Yun-hua Xu

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Yao Bai

China University of Mining and Technology

Juntao Liu

Chinese Academy of Medical Sciences & Peking Union Medical College

Yang Xiang

Peking Union Medical College Hospital

Na Hao

Harvard University

Xiao-lan Lian

Chinese Academy of Medical Sciences & Peking Union Medical College

Xu-ming Bian

Second Affiliated Hospital of Jilin University

Wei-xin Dai

Chinese Academy of Medical Sciences & Peking Union Medical College

Qingwei Qi

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhi-sheng Guo

China Nerin Engineering (China)

Nian-hu Sun

University of California, San Francisco

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking Union Medical College Hospital

National Clinical Research Center for Digestive Diseases

Academy of Medical Sciences

China University of Mining and Technology

Chinese Academy of Sciences

Harbin Engineering University

Ministry of Industry and Information Technology

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Institute of Hydrobiology

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[Prenatal diagnosis and clinical management of a twin pregnancy consisting of a complete mole and coexisting fetus].

PubMed (2003)

Qingwei Qi Yang Xiang Na Hao Juntao Liu Yun-hua Xu

To discuss the differential diagnosis of the hydatidiform mole and a coexisting fetus, to study the prenatal diagnosis and the clinical management of a twin pregnancy consisting of a complete mole and coexisting fetus (CMCF).Two cases of CMCF were reported retrospectively.In the first case, the hydatidiform mole and a coexisting fetus was found by B mode ultrasound at the 10th gestational week, the patient asked to terminate the pregnancy. The interphase FISH and karyotype analysis of the normal villi and the mole showed both of them were diploid, thus the CMCF was diagnosed. In the second case, the hydatidiform mole and a coexisting fetus was found by B mode ultrasound at the 21st gestational week. Transabdominal chorionic villi sampling and amniocentesis was performed, interphase FISH and karyotype analysis of the mole and the amniotic fluid showed both of them were diploid, thus the CMCF was diagnosed prenatally. The pregnancy was continued and premature rupture of membrane happened at the 28th gestational week, the cesarean section was performed. The neonate was healthy. The karyotype analysis of the placenta and the neonate was accordant with the prenatal diagnosis.As long as the hydatidiform mole and a coexisting fetus was found the prenatal diagnosis must be performed in order to differentiate the CMCF and the partial hydatidiform mole (PHM). The transabdominal chorionic villi sampling and the amniocentesis were ideal methods, interphase FISH and karyotype analysis of the mole and the amniotic fluid should be performed. If both of them were diploid, the CMCF could be diagnosed. The clinical management of CMCF should be done individually. If both of them were triploid, the PHM could be diagnosed.

Amniocentesis

Partial Hydatidiform Mole

Chorionic villus sampling

Mole

Chorionic villi

Twin Pregnancy

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High-risk pregnancy in China

Yun-hua Xu Xu-ming Bian

OBGYN.net Conference Coverage OBGYN.net visits China-OBGYN.net in a meeting underwritten by InSightec March 2006

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[Effects of maternal hyperthyroidism and antithyroid drug therapy on congenital malformation of newborn infants].

PubMed (2005)

Xiao-lan Lian Yao Bai Yun-hua Xu Wei-xin Dai Zhi-sheng Guo

To evaluate the relationship between the incidence of congenital malformations of newborns and maternal hyperthyroidism with antithyroid drug (ATD) therapy during pregnancy.The clinical data of 100 cases of pregnant women with hyperthyroidism and their 101 offsprings born in Peking Union Medical College Hospital during 1983-2003 were analyzed retrospectively. According to the maternal thyroid function, and antithyroid drugs taken during the first trimester of pregnancy, subjects were divided into different groups. The incidence of congenital malformations of newborns and risk factors, especially the effects of maternal hyperthyroidism with antithyroid drug therapy were analysed.The prevalence of congenital malformation in infants born to mothers who had hyperthyroidism during pregnancy (6.9%, 7/101) was significantly higher than that of all the infants born in the same hospital during the same period (0.9%, 212/22 765, P < 0.01). The difference of the incidence of malformed infants born to mothers with hyperthyroidism (9.6%, 5/52) or euthyroidism (4.1%, 2/49) during the first trimester was not significant (P > 0.05). The incidence of malformed infants whose mothers received methimazole (MMI; 41.7%, 5/12) was significantly higher than that of mothers treated with propylthiouracil (PTU) (3.6%, 1/28) and without ATDs (1.6%, 1/61), respectively (P < 0.01). The Loglinear model analyses showed that mothers receiving MMI during the first trimester of pregnancy was independent risk factor for the increased incidence of malformation of their infants (L.R. square = 15.668, P = 0.0003).The risk of congenital malformation in infants whose mothers take MMI during the first trimester may be increased. Therefore, we suggest that MMI should not be used as a choice of drug in treatment of pregnant women with hyperthyroidism.

Propylthiouracil

Congenital hypothyroidism

Antithyroid agent

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Citations (8)