Chuxiao Shao

Lishui University

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Chaoyong Tu

Wenzhou Medical University

Xiaolong Qi

Zhongda Hospital Southeast University

Shuanghu Wang

Lishui City People's Hospital

Peiwu Geng

Lishui University

Abdullah Al Mamun

Wenzhou Medical University

Hongqiu Pan

Jiangsu University

Zicheng Jiang

National Tsing Hua University

Ye Gu

Jiangnan University

Safaet Alam

Bangladesh Council of Scientific and Industrial Research

Junqiang Lei

Lanzhou University

Cooperative Institutions

Zhejiang University

116

Wenzhou Medical University

116

Lishui Central Hospital

Lishui University

Southern Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Lanzhou University

Peking University

Fudan University

Hangzhou First People's Hospital

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The value of preoperative systemic immune-inflammation index in predicting vascular invasion of hepatocellular carcinoma: a meta-analysis

Figshare (2021)

Yifeng Wu Chaoyong Tu Chuxiao Shao

Vascular invasion and systemic immune-inflammation index (SII) are risk factors for the prognosis of patients with hepatocellular carcinoma. At present, the correlation between the two is not clear. This meta-analysis explored the relationship between preoperative SII and vascular invasion in patients with hepatocellular carcinoma. According to the search formula, the Pubmed, Embase, Cochrane, Web of Science, and CNKI databases were searched for the relevant research until March 2020. After the quality evaluation of the included literature, the odds ratio (OR) and its corresponding 95% confidence interval (CI) were used as the effect measure. Stata 15. 0 software was used for statistical analysis. The meta-analysis eventually included seven retrospective cohort studies of 3583 patients with hepatocellular carcinoma. The results showed that the choice of SII cut-off value affects SII's efficiency in predicting the risk of vascular invasion. In the cohort of studies with appropriate SII cut-off value, the high SII preoperative group had a higher risk of vascular invasion (OR=2.62; 95%CI: 2.07-3.32; P=0.000) and microvascular invasion (OR=1.82; 95%CI: 1.01-3.25; P=0.045) than the low SII group. The tumor diameter (OR=2.88; 95%CI: 1.73-4. 80; P=0.000) of the high SII group was larger than that of the low SII group. There was no publication bias in this study (Begg's test, P=0.368). As a routine, cheap, and easily available index, SII can provide a certain reference value for clinicians to evaluate vascular invasion before operation.

Value (mathematics)

10.6084/m9.figshare.14317670

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[Preliminary application of transoral robotic thyroidectomy: experience from an initial 30 cases].

PubMed (2021)

X L Li Qiang He C Y Li M Wang Dayong Zhuang

Objective: To examine the surgical outcome of transoral robotic thyroidectomy. Methods: Clinic data of total 30 cases of transoral robotic thyroidectomy at the Department of Thyroid and Breast Surgery, the 960th Hospital of People's Liberation Army from May 2020 to December 2020 were analyzed retrospectively. There were 3 males and 27 females, aged (31.5±11.0) years (range: 17 to 55 years), including 6 cases of benign tumor and 24 cases of malignant cancer (all papillary thyroid carcinoma). An inverted U-shaped incision 1.5 cm in length was made over the end of the frenulum of the lower lip. A wide subplatysmal space was created by bluntly passing with a vascular tunneller (8 mm diameter), and a 12 mm trocar was inserted through the lip incision for the camera port. Lateral oral mucosal incisions 8 mm in length were made near both lateral labial commissures, 8 mm robot trocars were inserted through the incisions. An 5 mm trocar was inserted through an incision made along the patient's right axillary fold into the subplatysmal working space and was connected with 5 mm ProGrasp for counter traction during the operation and for later drain insertion. Numerical scoring system (NSS) was used to assess cosmetic effect 1 month post-operation. Results: All the 30 transoral robotic thyroidectomies was successful, no case conversed to open operation. Postoperative hospital stay was (6.3±1.2) days (range: 4 to 10 days). The tumor size of thyroid cancers was (5.3±3.0) mm (range: 2 to 15 mm). Lymph node metastasis was observed in 12 cases. The retrieved central lymph node number was 10.5±4.4 (range: 4 to 20), while the central metastatic lymph node number was 2(2) (range: 1 to 11). Postoperative transient hypoparathyroidism occurred in 2 cases. Permanent hypoparathyroidism and vocal cord palsy didn't occur. Other surgical complications included hematoma, surgical site infection and perforation of chin flap, retrospectively in 1 case. Local regional lymph node recurrence wasn't developed during 1 to 7 months follow-up. All patients were satisfied with the postoperative cosmetic outcomes,NSS was 9.4±0.8 (range: 8.7 to 9.6). Conclusion: Transoral robotic thyroidectomy is safe and effective, suitable for early thyroid cancers without lateral lymph node metastasis, and has superior cosmetic results when the patients are selected carefully.目的：探讨经口腔前庭入路机器人甲状腺手术的安全性和有效性。方法：回顾性分析联勤保障部队第九六〇医院甲状腺乳腺外科2020年5月至2020年12月连续收治的30例行经口腔前庭入路机器人甲状腺手术患者的临床资料。男性3例，女性27例，年龄（31.5±11.0）岁（范围：17~55岁）。甲状腺良性肿瘤6例，恶性肿瘤24例。观察孔位于下唇系带前方远离牙龈根部1 cm处，第1、2操作孔位于双侧第一前磨牙根部水平靠近唇侧处，分别连接双极马里兰钳和超声刀，第3操作孔位于右侧腋窝皱襞处，连接5 mm精细操作钳。术后1个月采用视觉数字评分系统评估美容效果满意度。结果： 30例患者均完成手术，无中转开放手术。甲状腺癌患者的病理类型均为甲状腺乳头状癌，肿瘤最大径（5.3±3.0）mm（范围：2~15 mm）。中央区淋巴结清扫数目（10.5±4.4）枚（范围：4~20枚），其中12例中央区淋巴结转移阳性。2例患者术后发生暂时性甲状旁腺功能减退，无永久性甲状旁腺功能减退和喉返神经损伤。其他术后并发症包括血肿1例，感染1例，颏下皮肤穿孔1例，未发生颏神经损伤。术后住院时间（6.3±1.2）d（范围：4~10 d）。经过1~7个月随访，患者未发生局部淋巴结复发或转移。所有患者均对术后美容效果满意，视觉数字评分为（9.4±0.8）分（范围：8.7~9.6分）。结论：对于严格筛选的早期甲状腺癌患者，经口腔前庭入路机器人甲状腺手术安全可行，美容效果较好。.

Areola

10.3760/cma.j.cn112139-20210104-00005

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Aspirin in hepatocellular carcinoma: Is it an out-of-date or promising treatment?

iLiver (2022)

Xun Qiu Fengqiang Gao Kai Wang Zhensheng Zhang Chuxiao Shao

Hepatocellular carcinoma (HCC) is one of the most aggressive human malignancies with a dismal survival rate. Few strategies can effectively prevent the occurrence of HCC. Although immunotherapy has significantly improved HCC-related survival in recent years, this systemic therapy is very expensive and lays a heavy burden on most HCC patients. Aspirin, which is currently one of the most widely used medications in analgesic and cardiovascular diseases, is reported to have anti-tumor effects on HCC. Most importantly, long-term administration of low-dose aspirin does not significantly increase the risk of gastrointestinal bleeding. Owing to its cost-effectiveness and wide use, aspirin can be easily applied as an HCC treatment and is affordable for a wide range of patients. Therefore, deeper understanding and more attention are needed to extend the frontline of aspirin's preventive and therapeutic potential into cancer research and management. In this review, we discuss the preventive effect of aspirin on HCC in the context of different etiological factors, including hepatitis B or hepatitis C virus infection, non-alcoholic fatty liver disease, and alcohol-associated liver disease. The therapeutic role of aspirin in resectable or unresectable HCC management is also discussed. Furthermore, the mechanisms underlying the anti-cancer effects of aspirin on HCC are fully reviewed and discussed in the following two aspects: the effect of aspirin on multi-oncogenic signaling pathways in HCC (e.g., AMPK, Wnt/β-catenin, NF-κB) and aspirin-mediated immunometabolic responses in liver diseases. These findings indicate aspirin is a promising agent for populations at risk and HCC patients to prevent or treat HCC.

Hepatitis B

10.1016/j.iliver.2022.03.003

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Isolation, Structure Elucidation, and Bioactivity Evaluation of Two Alkaloids From Piper chaba H. Stem: A Traditional Medicinal Spice and Its Chemico‐Pharmacological Aspects

Food Science & Nutrition (2024)

Shabiba Parvin Shandhi Fahmida Tasnim Richi Safaet Alam Kutub Uddin Ahamed Nazim Uddin Emon

ABSTRACT Bangladesh is endowed with an abundance of excellent medicinal plant resources. A well‐known traditional medicinal plant Piper chaba H. from the Piperaceae family is rich in bioactive phytochemicals that have antidiarrheal, antimicrobial, analgesic, antioxidant, anticancer, and cytotoxic effects. This plant is locally known as “Chuijhal,” and the stem is used as spices. In the current research program, the stems of the P. chaba plant were selected and its chemical and biological investigations such as antidiarrheal, antimicrobial, and analgesic effects were performed. Moreover, docking models were accomplished by exploiting PyRx‐Virtual Screening software and implied that isolated compounds of P. chaba exert different pharmacological activity by inhibiting their targeted receptors. Phytochemical investigations revealed the isolation of Chingchengenamide A, a relatively rare alkaloid from the stems of P. chaba . Another alkaloid Chabamide I which is a piperine dimer was also isolated. Their structures were confirmed by comparing these compounds' spectral data ( 1 H and 13 C NMR) with their previously published spectral data. Antidiarrheal activity shows a percent reduction of diarrhea by 46.67% and 40%, respectively, for Chabamide I and Chingchengenamide A (at 20 mg/kg b.w.) compared with an 80% reduction by standard loperamide. Similarly, the percent reduction of writhing was 53.06% and 42.86%, respectively, for Chabamide I and Chingchengenamide A at similar doses compared with an 80% reduction by diclofenac sodium considered as standard. Both the alkaloids showed auspicious outcomes against test microorganisms during disk diffusion antimicrobial assay. Molecular docking and ADME/T analysis of the alkaloids also validate a potent pharmacological basis for the traditional utilization of P. chaba in treating diarrhea, pain, and microbial infection. These results emphasize the need to investigate P. chaba as a potential source of natural therapies for common health issues, laying the foundation for future research.

Piperine

Phytochemical

Piperaceae

10.1002/fsn3.4585

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IDDF2023-ABS-0072 High prevalence of hepatic steatosis and fibrosis among patients with type 2 diabetes mellitus: a prospective community-based study

Xiaolong Qi Ruiling He Chuan Liu Chaoyang Sun Dengxiang Liu

Background

Chronic liver diseases and type 2 diabetes mellitus (T2DM) frequently coexist and impact synergistically, and T2DM may be one of the strongest risk factors for non-alcoholic steatosis to advanced fibrosis. We aimed to investigate the prevalence of hepatic steatosis and fibrosis, and identify risk factors associated with compensated advanced chronic liver diseases (cACLD) among Chinese adults with T2DM in the community.

Methods

This is a prospective, large-scale, community-based study recruiting registered adults with T2DM in six cities in China between June 2021 and November 2022. The baseline demographics, comorbidities, and vibration-controlled transient elastography-defined hepatic steatosis and fibrosis, in terms of controlled attenuation parameter (CAP) and liver stiffness measurement (LSM), were collected for analysis.

Results

A total of 3,196 patients with T2DM in the community (age: 65±9 years; body mass index: 24.7±3.3 kg/m²) were included in the study. The prevalence of steatosis (CAP ≥248 dB/m) and cACLD (LSM ≥10 kPa) was 60% and 9%, respectively. Additionally, 12%, 7%, 7%, and 3% of patients had mild (F1), moderate (F2), severe (F3) fibrosis, and cirrhosis (F4), respectively. The distribution of mild (S1), moderate (S2), and severe (S3) steatosis was 14%, 8%, and 38%, respectively (IDDF2023-ABS-0072 Figure 1. Proportion of patients with T2DM screened in community having liver diseases (A) Proportion of subjects having NAFLD and cACLD (B) severity of fibrosis in subjects (C) Severity of S). Furthermore, 5% of patients with non-obesity (body mass index 50 years, body mass index, and the presence of hypertension were independent predictors of cACLD among patients with T2DM in the community.

Conclusions

We found a considerable prevalence of hepatic steatosis and fibrosis in community patients with T2DM. It is imperative to carry out screening to promote further intervention of T2DM patients.

Steatosis

Transient elastography

10.1136/gutjnl-2023-iddf.129

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Clinical Characteristics of COVID-19 Patients With Pre-existing Hepatitis B Virus Infection: A Multicenter Report

The American Journal of Gastroenterology (2020)

Qing‐Yu He Guo Zhang Ye Gu Jitao Wang Qiyuan Tang

He, Qing MD1; Zhang, Guo MD2; Gu, Ye MD3; Wang, Jitao MD4; Tang, Qiyuan MD1; Jiang, Zicheng MD5; Shao, Chuxiao MD6; Zhang, Hongguang MD7; Chen, Zhenhuai MD8; Ma, Baoyi MD9; Liu, Dengxiang MD4; Xie, Guanghang MD10; Xu, Dan MD10; Huang, Yifei MD10; Zhang, Haijun MD10; Liang, Mingkai MD10; Huang, Huihong MD5; Wang, Yan MD3; Liu, Hongyan MD3; Yang, Jie MD6; Pan, Hongqiu MD7; Zou, Shengqiang MD7; Li, Fujian MD8; Wang, Fang MD1; Liu, Chuan MD10; Wang, Wenjuan MD2; Xiong, Bin MD11; Li, Xun MD10; Liu, Lei MD1; Yang, Jianrong MD2; Qi, Xiaolong MD10 Author Information

Zhàng

10.14309/ajg.0000000000000924

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Citations (26)

Carvedilol to prevent hepatic decompensation of cirrhosis in patients with clinically significant portal hypertension stratified by new non-invasive model (CHESS2306)

Clinical and Molecular Hepatology (2024)

Chuan Liu Hong You Qing‐Lei Zeng Yu Jun Wong Bingqiong Wang

Non-invasive models stratifying clinically significant portal hypertension (CSPH) are limited. Herein, we developed a new non-invasive model for predicting CSPH in patients with compensated cirrhosis and investigated whether carvedilol can prevent hepatic decompensation in patients with high-risk CSPH stratified using the new model.

Carvedilol

Decompensation

10.3350/cmh.2024.0198

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Citations (3)

Value of inflammatory index in blood routine on the prognosis of hepatocellular carcinoma

International Journal of Surgery (2020)

Yifeng Wu Chaoyong Tu Chuxiao Shao

Monocyte

10.3760/cma.j.issn.1673-4203.2020.03.013

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A case report of rectal adenocarcinoma with intrahepatic cholangiocarcinoma of the liver

Journal of International Medical Research (2019)

Jing-Qiang Guo Jingjing Zou Jinde Zhu Chuan Jiang Chuxiao Shao

Objective In this case report, we describe our experience with a patient who was treated for rectal adenocarcinoma complicated with primary cholangiocarcinoma of the liver and highlight the problems in the diagnosis and treatment of these potentially fatal lesions. Methods In the clinical setting, we often use the concept of “monism” for diagnosis and treatment. In this report, we review the diagnosis and treatment of rectal adenocarcinoma complicated with primary cholangiocarcinoma of the liver. Results Four months after surgery, the patient’s carbohydrate antigen 19-9 level was elevated, and positron emission tomography/computed tomography showed multiple liver metastases. The patient underwent three rounds of transarterial chemoembolisation and two rounds of radiofrequency ablation at our hospital for recurrent hepatocellular carcinoma. The clinical response was poor and indicative of progression of intrahepatic lesions. Conclusion A preoperative multidisciplinary team, rapid intraoperative pathological examination, and active comprehensive postoperative treatment are necessary to improve the prognosis of multiple primary tumours.

Intrahepatic Cholangiocarcinoma

Multidisciplinary team

Carcinoembryonic antigen

10.1177/0300060519876751

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Indian Shot (Canna Indica L). Leaves Provide Valuable Insights into the Management of Inflammation and Other Associated Disorders Offering Health Benefits

Journal of Inflammation Research (2024)

Mohammad Abdullah Taher Hasin Hasnat Safaet Alam Suriya Akter Shompa Mirola Afroze

Throughout history, plants have played a crucial role in advancing medicinal treatments by providing a diverse range of compounds for the development of innovative therapies.

Canna

10.2147/jir.s491700

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