G Kutschke

Ludwig-Maximilians-Universität München

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

B. Reitter

Johannes Gutenberg University Mainz

Peter Stoeter

Instituto Tecnológico de Santo Domingo

Rainer Boor

Kiel University

Goran Vučurević

Institute for Cardiovascular Diseases of Vojvodina

S. Boor

Harvard University

Sascha Meyer

Saarland University

C. Pfleiderer

Technical University of Munich

Ludwig Gortner

Saarland University

Yanick J. Crow

Institut des Maladies Génétiques Imagine

A. Hinzmann

University Medical Center of the Johannes Gutenberg University Mainz

Cooperative Institutions

Witten/Herdecke University

Klinikum Stuttgart

Ludwig-Maximilians-Universität München

Olgahospital

LMU Klinikum

Johannes Gutenberg University Mainz

University Medical Center of the Johannes Gutenberg University Mainz

University of Manchester

Boston Children's Hospital

University Hospital Heidelberg

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Temporary neonatal respiratory disorder – Early-onset-variation of Ondine's curse

Neuropediatrics (2010)

G Kutschke Zeynel Abidin Demir S Böckelman Eva Mildenberger

Backgrond information: Congenital central hypoventilation syndrome (CCHS, Undine's curse) is a rare congenital disorder of the autonomic control of breathing with reduced central chemoreceptor sensitivity. Mutations in the PHOX2B-gene, which plays a crucial role in the development of respiratory autonomous-neuronal control systems, are considered to possess strong pathogenetic relevance. Children with Undine's curse are typically intubated after birth and ventilated. As a rule they require lifetime mechanical ventilatory assistance, particularly during sleep. We will report on the case of an unusually mild, rapidly remitting symptomatology of CCHS, with the picture of a centrally caused neonatal respiratory distress syndrome.

10.1055/s-0030-1265623

Cite

Citations (0)

Epilepsia (2003)

Stephan Boor Goran Vučurević C. Pfleiderer Peter Stoeter G Kutschke

The localization of epileptic foci is an important issue in children with extratemporal epilepsies. However, the value of noninvasive methods such as the EEG-assisted functional magnetic resonance imaging (fMRI) has not been sufficiently investigated in children. As a model of extratemporal epilepsies, we studied 7 patients aged 5 to 12 (median 10) years with benign childhood epilepsy and centrotemporal (rolandic) spikes. Interictal spikes were recorded during the fMRI acquisition on a MR-compatible battery-powered digital EEG system with 16 channels. The fMRI sequences were correlated off-line with the EEG spikes and analyzed with the software Statistical Parametrical Mapping SPM99. The fMRI results demonstrated the spike-related activation in the perisylvian central region in three patients; we could not demonstrate fMRI activation despite active spiking in 2 patients, and 2 patients did not produce sufficient spikes for fMRI analysis. We currently consider the spike-related fMRI as a research tool that localizes epileptic activity in selected patients. Further improvements of the technique are necessary to allow a clinical application of this method.

Rolandic epilepsy

EEG-fMRI

10.1046/j.1528-1157.2003.27802.x

Cite

Citations (62)

Recurrent Severe Ulcers Due to Seizures

The Indian Journal of Pediatrics (2014)

Sascha Meyer Isabel Oster Sylvia Peterlini Ludwig Gortner G Kutschke

10.1007/s12098-014-1434-3

Cite

Citations (0)

Leukoencephalopathy with Calcifications and Cysts: A Purely Neurological Disorder Distinct from Coats Plus

Neuropediatrics (2014)

Joséphine Mayer Emma M. Jenkinson Paul R. Kasher Stavros Stivaros Andrea Berger

Objective With the identification of mutations in the conserved telomere maintenance component 1 (CTC1) gene as the cause of Coats plus (CP) disease, it has become evident that leukoencephalopathy with calcifications and cysts (LCC) is a distinct genetic entity. Patients and Methods A total of 15 patients with LCC were identified from our database of patients with intracranial calcification. The clinical and radiological features are described. Results The median age (range) at presentation was 10 months (range, 2 days–54 years). Of the 15 patients, 9 presented with epileptic seizures, 5 with motor abnormalities, and 1 with developmental delay. Motor abnormalities developed in 14 patients and cognitive problems in 13 patients. Dense calcification occurred in the basal ganglia, thalami, dentate nucleus, brain stem, deep gyri, deep white matter, and in a pericystic distribution. Diffuse leukoencephalopathy was present in all patients, and it was usually symmetrical involving periventricular, deep, and sometimes subcortical, regions. Cysts developed in the basal ganglia, thalamus, deep white matter, cerebellum, or brain stem. In unaffected areas, normal myelination was present. No patient demonstrated cerebral atrophy. Conclusion LCC shares the neuroradiological features of CP. However, LCC is a purely neurological disorder distinguished genetically by the absence of mutations in CTC1. The molecular cause(s) of LCC has (have) not yet been determined.

10.1055/s-0033-1364180

Cite

Citations (44)

Funktionelle transkranielle Doppler-Sonographie zur Untersuchung der sprachlichen Hemisphärendominanz bei Kindern

Klinische Neurophysiologie (2003)

G Kutschke B. Reitter Annerose Keilmann

Eine Individualdiagnostik der sprachlichen Hemisphärendominanz ist mit derzeit verfügbaren, nicht-invasiven Untersuchungsmethoden (funktionelle MRI, MEG) in der Regel erst ab dem 10. Lebensjahr möglich. Demgegenüber bietet die funktionelle transkranielle Doppler-Sonographie gute Voraussetzungen, um zu einer Untersuchungsmethode für Kinder entwickelt zu werden. Es wurde ein Block-Paradigma mit interaktivem Untersuchungsablauf verwendet, zur Induktion sprachlicher Hirnaktivität eine still auszuführende Wortgenerierungsaufgabe eingesetzt. Bei n=18 normal entwickelten rechtshändigen Kindern (Alter 6,2±0,5 Jahre, 10 m, 8 w) wurde die Links-Rechts-Differenz der Blutflussgeschwindigkeit in den mittleren Hirnbasisarterien während der Ruhe- und Aktivierungsphasen (5s bzw. 15s) verglichen. Es ließ sich bei 17 von 18 Kindern ein geringgradiger, aber signifikanter linkshemisphärischer Anstieg der Blutflussgeschwindigkeit feststellen, der bei Jungen stärker ausfiel (p<0,05). Die funktionelle transkranielle Doppler-Sonographie erscheint für die nicht-invasive individuelle Untersuchung der Sprachlateralität schon im frühen Kindesalter geeignet. Im Hinblick auf einen möglichen Einsatz bei der Diagnostik vor Hirnoperationen ist die Validierung mit invasiven Verfahren anzustreben.

10.1055/s-2003-816474

Cite

Citations (0)

P 1106. Involvement of the Cardial Autonomous Nervous System in Mitochondrial Neurogastrointestinal Encephalopathy Syndrome

Neuropediatrics (2018)

G Kutschke Rüdiger Adam Michael Eichinger Michal Fischer Christoph Kampmann

Mitochondrial neurogastrointestinal encephalopathy (MNGIE) syndrome, inherited in an autosomal-recessive pattern, is caused by a mutation in the TYMP gene, which encodes for the cytosolic thymidine phosphorylase (TMP). This leads to a disorder in mitochondrial DNA replication and repair. Clinically, MNGIE is characterized by the association of gastrointestinal motility disorder, anorexia, peripheral neuropathy, chronically progredient external ophthalmoplegia, and leukoencephalopathy. Due to the insidious course with initially unspecific gastrointestinal symptomatology, this very rare disease, which predominantly manifests in childhood, is often diagnosed late. However, its prognosis depends on a timely diagnosis and therapy. An early clinical diagnosis could be aided by the detection of the involvement of other organ systems usually affected by MNGIE. So far, an involvement of the autonomous nervous system (ANS) has only been reported in the context of histopathological examinations of the intestinal innervation. However, when translating animal experiment findings on tissue expression of TMP in the ANS to humans, one would expect a disorder in the vegetative function of other organs as well. The question of an involvement of the autonomous cardiac afference, which could be detected using simple clinical means and used for an early diagnosis, has not been dealt with in casuistic publications so far.

Thymidine phosphorylase

Mitochondrial disease

10.1055/s-0038-1676023

Cite

Citations (0)

Complementary and alternative medicine in paediatrics: a systematic overview/synthesis of Cochrane Collaboration reviews

Schweizerische medizinische Wochenschrift (2013)

Susan A. Meyer Ludwig Gortner A Larsen G Kutschke Sven Gottschling

BACKGROUND: A high prevalence of complementary and alternative medicine (CAM) use has been documented in children with chronic illnesses. Conversely, evidence-based medicine is considered an important contributor in providing the best quality of care. METHODS: We performed a systematic overview/synthesis of all Cochrane reviews published between 1995 and 2012 in paediatrics that assessed the efficacy, and clinical implications and limitations of CAM use in children. Main outcome variables were: percentage of reviews that concluded that a certain intervention provides a benefit, percentage of reviews that concluded that a certain intervention should not be performed, and percentage of studies that concluded that the current level of evidence is inconclusive. RESULTS: A total of 135 reviews were included – most from the United Kingdom (29/135), Australia (24/135) and China (24/135). Only 5/135 (3.7%) reviews gave a recommendation in favour of a certain intervention; 26/135 (19.4%) issued a conditional positive recommendation, and 9/135 (6.6%) reviews concluded that certain interventions should not be performed. Ninety-five reviews (70.3%) were inconclusive. The proportion of inconclusive reviews increased during three, a priori-defined, time intervals (1995–2000: 15/27 [55.6%]; 2001–2006: 33/44 [75%]; and 2007–2012: 47/64 [73.4%]). The three most common criticisms of the quality of the studies included were: more research needed (82/135), low methodological quality (57/135) and small number of study participants (48/135). CONCLUSIONS: Given the disproportionate number of inconclusive reviews, there is an ongoing need for high quality research to assess the potential role of CAM in children. Unless the study of CAM is performed to the same science-based standards as conventional therapies, CAM therapies risk being perpetually marginalised by mainstream medicine.

Cochrane collaboration

10.4414/smw.2013.13794

Cite

Citations (40)

Sensory motor neuropathy, myopathy, white matter abnormalities and lethal intestinal motility disturbance in a 15 years old boy - mitochondrial dysfunction due to thymidine phosphoryase deficiency

Neuropediatrics (2006)

G Kutschke Christina Lampe B Oberman B. Reitter

Motor dysfunction

Sensory neuropathy

10.1055/s-2006-974140

Cite

Citations (0)

Interactive functional Doppler sonography for evaluation of hemispheric dominance of language in infants

Neuropediatrics (2005)

G Kutschke B. Reitter

As known from patients suffering from central nervous insults, language disturbances often result from left hemispheric brain lesions and usually cannot be compensated after an age of approximately 5 years. Planning intracerebral operations close to areas potentially important for language control requires to determine the dominant hemisphere. For this purpose we tested functional transcranial Doppler sonography (fTCD) in infants.

Doppler sonography

Dominance (genetics)

Transcranial Doppler

Right hemisphere

10.1055/s-2005-867973

Cite

Citations (0)

Use of gabapentin to reduce chronic neuropathic pain in Fabry disease

Journal of Inherited Metabolic Disease (2003)

Markus Ries Eugen Mengel G Kutschke K. S. Kim Frank Birklein

10.1023/a:1025127723729

Cite

Citations (63)