Benedetta Corvaro

Marche Polytechnic University

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Stefano Menzo

Marche Polytechnic University

Sara Caucci

Marche Polytechnic University

Vanessa De Pace

Ospedale Policlinico San Martino

Roberto Ferrarese

IRCCS Ospedale San Raffaele

Teresa Rocco

Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona

Marco Iannetta

University of Rome Tor Vergata

Ilaria Vicenti

University of Siena

Daniela Francisci

University of Perugia

Luca Carioti

University of Rome Tor Vergata

Spinello Antinori

University of Milan

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Istituti di Ricovero e Cura a Carattere Scientifico

Marche Polytechnic University

Ospedali Riuniti di Ancona

Azienda Ospedaliero Universitaria Ospedali Riuniti

University of Milan

University of Rome Tor Vergata

Luigi Sacco Hospital

Università Cattolica del Sacro Cuore

Ospedali Riuniti Umberto I

University of Padua

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Weak Cross-Lineage Neutralization by Anti SARS-CoV-2 Spike Antibodies after Natural Infection or Vaccination Is Rescued by Repeated Immunological Stimulation

Vaccines (2021)

Sara Caucci Benedetta Corvaro Sofia Maria Luigia Tiano Anna Valenza Roberta Longo

After over one year of evolution, through billions of infections in humans, SARS-CoV-2 has evolved into a score of slightly divergent lineages. A few different amino acids in the spike proteins of these lineages can hamper both natural immunity against reinfection, and vaccine efficacy. In this study, the in vitro neutralizing potency of sera from convalescent COVID-19 patients and vaccinated subjects was analyzed against six different SARS-CoV-2 lineages, including the latest B.1.617.2 (or Delta variant), in order to assess the cross-neutralization by anti-spike antibodies. After both single dose vaccination, or natural infection, the neutralizing activity was low and fully effective only against the original lineage, while a double dose or a single dose of vaccine, even one year after natural infection, boosted the cross-neutralizing activity against different lineages. Neither binding, nor the neutralizing activity of sera after vaccination, could predict vaccine failure, underlining the need for additional immunological markers. This study points at the importance of the anamnestic response and repeated vaccine stimulations to elicit a reasonable cross-lineage neutralizing antibody response.

Lineage (genetic)

10.3390/vaccines9101124

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Citations (4)

On the lookout for influenza viruses in Italy during the 2021-2022 season: Along came A(H3N2) viruses with a new phylogenetic makeup of their hemagglutinin

Virus Research (2022)

Cristina Galli Laura Pellegrinelli Federica Giardina Guglielmo Ferrari Sara Colonia Uceda Renteria

To assess influenza viruses (IVs) circulation and to evaluate A(H3N2) molecular evolution during the 2021-2022 season in Italy.

Strain (injury)

10.1016/j.virusres.2022.199033

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Citations (13)

Response to BNT162b2 Sars-Cov-2 Vaccine in Recipients of Allogeneic Hematopoietic Stem Cell Transplant

Blood (2021)

Francesco Saraceni Alessandro Fiorentini Sonia Morè Selene Guerzoni Bruna Puglisi

Seroconversion

10.1182/blood-2021-152907

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Epidemiological and Clinical Features of SARS-CoV-2 Variants Circulating between April–December 2021 in Italy

Viruses (2022)

Alessia Lai Annalisa Bergna Carla Della Ventura Stefano Menzo Bianca Bruzzone

SARS-CoV-2 is constantly evolving, leading to new variants. We analysed data from 4400 SARS-CoV-2-positive samples in order to pursue epidemiological variant surveillance and to evaluate their impact on public health in Italy in the period of April-December 2021. The main circulating strain (76.2%) was the Delta variant, followed by the Alpha (13.3%), the Omicron (5.3%), and the Gamma variants (2.9%). The B.1.1 lineages, Eta, Beta, Iota, Mu, and Kappa variants, represented around 1% of cases. There were 48.2% of subjects who had not been vaccinated, and they had a lower median age compared to the vaccinated subjects (47 vs. 61 years). An increasing number of infections in the vaccinated subjects were observed over time, with the highest proportion in November (85.2%). The variants correlated with clinical status; the largest proportion of symptomatic patients (59.6%) was observed with the Delta variant, while subjects harbouring the Gamma variant showed the highest proportion of asymptomatic infection (21.6%), albeit also deaths (5.4%). The Omicron variant was only found in the vaccinated subjects, of which 47% had been hospitalised. The diffusivity and pathogenicity associated with the different SARS-CoV-2 variants are likely to have relevant public health implications, both at the national and international levels. Our study provides data on the rapid changes in the epidemiological landscape of the SARS-CoV-2 variants in Italy.

2019-20 coronavirus outbreak

Sars virus

Betacoronavirus

Pandemic

Molecular Epidemiology

Coronavirus Infections

10.3390/v14112508

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Citations (14)

Epidemiological and Clinical Features of SARS-CoV-2 Variants Circulating between April-December 2021 in Italy

Alessia Lai Annalisa Bergna Carla Della Ventura Stefano Menzo Bianca Bruzzone

SARS-CoV-2 is constantly evolving leading to new variants. We analysed data from 4,400 SARS-CoV-2-positive samples in order to continue variant surveillance in Italy to evaluate their epidemiological and relative impact on public health in the period April-December 2021. The main circulating strain (76.2%) was Delta followed by Alpha (13.3%), Omicron (5.3%) and Gamma variants (2.9%). B.1.1 lineages, Eta, Beta, Iota, Mu and Kappa variants represented around 1% of cases. Overall, 48.2% of subjects were not vaccinated with a lower median age compared to vaccinated subjects (47 vs. 61 years). An increasing number of infections in vaccinated subjects was observed overtime, with the highest proportion in November (85.2%). Variants correlated with clinical status; the largest proportion of symptomatic patients (59.6%) was observed among Delta variant, while subjects harboring Gamma variant showed the highest proportion of asymptomatics (21.6%), albeit also of deaths (5.4%). The Omicron variant was only found in vac-cinated subjects, of which 47% were hospitalized. Diffusivity and pathogenicity associated with the different SARS-CoV-2 variants are likely to have relevant public health implications, both at national and international level. Our study pro-vides data on the rapid changes in the epidemiological landscape of SARS-CoV-2 variants in Italy.

Molecular Epidemiology

10.20944/preprints202209.0241.v1

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Citations (6)