Yurie Fukui

Komatsu (Japan)

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Kôichi Narita

Tohoku Medical and Pharmaceutical University

Tadashi Katoh

Tohoku Medical and Pharmaceutical University

Minoru Yoshida

RIKEN Center for Sustainable Resource Science

Akihiro Ito

Tokyo University of Pharmacy and Life Sciences

Takao Yamori

Japanese Foundation For Cancer Research

Yui Sano

Komatsu (Japan)

Singo Dan

Japanese Foundation For Cancer Research

Cooperative Institutions

The University of Tokyo

Tohoku Medical and Pharmaceutical University

Komatsu (Japan)

Tohoku University

Sendai University

RIKEN Center for Sustainable Resource Science

RIKEN

Genomics (United Kingdom)

Japanese Foundation For Cancer Research

Osaka University

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ChemInform Abstract: Enantioselective Total Synthesis of Dysidavarone A, a Novel Sesquiterpenoid Quinone from the Marine Sponge Dysidea avara.

ChemInform (2014)

Yurie Fukui Kôichi Narita Tadashi Katoh

10.1002/chin.201435201

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Citations (0)

Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities

European Journal of Medicinal Chemistry (2012)

Kôichi Narita Yurie Fukui Yui Sano Takao Yamori Akihiro Ito

Depsipeptide

Romidepsin

Histone deacetylase inhibitor

Amide

10.1016/j.ejmech.2012.12.023

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Citations (26)

ChemInform Abstract: Total Synthesis of Bicyclic Depsipeptides Spiruchostatins C and D and Investigation of Their Histone Deacetylase Inhibitory and Antiproliferative Activities.

ChemInform (2013)

Kôichi Narita Yurie Fukui Yui Sano Takao Yamori Akihiro Ito

Abstract Spiruchostatins C (Ia) and D (Ib) possess extremely potent inhibitory activities against cyclic depsipeptide histone deacetylase 1, better than previously known spiruchostatins A and B and the clinically approved depsipeptide FK228.

Depsipeptide

Histone deacetylase inhibitor

10.1002/chin.201327188

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Citations (0)

Enantioselective Total Synthesis of Dysidavarone A, a Novel Sesquiterpenoid Quinone from the Marine Sponge Dysidea avara

Chemistry - A European Journal (2014)

Yurie Fukui Kôichi Narita Tadashi Katoh

Abstract Dysidavarone A, a structurally unprecedented sesquiterpenoid quinone, was synthesized in 30 % overall yield in a longest liner sequence of 13 steps from commercially available o ‐vanillin. A highly strained and bridged eight‐membered carbocyclic core was established by the C7C21 carbon bond formation through a copper enolate mediated Michael addition to the internal quinone ring.

Sponge

10.1002/chem.201304809

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Citations (28)

Total synthesis of burkholdacs A and B and 5,6,20-tri-epi-burkholdac A: HDAC inhibition and antiproliferative activity

European Journal of Medicinal Chemistry (2014)

Yurie Fukui Kôichi Narita Singo Dan Takao Yamori Akihiro Ito

Depsipeptide

Romidepsin

Histone deacetylase inhibitor

Amide

10.1016/j.ejmech.2014.02.044