Wuhong Chen

Chinese Academy of Sciences

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Youhong Hu

Shanghai Institute of Materia Medica

Jianping Zuo

China University of Mining and Technology

Li Yang

Chinese Academy of Sciences

Yuyuan Xie

Shanghai Institute of Materia Medica

Limin Zeng

State Key Joint Laboratory of Environment Simulation and Pollution Control

Xiankun Tong

Shanghai Institute of Materia Medica

Chunhao Yang

Chinese PLA General Hospital

Heng Li

Dana-Farber Cancer Institute

Guozhang Long

Shanghai Institute of Materia Medica

Feifei Liu

Chinese Academy of Sciences

Cooperative Institutions

Chinese Academy of Sciences

Shanghai Institute of Materia Medica

University of Chinese Academy of Sciences

Nanjing University of Chinese Medicine

Capital Medical University

Peking University

Huazhong University of Science and Technology

National Center for Drug Screening

Sun Yat-sen University

Zhejiang University

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Discovery of Phthalazinone Derivatives as Novel Hepatitis B Virus Capsid Inhibitors

Journal of Medicinal Chemistry (2020)

Wuhong Chen Feifei Liu Qiliang Zhao Xinna Ma Dong Lu

HBV capsid assembly has been viewed as an attractive target for new antiviral therapies against HBV. On the basis of a lead compound 4r, we further investigated this target to identify novel active compounds with appropriate anti-HBV potencies and improved pharmacokinetic (PK) properties. Structure–activity relationship studies based on metabolic pathways of 4r led to the identification of a phthalazinone derivative 19f with appropriate anti-HBV potencies (IC50 = 0.014 ± 0.004 μM in vitro), which demonstrated high oral bioavailability and liver exposure. In the AAV-HBV/mouse model, administration of 19f resulted in a 2.67 log reduction of the HBV DNA viral load during a 4-week treatment with 150 mg/kg dosing twice daily.

IC50

10.1021/acs.jmedchem.0c00346

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Citations (21)

A prodrug of the capsid assembly modulator improved druggability and lowing HBsAg and HBeAg for the treatment of chronic hepatitis B

European Journal of Medicinal Chemistry (2023)

Wuhong Chen Ying Gong Guozhang Long Xinran Wang Yu‐Rong Yang

cccDNA

HBeAg

Druggability

Seroconversion

10.1016/j.ejmech.2023.115485

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Citations (3)

Discovery of highly potent SARS-CoV-2 Mpro inhibitors based on benzoisothiazolone scaffold

Bioorganic & Medicinal Chemistry Letters (2022)

Weixiong Chen Bo Feng Sheng Han Peipei Wang Wuhong Chen

IC50

High-Throughput Screening

Drug Development

Structure–activity relationship

2019-20 coronavirus outbreak

10.1016/j.bmcl.2022.128526

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Citations (17)

Direct asymmetric aldol reactions catalyzed by (4R)‐4‐(β‐Naphthalenyl)methoxy‐(S)‐proline

Chirality (2005)

Zongxuan Shen Wuhong Chen Hong Jiang Yi Ding Xiaoqing Luo

A novel proline derivative, (4R)-4-(beta-Naphthalenyl)methoxy-(S)-proline, was conveniently prepared from the naturally occurring (4S)-hydroxy-(S)-proline; 5 mol % of this compound efficiently catalyzes the asymmetric aldol reactions of various benzaldehydes with acetone in excess of acetone as the solvent, giving the aldol adducts in good yields with ee up to 89.8%.

Aldol reaction

Derivative (finance)

10.1002/chir.20107

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Citations (14)

19F NMR spectroscopy as a tool to detect rotations in fluorine substituted phenyl compounds

Tetrahedron (2020)

Mingming Sun Wuhong Chen Tao Zhang Zhenjun Liu Junchao Wei

Atropisomer

Conformational isomerism

Chemical shift

10.1016/j.tet.2020.131679

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Citations (7)

Synthetic Approach to 4a-Methyltetrahydrofluorene-Type Diterpenoids via an Aromatic Oxidation of Phenol Derivatives

Synthetic Communications (2011)

Wuhong Chen Koichi S. Kobayashi Kazunori Takahashi Toshio Honda

Abstract An intramolecular aromatic oxidation of a phenolic compound with a hypervalent iodine reagent afforded the coupling product, in which the coupling took place at the para-position of the methoxy goup of the starting material instead of the desired para-position of the isopropenyl group, unfortunately.

Hypervalent molecule

10.1080/00397911.2010.518274

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Citations (7)

ChemInform Abstract: Synthetic Approach to 4a‐Methyltetrahydrofluorene‐Type Diterpenoids via an Aromatic Oxidation of Phenol Derivatives.

ChemInform (2012)

Wuhong Chen Koichi S. Kobayashi Kazunori Takahashi Toshio Honda

Abstract An aromatic oxidation with a hypervalent iodine reagent is used as a strategy for the preparation of the title compounds.

Hypervalent molecule

Terpene

10.1002/chin.201218207

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Citations (0)

Cross-cultural Communication Strategies Research of Socializing Apps During Internet Era

Advances in Social Science, Education and Humanities Research/Advances in social science, education and humanities research (2021)

Yuheng Wang Wuhong Chen

At present, many software products are trying to achieve cross-cultural communication overseas, and TikTok has been considered a successful case.Against this background, this paper uses the encoding/decoding theory to study the experience of TikTok's remarkable success in cross-cultural communication.This paper mainly uses the method of case study and the method of comparative study to explore the different communication strategies of the app in China and the US and their commonalities during the communication process.Based on the encoding/decoding theory, this paper separately analyzes the app's communication advantages in the different stages of encoding, decoding, and circulation.The research directions and research methods selected in this paper are innovative and practical, which enriches the development of the encoding/decoding theory and expands its explanatory power and scope of application.At the same time, one of the most successful apps for cross-cultural communication, TikTok, is used as the research object to provide a reference for corporation operators of social apps and other transcultural communicators.

10.2991/assehr.k.210806.084

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Citations (5)

A novel phthalazinone derivative as a capsid assembly modulator inhibits hepatitis B virus expression

Antiviral Research (2023)

Li Yang Ying Gong Feifei Liu Wuhong Chen Xinran Wang

HBcAg

HBeAg

10.1016/j.antiviral.2023.105763

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Citations (3)

Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety