Valentina A. Zenkova

Gause Institute of New Antibiotics Russian Academy of Medical Sciences

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Olga V. Efremenkova

Gause Institute of New Antibiotics Russian Academy of Medical Sciences

ИА

И. А. Маланичева

Gause Institute of New Antibiotics Russian Academy of Medical Sciences

Irina V. Tolstych

Gause Institute of New Antibiotics Russian Academy of Medical Sciences

АМ

А. М. Королев

Gause Institute of New Antibiotics Russian Academy of Medical Sciences

Tatiana A. Efimenko

Gause Institute of New Antibiotics Russian Academy of Medical Sciences

ГС

Г. С. Катруха

Gause Institute of New Antibiotics Russian Academy of Medical Sciences

МИ

М. И. Резникова

Academy of Medical Sciences

СП

С. П. Синеокий

Genetika

ОД

О. Д. Тарасова

Genetika

Yuri V. Dudnik

Gause Institute of New Antibiotics Russian Academy of Medical Sciences

Cooperative Institutions

Gause Institute of New Antibiotics Russian Academy of Medical Sciences

Russian Academy of Sciences

Academy of Medical Sciences

Lomonosov Moscow State University

Institute of Bioorganic Chemistry

Genetika

SINTEF

Norwegian University of Science and Technology

Moscow State University

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[Isolation and study of antibiotic INA-1132 (chlorothricin), produced by actinomycete strain].

PubMed (2008)

Л. П. Терехова О. А. Галатенко Alexey S. Trenin I. V. Tolstykh Valentina A. Zenkova

Taxonomic properties of strain INA-1132 producing antibiotic INA-1132 are described. The antibiotic showed activity against grampositive bacteria and fungi. The strain was classified as belonging to the genus Streptomyces and by its taxomic characteristics is most close to S. baarnensis. The experiments with the bacterial culture Halobacterium salinarum (previously H. halobium) revealed hypolipidemic activity of the antibiotic, i. e. its ability to inhibit biosynthesis of sterols. Conditions for the production of the antibiotic, methods of its isolation and purification, as well as the results of the chemical structure elucidation are described. By its physicochemical properties the antibiotic is identical to chlorothricin. The structure of antibiotic INA-1132 was ascertained by X-ray analysis. Conformation of the molecule of chlorothricin (antibiotic 1132) was determined for the first time.

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Citations (1)

Antimicrobial Activity of Coprinus Pers. Isolates

International journal of medicinal mushrooms (2001)

Olga V. Efremenkova Ekaterina Y. Ershova Irina V. Tolstych Valentina A. Zenkova Yuri V. Dudnik

Coprinus

10.1615/intjmedmushr.v3.i2-3.550

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Citations (3)

[Isolation of cephamycins from actinomycete cultures].

PubMed (1977)

M S Iurina M F Lavrova Valentina A. Zenkova T S Maksimova O L Ol'khovatova

A method for isolation of cephamycins from culture fluids of actinomycetes was developed. It included the stage of effective purification of sulfocation exchange resin SDV-3 (H+) with water desorption. Further purificiation of the antibiotics was achieved with sorption on anion exchange resin and fractional precipitation. The method provided 95-96 per cent purity level of the preparations.

Isolation

Ion-exchange resin

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Antimicrobial Activity of Medicinal Mushrooms from the Genus Coprinus (Fr.) S. F. Gray (Agaricomycetideae)

International journal of medicinal mushrooms (2003)

Valentina A. Zenkova Olga V. Efremenkova Ekaterina Y. Ershova Irina V. Tolstych Yuri V. Dudnik

Antimicrobial activity of 14 strains of 6 species of the genus Coprinus (family Coprinaceae, Agaricales s.l.): C. micaceus (Bull.: Fr.) Fr. VKM F-2945, VKM F-2946, C. delicatulus Apinis VKPM F-248, C. comatus (Mull.: Fr.) Pers. 2957, C. congregatus (Bull.) Fr. 2961, 3003, C. radiatus (Bolt.) Fr. 2965 , 2987, C. digitalis (Batsch) Fr. 2956, Coprinus sp. 2958, 2959, 2960-1, 2960-2, 3002 were studied. Antimicrobial activity was found in 13 strains. The test organisms selected for the antimicrobial activity study were Bacillus subtilis AONN 6633, B. mycoides 537, B. pumilis NCTC 8241, Leuconostoc mesenteroides VKPM B-4177, Micrococcus luteus NCTC 8340, Staphylococcus aureus FDA 209P, INA 00761, INA 00762, Escherichia coli ATCC 25922, Comamonas terrigena ATCC 8461, Pseudomonas aeruginosa ATCC 27853, Aspergillus niger INA 00760, Saccharomyces cerevisiae RIA 259, and Candida albicans INA 00763. The biosynthesis levels were different and in some strains activity was found only after extraction and concentration of biologically active substances from mycelium or cultural liquid. One strain demonstrated a wide spectrum of antimicrobial activity (against Gram-positive and Gram-negative bacteria as well as against fungi); 3 strains against Gram-positive bacteria only; 5 strains against Gram-positive and Gram-negative bacteria; 3 against Gram-positive bacteria and microfungi. Coprinus representatives are a possible source of antibacterial antibiotics.

Micrococcus luteus

Coprinus

Antibiosis

10.1615/intjmedmushr.v5.i1.50

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Citations (8)

New antibiotics produced by Bacillus subtilis strains

Microbiology (2014)

И. А. Маланичева D. G. Kozlov Tatiana A. Efimenko Valentina A. Zenkova Г. С. Катруха

Strain (injury)

10.1134/s0026261714040110

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Citations (4)

Ключевые слова: бактерии, продуценты антибиотиков, базидиальные грибы, анти- биотикорезистентность, метициллинрезистентность, Bacillus subtilis.

Tatiana A. Efimenko И. А. Маланичева Valentina A. Zenkova M. I. Resnikova А. М. Королев

ИЗЫСКАНИЕ ПРОДУЦЕНТОВ НОВЫХ АНТИБИОТИКОВ СРЕДИ БАКТЕРИЙ, ВЫДЕЛЕННЫХ ИЗ ПЛОДОВЫХ ТЕЛ БАЗИДИАЛЬНЫХ ГРИБОВ НИИ по изысканию новых антибиотиков им. Г.Ф. Гаузе РАМН, Москва, Россия Цель. Поиск продуцентов новых природных антибиотиков, эффективных в отно-шении болезнетворных форм бактерий с устойчивостью к антибиотикам. Материалы и методы. Из ткани плодовых тел базидиальных грибов выделяли бак-териальные штаммы, у которых при глубинном культивировании определяли антибиоти-ческую активность в отношении 12 бактериальных и грибных тест-культур. Химически-ми методами выделены и исследованы антибиотики, образуемые двумя бактериальными штаммами. Микробиологическими и генетическими методами определена принадлеж-ность двух бактериальных продуцентов к виду

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Антимикробные свойства антибиотика эремоксиларина а, образуемого аскомицетным грибом из класса Sordariomycetes в условиях глубинного культивирования

Antibiot Khimioter = Antibiotics and Chemotherapy (2015)

Olga V. Efremenkova Б Ф Васильева Valentina A. Zenkova А. М. Королев Ю Н Лузиков

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Antimicrobial and Antitoxic Action of Pleurotus ostreatus (Jacq.: Fr.) Kumm. Extracts

International journal of medicinal mushrooms (2001)

Valeriy P. Gerasimenya Olga V. Efremenkova О. В. Камзолкина Tatyana A. Bogush Irina V. Tolstych