Vorob'ev Kv

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Co-Authors

Gankovskaia Lv

Koval'chuk Lv

Gamalei Institute of Epidemiology and Microbiology

Tyrnova Ev

Khmel'nitskaia Nm

Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech

Kliachko Ll

Zimina Sa

ЕВ

Е. В. Даев

St Petersburg University

Ankhimova Es

Biomedical Primate Research Centre

Kosenko Va

Riazantsev Sv

Cooperative Institutions

Institute of Experimental Medicine

St Petersburg University

Research Institute of Influenza

Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech

Czech Academy of Sciences, Institute of Experimental Medicine

Academy of Medical Sciences

Federal Almazov North-West Medical Research Centre

Russian Academy of Sciences

State Research Institute of Highly Pure Biopreparations

Pavlov Institute of Physiology of the Russian Academy of Sciences

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[Interstrain differences in mice in developing migration inhibition factors to Candida albicans antigens].

PubMed (1983)

Vorob'ev Kv Gankovskaia Lv Koval'chuk Lv Shabanova Lf

The authors studied the time course of MIF production by lymphocytes of CBA (H-2k), C57BL/6J (H-2b) and (CBA X C57BL/6J) F1 (H-2b/H-2k) mice sensitized to Candida albicans antigens. The interstrain differences in lymphokin production were identified, CBA mice appeared to be highly responsive, whereas C57BL/6J to be low-responsive. Partial hybridological analysis made it possible to ascertain the presence of the dominant type heredity of high MIF production in response to Candida albicans antigens.

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[The formation of an immune response in volunteers inoculated with a live recombinant influenza vaccine].

PubMed (1991)

Vorob'ev Kv Rudenko Lg Islamova It Grigor'eva Ep Andrej Egorov

The capacity of a live influenza vaccine (LIV) to stimulate cytotoxic cells (ADCMC and NK) was studied in 49 volunteers and 56 patients with influenza. Experimental batches of LIV from influenza A and B viruses prepared by genetic recombination on the basis of cold-adapted attenuation donors were used. Type A and B LIV were shown to stimulate the cytotoxic cell-mediated and humoral immunity; the intensity of immune response, however, depended on the molecular genetic characteristics of the vaccine (genome structure, properties of the donor of attenuation), its biological activity and capacity of reproduction in tissues.

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[Genotype-specific changes of certain functional indicators of immunocompetent cells in male laboratory mice under conditions of pheromone stress].

PubMed (2000)

Е. В. Даев Vorob'ev Kv Shustova Ti Zimina Sa Samotokin Mb

Mature laboratory male mice CBA, C57BL/6, BALB/c, and hybrids CBAB6F1 were exposed for 2 or 24 h to vapors of 2,5-dimethylpyrazine (DMP), which is a pheromone of the house mouse. This caused changes in the content of noradrenaline within the nerve fibers of both nasal mucosa and vascular testis tunic and an inhibition of leukocyte migration in the peripheral blood. Intrastrain distinctions were also revealed in the level of spontaneous leukocyte migration and intensity of the response to the DMP. The mechanisms underlying these effects and their possible adaptive significance are discussed.

Emotional stress

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[Production of a factor inhibiting macrophage migration to the Candida albicans antigen in mice and their resistance to this microorganism].

PubMed (1985)

Vorob'ev Kv Vasil'ev Od Gankovskaia Lv

Resistance to C. albicans, an opportunistic microorganism, has been studied in CBA and C57BL/6 mice, oppositely responsive in the production of the factor inhibiting migration of macrophages to antigen obtained from this fungus. The study has shown that CBA mice, highly responsive in the macrophage migration inhibiting factor, are less resistant to C. albicans, while C57BL/6 mice with low response to this antigen are more resistant to this infective agent. Macrophages play, probably, a certain role in the generalization of the process because not all phagocytized C. albicans cells are digested.

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[The phenotypic expression of the genes controlling the yield of a factor suppressing macrophage migration to Candida albicans antigens and tuberculin in mice].

PubMed (1990)

Vorob'ev Kv Gankovskaia Lv Koval'chuk Lv Vasil'ev Od

The regulation of the synthesis of factor inhibiting the migration of macrophages in response to C. albicans antigen in CBA (H-2k) and C57BL/6 (H-2b) mice has been studied. The low level of macrophage migration inhibition factor in response to this antigen is due to the existence of cyclophosphamide-inhibited specific suppressors. Differences between various strains of mice ensue from different activity of suppressors of thymic origin, whose nature has been revealed as the result of the transfer of marrow cells treated with anti-Thy-1 serum.

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[Nature of the cells regulating the production of a migration inhibition factor in C57BL/6 strain mice with low response to Candida albicans antigen].

PubMed (1984)

Vorob'ev Kv Koval'chuk Lv Gankovskaia Lv

The authors studied cell regulation of macrophage migration inhibition factor (MIF) in response to Candida albicans antigen in C57BL/6 mice. It was revealed that low MIF production in response to this antigen is determined by the existence of specific suppressors which are inhibited by cyclophosphamide. The differences between the mouse lines are accounted for by different activity of suppressor cells of the thymic origin, which is confirmed by the treatment with anti-Thy1-serum and by bone marrow cell transfer.

Strain (injury)

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[Methods for obtaining and examining exocrine secretion for assessment of some parameters of local immunity].

PubMed (1997)

Khmel'nitskaia Nm Riazantsev Sv Kliachko Ll Ankhimova Es Vorob'ev Kv

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[A comparative study of conservative treatment schemes in chronic tonsillitis in children].

PubMed (1998)

Khmel'nitskaia Nm Vorob'ev Kv Kliachko Ll Ankhimova Es Kosenko Va

Three schemes of conservative treatment of chronic tonsillitis in children are compared. Chelidonium majus L. tincture improved tonsillar function, cellular and humoral immunity, nonspecific resistance, promoted a reduction in the number of recurrences.

Chronic tonsillitis

Chelidonium

Tincture (heraldry)

Conservative Treatment

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Citations (6)

[An assessment of the immune status of the mucosal membranes in chronic rhinosinusitis].

PubMed (1998)

Khmel'nitskaia Nm Riazantsev Sv Kokriakov Vn Vorob'ev Kv Aleshina Gm

The authors studied immune status of upper respiratory tracts mucosa in patients with different forms of chronic rhinosinusitis (purulent, polypous, vasomotor) in comparison to control subjects. An original complex of laboratory diagnostic techniques is proposed which can assess functional condition of the defense barriers of the upper respiratory tract mucosa in chronic inflammation, estimate impairment of specific and nonspecific resistance. This facilitates choice of optimal scheme of pathogenetic therapy of chronic inflammation in the upper respiratory tracts.

Respiratory tract

Chronic Rhinosinusitis

Immune status

Mucous membrane

Vasomotor Rhinitis

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[Role of suppressor cells in the regulation of production of the macrophage migration inhibitory factor in mice with opposite reaction to tuberculin and Candida albicans antigens].

PubMed (1983)

Vorob'ev Kv Gankovskaia Lv Koval'chuk Lv

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