ABSTRACT Patients with type 2 diabetes mellitus (DM) are more susceptible to microvascular complications. However, whether DM is associated with coronary microvascular dysfunction (CMD) is unclear. This observational study used data from the Coronary Microvascular Disease Registry (CMDR) (NCT05960474) and included patients with angina and no obstructive coronary artery disease (ANOCA) who underwent invasive CMD evaluation using the CoroVentis CoroFlow System (Abbott Vascular, Santa Clara, CA). Patient demographics, comorbidities, laboratory data, echocardiography, coronary angiography, and microvascular physiology results were analyzed. Among the 271 patients, 73 (26.9%) had DM. These patients were more likely to be African American (68.1% vs. 47.0%) and had higher rates of hypertension (93.2% vs. 74.2%), hyperlipidemia (89.0% vs. 68.7%), and chronic kidney disease (17.8% vs. 8.1%) than those without DM. Invasive coronary functional testing showed no significant differences in the index of microcirculatory resistance (IMR) (17.82 ± 8.17 vs. 19.37 ± 13.14, p = 0.268) or coronary flow reserve (CFR) (3.24 ± 1.73 vs. 3.21 ± 1.86, p = 0.909) between diabetic and nondiabetic patients. Similarly, in those testing positive for CMD, there were no significant differences in IMR (27.8 ± 7.4 vs. 32.35 ± 15.22, p = 0.108) or CFR (2.42 ± 1.09 vs. 2.05 ± 0.94, p = 0.199). Although patients with DM exhibited more comorbidities, CMD physiology indices were comparable between the groups.

Fractional Flow Reserve

Coronary flow reserve

Endothelial Dysfunction

10.1002/ccd.31429

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GENDER VARIATION IN CLINICAL OUTCOMES IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND CARDIOGENIC SHOCK: ANALYSIS FROM LARGE US HEALTHCARE SYSTEM

Journal of the American College of Cardiology (2023)

Mohit Pahuja Ryan Kabir Adam Johnson Itsik Ben‐Dor Hayder Hashim

Variation (astronomy)

Healthcare system

10.1016/s0735-1097(23)01571-1

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CORONARY MICROVASCULAR DYSFUNCTION (CMD) AS A LONG TERM SEQUELAE OF IMMUNE CHECKPOINT INHIBITOR (ICI)-RELATED MYOCARDITIS

Journal of the American College of Cardiology (2023)

Seyed Ebrahim Kassaian Hayder Hashim Eric E. Morgan Joshua E. Reuss Gaby Weissman

Cardiac Dysfunction

10.1016/s0735-1097(23)03399-5

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Noncompliant Balloon Shaft Rupture Resulting in Ascending Aortic Dissection

КАРДИОЛОГИЯ УЗБЕКИСТАНА (2023)

Ryan Kabir Gaby Weissman Toby Rogers Hayder Hashim Lowell F. Satler

Thoracic aorta

10.1016/j.jcin.2022.10.031

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Adverse events and failure modes related to Impella CP: Insights from the FDA MAUDE database

Cardiovascular revascularization medicine (2025)

Kalyan R. Chitturi Ryan Wallace Abhishek Chaturvedi Ilan Merdler Nauman Khalid

Impella

10.1016/j.carrev.2025.02.007

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Prevalence of Arrhythmias in Patients With Coronary Microvascular Dysfunction

Catheterization and Cardiovascular Interventions (2024)

Kalyan R. Chitturi Sant Kumar Andrew P. Hill Marta Lorente‐Ros Matteo Cellamare

Coronary microvascular dysfunction (CMD) is an important cause of angina with nonobstructive coronary arteries (ANOCA). It is unclear whether CMD is associated with arrhythmia.

Coronary arteries

Coronary angiogram

Endothelial Dysfunction

10.1002/ccd.31324

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Avoiding Patient-Stent Mismatch: Incorporating Optical Coherence Tomography Into Routine Practice

Cardiovascular revascularization medicine (2019)

Evan Shlofmitz Hayder Hashim

10.1016/j.carrev.2019.02.008

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