Yi-Fu Kong

Xiamen University

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Yi‐Ming Li

Yantai University

Jing Shi

University of Science and Technology of China

Hua‐Jian Xu

Hefei University of Technology

Jingsi Bai

South China University of Technology

Guo‐Chao Chu

Tsinghua University

Chieh-Yang Cheng

Yuan's General Hospital

Yi Jin

University of Manchester

Donald Bierer

Bayer (Germany)

Yehai Wang

University of Science and Technology of China

Jun Wang

Hong Kong Baptist University

Cooperative Institutions

Hefei University of Technology

University of Science and Technology of China

Chinese Academy of Sciences

Hefei University

Cardiff University

Anhui Medical University

China National Petroleum Corporation (China)

Jiangxi University of Traditional Chinese Medicine

Collaborative Innovation Center of Chemistry for Energy Materials

Xiamen University

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Efficient synthesis of hydrocarbon-bridged diaminodiacids through nickel-catalyzed reductive cross-coupling

Tetrahedron Letters (2017)

Tao Wang Yi-Fu Kong Yang Xu Jian Fan Hua‐Jian Xu

Coupling reaction

Reductive elimination

10.1016/j.tetlet.2017.09.006

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Citations (14)

Acid-sensitive auxiliary assisted atypical diubiquitin synthesis exploiting thiol-ene coupling

Tetrahedron Letters (2019)

Hua Xiao Jingsi Bai Yi-Fu Kong Guo‐Chao Chu Jing Shi

Ene reaction

Thiol

10.1016/j.tetlet.2019.151123

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Citations (2)

Chemical Synthesis of K33 Acetylated SUMO Protein

Gaodeng xuexiao huaxue xuebao (2016)

Yehai Wang Yi-Fu Kong Chenchen Chen Yi‐Ming Li

10.7503/cjcu20160417

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Citations (1)

Deciphering the Synthetic and Refolding Strategy of a Cysteine-Rich Domain in the Tumor Necrosis Factor Receptor (TNF-R) for Racemic Crystallography Analysis and d-Peptide Ligand Discovery

ACS Bio & Med Chem Au (2023)

Alexander J. Lander Yi-Fu Kong Yi Jin Chuanliu Wu Louis Y. P. Luk

Many cell-surface receptors are promising targets for chemical synthesis because of their critical roles in disease development. This synthetic approach enables investigations by racemic protein crystallography and ligand discovery by mirror-image methodologies. However, due to their complex nature, the chemical synthesis of a receptor can be a significant challenge. Here, we describe the chemical synthesis and folding of a central, cysteine-rich domain of the cell-surface receptor tumor necrosis factor 1 which is integral to binding of the cytokine TNF-α, namely, TNFR-1 CRD2. Racemic protein crystallography at 1.4 Å confirmed that the native binding conformation was preserved, and TNFR-1 CRD2 maintained its capacity to bind to TNF-α (KD ≈ 7 nM). Encouraged by this discovery, we carried out mirror-image phage display using the enantiomeric receptor mimic and identified a d-peptide ligand for TNFR-1 CRD2 (KD = 1 μM). This work demonstrated that cysteine-rich domains, including the central domains, can be chemically synthesized and used as mimics for investigations.

10.1021/acsbiomedchemau.3c00060

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Efficient semi-synthesis of ubiquitin-7-amino-4-methylcoumarin

Tetrahedron (2018)

Guo‐Chao Chu Jingsi Bai Yi-Fu Kong Jian Fan S. S. Sun

Aminolysis

Thioester

Deubiquitinating enzyme

10.1016/j.tet.2018.05.081

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Citations (10)