Hongying Shan

Chinese Academy of Agricultural Sciences

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Fabio Pasin

Universitat Politècnica de València

Juan Antonio Garcı́a

Universidad Autónoma de Madrid

Qingwen Wang

Peking University Shenzhen Hospital

Aiming Wang

Agriculture and Agri-Food Canada

Linhao Ge

Chinese Academy of Agricultural Sciences

Fangfang Li

Chinese Academy of Agricultural Sciences

Xueping Zhou

China National Rice Research Institute

Bernardo Rodamilans

Centro Nacional de Biotecnología

Mingxuan Jia

Chinese Academy of Agricultural Sciences

Carmen Simón‐Mateo

Universidad Autónoma de Madrid

Cooperative Institutions

Chinese Academy of Agricultural Sciences

Institute of Plant Protection

Shanghai Jiao Tong University

Chinese Academy of Sciences

Peking University Shenzhen Hospital

Peking University

Zhejiang University

Chinese Academy of Medical Sciences & Peking Union Medical College

Consejo Superior de Investigaciones Científicas

Fudan University

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The relationships of CD8+ T cell subsets in RA patients with disease activity and clinical parameters

International Immunopharmacology (2022)

Juan He Yu Li Jian Chen Qi Wu Hongying Shan

Erythrocyte sedimentation rate

Pathogenesis

10.1016/j.intimp.2022.109399

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Citations (4)

An autoimmune disease variant of IgG1 modulates B cell activation and differentiation

Science (2018)

Xiangjun Chen Xiaolin Sun W. Yang Bing Yang Xiaozhen Zhao

An IgG1 SNP enhances autoimmunity One common feature of autoimmune diseases like systemic lupus erythematosus (SLE) is the presence of high titers of self-reactive antibodies. These result in immune complexes, inflammation, and tissue pathology. Consequently, the checkpoints that normally keep immunoglobulin G (IgG)–positive autoreactive B cells in check are of intense interest. Chen et al. report the presence of a common IgG1 single-nucleotide polymorphism (SNP) in East Asian populations (hIgG1-G396R). This SNP was enriched in SLE patients and associated with increased disease severity. Humans with this SNP, as well as knockin mice, showed enhanced plasma cell accumulation and antibody production. This SNP enhanced IgG1 immunoglobulin tail tyrosine motif phosphorylation, triggering longer adaptor protein Grb2 dwell times in immunological synapses and hyper–Grb2–Bruton's tyrosine kinase signaling after antigen binding. Science , this issue p. 700

10.1126/science.aap9310

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Citations (42)

Characterization of P1 leader proteases of the Potyviridae family and identification of the host factors involved in their proteolytic activity during viral infection

Hongying Shan

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Potyviridae

Viral infection

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Citations (2)

Deubiquitination of aryl hydrocarbon receptor (AhR) by USP21 negatively regulates Th17 cells differentiation

Journal of Leukocyte Biology (2024)

Lingbiao Wang Hao Cheng Xiaoxia Wang Fangming Zhu Na Tian

Abstract Aryl hydrocarbon receptor (AhR) is a key transcription factor that modulates the differentiation of T helper 17 (Th17) cells. How AhR is regulated at the post-translational level in Th17 cells remains largely unclear. Here, we identify USP21 as a newly defined deubiquitinase of AhR. We demonstrate that USP21 interacts with and stabilizes AhR by removing the K48-linked polyubiquitin chains from AhR. Interestingly, USP21 inhibits the transcriptional activity of AhR in a deubiquitinating-dependent manner. USP21 deubiquitinates AhR at the K432 residue, and the maintenance of ubiquitination on this site is required for the intact transcriptional activity of AhR. Moreover, the deficiency of USP21 promotes the differentiation of Th17 cells both in vitro and in vivo. Consistently, adoptive transfer of USP21-deficient naïve CD4+ T cells elicits more severe colitis in Rag1−/− recipients. Therefore, our study reveals a novel mechanism in which USP21 deubiquitinates AhR and negatively regulates the differentiation of Th17 cells.

Deubiquitinating enzyme

10.1093/jleuko/qiae148

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Abscisic Acid Connects Phytohormone Signaling with RNA Metabolic Pathways and Promotes an Antiviral Response that Is Evaded by a Self-Controlled RNA Virus

Plant Communications (2020)

Fabio Pasin Hongying Shan Beatriz García Maren Müller David San León

A complex network of cellular receptors, RNA targeting pathways, and small-molecule signaling provides robust plant immunity and tolerance to viruses. To maximize their fitness, viruses must evolve control mechanisms to balance host immune evasion and plant-damaging effects. The genus Potyvirus comprises plant viruses characterized by RNA genomes that encode large polyproteins led by the P1 protease. A P1 autoinhibitory domain controls polyprotein processing, the release of a downstream functional RNA-silencing suppressor, and viral replication. Here, we show that P1Pro, a plum pox virus clone that lacks the P1 autoinhibitory domain, triggers complex reprogramming of the host transcriptome and high levels of abscisic acid (ABA) accumulation. A meta-analysis highlighted ABA connections with host pathways known to control RNA stability, turnover, maturation, and translation. Transcriptomic changes triggered by P1Pro infection or ABA showed similarities in host RNA abundance and diversity. Genetic and hormone treatment assays showed that ABA promotes plant resistance to potyviral infection. Finally, quantitative mathematical modeling of viral replication in the presence of defense pathways supported self-control of polyprotein processing kinetics as a viral mechanism that attenuates the magnitude of the host antiviral response. Overall, our findings indicate that ABA is an active player in plant antiviral immunity, which is nonetheless evaded by a self-controlled RNA virus.

RNA Silencing

Picornavirus

10.1016/j.xplc.2020.100099

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Citations (49)

Structure of Mumps virus nucleocapsid ring

Xin Su Qianwen Shen Hongying Shan

Mumps virus

10.2210/pdb7ewq/pdb

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Truncation of a P1 leader proteinase facilitates potyvirus replication in a non‐permissive host

Molecular Plant Pathology (2017)

Hongying Shan Fabio Pasin Ioannis E. Tzanetakis Carmen Simón‐Mateo Juan Antonio Garcı́a

The Potyviridae family is a major group of plant viruses that includes c. 200 species, most of which have narrow host ranges. The potyvirid P1 leader proteinase self-cleaves from the remainder of the viral polyprotein and shows large sequence variability linked to host adaptation. P1 proteins can be classified as Type A or Type B on the basis, amongst other things, of their dependence or not on a host factor to develop their protease activity. In this work, we studied Type A proteases from the Potyviridae family, characterizing their host factor requirements. Our in vitro cleavage analyses of potyvirid P1 proteases showed that the N-terminal domain is relevant for host factor interaction and suggested that the C-terminal domain is also involved. In the absence of plant factors, the N-terminal end of Plum pox virus P1 antagonizes protease self-processing. We performed extended deletion mutagenesis analysis to define the N-terminal antagonistic domain of P1. In viral infections, removal of the P1 protease antagonistic domain led to a gain-of-function phenotype, strongly increasing local infection in a non-permissive host. Altogether, our results shed new insights into the adaptation and evolution of potyvirids.

Potyviridae

Host factors

Tobacco etch virus

10.1111/mpp.12640

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Citations (37)

ErMiao San Inhibits Angiogenesis in Rheumatoid Arthritis by Suppressing JAK/STAT Signaling Pathways

Evidence-based Complementary and Alternative Medicine (2020)

Lianhua He Qingxia Qin Juan He Han Wang Yiping Hu

ErMiao San (EMS) is composed of the Cortex Phellodendri chinensis and Atractylodes lancea , and it has the function of eliminating heat and excreting dampness in terms of traditional Chinese medicine to damp heat syndrome. Previous reports indicate that EMS possesses anti‐inflammatory activity; however, its action on angiogenesis of rheumatoid arthritis (RA) has not been clarified. The present study aims to determine the antiangiogenic activity of EMS in collagen‐induced arthritis (CIA) mice and in various angiogenesis models. Our data showed that EMS (5 g/kg) markedly reduced the immature blood vessels in synovial membrane tissues of inflamed joints from CIA mice. It also inhibited vascular endothelial growth factor (VEGF)‐induced microvessel sprout formation ex vivo . Meanwhile, EMS suppressed VEGF‐induced migration, invasion, adhesion, and tube formation of human umbilical vein endothelial cells (HUVECs). Moreover, EMS significantly reduced the expression of angiogenic activators including interleukin (IL)‐1 β , IL‐6, and tumor necrosis factor‐alpha (TNF‐ α ) in synovium of CIA mice. More interestingly, EMS blocked the autophosphorylation of VEGF‐induced JAK1, STAT1, and STAT6 in CIA mice and VEGF‐induced HUVECs. These findings suggest for the first time that EMS possesses the antiangiogenic effect in RA in vivo, ex vivo , and in vitro by interrupting the targeting of JAK/STAT activation.

10.1155/2020/4381212

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Citations (15)

microRNA-520c-3p suppresses NLRP3 inflammasome activation and inflammatory cascade in preeclampsia by downregulating NLRP3

Inflammation Research (2019)

Zhaochun Liu Xia Zhao Hongying Shan Huan Gao Ping Wang

Pyrin domain

Proinflammatory cytokine

10.1007/s00011-019-01246-8

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Citations (37)

SUMOylation-modified Pelota-Hbs1 RNA surveillance complex restricts the infection of potyvirids in plants

Molecular Plant (2023)

Linhao Ge Buwei Cao Rui Qiao Hongguang Cui Shaofang Li

10.1016/j.molp.2022.12.024

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Citations (20)