Cristina Longo

University of Amsterdam

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Anke H. Maitland‐van der Zee

Amsterdam University Medical Centers

Gillian Bartlett

Texas A&M University

Susanne J. H. Vijverberg

University of Amsterdam

Francine M. Ducharme

Université de Montréal

Vasiliki Rahimzadeh

Baylor College of Medicine

E Fassio

Hospital Posadas

Lucie Blais

Université de Montréal

Graciela Landeira

Hospital Posadas

Gerard H. Koppelman

University of Groningen

Robert W. Platt

McGill University

Cooperative Institutions

McGill University

University of British Columbia

University of Toronto

McMaster University

Université de Montréal

McGill University Health Centre

University of Manitoba

Amsterdam University Medical Centers

University of Amsterdam

University of Padua

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LONG TERM FOLLOW-UP AND OUTCOME OF LIVER TRANSPLANTATION FROM HCV POSITIVE DONORS: A EUROPEAN MULTICENTRIC CASE-CONTROL STUDY

Transplantation (2010)

Roberto Ballarin Alessandro Cucchetti Mario Spaggiari Roberto Montalti Fabrizio Di Benedetto

BALLARIN, R.1; CUCCHETTI, A.2; SPAGGIARI, M.1; MONTALTI, R.1; DI BENEDETTO, F.1; VALMASONI, M.3; LONGO, C.4; DE RUVO, N.1; CAUTERO, N.1; GUERRINI, G. P.1; NADALIN, S.5; TROISI, R.6; CILLO, U.3; PINNA, A. D.2; BURRA, P.7; GERUNDA, G. E.1 Author Information

10.1097/00007890-201007272-00327

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Motor Vehicle Collision–Related Accidents in Pregnancy [310]

Obstetrics and Gynecology (2015)

Tania Azar Cristina Longo Lisa Oddy Haim A. Abenhaim

INTRODUCTION: Motor vehicle accidents (MVAs) are a major contributor of worldwide morbidity and mortality; however, relatively little is known about the incidence and consequences of traffic accidents on pregnant women. Our aim is to compare rates and outcomes of motor vehicle collision-related accidents in pregnant women. METHODS: We conducted a population-based retrospective cohort study using the Healthcare Cost and Utilization Project Nationwide Inpatient Sample database from 2003 to 2011. The risk of different motor vehicle accidents and injuries were compared among pregnant and non-pregnant subjects using conditional logistic regression. RESULTS: We identified 5,936 cases of collision-related motor vehicle accidents in pregnancy and aged-matched them at a one-to-10 ratio to 59,360 nonpregnant women with collision-related motor vehicle accidents. As compared with nonpregnant women, pregnant women admitted after a motor vehicle accident suffered less severe injuries and consequently required fewer therapeutic interventions and a shorter hospital stay. Pregnant women who had a collision-related motor vehicle accident were however at increased risk of requiring genitourinary surgery (odds ratio [OR] 1.45, 95% confidence interval [CI] 1.24–1.69). When restricted to women with a fracture, pregnant women were even more likely to require genitourinary surgery (OR 2.93, 95% CI 2.32–3.71) as well as require a blood transfusion (OR 1.21, 95% CI 1.01–1.44). CONCLUSION: Pregnant women admitted to hospital after a collision-related motor vehicle accident tend to sustain less severe injuries compared with non-pregnant women. However, the influence of admissions for fetal monitoring, rather than maternal injury, cannot be determined from our dataset. Pregnant women who experienced a collision-related motor vehicle accident also require less surgical intervention, with the exception of genitourinary surgery, which may be indicative of more cesarean deliveries.

Seat belt

10.1097/01.aog.0000463562.14329.39

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A potential outcomes approach to defining and estimating gestational age-specific exposure effects during pregnancy

Statistical Methods in Medical Research (2022)

Mireille E. Schnitzer Steve Ferreira Guerra Cristina Longo Lucie Blais Robert W. Platt

Many studies seek to evaluate the effects of potentially harmful pregnancy exposures during specific gestational periods. We consider an observational pregnancy cohort where pregnant individuals can initiate medication usage or become exposed to a drug at various times during their pregnancy. An important statistical challenge involves how to define and estimate exposure effects when pregnancy loss or delivery can occur over time. Without proper consideration, the results of standard analysis may be vulnerable to selection bias, immortal time-bias, and time-dependent confounding. In this study, we apply the “target trials” framework of Hernán and Robins in order to define effects based on the counterfactual approach often used in causal inference. This effect is defined relative to a hypothetical randomized trial of timed pregnancy exposures where delivery may precede and thus potentially interrupt exposure initiation. We describe specific implementations of inverse probability weighting, G-computation, and Targeted Maximum Likelihood Estimation to estimate the effects of interest. We demonstrate the performance of all estimators using simulated data and show that a standard implementation of inverse probability weighting is biased. We then apply our proposed methods to a pharmacoepidemiology study to evaluate the potentially time-dependent effect of exposure to inhaled corticosteroids on birthweight in pregnant people with mild asthma.

Inverse probability weighting

Marginal structural model

Pharmacoepidemiology

Inverse probability

10.1177/09622802211065158

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Assessing the Quality of Deliberative Stakeholder Consultations with Pediatric Palliative Care Clinicians and Oncologists in Canada

Research Square (Research Square) (2020)

Vasiliki Rahimzadeh Cristina Longo Justin Gagnon Conrad V. Fernandez Gillian Bartlett

Abstract Objective —This paper presents findings from a quality assessment of deliberative stakeholder consultations with healthcare professionals in Canada on the implementation of a precision diagnostic for life-threatening pediatric brain tumors. Background —Advanced understanding of the basic biology and pharmacogenomics of pediatric brain tumors portend a clinical future in which oncologists base their clinical decisions in large part on results from laboratory derived tests (LDT) using next generation sequencing. Less is known, however, about how interprofessional healthcare teams perceive the opportunities and challenges of adopting LDTs in clinical practice, or how to best communicate LDT results to pediatric patients and their families. Deliberative stakeholder consultations present a promising alternative to traditional deliberative democratic methods. They allow researchers to unveil normative ethical and social values underpinning a forthcoming policy or new standard of care from the perspectives of key stakeholder groups, as well as make practical recommendations relevant for implementation. Methods —Using the DeVries framework for assessing the quality of deliberative process and information , we analyzed data from 44 post-consultation evaluation surveys from pediatric oncology and palliative care teams at two tertiary pediatric healthcare centers in Canada. Medians/means based on a 10-point Likert scale are reported. We also conducted turn-taking analysis and word-contribution analysis from the text transcriptions of each deliberation to assess equality of participation . Results —Deliberants agreed the quality of the deliberative process was fair (averages ranging from 9-10/10) and the opportunities to both receive expert information and discuss with others about the implementation of a new LDT were helpful (9.5/10). While the session improved understanding of the implementation barriers and opportunities, the session had marginal effects on deliberants’ perceived impact on their own clinical practice where median ratings ranged from 3-10/10. Participation was proportionate in at least four of the six deliberations, where no deliberant took more than 20% of total turns and contributed equal to, or less than 20% of total words. Conclusion —The quality assessments performed lend evidence to the informational value and overall fairness of the deliberative process achieved in this study to identify implementation and communication needs of healthcare professionals at the point when LDTs become standard for diagnosing life-threatening brain tumors in children.

Deliberation

10.21203/rs.3.rs-72810/v1

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PRevention of COVID-19 with Oral Vitamin D supplemental Therapy in Essential healthCare Teams (PROTECT): Ancillary study of a randomised controlled trial

Research Square (Research Square) (2022)

Banafsheh Hosseini Cécile Tremblay Cristina Longo Shirin Golchi John A. White

Abstract Background The study objectives were to ascertain the efficacy of vitamin D supplementation in rapidly increasing serum vitamin D and of implementation of a hybrid (virtual and in-person) trial. Methods In a randomised triple-blind controlled trial, healthcare workers were allocated to receive an oral bolus of 100,000 IU with 10,000 IU/week vitamin D 3 or placebo. The co-primary outcomes of this ancillary study were the change from baseline in serum 25-hydroxyvitamin D [(Δ) 25(OH)D] and proportion with vitamin D sufficiency (25(OH)D ≥ 75nmol/L), at endpoint. Adherence to supplements and procedures as well as adverse event rates were documented. Results Thirty-four (19 intervention, 15 control) subjects were randomised, with 28 (41%) virtual visits. After 44.78 ± 11.00 days from baseline, a significant adjusted group difference of 44.2 (34.7, 53.8) nmol/L was observed in the Δ 25(OH)D (95%CI) in favor of supplementation; 77.8% of intervention, and 13.3% of control, patients were vitamin D sufficient (OR:6.11, 95%CI:1.6, 22.9 ). The adherence to intervention was 94.7% in the intervention and 100% in the control groups. Irrespective of visit type, high adherence was observed in sampling procedures and completion of fortnightly online questionnaire. No adverse events attributable to vitamin D were reported. Conclusion The vitamin D supplementation rapidly and safely raised 25(OH)D levels to sufficient levels for a biological effect. Similarly high adherence to study procedures was observed with virtual and in-person participation. Trial registration: This trial was registered at https://clinicaltrials.gov on July 23, 2020 (#NCT04483635)

Clinical endpoint

10.21203/rs.3.rs-1588325/v1

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Citations (3)

[Primary empty sella in the developmental years. Considerations on 8 cases].

PubMed (1988)

Cristina Longo Louis Ferrari D Gianola M Salmoiraghi I Nosari

Empty sella syndrome

Primary (astronomy)

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