Vitaliy Grudtsov

Research and Production Complex Technological Centre

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Alexander Kuznetsov

Russian Academy of Sciences

НВ

Н. В. Комарова

Research and Production Complex Technological Centre

Dmitriy Ryazantsev

Institute of Bioorganic Chemistry

Mariia Andrianova

Research and Production Complex Technological Centre

ЕВ

Е. В. Кузнецов

Kuban State Agrarian University

Kirill Puchnin

Russian Academy of Sciences

Andrey Sheshil

Russian Academy of Sciences

Mark Shustinskiy

Russian Academy of Sciences

E. N. Rybachek

Research and Production Complex Technological Centre

A. N. Saurov

Russian Academy of Sciences

Cooperative Institutions

Russian Academy of Sciences

Research and Production Complex Technological Centre

Institute of Nanotechnology

Lomonosov Moscow State University

Moscow Technological Institute

Moscow State University

City Clinical Hospital No15 named. O. M. Filatova

Moscow Power Engineering Institute

Ufa Institute of Chemistry

Czech Academy of Sciences, Institute of Geology

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Methods of surface chemical patterning

Nanoindustry Russia (2016)

Alexander Kuznetsov Kirill Puchnin Vitaliy Grudtsov

Рассмотрены масочные и безмасочные методы функционализации для формирования рисунков на поверхностях различных материалов.The mask and mask-free methods of functionalization for the surface patterning of different materials are considered.

Surface Modification

10.22184/1993-8578.2016.70.8.110.117

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A Portable Readout System for Biomarker Detection with Aptamer-Modified CMOS ISFET Array

Sensors (2024)

Dmitriy Ryazantsev Mark Shustinskiy Andrey Sheshil Alexey Titov Vitaliy Grudtsov

Biosensors based on ion-sensitive field effect transistors (ISFETs) combined with aptamers offer a promising and convenient solution for point-of-care testing applications due to the ability for fast and label-free detection of a wide range of biomarkers. Mobile and easy-to-use readout devices for the ISFET aptasensors would contribute to further development of the field. In this paper, the development of a portable PC-controlled device for detecting aptamer-target interactions using ISFETs is described. The device assembly allows selective modification of individual ISFETs with different oligonucleotides. Ta2O5-gated ISFET structures were optimized to minimize trapped charge and capacitive attenuation. Integrated CMOS readout circuits with linear transfer function were used to minimize the distortion of the original ISFET signal. An external analog signal digitizer with constant voltage and superimposed high-frequency sine wave reference voltage capabilities was designed to increase sensitivity when reading ISFET signals. The device performance was demonstrated with the aptamer-driven detection of troponin I in both reference voltage setting modes. The sine wave reference voltage measurement method reduced the level of drift over time and enabled a lowering of the minimum detectable analyte concentration. In this mode (constant voltage 2.4 V and 10 kHz 0.1Vp-p), the device allowed the detection of troponin I with a limit of detection of 3.27 ng/mL. Discrimination of acute myocardial infarction was demonstrated with the developed device. The ISFET device provides a platform for the multiplexed detection of different biomarkers in point-of-care testing.

ISFET

Aptamer

SIGNAL (programming language)

Sine wave

10.3390/s24103008

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Design of CMOS Readout Circuits for ISFET Aptasensor

Dmitriy Ryazantsev Andrey Sheshil Vitaliy Grudtsov E. N. Rybachek Amir Gabdrakhmanov

We present the design and integration of ISFET aptasensor readout circuits on a single silicon substrate, integrated into a 1.2-μm 5V complementary metal oxide semiconductor process. The ISFET is based on a MOSFET with its gate connected to a metal pad brought to the surface of the chip through passivation opening. The ISFET design was determined by the ratio of the areas of the MOSFET and the sensitive surface of the floating gate. An aluminum oxide film was formed as the sensitive surface. Readout circuits based on differential measurements have been developed to implement a differentiation circuit into the chip using an instrumentation amplifier and due to processing by an external device using a repeater circuit and a transimpedance amplifier. For all circuits, an amplifier with a calculated gain of more than 1000 and a phase margin of 60.4 degrees at a frequency of 5.77 MHz and a gain margin of 7 dB at a frequency of 10.3 MHz with a load of 15 pF and 50 kOhm was used. DC measurements of the manufactured circuits were carried out and their operability was shown in direct contact with a metal probe and in contact with a buffer solution biased using platinum reference electrode. For the repeater and instrumentation amplifier circuits, the linearity of the characteristics is close to 1, and for the transimpedance amplifier circuit more than 0.98. The developed device provides a basis for the development of aptasensors for biomarkers detection.

Transimpedance amplifier

ISFET

Instrumentation amplifier

10.1109/usbereit58508.2023.10158829

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Automatic Parameter Extraction Technique for MOS Structures by C-V Characterization Including the Effects of Interface States

Measurement Science Review (2016)

Dmitriy Ryazantsev Vitaliy Grudtsov

Abstract An automatic MOS structure parameter extraction algorithm accounting for quantum effects has been developed and applied in the semiconductor device analyzer Agilent B1500A. Parameter extraction is based on matching the experimental C-V data with numerical modeling results. The algorithm is used to extract the parameters of test MOS structures with ultrathin gate dielectrics. The applicability of the algorithm for the determination of distribution function of DOS and finding the donor defect level in silicon is shown.

Interface (matter)

Characterization

Experimental data

10.1515/msr-2016-0033

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A METHOD TO DETECT ENZYMATIC REACTIONS WITH FIELD EFFECT TRANSISTOR

Sensors International (2024)

Alexander Kuznetsov Mariia Andrianova Dmitriy Ryazantsev Andrey Sheshil Vitaliy Grudtsov

10.1016/j.sintl.2024.100302

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CMOS-compatible biosensor for L-carnitine detection

Biosensors and Bioelectronics (2018)

Mariia Andrianova Е. В. Кузнецов Vitaliy Grudtsov Alexander Kuznetsov

ISFET

Linear range

Subthreshold conduction

10.1016/j.bios.2018.07.044

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Citations (27)

Off-Stoichiometry Thiol–Enes Polymers Containing Silane Groups for Advanced Packaging Technologies

Polymers (2022)

Kirill Puchnin Dmitriy Ryazantsev Vitaliy Grudtsov Yaroslav V. Golubev Alexander Kuznetsov

New modified off-stoichiometry thiol-enes polymers, called OSTE-MS polymers, were developed by introducing mercaptosilane into the polymer mixture. This modification made it possible to introduce silane groups into the polymer frame, due to which the polymer gained the ability to bond with silicon wafers without modification of the wafer surface by any adhesive. The optimal composition for creating 3D polymer structures on a chip was selected, which consists of a volume ratio of 6:6:1 of allyl monomer, mercapto monomer, and mercaptosilane, respectively. The hardness, shift force, tensile strength, Young's modulus, optical transparency, glass transition temperature, thermal stability, and chemical resistance of the OSTE-MS polymer, and the viscosity for the prepolymer mixture were studied. On the basis of the OSTE-MS polymer, 3D polymer structures of the well type and microfluidic system on the silicon chips were obtained.

Prepolymer

Thermal Stability

Surface Modification

10.3390/polym14101988

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CCDC 1952855: Experimental Crystal Structure Determination

The Cambridge Structural Database (2021)

Kirill Puchnin Vitaliy Grudtsov Mariia Andrianova Stanislav I. Bezzubov Alexander Kuznetsov

10.5517/ccdc.csd.cc23k3b4

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Development of an Integrated CMOS-Microfluidics for Bioelectronic Nose

IEEE Sensors (2018)

Alexander Kuznetsov Е. В. Кузнецов E. N. Rybachek Kirill Puchnin Vitaliy Grudtsov

Integration of microfluidic systems within an integrated circuit is a promising approach for developing new generation of bioelectronic noses. In this paper, we present fabrication techniques for a microsystem consisting of an array of ion sensitive field-effect transistors in hydrophilic cell under a hydrophobic membrane. Sacrificial aluminum etching technique was used to form capillary microchannels, and self-assembled monolayers were used for achieving hydrophobic properties of the membrane and hydrophilic properties of the microchannels. The developed microsystem with membrane pore size 4 μm ² was shown to hold liquid, achieving stable air-liquid interface for extraction of molecules from gaseous phase.

Microsystem

ISFET

10.1109/icsens.2018.8589687

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Off-Stoichiometry Thiol–Ene Polymers: Inclusion of Anchor Groups Using Allylsilanes

Polymers (2023)

Kirill Puchnin Dmitriy Ryazantsev Egor V. Latipov Vitaliy Grudtsov Alexander Kuznetsov

The use of polymers in silicon chips is of great importance for the development of microelectronic and biomedical industries. In this study, new silane-containing polymers, called OSTE-AS polymers, were developed based on off-stoichiometry thiol-ene polymers. These polymers can bond to silicon wafers without pretreatment of the surface by an adhesive. Silane groups were included in the polymer using allylsilanes, with the thiol monomer as the target of modification. The polymer composition was optimized to provide the maximum hardness, the maximum tensile strength, and good bonding with the silicon wafers. The Young's modulus, wettability, dielectric constant, optical transparency, TGA and DSC curves, and the chemical resistance of the optimized OSTE-AS polymer were studied. Thin OSTE-AS polymer layers were obtained on silicon wafers via centrifugation. The possibility of creating microfluidic systems based on OSTE-AS polymers and silicon wafers was demonstrated.

Ene reaction

Microelectronics

10.3390/polym15061329

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Citations (1)