Steven D. Shapiro

University of Southern California

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i-10 index

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Co-Authors

Fawaz Al‐Mufti

Westchester Medical Center

Haris Kamal

Memorial Healthcare System

Chirag D. Gandhi

Westchester Medical Center

Eliza C. Miller

Columbia University

Stephan A. Mayer

New York Medical College

Alis J. Dicpinigaitis

Weill Cornell Medicine

Eric Feldstein

Westchester Medical Center

Joshua Z. Willey

Columbia University

Gurmeen Kaur

Westchester Medical Center

Bernard Chang

Columbia University Irving Medical Center

Cooperative Institutions

New York Medical College

Westchester Medical Center

Columbia University

Neurological Surgery

Columbia University Irving Medical Center

Icahn School of Medicine at Mount Sinai

NewYork–Presbyterian Hospital

Washington University in St. Louis

Johns Hopkins University

New York Hospital Queens

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Interferon γ Induction of Pulmonary Emphysema in the Adult Murine Lung

The Journal of Experimental Medicine (2000)

Zhongde Wang Tao Zheng Zhou Zhu Robert Homer Richard J. Riese

Chronic inflammation containing CD8(+) lymphocytes, neutrophils, and macrophages, and pulmonary emphysema coexist in lungs from patients with chronic obstructive pulmonary disease. Although this inflammatory response is believed to cause the remodeling that is seen in these tissues, the mechanism(s) by which inflammation causes emphysema have not been defined. Here we demonstrate that interferon gamma (IFN-gamma), a prominent product of CD8(+) cells, causes emphysema with alveolar enlargement, enhanced lung volumes, enhanced pulmonary compliance, and macrophage- and neutrophil-rich inflammation when inducibly targeted, in a transgenic fashion, to the adult murine lung. Prominent protease and antiprotease alterations were also noted in these mice. They included the induction and activation of matrix metalloproteinase (MMP)-12 and cathepsins B, H, D, S, and L, the elaboration of MMP-9, and the selective inhibition of secretory leukocyte proteinase inhibitor. IFN-gamma causes emphysema and alterations in pulmonary protease/antiprotease balance when expressed in pulmonary tissues.

10.1084/jem.192.11.1587

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Citations (398)

Abstract 1122‐000024: Stereotactic IntraCerebral Underwater Blood Aspiration Improves Survival Following Intracerebral Hemorrhage as Compared to Predicted Mortality

Stroke Vascular and Interventional Neurology (2021)

Steven D. Shapiro Miryam Alkayyali Alexandra S. Reynolds Kaitlin Reilly Magdy Selim

This meeting abstract was removed due to the OA licensing requirements of this journal. The full abstract is listed here : https://www.svin.org/files/SVIN_2021_Abstracts_for_Web.pdf

10.1161/svin.01.suppl_1.000024

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Citations (0)

Evaluation of A Rapid Outpatient Stroke Clinic for TIA and Minor Stroke Patients in the Emergency Department (P3.3-054)

Neurology (2019)

Rachel Mehendale Steven D. Shapiro Bernard Chang Eliza C. Miller Sara Rostanski

Minor stroke

Stroke

Outpatient clinic

Minor (academic)

10.1212/wnl.92.15_supplement.p3.3-054

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Citations (0)

Prospective study of long-term pulmonary manifestations of mantle irradiation

International Journal of Radiation Oncology*Biology*Physics (1990)

Susan J. Shapiro Steven D. Shapiro William B. Mill Edward J. Campbell

Air trapping

10.1016/0360-3016(90)90500-j

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Citations (73)

Safety and Feasibility of a Rapid Outpatient Management Strategy for Transient Ischemic Attack and Minor Stroke: The Rapid Access Vascular Evaluation–Neurology (RAVEN) Approach

Annals of Emergency Medicine (2019)

Bernard Chang Sara Rostanski Joshua Z. Willey Eliza C. Miller Steven D. Shapiro

Stroke

Minor stroke

Transient (computer programming)

Minor (academic)

10.1016/j.annemergmed.2019.05.025

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Citations (29)

Accelerated enlargement of experimental abdominal aortic aneurysms in a mouse model of chronic cigarette smoke exposure

Journal of the American College of Surgeons (2004)

Celine Buckley Charles W. Wyble Martin Borhani Terri L. Ennis Dale K. Kobayashi

Abdominal aorta

Pancreatic elastase

10.1016/j.jamcollsurg.2004.08.010

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Citations (52)

A hospital’s perspective: economic evaluation of hospitalization vs rapid outpatient evaluation for TIA and minor strokes. (P3.3-010)

Neurology (2019)

Steven D. Shapiro Jorge Luna Rachel Mehendale Babak B. Navi Benjamin Kummer

May 7, 2019April 9, 2019Free AccessA hospital’s perspective: economic evaluation of hospitalization vs rapid outpatient evaluation for TIA and minor strokes. (P3.3-010)Steven Shapiro, Jorge Luna, Rachel Mehendale, Babak Navi, Benjamin Kummer, Sara Rostanski, Claudia Rosen, David Vawdrey, Bernard Chang, Eliza Miller, Mitchell Elkind, and Joshua WilleyAuthors Info & AffiliationsApril 9, 2019 issue92 (15_supplement)https://doi.org/10.1212/WNL.92.15_supplement.P3.3-010 Letters to the Editor

Minor (academic)

Miller

Outpatient clinic

10.1212/wnl.92.15_supplement.p3.3-010

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Citations (0)

Clinical heterogeneity in the tricho-dento-osseous syndrome

Human Genetics (1983)

F Quattromani Steven D. Shapiro Robert S. Young Ronald J. Jorgenson J. W. Parker

Enamel hypoplasia

10.1007/bf00327105

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