Alper Parlakgümüş

Sağlık Bilimleri Üniversitesi

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Co-Authors

Ali Ezer

Başkent University

Sedat Yıldırım

Başkent University

TÇ

Tamer Çolakoğlu

Başkent University

KÇ

Kenan Çalışkan

Başkent University

Sedat Bellı

Başkent University

Osman Erdoğan

Sağlık Bilimleri Üniversitesi

Oİ

Oktay İrkörücü

University of Sharjah

Fılız Bolat

Başkent University

Hakan Yabanoğlu

Başkent University

Gökhan Moray

Royal Free London NHS Foundation Trust

Cooperative Institutions

Başkent University

Hacettepe University

Başkent University Hospital

Sağlık Bilimleri Üniversitesi

Adana Hospital

Cukurova University

Adana Numune Eğitim ve Araştırma Hastanesi

Hacettepe University Hospital

University of Health Science

Adana Science and Technology University

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Invasive and Non-invasive Ductal Carcinoma within Malignant Phyllodes Tumour with Axillary Lymph Node Metastases

Journal of College of Physicians And Surgeons Pakistan (2022)

Osman Erdoğan Alper Parlakgümüş Zeynel Abidin Taş Kemal Yener Ümit Turan

Phyllodes tumours are uncommon breast neoplasms constituting 1-2% of breast malignancies.Metastasis is usually haematogenous, and axillary lymph node dissection is not routinely performed.A phyllodes tumour with concomitant invasive ductal carcinoma (IDC) is even rarer.When IDCor ductal carcinoma in-situ (DCIS) is detected, the management of the condition changes completely.We report a case of a 22-year female presenting with a mass in the right breast and palpable axillary lymph nodes.The pathological examination demonstrated a malignant phyllodes tumour with concomitant IDC and DCIS.The patient elected to have modified radical mastectomy, and the pathological examination showed metastasis in the axillary lymph nodes.The patient was administered appropriate therapy.At the last visit, she did not have the clinical signs of disease.This is the first youngest case of axillary lymph node metastases with both DCIS and IDC on pathological examination in malignant phyllodes tumour.

Concomitant

Axillary lymph nodes

Modified Radical Mastectomy

10.29271/jcpsp.2022.supp2.s92

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Citations (2)

Multiple Primary Malignant Neoplasms in the Presence of Concomitant Chilaiditi Syndrome

Turkish Journal of Colorectal Disease (2018)

Ali Ezer Alper Parlakgümüş

Concomitant

Primary (astronomy)

10.4274/tjcd.92679

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Citations (0)

Coexisting Primary Malignant Lymphoma and Adenocarcinoma of the Intestinal Tract

Turkish Journal of Colorectal Disease (2017)

Ali Ezer Alper Parlakgümüş

Malignant lymphoma

Primary (astronomy)

10.4274/tjcd.85619

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Effects of a Tissue Sealing-Cutting Device Versus Monopolar Electrocautery on Early Pilonidal Wound Healing: A Prospective Randomized Controlled Trial

Diseases of the Colon & Rectum (2011)

Alper Parlakgümüş Ali Ezer Kenan Çalışkan Servet Emeksiz Jale Karakaya

Monopolar electrocauterization produces thermal effects on neighboring tissues, causing tissue damage. Recently, tissue sealing-cutting devices, which are easy to use and achieve simultaneous selective sealing and cutting with less production of heat, have been used.The aim of this study was to investigate the effects of a tissue sealing-cutting device vs monopolar electrocautery on wound healing in the early postoperative period after pilonidal sinus surgery.This study was a prospective randomized clinical trial.This study was conducted at Military Hospital, Eskisehir, Turkey.In total, 128 patients with chronic pilonidal disease were randomly assigned into 2 clinically comparable groups between December 2009 and June 2010.Pilonidal sinus excision was performed with monopolar electrocautery in the control group (n = 64) and with a tissue sealing-cutting device in the study group (n = 64). Data regarding wound healing, demographic variables, history, physical examination findings, defect dimensions, and scores for a visual analog scale were recorded.The main outcomes measured were surgical site infection, early wound failure (dehiscence), and unhealed wound rate.: Wound infection and dehiscence rates were significantly lower (P = .01 and .02), but the duration of surgery was significantly longer (P < .01) in the tissue sealing-cutting group. The unhealed wound rate was 12.5% in the electrocautery group and 4.7% in the tissue sealing-cutting group (P = .01). When the distance from the lowest margin to the anus was 5 cm or less, wound infection and dehiscence rates were lower in the tissue sealing-cutting group (P < .01 and .03).We could not obtain data regarding the cost-effectiveness of the instruments.A tissue sealing-cutting device in pilonidal sinus surgery yields better wound healing than monopolar electrocautery.

Colorectal Surgery

10.1097/dcr.0b013e318222e334

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Citations (11)

High Dose Oral Furosemide with Salt Ingestion in the Treatment of Refractory Ascites of Liver Cirrhosis

Clinical and investigative medicine (2016)

Tolga Yakar Mehmet Demir Özlem Doğan Alper Parlakgümüş Birol Özer

We aimed to evaluate and compare the efficacy and safety of high-dose furosemide+salt orally by comparing HSS+ furosemide (i.v.) and repeated paracentesis in patients with RA.This was a prospective study of 78 cirrhotic patients with RA, randomized into three groups: Group A (n= 25) i.v. furosemide (200-300 mg bid) and 3% hypotonic saline solution (HSS) (once or twice a day); Group B (n= 26) oral furosemide tablets (360-520 mg bid) and salt (2.5 g bid); and, Group C (n= 27) repeated large-volume-paracentesis (RLVP) with albumin infusion. Patients without hyperkalemia were administrated 100 mg of spironolactone/day. During the follow-up; INR, creatinine, and total bilirubin levels were measured to determine the change in MELD (model of end stage liver disease) score.Hepatic encephalopathy (HE), severe episodes of spontaneous bacterial peritonitis (SBP) and pleural effusions (PE) occurred more frequently in Group C. Improvement in Child-Pugh and MELD score was better in Group A and B than Group C. In Group B, improvements were seen in the Child-Pugh and MELD score, reduction in body weight, duration and number of hospitalization. In Groups A and B, remarkable increases in diuresis were observed (706±116 to 2425±633 mL and 691±111 to 2405±772 mL) and serum sodium levels also improved. HE and SBP were occurred more often in group C (p<0.002). Hospitalization decreased significantly in Group B (p<0.001). There was no significant difference in survival among groups.High dose oral furosemide with salt ingestion may be an alternative, effective, safe and well-tolerated method of therapy for RA.

Paracentesis

Liver disease

10.25011/cim.v39i6.27502

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Citations (12)

Comparison of Immigrants and Turkish Patients in Terms of Malnutrition and its Effects on Mortality among patients hospitalized in the ICU with Gastrointestinal Cancers

Bakirkoy Tip Dergisi / Medical Journal of Bakirkoy (2020)

Begüm Şeyda Avcı Adnan Kuvvetli Alper Parlakgümüş

Objective: The aim of this study was to compare the effects of malnutrition on mortality in immigrants and Turkish patients hospitalized in our ICU with the indication of gastrointestinal cancer. Method: This study was performed as a prospective observational study. One-hundered and three (41.3%) patients were Turkish and 146 (58.7%) were immigrants (all Syrian). Age, body mass index (BMI), duration of hospitalization, albumin value, and 30-day and 6-month mortality rates were evaluated. Also, the following assessment tools were calculated: Subjective Global Assessment (SGA), Nutrition risk screening-2002 (NRS), Charlson Comorbidity Index (CCI) Acute Physiology and Chronic Health Evaluation (APACHE) II and III. Results: In total, 150 (60.2%) patients had moderate (SGA B), while 71 (28.5%) patients had severe malnutrition (SGA C). The frequency of SGA C in the immigrants was significantly higher than Turkish ciitzens (p=0.004). The overall mortality rate in our study was 36.9%. No significant difference was found between Turkish citizens and immigrants in terms of overall mortality (p=0.592). Albumin value, APACHE II, APACHE III, CCI and NRS scores were significantly higher in those that died within 30 days. The APACHE 3 score was the most successful tool in predicting 30-day mortality according to ROC analyses. Conclusion: This study revealed that malnutrition is a significant problem for both immigrants and Turkish citizens hospitalized in the ICU. Although there are tools specific for malnutrition assessment, APACHE III score was found to have the highest likelihood to predict mortality.

10.5222/bmj.2020.41275

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Surgical Treatment Modalities for Complicated Aneurysms and Pseudoaneurysms of Arteriovenous Fistulas

The Journal of Vascular Access (2012)

Sedat Bellı Alper Parlakgümüş Tamer Çolakoğlu Ali Ezer Sedat Yıldırım

This study was designed to determine the clinical presentation, characteristics, and management of aneurysm/pseudoaneurysm formation (APF) in dialysis access fistulas.The treatment methods and outcomes of 31 patients who underwent surgery for APF in dialysis access fistulas were retrospectively reviewed over a 9-year period.We performed 1558 operations for arteriovenous fistulas (AVFs) between 2000 and 2009 at our centre. Of the 1558 operations, 35 were carried out for APFs (2.2%) on 31 patients. Thirty of these operations were restorative. Twenty-two (71%) of these patients had their original access done elsewhere, and all corrective surgeries were performed at our hospital. Approximately 52% of the subjects were female, with a mean age of 45.7 ± 17 years. The mean duration of end-stage renal disease was 70.2 ± 51.5 months. The mean number of AVFs per patient was 2.2 ± 1.5. Synthetic grafts were used in five patients (16.1%). Most of the procedures were left-sided (67.7%) and brachial-cephalic fistulas (48.3%). Among 31 complications, 22 were arterial/venous aneurysms (71%) and nine were pseudoaneurysms (29%). Fourteen patients (46.6%) were treated by excision of the aneurysm and primary suture repair. The post-intervention primary patencies for all revised APFs were 68%, 56%, and 52% at 1, 6, and 12 months, respectively. Dysfunction of AVF (16.1%) and bleeding (12.9%) were the most encountered complications after aneurysmectomy.Reformative operations should be considered in cases of urgency and irresponsiveness to endovascular surgery rather than closing the fistulas directly, as it prolongs the duration of AVF patency.

Modalities

Treatment modality

10.5301/jva.5000077

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Citations (26)

Wandering spleen accompanied by hilar angiomatosis causing intestinal obstruction in a paraplegic patient

The Turkish Journal of Gastroenterology (2009)

Alper Parlakgümüş Sedat Yıldırım Ali Ezer N. Emrah Koçer Naime Tokmak

Angiomatosis

Wandering spleen

Intestinal pseudo-obstruction

10.4318/tjg.2009.0018

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Citations (1)

A different technique for the closure of trocar sites

Clinical and Experimental Obstetrics & Gynecology (2015)

Cengiz Yalçınkaya Gonca Çoban Alper Parlakgümüş P. Çaglar Çaglar Harun Çöloğlu

This study aims to present a different technique for the closure of trocar sites in laparoscopic surgeries.Retrospective records of cases who received the new closure technique were collected. Multifilament synthetic absorbable suture was used in this technique, with no additional tools.This technique was applied in a total of ten cases, which included myomectomy, hysterectomy, sacrocolpopexy, and ectopic pregnancy. No intraoperative and postoperative complications were seen in any of the cases.This new and relatively easy-to-use technique can be used as an alternative technique for the closure of trocar sites in laparoscopy.

Closure (psychology)

10.12891/ceog1729.2015

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Citations (0)

GnRH Agonists and antagonists in cyclophosphamide-induced ovarian damage: friend or foe?

Fertility and Sterility (2013)

Huriye Ayşe Parlakgümüş Esra Bulgan Kılıçdağ Fılız Bolat Bülent Haydardedeoğlu Alper Parlakgümüş

10.1016/j.fertnstert.2013.07.1462

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Citations (1)