Katsumi Yamada

Tokyo Polytechnic University

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Koichi Yokono

Tokyo-Kita Medical Center

Hisafumi Yasuda

Hyogo University of Health Sciences

Masao Nagata

Takasago (Japan)

Hiroaki Moriyama

Kobe University

Ikuo Kokufu

Takara (Japan)

Reiko Kotani

Kobe University

Kazuhiro Fukuda

Juntendo University

T Yano

Itami City Hospital

Kenta Hara

Tokyo-Kita Medical Center

Yasuyo Okumachi

Saiseikai Nakatsu Hospital

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Kobe University

The University of Tokyo

Osaka University

Kyoto University

Nagoya University

Gunma University

Toho University

Itami City Hospital

Chiba University

Tohoku University

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Ventricular fibrillation by anaphylaxis following consumption of blue_skinned fish

Acute Medicine & Surgery (2015)

Saori Otsubo Takashi Nishiyama Naoki Okada Yukio Ando Katsumi Yamada

Approximately 4_h after eating mackerel sushi, a 65_year_old man developed generalized itchiness and redness, after which he became unresponsive. He went into a state of ventricular fibrillation but after he was defibrillated twice, his heartbeat returned. The electrocardiogram obtained immediately after hospitalization showed some ST_segment depression, but a subsequent electrocardiogram showed improvement. Coronary CT showed no obvious stenosis or plaque in the coronary artery.Results of an IgE_RAST test confirmed that the level of allergen_specific IgE for mackerel measured <0.10_UA/mL, while the level for anisakis was 1.91_UA/mL.As for the mechanism leading to cardiac arrest, it is thought that the histamines and leukotrienes released from cardiac mast cells caused a coronary artery spasm (Kounis syndrome). This anaphylactic shock is considered to be a result of anisakis allergy, but in general cases of anaphylaxis resulting from consumption of blue_skinned fish.

Kounis syndrome

Anisakis

10.1002/ams2.144

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Citations (5)

[A case of effective weekly paclitaxel administration for metastatic gastric cancer].

PubMed (2002)

Ikuo Kokufu Fumihiko Kimura Tomonori Tanei Hirokazu Taniguchi Kazuhiro Fukuda

We report a case of effective weekly paclitaxel (TXL) administration for metastatic gastric cancer. TXL (80 mg/m2) was infused over 1 hour after short premedication on an outpatient basis. Administration was continued for 3 weeks followed by 1 week rest. A 74-year-old man was diagnosed with recurrence 49 months after surgery for gastric cancer. He was treated with 5-fluorouracil and cisplatin, and thrombocytopenia (grade 3) and creatinin elevation (grade 1) were observed and assessed as progressive disease 2 months after the treatment. We attempted weekly TXL administration and after 5 courses assessed the patient as having a partial response. The treatment is ongoing. The toxic event was leukopenia (grade 2), with no episode of thrombocytopenia. The patient did not complain of nausea or vomiting, and his quality of life was fair during the treatment. Weekly TXL administration is a useful treatment for metastatic gastric cancer.

Leukopenia

Premedication

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Citations (1)

MS367 THE TWISTED CAROTID BIFURCATION AND MICROTHROMBENDARTERECTOMY

Atherosclerosis Supplements (2010)

Hiroyuki Katano Katsumi Yamada

Carotid bifurcation

10.1016/s1567-5688(10)70868-0

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Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice

Diabetes Research and Clinical Practice (2007)

Hiroaki Moriyama Masao Nagata Takashi Arai Yasuyo Okumachi Katsumi Yamada

Insulitis

NOD mice

10.1016/j.diabres.2007.01.050

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Citations (4)

Nicotinamide prevents lymphocytic infiltration in submandibular glands but not the appearance of anti-salivary duct antibodies in non-obese diabetic (NOD) mice.

PubMed (1985)

Katsumi Yamada Toshiaki Hanafusa Hiroko Fujino-Kurihara Atsushi Miyazaki Hideaki Nakajima

Previously we have shown that nicotinamide prevents spontaneously occurring diabetes associated with insulitis in non-obese diabetic (NOD) mice. In this study we injected nicotinamide (0.5 mg/g) or saline (0.01 ml/g) into female NOD mice daily during a period between 4 and 16 weeks of age. At the end of the treatment, periductal and perivascular lymphocytic infiltration in submandibular glands was observed in 91% of saline-injected control mice and 36% of nicotinamide-injected mice (P less than 0.01). No significant difference was observed in the prevalence of anti-salivary duct antibodies or antinuclear antibodies between the nicotinamide group and the saline group. Nicotinamide may alter cell-mediated, but not humoral, immunity to salivary gland cells, resulting in the prevention of submandibulitis.

Insulitis

NOD mice

Nicotinamide phosphoribosyltransferase

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Citations (3)

Factors in Vertical Transmission of HBV

Pediatrics International (1986)

Kohachiro Sugiyama Katsumi Yamada Yoshiro Wada

10.1111/j.1442-200x.1986.tb00731.x

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[Weekly paclitaxel therapy for metastatic breast cancer].

PubMed (2002)

Ikuo Kokufu Hirokazu Taniguchi Fumihiko Kimura Kazuhiro Fukuda Masayuki Yamamoto

We treated 12 patients with metastatic breast cancer with weekly paclitaxel therapy. Paclitaxel was administrated by 1 hour infusion at a dose of 80 mg/m2 after short premedication every week on an outpatient basis. Administration was continued for 3 weeks followed by 1 week rest. All patients had received prior metastatic chemotherapy, and prior anthracycline therapy was done in 66.7% of the patients. Partial responses were observed in 66.7% of the patients and progressive disease in 33.3%. The response rate was 66.7%. Responses were observed in 62.5% of the patients with prior anthracycline therapy. Grade 3/4 leukopenia and neutropenia occurred in 25% of the patients, respectively, and no grade 3/4 peripheral neuropathy was observed. Dyspnea occurred in 25% of the patients and was grade 3 in 16.7%. Dyspnea is thought to be one of the adverse events requiring caution with weekly paclitaxel administration. Weekly paclitaxel therapy is effective and well tolerated in patients with metastatic breast cancer.

Leukopenia

Premedication

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Very high flow injection rate for upper abdominal CT angiography

The Japanese journal of gastro-enterology (2000)

Yasukazu Shioyama Masahiko Kimura T Hagihira Katsumi Yamada Masao Kawashima

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NO-mediated cytotoxicity contributes to multiple low-dose streptozotocin-induced diabetes but not to NOD diabetes

Diabetes Research and Clinical Practice (2008)

Hisafumi Yasuda Zhenzi Jin Maki Nakayama Katsumi Yamada Minoru Kishi

10.1016/j.diabres.2008.11.029

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Citations (13)

A Case of Colo-colic Intussusception due to Juvenile Polyp.

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) (2001)

Yong-Hwi Kim Masayuki Yamamoto Kazuhiro Fukuda Ikuo Kokufu T Yano

小児腸重積症は,しばしばみられる疾患であるが,その多くは回腸結腸型であり器質的原因を有するものは稀とされていた.今回,われわれが経験した結腸結腸型は極めて稀であり,その原因が若年性大腸ポリープによる症例は本邦でも少ない.また,内視鏡的ポリープ切除により治癒しえたので報告する. 症例は6歳,男児.腹痛,鮮血便のため入院となった.腹部所見で膀左側に腫瘤を触知しCT検査にて腸重積と診断され,高圧浣腸で整復するが,再度重積を生じたため,当科紹介となった.注腸造影では下行結腸S状結腸移行部にカニの爪状陰影を認め,先進部に径2.5cm大のポリープ様陰影があったため,大腸内視鏡検査を施行した.下行結腸脾曲側に山田IV型の径2.5cm大ポリープがありポリペクトミーを施行した.その後,症状なく, 4日目に退院した.病理組織所見は若年性ポリープであった.

10.3919/jjsa.62.2971

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