Fas and Fas ligand (FasL) polymorphisms in the promoter regions influence transcriptional activities. The interaction of these two genes plays a crucial role in apoptotic cell death regulation. They have been associated with esophageal, lung, uterine cervical, and urinary bladder cancers in human. We performed a case-control study to investigate the association between Fas and FasL polymorphisms and acute myeloid leukemia (AML) risk. Fas−1377G>A (rs2234767), −670T>C (rs1800682), and FasL−844T>C (rs763110) polymorphisms in 592 AML patients and 858 healthy controls were genotyped and tested for associations between polymorphisms and AML risk. There were no significant differences in genotypic and haplotypic distributions and gene-gene interaction between patients and controls in the overall analysis (p > 0.05). These results suggested that polymorphisms of Fas and FasL genes were not associated with AML risk in the Korean population.
The damage caused by oxidative stress and exposure to cigarette smoke and alcohol necessitate DNA damage repair and transport by multidrug resistance-1 (MDR1). To explore the association between polymorphisms in these genes and non-Hodgkin lymphoma risk, we analyzed 15 polymorphisms of 12 genes in a population-based study in Korea (694 cases and 1700 controls). Four genotypes of DNA repair pathway genes (XRCC1 399 GA, OGG1 326 GG, BRCA1 871 TT, and WRN 787 TT) were associated with a decreased risk for NHL [odds ratio (OR)XRCC1 GA = 0.80, p = 0.02; OROGG1 GG = 0.70, p = 0.008; ORBRCA1 TT = 0.71, p = 0.048; ORWRN TT = 0.68, p = 0.01]. Conversely, the MGMT 115 CT genotype was associated with an increased risk for NHL (OR = 1.25, p = 0.04). In the MDR1 gene, the 1236 CC genotype was associated with a decreased risk for NHL (OR = 0.74, p = 0.04), and the 3435 CT and TT genotypes were associated with an increased risk (OR3435CT = 1.50, p < 0.0001; OR3435TT = 1.43, p = 0.02). These results suggest that polymorphisms in the DNA repair genes XRCC1, OGG1, BRCA1, WRN1, and MGMT and in the MDR1 gene may affect the risk for NHL in Korean patients.
Abstract Background Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that plays a role in DNA repair, differentiation, proliferation, and cell death. The polymorphisms of PARP-1 have been associated with the risk of various carcinomas, including breast, lung, and prostate. We investigated whether PARP-1 polymorphisms are associated with the risk of non-Hodgkin lymphoma (NHL). Methods Subjects from a Korean population consisting of 573 NHL patients and 721 controls were genotyped for 5 PARP-1 polymorphisms (Asp81Asp, Ala284Ala, Lys352Lys, IVS13+118A>G, and Val762Ala) using High Resolution Melting polymerase chain reaction (PCR) and an automatic sequencer. Results None of the 5 polymorphisms were associated with overall risk for NHL. However, the Val762Ala polymorphism was associated with reduced risk for NHL in males [odds ratio (OR), 0.62; 95% confidence interval (CI), 0.41-0.93 for CC genotype and OR, 0.84; 95% CI, 0.60-1.16 for TC genotype] with a trend toward a gene dose effect (p for trend, 0.02). The Asp81Asp (p for trend, 0.04) and Lys352Lys (p for trend, 0.03) polymorphisms revealed the same trend. In an association study of PARP-1 haplotypes, the haplotype-ACAAC was associated with decreased risk of NHL in males (OR, 0.75; 95% CI, 0.59-0.94). Conclusion The present data suggest that Val762Ala, Asp81Asp, and Lys352Lys polymorphisms and the haplotype-ACAAC in PARP-1 are associated with reduced risk of NHL in Korean males.
이 논문의 목적은 자동차 램프의 초음파 접합 공정을 합성한 자동차 램프 생산시스템에 관한 연구이다. 램프어셈블리를 생산할 때 독립된 단순 공정에 의해 사출과 초음파 접합, 항온풀림, 조립과 포장을 하던 분리된 작업공정을 원스텝(One-step) 일관공정으로 합성하여 초음파 접합시 발생되는 미세한 발생가스와 소음에 대하여 작업자에게 미치는 영향을 최소화하였다. 또한, 합성 공정에 의한 에너지 저감과 이를 자동공정에 의해 생산함으로써 생산 효율을 극대화하였다. 이 방식은 제어시스템의 타당성을 검토하기 위해 수학적 모델링을 하였고, 이들 수식을 이용하여 플랜트의 전달함수와 필요에 따라 bode선도를 이용하여 안정성과 적합한 제어기를 선정하였다. 이 연구에서 사출 물을 뒤집기 위한 $180^{\circ}$ 회전 제어장치는 중력의 영향으로 비선형 항 $M_{eq}\;lcos{\theta}(t)$이 나타났고, 이를 해결하기위해 피드포워드 제어기법을 적용하여 시스템의 선형화 및 안정화를 확보하였다. The purpose of this paper is to study of the vehicle lamp manufacturing system composing ultrasonic waves connection process. Making lamp assembly plant, it was produced in the separate process as the injection molding, ultrasonic waves bonding, annealing in the constant temperature, lamp assembling and packing. But the improvement method producing the lamp was added with one-step process by one automation technique. As a result, welding with ultrasonic waves process, the method decreased the energy consumption and noise during ultrasonic waves welding. Therefore, this method used the mathematics modeling for checking validity, it selected the stability and suitable controller using transfer function of plant and bode chart. In this study, the $180^{\circ}$ revolution control system to turn injection part upside down was $M_{eq}\;lcos{\theta}(t)$ because of gravity influence. It effected to unstable condition a system. For solving this problem, it aimed the linearization and stabilization of system by elimination $M_{eq}\;lcos{\theta}(t)$ as applying Free-forward control technique.
Abstract Global DNA hypomethylation may result in chromosomal instability and cancer risk. This study was performed to determine the association between DNA hypomethylation in derived from whole blood and non-Hodgkin lymphoma. We analyzed DNA of 506 NHL and 1680 control subjects at Chonnam National University Hwasun Hospital, Korea. Global DNA methylation levels were assessed using bisulfited-PCR pyrosequencing of long interspersed nuclear element-1 (LINE-1). All participants were subsequently categorized into quartiles by mean % in control. When the highest quartile was considered as a reference category (Q4), the following adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were observed for decreasing methylation quartiles OR(Q3)=2.36 (95% CI:1.40-3.97); OR(Q2)=4.67 (95% CI: 2.89-7.55) and OR(Q1)=17.56 (11.19-27.56). This is, to the best of our knowledge, the first study to show that global DNA hypomethylation was significantly associated with increased for NHL risk in a large case-control study. These findings suggest that global methylation levels in genomic DNA may be play important role in the NHL risk. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 143.
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