Deborah L. Zink

Research Field

gamma-Pyrone-3-acetic acid (L-741,494) is a novel metabolite produced by a culture of the fungal genus Xylaria. This substance is a water-soluble, competitive, irreversible inhibitor of Interleukin-1 beta Converting Enzyme that is inactive against papain and trypsin. It has a mol wt of 154 and an empirical formula of C7H6O4. We propose the name xylaric acid for this compound.

10.1021/np50108a011

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Citations (26)

Structure and Semisynthesis of Platensimide A, Produced by Streptomyces platensis

Organic Letters (2008)

Kithsiri Herath Chaowei Zhang Hiranthi Jayasuriya John G. Ondeyka Deborah L. Zink

Platensimycin and platencin are novel natural product antibiotics that inhibit bacterial growth by inhibiting condensing enzymes FabF and FabF/FabH of fatty acid biosynthesis pathways, respectively. Continued search for the natural congeners of these compounds led to the isolation of platensic acid, the free C-17 tetracyclic enoic acid, and platensimide A, a 2,4-diaminobutyric acid amide derivative. Isolation, structure, semisynthesis, and activity of these compounds are described.

Semisynthesis

Natural product

Streptomyces griseus

Amide

10.1021/ol800251v

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Citations (54)

Isolation and structure elucidation of viridiofungins A, B and C

Tetrahedron Letters (1993)

Guy H. Harris E. Tracy Turner Jones María Meinz Mary Nallin-Omstead Gregory L. Helms

Isolation

Broad spectrum

Squalene

Structure–activity relationship

10.1016/s0040-4039(00)73961-x

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Citations (58)

Microbial hydroxylation of rustmicin (galbonolide A) and galbonolide B, two antifungal products produced by Micromonospora sp.

Journal of Molecular Catalysis B Enzymatic (2001)

Ali Shafiee Guy H. Harris Haideh Motamedi Mark Rosenbach T Chen

Micromonospora

Hydroxylation

10.1016/s1381-1177(00)00067-9

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Citations (10)

Pramanicin, a novel antimicrobial agent from a fungal fermentation

Tetrahedron (1994)

Robert E. Schwartz Gregory L. Helms Evon A. Bolessa Kenneth E. Wilson R.A. Giacobbe

Side chain

10.1016/s0040-4020(01)80843-7

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Citations (80)

ChemInform Abstract: Discovery and Antibacterial Activity of Lucensimycin C from Streptomyces lucensis.

ChemInform (2008)

Sheo B. Singh Deborah L. Zink Kithsiri Herath Óscar Salazar Olga Genilloud

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

10.1002/chin.200833208

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Citations (0)

Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase

Tetrahedron Letters (1998)

Sheo B. Singh Deborah L. Zink Michael Goetz Anne W. Dombrowski Jon D. Polishook

Phoma

Integrase inhibitor

10.1016/s0040-4039(98)00269-x

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Citations (163)

ChemInform Abstract: Isolation, Structure and Fatty Acid Synthesis Inhibitory Activities of Platensimycin B₁—B₃ from Streptomyces platensis.

ChemInform (2009)

Chaowei Zhang John G. Ondeyka Deborah L. Zink Bruce Burgess Jun Wang

Isolation

10.1002/chin.200910204

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Citations (0)

Isolation, Structure and HIV‐1 Integrase Inhibitory Activity of Exophillic Acid, a Novel Fungal Metabolite from Exophiala pisciphila.

ChemInform (2004)

John G. Ondeyka Deborah L. Zink Anne W. Dombrowski Jon D. Polishook Peter J. Felock

Abstract For Abstract see ChemInform Abstract in Full Text.

Isolation

Integrase inhibitor

10.1002/chin.200425213

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Citations (0)

Candelalides A−C: Novel Diterpenoid Pyrones from Fermentations of Sesquicillium candelabrum as Blockers of the Voltage-Gated Potassium Channel Kv1.3

Organic Letters (2000)

Sheo B. Singh Deborah L. Zink Anne W. Dombrowski Gabe Dezeny Gerald F. Bills

[figure: see text] Blockers of the voltage-gated potassium channel Kv1.3 are potential immunosuppressants. Candelalides A-C are three novel diterpenoid pyrones that block this channel. The structure, stereochemistry, and activity against Kv1.3 are described.

Voltage-gated potassium channel

Potassium channel blocker

10.1021/ol006891x

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Citations (38)

Deborah L. Zink

Papers

Citation

H-Index

i-10 index

Papers

Citation

H-Index

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