Yu‐Hsiang Tseng

Kaohsiung Veterans General Hospital

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Che‐Yi Chou

China Medical University Hospital

Chuen‐Ming Shih

China Medical University

Walter Chen

National Taipei University of Technology

Lee-Wei Chen

Kaohsiung Veterans General Hospital

Chang‐Min Chung

Chiayi Chang Gung Memorial Hospital

Po‐Chang Wang

Chiayi Chang Gung Memorial Hospital

Yu‐Sheng Lin

Chiayi Chang Gung Memorial Hospital

Yu‐Wen Cheng

Chang Gung Memorial Hospital

Ming‐Shyan Lin

Chiayi Chang Gung Memorial Hospital

Yen‐Fu Chen

National Yunlin University of Science and Technology

Cooperative Institutions

Chang Gung Memorial Hospital

Chang Gung University

China Medical University

China Medical University Hospital

Chiayi Chang Gung Memorial Hospital

Memorial Hospital of South Bend

China Medical University

Kaohsiung Veterans General Hospital

National Yang Ming Chiao Tung University

Linkou Chang Gung Memorial Hospital

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Chronic Hepatitis C Infection Is Associated with Higher Hemoglobin Levels in Hemodialysis Patients, But Hepatitis B Infection Is Not

Dialysis & Transplantation (2008)

Chih‐Bin Chen Che‐Yi Chou Yu‐Hsiang Tseng Chiu‐Ching Huang Walter Chen

Abstract BACKGROUND Chronic hepatitis is associated with increased hemoglobin level in patients with end‐stage renal disease. The aim of this study was to define the individual and combined influence of chronic hepatitis B and C infections on red blood cell status. METHODS A total of 524 chronic hemodialysis patients at 5 hemodialysis centers were retrospectively reviewed for the period from March 1 to June 31, 2005. The results of testing using a third‐generation enzyme‐linked immunosorbent assay showed that 345 patients (65.8%) had neither HBV nor HCV (NBC), 55 patients (10.5%) had HBV, 108 (20.6%) had HCV, and 16 (3.1%) had concurrent HBV and HCV infection (BBC). Differences between the 4 groups of patients in the parameters studied were investigated using a multivariate general linear model with the Sidak post hoc test. RESULTS The hemoglobin and hematocrit of patients with HCV were 10.5 ± 1.6 g/dL and 31.6% ± 4.7%, respectively, which were significantly higher than the 9.9 ± 1.4 g/dL and 29.7% ± 4% of NBC patients ( p = 0.002 and p = 0.001). The erythropoietin (EPO) dose given to patients with HCV was 39.3 ± 40.3 IU/kg/week, significantly lower than the 58.1 ± 40.6 IU/kg/week for those with NBC. The results of the multivariate linear regression analysis suggested that erythropoietin dose, elevated liver functional test results, and HCV infection were major factors affecting red cell production ( p < 0.001, p < 0.02, and p < 0.05, respectively). CONCLUSION Hepatitis C virus infection was associated with an increased number of red blood cells, which led to a lowering of the necessary EPO dose, whereas hepatitis B virus infection was not.

Hepatitis C

Liver disease

Hepatitis B

10.1002/dat.20173

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Citations (5)

Association of brachial-ankle pulse wave velocity with atherosclerosis and presence of coronary artery disease in older patients

Clinical Interventions in Aging (2015)

Chang‐Min Chung Yu‐Hsiang Tseng Yu‐Sheng Lin Jen‐Te Hsu Po‐Chang Wang

Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess risk of cardiovascular disease in Asia. We examined whether baPWV was associated with coronary atherosclerosis and presence and extent of coronary artery disease (CAD) in older patients with chest pain.This cross-sectional study enrolled 370 consecutive patients >65 years old who underwent baPWV measurement and elective coronary angiogram for suspected CAD at a single cardiovascular center, between June 2013 and July 2014.In addition to diabetes mellitus and body mass index, baPWV was one of the statistically meaningful predictors of significant CAD (diameter of stenosis >50%) in a multivariate analysis. When the extent of CAD was classified as nonsignificant or significant CAD (ie, one-, two-, and three-vessel disease), there was a significant difference in baPWV between the significant and nonsignificant CAD groups, but not between the three significant CAD groups. Multivariate linear regression analyses showed that the number of diseased vessels and baPWV were both significantly associated with the SYNTAX (SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery) score. The cutoff value of baPWV at 1,874 cm/s had a sensitivity of 60.1%, specificity of 70.8%, and area under receiver operating characteristic curve of 0.639 in predicting CAD.Arterial stiffness determined by baPWV was associated independently with CAD severity, as assessed by angiography and the SYNTAX score in older patients with chest pain. As a result, increased arterial stiffness assessed by baPWV is associated with the severity and presence of CAD in older patients.

Brachial artery

Wave velocity

Association (psychology)

10.2147/cia.s89568

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Citations (21)

Influence of Intravenous Drug Abuse on Native Arteriovenous Fistula Thrombosis in Chronic Hemodialysis Patients

Therapeutic Apheresis and Dialysis (2008)

Che‐Yi Chou Yu‐Hsiang Tseng Chuen‐Ming Shih Chiu‐Ching Huang Walter Chen

Abstract: The influence of intravenous drug abuse (IVDA) on native arteriovenous fistula thrombosis (NAT) in chronic hemodialysis patients is unknown. We conducted a retrospective study of 123 chronic hemodialysis patients incarcerated in a male prison in Mid‐Taiwan. All patients were dialyzed three times per week, 4 h per session. The development of NAT was compared in patients with a history of IVDA (42, 34.1%) and those without (81, 65.9%). A total of 36 patients experienced one or more NAT episodes in 6 years and 29 (80.6%) of them had a history of IVDA. In these 29 patients, 22 (75.9%) relied on repeated thrombectomy or thrombolysis therapy to maintain patent vascular access. In Kaplan–Meier survival analysis, patients with a history of IVDA were prone to develop NAT (log‐rank, P < 0.001). The result of Cox regression suggested that a history of IVDA, independent of diabetes, was associated with the development of NAT. Patients with a history of IVDA, even after IVDA has stopped, were still prone to develop NAT and vascular access infection.

10.1111/j.1744-9987.2008.00562.x

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Citations (4)

Infection of Mycoplasma hominis in the left lower leg amputation wound of a patient with diabetes: a case report

Journal of Medical Case Reports (2024)

L.-Y. Kuo Yu‐Hsiang Tseng Lee-Wei Chen Tso-Ping Wang Ciao-Shan Chen

Mycoplasma hominis is typically found on the mucosal epithelium of the human genital tract, with infections being rare. However, when the mucosal barrier is compromised or in individuals with weakened immune systems, this microorganism can trigger infections in both intragenital and extragenital sites. This study offers a comprehensive overview of infections caused by the rare pathogen M. hominis. This overview helps laboratories identify M. hominis infections in a timely manner, thereby enabling earlier clinical intervention for patients. A 75-year-old Taiwanese man with type 2 diabetes mellitus initially underwent a left lower extremity amputation following a severe infection caused by necrotizing fasciitis. Subsequently, a poorly healing wound developed at the site of amputation. Upon culturing the wound abscess, M. hominis was isolated and identified as the causative agent. Through this case, we present clinical and microbiological observations along with a review of the literature to deepen our understanding of M. hominis. Our findings can be used to develop laboratory diagnostic protocols and innovative therapeutic approaches.

Surgical oncology

Mycoplasma hominis

10.1186/s13256-024-04718-6

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Citations (1)

In-hospital and post-discharge outcomes of pediatric acute myocarditis underwent after high-dose steroid or intravenous immunoglobulin therapy

BMC Cardiovascular Disorders (2019)

Ming‐Shyan Lin Yu‐Hsiang Tseng Mei‐Yen Chen Chang‐Min Chung Ming-Horng Tsai

High-dose steroids and intravenous immunoglobulin (IVIG) are controversial treatments for pediatric patients with acute myocarditis. This study aimed to investigate their efficacies in the Taiwanese pediatric population.This study evaluated 5563 acute myocarditis patients from the Taiwan's National Health Insurance Research Database and identified 1542 pediatric patients hospitalized for acute myocarditis between January 1, 2001 and December 31, 2011. The exclusion criteria were age of > 11 years, associated cardiovascular comorbidities, autoimmune disease, malignancy before the index hospitalization, extracorporeal membrane oxygenation, intra-aortic balloon pumping, and dual therapy using IVIG and high-dose steroids.After 2:1 propensity score matching, we identified 208 subjects without steroid therapy and 104 subjects who received high-dose steroids. The mean age in that cohort was 2.6 ± 2.9 years, and high-dose steroid therapy had no significant effects on major in-hospital complications and post-discharge outcomes. After 2:1 propensity score matching, we identified 178 subjects without IVIG therapy and 89 subjects who received IVIG. The mean age in that cohort was 2.0 ± 2.1 years, and IVIG had no significant effects on the major outcomes.The present study revealed that high-dose steroid or IVIG therapy had no significant effects on major in-hospital complications, late heart failure hospitalization, and long-term mortality.

Angiology

10.1186/s12872-018-0981-3

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Citations (21)

Association between betel-nut chewing and chronic kidney disease in men

Public Health Nutrition (2008)

Che‐Yi Chou Shi‐Yann Cheng Jiung-Hsiun Liu Wen-Chun Cheng I-Min Kang

Betel-nut use is associated with metabolic syndrome and obesity. However, the association between betel-nut chewing and risk for chronic kidney disease (CKD) is unknown. The present study was conducted to determine the association between betel-nut chewing and CKD in men.We retrospectively reviewed health-check records of 3264 men in a hospital-based cross-sectional screening programme from 2003 to 2006. CKD was defined as estimated glomerular filtration rate less than 60 ml/min/1.73 m2 calculated by the Modification of Diet in Renal Disease formula. Risk factors for CKD including diabetes, hypertension, BMI, smoking, alcohol consumption and age were also considered.A total of 677 (20.7 %) men were found to have CKD and 427 (13.1 %) participants reported a history of betel-nut use. The prevalence (24.8 %) of CKD in betel-nut users was significantly higher than that (11.3 %) of participants without betel-nut use (P = 0.026). In multivariate logistic regression analysis with adjustments for age, hypertension, diabetes and hyperlipidaemia, betel-nut use was independently associated with CKD (P < 0.001). The adjusted odds ratio for betel-nut use was 2.572 (95 % CI 1.917, 3.451).Betel-nut use is associated with CKD in men. The association between betel-nut use and CKD is independent of age, BMI, smoking, alcohol consumption, hypertension, diabetes and hyperlipidaemia.

Betel

10.1017/s1368980008003339

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Citations (41)

Assessment of imprinting- and genetic variation-dependent monoallelic expression using reciprocal allele descendants between human family trios

Scientific Reports (2017)

Trees‐Juen Chuang Yu‐Hsiang Tseng Chia-Ying Chen Yi-Da Wang

Genomic imprinting is an important epigenetic process that silences one of the parentally-inherited alleles of a gene and thereby exhibits allelic-specific expression (ASE). Detection of human imprinting events is hampered by the infeasibility of the reciprocal mating system in humans and the removal of ASE events arising from non-imprinting factors. Here, we describe a pipeline with the pattern of reciprocal allele descendants (RADs) through genotyping and transcriptome sequencing data across independent parent-offspring trios to discriminate between varied types of ASE (e.g., imprinting, genetic variation-dependent ASE, and random monoallelic expression (RME)). We show that the vast majority of ASE events are due to sequence-dependent genetic variant, which are evolutionarily conserved and may themselves play a cis-regulatory role. Particularly, 74% of non-RAD ASE events, even though they exhibit ASE biases toward the same parentally-inherited allele across different individuals, are derived from genetic variation but not imprinting. We further show that the RME effect may affect the effectiveness of the population-based method for detecting imprinting events and our pipeline can help to distinguish between these two ASE types. Taken together, this study provides a good indicator for categorization of different types of ASE, opening up this widespread and complex mechanism for comprehensive characterization.

Imprinting (psychology)

Reciprocal

Genomic Imprinting

10.1038/s41598-017-07514-z

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Citations (9)

Prevalence, Prognostic Factors, and Survival Analysis of Systemic Lupus Erythematosus-Related Serositis

Formosan journal of rheumatology (2015)

Yen‐Fu Chen Yu‐Wen Cheng Cheng-Yen Yu Yu‐Hsiang Tseng Zhengjia Wu

Objective: To investigate the risk factors associated with systemic lupus erythematosus (SLE)-related serositis and its long-term outcome in Chinese patients. Method: Medical records of 609 hospitalized SLE patients who were followed up in Chang Gung Medical Center in Taiwan from 2005 to 2011 were retrospectively reviewed. Results: All 609 patients (89% women) who were fulfilled at least 4 of the ACR criteria for SLE and were included in the study. The mean ages at onset and at admission were 35.8 ± 16.5 years and 40.3 ± 16.0 years, respectively. Two hundred and thirty four patients (38%) had SLE-related serositis. 111 (18%) had pericarditis, 202 (33%) had pleuritis. 79 (13%) had concomitant pleuritis and pericarditis. Multivariate analysis indicated that the admission ages, proteinuria, thrombocytopenia, and lymphopenia, were independent predictors of serositis. Of the 609 SLE patients, 94 patients (15.4%) died during the study period. Of the 94 mortality cases, 63 patients had serositis. Multivariate Cox regression analysis indicated that the independent predictors of mortality were age ＞ 50 years at admission (Hazard ratio(HR) 3.10, p ＜ 0.001), thrombocytopenia (HR 3.23, p ＜ 0.001), serositis (HR 3.03, p ＜ 0.001), seizure (HR 2.13, p = 0.007) and leukopenia (HR 1.78, p = 0.041). Conclusion: This study underlines the prevalence and outcome of serositis in SLE, which is significant related to survival rates of patients. Survival was significantly lower in patients with serositis than in patients without serositis. Close follow up of SLE patients with serositis may be necessary.

Serositis

Concomitant

10.6313/fjr.2015.29(01).02

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598-P: Risk Factors of Amputation In Patients with Diabetic Charcot Foot In Taiwan

Diabetes (2020)

Yu‐Hsiang Tseng Lee-Wei Chen

Charcot foot is a rare and severe complication of DM neuropathy. Patients with diabetic Charcot foot could progress to chronic ulcer or amputation in severe condition. However, there were few studies addressing the risk factors of amputation in Charcot foot. This study aimed to compare the risks of chronic ulcer or amputation in diabetic Charcot foot. A total of 25 patients with Charcot foot were enrolled from 2010 to 2019 in Kaohsiung Veterans General Hospital. We analyzed the correlation between underlying diseases with chronic ulcer or amputation. The average of our patients was 55±13.3 years old with 34.4±31.1 months following up. In patients below 50 years old with obesity (BMI>24), higher prevalence of Charcot foot was noted compared with those with BMI<24 (p<0.05). The Charcot foot patients have a 7-times higher risk of amputation compared with patients with chronic ulcer (p<0.05), 2.6-times higher risk compared with patients with peripheral arterial occlusion diseases (p<0.05), and 5-times higher risk with patients with osteomyelitis (p<0.05). A Higher risk of amputation was also noted in Charcot foot patients with more than 2 times debridement (OR:5.05, p<0.05). A higher prevalence of osteomyelitis was noted in patients of Charcot foot with chronic ulcer than those without chronic ulcer (p<0.05). Patients with diabetic Charcot foot have a higher risk of amputation compared with patients with chronic ulcer or peripheral arterial occlusion diseases. Osteomyelitis should be aware in chronic ulcer patients with Charcot foot. It’s important to control the ulceration and infection progression in this group of patients. Overweight is an important risk factor for Charcot foot in young patients. Disclosure Y. Tseng: None. L. Chen: None.

Foot (prosody)

Diabetic foot ulcer

10.2337/db20-598-p

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