Nobuo SEO

Yamagata City Hospital Saiseikan

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Masaru Tsukamoto

Cardiovascular Center Hokkaido Ohno Hospital

Shuichi Ishiyama

Sendai Shakai Hoken Hospital

Akira Fuse

Nippon Medical School

Keiji Ohta

Okayama University

Masahiro Urayama

Yamagata City Hospital Saiseikan

Hajime IIZAWA

Yamagata Prefectural Central Hospital

Kiyoshi Kawaguchi

University of Toyama

Hiroshi Kawamura

Muroran Institute of Technology

Shigeru Katagiri

Doshisha University

J Kameyama

International University of Health and Welfare

Cooperative Institutions

The University of Tokyo

Kyoto University

Chiba University

Hokkaido University

Yamagata University

Osaka University

Keio University

Nagoya University

Tohoku University

National Hospital Organization

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Subcutaneous seeding of small hepatocellular carcinoma after fine needle aspiration biopsy

Journal of Gastroenterology and Hepatology (1993)

Nobuo Yamada Haruhide Shinzawa Katsuaki Ukai Hiroto Wakabayashi Hitoshi Togashi

Abstract Ultrasonically guided fine needle (21 gauge) aspiration biopsy (FNAB) was performed on a patient with a hepatocellular carcinoma (HCC) measuring 1.5 × 1.5 cm in segment VI of the liver. The tumour was located just beneath the liver surface. Subsegmentectomy of segment VI was performed. Twelve months after the biopsy and 10 months after the operation, levels of alpha‐fetoprotein (AFP) and protein induced by Vitamin K absence or antagonist‐II (PIVKA‐II) increased gradually without any evidence of recurrence of HCC in the liver. Thirteen months after the biopsy, the patient palpated a hard subcutaneous nodule 1.5 cm in diameter in the right lower anterior chest wall at the insertion site of the biopsy needle. A subcutaneous tumour was excised and histological examination revealed moderately differentiated HCC. The levels of AFP and PIVKA‐II normalized thereafter. These tumour markers were therefore useful for diagnosing the subcutaneous nodule as a metastatic HCC. The patient is currently doing well without further recurrence of HCC or needle‐tract seeding 23 months after subsegmentectomy and 11 months after excision of the subcutaneous tumour.

Nodule (geology)

Aspiration biopsy

10.1111/j.1440-1746.1993.tb01513.x

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Citations (51)

Clinical evaluation of porto-systemic collaterals in patients with portal hypertension.

The Japanese Journal of Gastroenterological Surgery (1986)

Shuichi Ishiyama Nobuo SEO Akira Fuse Shigeru Katagiri Hajime IIZAWA

門脈圧亢進症66例の側副血行路について検討した.遠肝性側副血行路のうち左胃静脈の発生頻度が最も高く, 次いで短胃, 脾-後腹膜, 下腸間膜, 傍臍, 脾-腎静脈の順であった.左胃静脈の直径が大きいと静脈瘤の程度も高度であったが, 門脈圧や有効肝血流量との間には相関がなかった.食道静脈瘤の形成に関与しない側副血行路が太くなると門脈圧は低下する傾向があり, 有効肝血流量は有意に低下した.これらの側副血行路の直径の和が10mm以上の症例で食道静脈瘤からの吐血歴があるものはなかったが, 猪瀬型肝性脳症を示すものがあった.門脈圧亢進症の治療においては側副血行路の状態を十分把握する必要があると考えられた.

Systemic circulation

10.5833/jjgs.19.746

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Citations (1)

CLINICAL SIGNIFICANCE OF THE HYPERDYNAMIC STATE IN THE IMMEDIATE POSTOPERATIVE PERIOD IN ESOPHAGEAL VARICES DUE TO LIVER CIRRHOSIS

The journal of the Japanese Practical Surgeon Society (1989)

Hiroshi Kawamura Shuichi Ishiyama Nobuo SEO Akira Fuse Hajime IIZAWA

To determine postoperative significance of hyperdynamic state in esophageal varices due to liver cirrhosis, sixteen patients undergone transthoracic esophageal transection and eight undergone devascularization of the proximal stomach and splenectomy were divided into two groups, either of which was given dobutamine, 3μg/kg/min, d.i.v., immediately after surgery and the remaining was not given. The two groups were compared in systemic hemodynamics and oxygen metabolism. Dobutamine had no effect on systemic hemodynamics and oxygen metabolism after transthoracic esophageal transection. In patients undergone devascularization of the proximal stomach and splencetomy, however, dobutamine increased the cardiac index and oxygen consumption and maintained oxygen delivery. Furthermore, in these patients given dobutamine the ICG-K value which reflects hepatic blood flow, was maintained whereas it was decreased in controls. These results suggest that, to support systemic hemodynamics, oxygen metabolism and hepatic blood flow in patients who have undergone devascularization of the proximal stomach and splenectomy for esophageal varices due to liver cirrhosis, maintenance of postoperative hyperdynamic state with dobutamine is important.

Dobutamine

Hyperdynamic circulation

Cardiac index

10.3919/ringe1963.50.1099

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A CASE OF SPLENIC RUPTURE WITH INFECTIOUS MONONUCLEOSIS

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) (2006)

Masahiro Urayama Nobuo SEO Keiji Ohta Kiyoshi Kawaguchi Toshihiro Watanabe

症例は30歳,男性.平成17年3月中旬,風邪症状が改善せず,当院内科初診.急性化膿性扁桃炎の診断で治療したが,軽快せず,初診より2日目に再来し,採血検査にて黄疸および肝機能障害を認め,急性肝炎の疑いで入院した.入院2日目の夕方より,左季肋部痛が出現し,翌朝ショックとなった.腹部超音波および腹部CT検査の結果,脾臓破裂による腹腔内出血と診断し,緊急手術を行った.腹腔内には約1,800mlの出血を認めた.出血源はやはり腫大した脾臓で,被膜が破れて出血していた.止血温存は困難と判断し,脾臓を摘出した.病理組織学的にはCD8陽性のTリンパ球が浸潤していた.抗体検査の結果によりEBウイルスの初感染による伝染性単核球症と診断した.伝染性単核球症の合併症の一つに脾破裂があげられるものの,その頻度は0.1～0.5%とされ,非常に稀な例と考えられ,報告した.

Mononucleosis

10.3919/jjsa.67.2946

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Citations (5)

Desirable future clinical trial 7. From the lawyer's standpoint.

Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics (1998)

Nobuo SEO

10.3999/jscpt.29.755

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A CASE OF LYMPHOERITHELIAL CYST OF THE PANCREAS

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) (2005)

Kiyoshi Kawaguchi Nobuo SEO Keiji Ohta Masahiro Urayama Yasuaki KARUBE

比較的稀な膵リンパ上皮嚢胞の1例を経験した.症例は77歳,女性.近医にて胸部X線検査で異常を指摘され,当院で精査目的に行った胸腹部CT検査で,膵体部に腫瘤があり入院.腹部CTでは膵体部に境界明瞭な3cm大の腫瘤を認めた.単純,造影ともに低吸収で,被膜と内部の隔壁様構造にやや造影効果を認めた. MRIではT1, T2ともに低信号. EUSでは境界明瞭で内部エコーが不均一な腫瘤であった.血管造影は異常なく, ERPでは主膵管の圧排像のみ認めた.嚢胞性膵疾患で悪性も完全には否定出来ないため,膵尾側切除を施行した.病理結果は膵リンパ上皮嚢胞であった.本邦報告例はほとんどが男性であるが,本症例は女性であり,また検索しえた限りでは最高齢者であった.

10.3919/jjsa.66.1448

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Tubulin and high molecular weight microtubule-associated proteins as endogenous substrates for protein carboxymethyltransferase in brain

Biochimie (1987)

Keiji Ohta Nobuo SEO Tadashi Yoshida Koichi Hiraga Syozo Tuboi

10.1016/0300-9084(87)90150-7

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Citations (16)

EFFECT OF FRESH FROZEN PLASMA ON IMMUNOLOGICAL FUNCTION IN PATIENTS AFTER HEPATECTOMY FOR HEPATOCELLULAR CARCINOMA

The journal of the Japanese Practical Surgeon Society (1994)

Akira Fuse Shuichi Ishiyama Nobuo SEO Hiroshi Kawamura Masahiro Urayama

The effects of administration of fresh frozen plasma (FFP) to posthepatectomy patients were studied in terms of immunological function. The subjects were 10 patients undergoing almost same degree of hepatectomy without blood transfusion. Five patients of them received FFP after hepatectomy (FFP group) and another 5 patients, albumin (Non-FFP group), and the both groups were compared for changes in immunological function for 14 postoperative days. 1) Humoral immunity: Plasma fibronectin value did not show marked decrease in both groups, but slightly decreased postoperatively in Non-FFP group. CH50 value showed no particular change postoperatively in both groups and there was no difference between two groups. 2) Cellular immunity: PHA blastogenesis in Non-FFP group tended to increase postoperatively. On the other hand, PHA blastogenesis in FFP group tended to decrease postoperatively. There was marked difference between two groups. CD4/CD8 radio in Non-FFP group was slightly higher than that in FFP group. From these results, it is suggested that FFP transfusion after hepatectomy may induce immunosuppression especially on the cellular immunity. Careful attitude would be essencial for posthepatectomy admininstration of FFP.

Fresh frozen plasma

Immunosuppression

Cellular immunity

Liver function

10.3919/ringe1963.55.813

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Sa1099 Clinical Studies of Gastrectomy for Gastric Cancer in Patients Over 80 Years Old

Gastroenterology (2012)

Kiyoshi Kawaguchi Keiji Ohta Nobuo SEO Masahiro Urayama Ryo Toya

10.1016/s0016-5085(12)60807-5

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