Mauricio Jadzinsky

El Hospital General de Agudos Carlos G. Durand

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Valeria Hirschler

Argentine Water and Sanitation (Argentina)

Isaac Faerman

Hospital Fernández

Claudio Aranda

El Hospital General de Agudos Carlos G. Durand

Dora Fox

Hospital Fernández

Claudio González

University of Buenos Aires

María de Luján Calcagno

University of Buenos Aires

Mario Maler

El Hospital General de Agudos Carlos G. Durand

Gustavo Maccallini

Ministerio de Salud - Provincia de Buenos Aires

Leticia Glocer

Fernandez Hospital

Adriana Oneto

Diagnostico Maipú

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El Hospital General de Agudos Carlos G. Durand

University of Buenos Aires

Hospital Fernández

Consejo Nacional de Investigaciones Científicas y Técnicas

Fernandez Hospital

Universidade de São Paulo

Universidade Federal de São Paulo

Universidad Bicentenaria de Aragua

Hospital Británico de Buenos Aires

Hospital Italiano de Buenos Aires

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Asymptomatic neurogenic bladder in juvenile diabetics

Diabetologia (1971)

Isaac Faerman Mario Maler Mauricio Jadzinsky E. Álvarez D. Fox

Cystometry

Atony

10.1007/bf01212549

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Citations (80)

Diabetes tipo 2 en la infancia y adolescencia Actualización

Valeria Hirschler Maria C. Preiti Alejandro Caamaño Mauricio Jadzinsky

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Citations (1)

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Diabetes Research and Clinical Practice (1991)

Milton T. W. Hearn Mary Michel Thomas Danne Mauricio Jadzinsky V Vondra

10.1016/0168-8227(91)90080-w

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Can Waist Circumference Identify Children With the Metabolic Syndrome?

Archives of Pediatrics and Adolescent Medicine (2005)

Valeria Hirschler Claudio Aranda María de Luján Calcagno Gustavo Maccalini Mauricio Jadzinsky

To determine in children the association between waist circumference (WC) and insulin resistance determined by homeostasis modeling (HOMA-IR) and proinsulinemia and components of the metabolic syndrome, including lipid profile and blood pressure (BP).Eighty-four students (40 boys) aged 6 to 13 years and matched for sex and age underwent anthropometric measurements; 40 were obese; 28, overweight; and 16, nonobese. Body mass index (BMI), WC, BP, and Tanner stage were determined. An oral glucose tolerance test, lipid profile, and insulin and proinsulin assays were performed. Children were classified as nonobese (BMI < 85th percentile), overweight (BMI, 85th-94th percentile), and obese (BMI > or = 95th percentile).There was univariate association (P < .01) between WC and height (r = 0.73), BMI (r = 0.96), Tanner stage (r = 0.67), age (r = 0.56), systolic BP (r = 0.64), diastolic BP (r = 0.61), high-density lipoprotein cholesterol level (r = 0.45), triglyceride level (r = 0.28), proinsulin level (r = 0.59), and HOMA-IR (r = 0.59). Multiple linear regression analysis using HOMA-IR as the dependent variable showed that WC (beta coefficient = 0.050 [95% confidence interval, 0.028 to 0.073]; P = .001) and systolic BP (beta coefficient = 0.033 [95% confidence interval, 0.004 to 0.062]; P = .004) were significant independent predictors for insulin resistance adjusted for diastolic BP, height, BMI, acanthosis nigricans, and high-density lipoprotein cholesterol level.Waist circumference is a predictor of insulin resistance syndrome in children and adolescents and could be included in clinical practice as a simple tool to help identify children at risk.

Lipid Profile

10.1001/archpedi.159.8.740

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Is Acanthosis Nigricans a Marker of Insulin Resistance in Obese Children?

Diabetes Care (2002)

Valeria Hirschler Claudio Aranda Adriana Oneto Claudio González Mauricio Jadzinsky

Acanthosis nigricans (AN) was proposed as an insulin resistance marker and an independent risk factor for type 2 diabetes (1). A number of studies had associated AN with insulin resistance (IR) and much higher prevalence of type 2 diabetes in childhood. (2) Although children with AN are often obese, only few studies have considered the roles of BMI and AN as independent markers of IR. The purpose of this research was to compare several indexes of IR (i.e., homeostasis model assessment of IR [HOMA-IR], insulin-like growth factor binding protein 1 [IGFBP1] levels, and base insulinemia) in obese children with and without AN and to determine the rate of association between AN and BMI, HDL, triglycerides, and other predictors of type 2 diabetes. A total …

Acanthosis Nigricans

10.2337/diacare.25.12.2353

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Multifocal motor neuropathy, type 1 diabetes and asymptomatic Hashimoto's thyroiditis: an unusual association

Neuromuscular Disorders (2005)

Ricardo Reisin Cristina Zurrú Carlos Buso Cintia Marchesoni A.M. Pardal

Subclinical infection

Multifocal motor neuropathy

10.1016/j.nmd.2005.01.008

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Es la circunferencia de cintura un componente del síndrome metabólico en la infancia

Valeria Hirschler Ana María Delfino G. Clemente Claudio Aranda María de Luján Calcagno

Aclaracion de intereses: No existio apoyo financiero para la realizacion del estudio. RESUMEN Objetivo. Determinar en ninos, la asociacion entre la circunferencia de la cintura (CC) y diferentes componentes del sindrome metabolico, incluyendo obesidad, indice de masa corporal (IMC), insulinorresistencia (HOMA-IR), proinsulina, perfil lipidico y tension arterial (TA). Poblacion, material y metodos. Se evaluaron las medidas antropometricas de 2.182 estudiantes (1.126 masculinos) de 6 a 13 anos de edad. Se aleatorizaron 68 ninos: 28 con sobrepeso (SP) y 40 obesos (OB) que se aparearon segun el sexo y la edad con 16 ninos de peso normal (No-OB) en los que se realizaron evaluaciones posteriores. En estos ninos se determino, ademas del indice de masa corporal (IMC) y la CC, la TA y el estadio de Tanner. Se realizo una prueba de tolerancia oral a la glucosa (PTOG) y se determino el perfil lipidico, la insulinemia y la proinsulinemia en este subgrupo. Los ninos se clasificaron como no-OB (IMC percentilo 95). Resultados. La CC presento una asociacion significativa y univariada con la talla (r= 0,73), el IMC (r= 0,96), el estadio de Tanner (r= 0,67), la edad (r= 0,56), la TA sistolica (r= 0,64), la TA diastolica (r= 0,61), el HDL (r= 0,45), trigliceridos (r= 0,28), proinsulina (r= 0,59) y HOMA-IR (r= 0,59). El analisis de regresion logistica que utilizo a la CC > percentilo 90o como variable dependiente, mostro que el HDL (exponente beta= 0,93, IC 95% 0,88-0,98, P= 0,01) y HOMA-IR (exponente beta= 1,997, IC 95%1,174-3,396) fueron factores de riesgo independientes para la CC, luego de ajustarlos por la edad y el estadio de Tanner, sexo, talla, TA y trigliceridos. La regresion lineal multiple con la HOMA-IR como variable dependiente mostro que la CC (coeficiente beta= 0,066 IC 95%: 0,007– 0,125; P= 0,0o29), edad (-0,389 IC 95%-0,611-/-0,167; P= 0,001) y estadio de Tanner (0,734 IC 95% 0,175/1,29; P= 0,011) fueron variables predictoras significativas e independientes para insulinorresistencia. Conclusiones. La CC es un predictor del sindrome de insulinorresistencia en ninos y podria incluirse en la practica clinica como una herramienta simple para identificar ninos con riesgo de presentar en el futuro enfermedad cardiovascular (ECV) y diabetes tipo 2. Palabras clave: obesidad, insulinorresistencia, circunferencia de cintura. SUMMARY Objective. To determine a) the association between waist circumference (WC) and insulin-resistance determined by homeostasis modeling (HOMA-IR) and proinsulinemia, lipid profile and blood pressure (BP) in children. Population, material and methods. 2,182 (1,126 male) students, aged 6 to 13 years, underwent anthropometric measurements, and 68 children –40 obese (OB)– and 28 overwight were randomized for more extensive testing, as well as 16 non-obese children matched for age and sex. Body mass index (BMI), WC, BP, and Tanner stage were determined in all subjects. The subgroup had oral glucose tolerance testing (OGTT), lipid profile, insulinemia and proinsulinemia assays. Children were classified as non-OB (BMI 95 percentile). Results. There was a univariate association between WC and height (r= 0.73), BMI (r= 0.96), Tanner stage (r= 0.67), age (r= 0.56), BMI (r= 0.96), systolic BP (r= 0.64), diastolic BP (r= 0.61), HDL (r= 0.45), triglycerides (r= 0.28), proinsulin (r= 0.59), and HOMA-IR (r= 0.59). Logistic regression analysis using WC >90o percentile (yes or no) as the dependent variable showed that HDL (Exp Beta 0.93, 95% CI 0.88-0.98, P= 0.01) and HOMA-IR (Exp Beta= 1.997, 95% CI 1.174-3.396) were significant independent risk factors for WC after adjusting for age as well as for Tanner stage, sex, height, blood pressure and triglycerides. Multiple linear regression analysis using HOMAIR as the dependent variable showed that WC (beta coefficient= 0.066 CI 95%: 0.007 0.125; P= 0.029), age (-0.389 CI 95%-0.611-/ -0.167; P= 0.001), and Tanner stage (0.734 CI 95%0.175/1.29; P= 0.011 respectively) were significant independent predictors for insulin resistance. Conclusion. WC is a predictor of the insulin-resistance syndrome in children and adolescents, and could be included in clinical practice as a simple tool to identify children at risk for future cardiovascular disease and T2DM.

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Citations (23)

Autonomic Neuropathy and Painless Myocardial Infarction in Diabetic Patients: Histologic Evidence of Their Relationship

Diabetes (1977)

Isaac Faerman E. Faccio José Milei R.Alcala Nuñez Mauricio Jadzinsky

Myocardial infarction is considered the prime cause of death among adult diabetic patients. In a great number of cases, during myocardial infarction the patients don't feel pain or it is atypical. Diagnosis can be neglected, and mortality increases. In search of an explanation for the absence of pain in these patients, the authors studied the autonomie nerve fibers of the heart muscle with argentic and combined techniques, looking for lesions in the sympathetic or parasympathetic nerve fibers that conduct pain. In the five cases of painless myocardial infarction studied, the nerve fibers showed typical lesions of diabetic neuropathy: beaded thickenings, spindle-shaped thickenings, fragmentation of fibers, and diminution of the number of fibers in the nerves. The patients in the control group (five diabetics with painful infarction, five diabetics without infarction, five nondiabetics with painful infarction, and five nondiabetics without infarction) had no lesions. These facts led us to assume that the absence of pain in diabetics with myocardial infarction could be due to a lesion of the afferent nerves that conduct pain.

10.2337/diab.26.12.1147

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Citations (196)

Neuropatía Diabética Visceral

Acta Diabetologica Latina (1973)

Mauricio Jadzinsky Isaac Faerman Dora Fox

10.1007/bf02590660

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Citations (6)

Vejiga neurogénica asintomática en niños diabéticos.

Revista Argentina de Urología (1975)

Enrique Alberto Alvarez Isaac Faerman Mauricio Jadzinsky Dora Fox Fanny Scudicky

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