An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.

10.1192/s0007125000064205

Cite

Citations (0)

Coproporphyria, Hereditary

Springer eBooks (2009)

Nils Peters Martin Dichgans Sankar Surendran Josep M. Argilés Francisco J. López‐Soriano

10.1007/978-3-540-29676-8_785

Cite

Citations (0)

Caroli's Syndrome

Springer eBooks (2009)

Nils Peters Martin Dichgans Sankar Surendran Josep M. Argilés Francisco J. López‐Soriano

10.1007/978-3-540-29676-8_292

Cite

Citations (0)

Cicatricial Alopecia

Springer eBooks (2009)

Nils Peters Martin Dichgans Sankar Surendran Josep M. Argilés Francisco J. López‐Soriano

10.1007/978-3-540-29676-8_6781

Cite

Citations (0)

Genetic studies of bipolar affective disorder in large families

The British Journal of Psychiatry (2001)

Douglas Blackwood Walter Muir Peter M. Visscher

Background Genetic factors are known to be important in the aetiology of bipolar disorder. Aims To review linkage studies in extended families multiply affected with bipolar disorder. Method Selective review of linkage studies of bipolar disorder emphasising the gains and drawbacks of studying large multiply-affected families and comparing the statistical methods used for data analysis. Results Linkage of bipolar disorder to several chromosome regions including 4p, 4q, 10p, 12q, 16p, 18q, 21q and Xq has first been reported in extended families. In other families chromosomal rearrangements associated with affective illnesses provide signposts to the location of disease-related genes. Statistical analyses using variance component methods can be applied to extended families, require no prior knowledge of the disease inheritance, and can test multilocus models. Conclusion Studying single large pedigrees combined with variance component analysis is an efficient and effective strategy likely to lead to further insights into the genetic basis of bipolar disorders.

Pedigree chart

Linkage (software)

Genetic linkage

Inheritance

10.1192/bjp.178.41.s134

Cite

Citations (35)

Multiplex amplicon quantification screening the ABCA13 gene for copy number variation in schizophrenia and bipolar disorder

Psychiatric Genetics (2012)

Ben Pickard Maarten Van Den Bossche M. P. Malloy Mandy Johnstone An Sofie Lenaerts

Pickard, Benjamin Simon; Van Den Bossche, Maarten J.A.; Malloy, Mary P.; Johnstone, Mandy; Lenaerts, An-Sofie; Nordin, Annelie; Goossens, Dirk; St Clair, David; Muir, Walter J.; Nilsson, Lars-Göran; Sabbe, Bernard; Adolfsson, Rolf; Blackwood, Douglas H.R.; Del-Favero, Jurgen Author Information

Multiplex

Amplicon

10.1097/ypg.0b013e32835185b3

Cite

Citations (9)