Yacouba Foupouapouognigni

Université de Yaoundé I

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Co-Authors

Richard Njouom

Centre Pasteur du Cameroun

Eric Nerrienet

Fondation Mérieux

Anfumbom Kfutwah

Centre Pasteur du Cameroun

Antoine Gessain

Institut Pasteur

Dominique Rousset

Institut Pasteur de la Guyane

Ahidjo Ayouba

Institut de Recherche pour le Développement

Serge Alain Sadeuh‐Mba

Centre Pasteur du Cameroun

Oliver G. Pybus

University of Oxford

Myriam Lavoie

Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean

Onana Boyomo

Université de Yaoundé I

Cooperative Institutions

Centre Pasteur du Cameroun

Inserm

Institut Pasteur

National Radiation Protection Agency of Cameroon

Istituto Zooprofilattico Sperimentale delle Venezie

Food and Agriculture Organization of the United Nations

Ministry of Livestock, Fisheries and Animal Industries

Seibersdorf Laboratories (Austria)

Centre National de la Recherche Scientifique

Université de Yaoundé I

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Low Rate of Mother-to-Child Transmission of HIV-1 After Nevirapine Intervention in a Pilot Public Health Program in Yaound??, Cameroon

JAIDS Journal of Acquired Immune Deficiency Syndromes (2003)

Ahidjo Ayouba Gilbert Tene Patrick Cunin Yacouba Foupouapouognigni Elisabeth Menu

To determine the percentage of infected children for whom nevirapine (NVP) was used to prevent peripartum mother-to-child transmission (MTCT) of HIV in Yaoundé, Cameroon.The study was a prospective Public Health Pilot Program covering a 3-year period (January 2000-December 2002).Counseled and consenting HIV-1-positive pregnant women were given a single dose of NVP at the onset of labor. Babies were given 2 mg/kg NVP syrup within the first 72 hours of life. NVP-treated children were regularly followed up and examined for HIV-1 infection at 6-8 weeks and 5-6 months through plasma viral load (VL) quantification with the bDNA system.One hundred twenty-three children were diagnosed with perinatal HIV-1 infection at 6-8 weeks and 5-6 months. Thirteen children (10.6% [13/123]; 95% confidence interval, 5.1-16) were infected and presented with high VLs, in general >500,000 copies/mL. Two children had intermediate VLs (between 50 and 3500 copies/mL) at both time points. One hundred seven children (87%) were considered not infected at 6-8 weeks of age.Our results indicate that the HIV-1 MTCT rate 6-8 weeks after NVP administration was not >13% (16/123), thus demonstrating the effectiveness of NVP for lowering the risk of HIV-1 MTCT in real-life settings.

Nevirapine

10.1097/00126334-200311010-00003

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Citations (65)

Simian T cell leukaemia virus type I subtype B in a wild-caught gorilla (Gorilla gorilla gorilla) and chimpanzee (Pan troglodytes vellerosus) from Cameroon

Journal of General Virology (2004)

Eric Nerrienet Laurent Meertens Anfumbom Kfutwah Yacouba Foupouapouognigni Ahidjo Ayouba

A serological survey for human T cell leukaemia virus (HTLV)/simian T cell leukaemia virus (STLV) antibodies was performed in 61 wild-caught African apes, including five gorillas and 56 chimpanzees originating from south Cameroon. Two young animals, a gorilla (Gorilla gorilla gorilla) and a chimpanzee (Pan troglodytes vellerosus), exhibited a pattern of complete HTLV-I seroreactivity. Sequence comparison and phylogenetic analyses using the complete LTR (750 bp) and a 522 bp fragment of the env gene indicated the existence of two novel STLV-I strains, both of which belonged to HTLV-I/STLV-I molecular clade subtype B, specific to central Africa. These first STLV-I strains to be characterized in gorilla and chimpanzee were closely related to each other as well as to several HTLV-I strains originating from inhabitants of south Cameroon, including pygmies. Such findings reinforce the hypothesis of interspecies transmission of STLV-I to humans, leading to the present day distribution of HTLV-I in central African inhabitants.

Gorilla

Simian

Troglodytes

10.1099/vir.0.19314-0

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Citations (27)

Detection and characterization of hepatitis B virus strains from wild-caught gorillas and chimpanzees in Cameroon, Central Africa

Infection Genetics and Evolution (2010)

Richard Njouom Serge Alain Sadeuh‐Mba Eric Nerrienet Yacouba Foupouapouognigni Dominique Rousset

Gorilla

Hylobates

Troglodytes

10.1016/j.meegid.2010.05.002

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Citations (19)

High Prevalence and Predominance of Hepatitis Delta Virus Genotype 1 Infection in Cameroon

Journal of Clinical Microbiology (2011)

Yacouba Foupouapouognigni Dominique Noah Noah Michèle Tagni Sartre Richard Njouom

Antibodies to the hepatitis delta virus (HDV) were found in 17.6% of 233 hepatitis B virus surface antigen-positive subjects in Cameroon. Phylogenetic analyses showed the presence of HDV-1, HDV-5, HDV-6, and HDV-7 genotypes. These results enrich the limited data on HDV prevalence and molecular diversity in Cameroon.

Hepatitis D virus

Hepatitis D

HEPATITIS DELTA

10.1128/jcm.01822-10

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Citations (44)

Human Parvovirus 4 Infection, Cameroon

Emerging infectious diseases (2012)

Myriam Lavoie Colin Sharp Jean‐Louis Pépin C R Pennington Yacouba Foupouapouognigni

In a post hoc analysis of samples collected in 2009, we determined seroprevalence of parvovirus 4 (PARV4) among elderly Cameroonians. PARV4 seropositivity was associated with receipt of intravenous antimalarial drugs, intramuscular streptomycin, or an intramuscular contraceptive, but not hepatitis C virus seropositivity. Findings suggest parenteral acquisition of some PARV4 infections.

Seroprevalence

10.3201/eid1804.110628

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Citations (20)

Highly Pathogenic Avian Influenza A(H5N8) Virus, Cameroon, 2017

Emerging infectious diseases (2018)

Abel Wade Simon Dickmu Jumbo Bianca Zecchin Alice Fusaro Taïga Taïga

Highly pathogenic avian influenza A(H5N8) viruses of clade 2.3.4.4 spread into West Africa in late 2016 during the autumn bird migration. Genetic characterization of the complete genome of these viruses detected in wild and domestic birds in Cameroon in January 2017 demonstrated the occurrence of multiple virus introductions.

Highly pathogenic

H5N1 genetic structure

10.3201/eid2407.172120

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Citations (24)

Molecular epidemiology of simian T-lymphotropic virus (STLV) in wild-caught monkeys and apes from Cameroon: a new STLV-1, related to human T-lymphotropic virus subtype F, in a Cercocebus agilis

Journal of General Virology (2001)

Eric Nerrienet Laurent Meertens Anfumbom Kfutwah Yacouba Foupouapouognigni Antoine Gessain

A serological survey for human T-lymphotropic virus (HTLV)/simian T-lymphotropic virus (STLV) antibodies was performed in 102 wild-caught monkeys and apes from 15 (sub)species originating from Cameroon. Two animals (a Mandrillus sphinx and a Cercocebus agilis ) exhibited a complete HTLV-1 seroreactivity pattern while two others lacked either the p24 (a Mandrillus sphinx ) or the MTA-1/gp46 bands (a Pan troglodytes ). Sequence comparison and phylogenetic analyses, using a 522 bp env gene fragment and the complete LTR, indicated that the two mandrill STLV strains belonged to the HTLV/STLV subtype D clade while the chimpanzee strain clustered in the HTLV/STLV subtype B clade. The Cercocebus agilis STLV strain, the first one found in this species, was closely related to the two HTLV/STLV subtype F strains. Such data indicate that the African biodiversity of STLV-1 in the wild is far from being known and reinforces the hypothesis of interspecies transmission of STLV-1 from monkeys and apes to humans leading to the present day distribution of HTLV-1 in African inhabitants.

Simian

Molecular Epidemiology

10.1099/0022-1317-82-12-2973

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Citations (50)

Endemicity And Genetic Diversity of Hepatitis Delta Virus Among Pygmies In Cameroon, Central Africa.

Research Square (Research Square) (2021)

Yacouba Foupouapouognigni Jacques Delors Mfonkou Toumansie Onana Boyomo Antoine Gessain Richard Njouom

Abstract A single study conducted two decades ago on hepatitis delta virus (HDV) infections among Baka Pygmies in Cameroon reported a very high antibody prevalence of 46%, but HDV genetic diversity has not yet been studied in this remote population. In the present study, we investigated the HDV seroprevalence and the genotype diversity in the three main Cameroonian Pygmy populations with chronic HBV infection. An unusually high (69.2%) level of HDV infection was found among HBsAg-positive Pygmies in Cameroon. Phylogenetic analyses showed the co-circulation of highly diverse HDV genotypes HDV-1 and HDV-7 in this population. These results highlighted the endemicity of HDV infection in Central Africa and suggest an african origin of HDV.

Seroprevalence

Hepatitis D virus

10.21203/rs.3.rs-776004/v1

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Citations (0)

Prevalence of hepatitis B virus infection among Cercopithecidae monkeys in Cameroon

Journal of Medical Primatology (2011)

Yacouba Foupouapouognigni Serge Alain Sadeuh‐Mba Richard Njouom

10.1111/j.1600-0684.2011.00471.x

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Citations (2)

Characterization of Hepatitis C Virus Recombination in Cameroon by Use of Nonspecific Next-Generation Sequencing

Journal of Clinical Microbiology (2015)

James Iles Richard Njouom Yacouba Foupouapouognigni David Bonsall Rory Bowden

ABSTRACT The importance of recombination in the evolution and genetic diversity of the hepatitis C virus (HCV) is currently uncertain. Only a small number of intergenotypic recombinants have been identified so far, and each has core and envelope genes classified as belonging to genotype 2. Here, we investigated two putative genotype 4/1 recombinants from southern Cameroon using a number of approaches, including standard Sanger sequencing, genotype-specific PCR amplification, and non-HCV-specific Illumina RNA sequencing (RNA-seq). Recombination between genotypes 1 and 4 was confirmed in both samples, and the parental lineages of each recombinant belong to HCV subtypes that are cocirculating at a high prevalence in Cameroon. Using the RNA-seq approach, we obtained a complete genome for one sample, which contained a recombination breakpoint at the E2/P7 gene junction. We developed and applied a new method, called Deep SimPlot, which can be used to visualize and identify viral recombination directly from the short sequence reads created by next-generation sequencing in conjunction with a consensus sequence.

Sanger sequencing

Viral quasispecies

Breakpoint

10.1128/jcm.00483-15

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Citations (31)