blood cell folate, linoleic acid, and total saturated, monounsaturated, and polyunsaturated fatty acids. Results: Estimated energy intake did not differ between the FFQ and 24 h-recalls. Deattenuated Pearson’s correlation coefficients, between energy-adjusted nutrient intake estimates from the FFQ and the 24 h-recalls, ranged from 0.41 (fat) to 0.88 (fiber) for macronutrients, and were around 0.6 for most micronutrients, except for vitamin E (0.27). Using the triad method, we obtained validity coefficients of 0.86 (95% Confidence Interval (CI) 0.36, 1.00) for serum folate, 0.86 (95% CI 0.18, 1.00) for red blood cell folate, and 1.00 (95% CI 0.42, 1.00) for vitamin B12. Validity coefficients for serum fatty acids ranged from 0.22 to 0.67. Conclusion: This FFQ is a reliable tool for estimating intake of energy, macronutrients, folate and vitamin B12 among women in mid-pregnancy.

Food frequency questionnaire

10.3390/nu12051341

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Citations (22)

Gestational hypertensive disorders and retinal microvasculature: the Generation R Study

BMC Medicine (2017)

Laura Benschop Sarah Schalekamp‐Timmermans Jeanine E. Roeters van Lennep Vincent W.V. Jaddoe Tien Yin Wong

Changes in the microvasculature associated with pre-eclampsia and gestational hypertension have been proposed as a potential pathway in the development of cardiovascular disease. We examined whether gestational hypertensive disorders, such as pre-eclampsia and gestational hypertension, are related to the maternal retinal microvasculature status after pregnancy.This study is part of an ongoing population-based prospective cohort study. During pregnancy and 6.2 years after the index pregnancy (90% range 5.7-7.4 years), we examined 3391 women with available information on pre-eclampsia, gestational hypertension, and retinal vascular calibers. Retinal arteriolar and venular calibers were measured in the left eye from digitized retinal photographs.Women with pre-eclampsia had smaller retinal arteriolar calibers 6 years after pregnancy than women with a normotensive pregnancy (adjusted difference: -0.40 standard deviation score [SDS]; 95% confidence interval [CI]: -0.62, -0.19). For women with previous gestational hypertension, similar trends were observed (-0.20 SDS; 95% CI: -0.34, -0.05). With respect to retinal venular calibers, we did not observe consistent trends for women with previous pre-eclampsia. However, in women with previous gestational hypertension, we observed larger venular calibers (0.22 SDS; 95% CI: 0.07-0.36) than in women with a previous normotensive pregnancy. The association of gestational hypertensive disorders with retinal vessel calibers was mediated through mean arterial pressure at the time of retinal imaging.Compared to women with a previous normotensive pregnancy, women with pre-eclampsia and gestational hypertension show an altered status of the microvasculature 6 years after the index pregnancy. This is reflected by smaller retinal arteriolar calibers and wider retinal venular calibers. These microvascular changes may possibly contribute to the development of cardiovascular disease in later life.

Gestational hypertension

Generation R

10.1186/s12916-017-0917-2

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Citations (19)

List of Contributors

Elsevier eBooks (2022)

Bhavisha Bakrania Ira M. Bernstein Graham J. Burton Tereza Cindrová‐Davies Marilyn J. Cipolla

10.1016/b978-0-12-818417-2.01002-2

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56. Maternal lipid profile in early pregnancy as marker for adverse perinatal outcomes

Pregnancy Hypertension (2018)

Maria C. Adank Laura Benschop Alet W. Kors Kelly R. Peterbroers Vincent W. V. Jaddoe

Lipid Profile

Generation R

10.1016/j.preghy.2018.08.188

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57. The impact of having twins on maternal cardiovascular adaptation during and after pregnancy

Pregnancy Hypertension (2018)

Maria C. Adank Sarah Schalekamp‐Timmermans M. Kamran Ikram Vincent W. V. Jaddoe Eric A.P. Steegers

Twin Pregnancy

Generation R

10.1016/j.preghy.2018.08.189

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Gestational lipid profile as an early marker of metabolic syndrome in later life: a population-based prospective cohort study

BMC Medicine (2020)

Maria C. Adank Laura Benschop Sophia P. van Streun Anna M. Smak Gregoor Monique T. Mulder

Abstract Background In pregnancy lipid levels increase with gestation resembling an atherogenic lipid profile. Currently it is unclear whether gestational lipid levels are associated with an adverse cardiovascular risk profile later in life. The aim of this study is to assess the association between gestational lipid levels and lipid levels and prevalence of the metabolic syndrome (MS) six years after pregnancy. Methods In plasma of 3510 women from the Generation R Study; a prospective population-based cohort, we measured lipid levels (total cholesterol, triglycerides and high-density lipoprotein cholesterol [HDL-c]), and low-density lipoprotein cholesterol (LDL-c), remnant cholesterol and non-HDL-c were calculated in early pregnancy (median 13.2 weeks, 90% range [10.5 to 17.1]) and six years after pregnancy (median 6.5 years, 90% range [6.2 to 7.8]). MS was assessed six years after pregnancy according to the NCEP/ATP3 criteria. We also examined the influence of pregnancy complications on these associations. Results Gestational lipid levels were positively associated with corresponding lipid levels six years after pregnancy, independent of pregnancy complications. Six years after pregnancy the prevalence of MS was 10.0%; the prevalence was higher for women with a previous placental syndrome (13.5%). Gestational triglycerides and remnant cholesterol in the highest quartile and HDL-c in the lowest quartile were associated with the highest risk for future MS, independent of smoking and body mass index. Conclusions Gestational lipid levels provide an insight in the future cardiovascular risk profile of women in later life. Monitoring and lifestyle intervention could be indicated in women with an unfavorable gestational lipid profile to optimize timely cardiovascular risk prevention.

Lipid Profile

Generation R

Quartile

10.1186/s12916-020-01868-4

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Citations (21)

Additional file 2: Table S1. of Sex-specific differences in fetal and infant growth patterns: a prospective population-based cohort study

Figshare (2016)

Zoe Broere-Brown Esmé J. Baan Sarah Schalekamp‐Timmermans Bero O. Verburg Vincent W. V. Jaddoe

Adjusted linear regression analyses on fetal growth. (XLSX 12 kb)

Table (database)

10.6084/m9.figshare.c.3617408_d2