Murat Akgül

Namık Kemal University

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Cenk Murat Yazıcı

Namık Kemal University

Haluk Akpınar

Istanbul Florence Nightingale Hospital

OÖ

Oktay Özman

Memorial Sisli Hospital

Cem Başataç

Istanbul Bilim University

ÖÇ

Önder Çınar

Samsun University

Eyüp Burak Sancak

Çanakkale Onsekiz Mart Üniversitesi

BÖ

Bülent Önal

Istanbul University-Cerrahpaşa

Mehmet Fatih Şahin

Namık Kemal University

ÇD

Çağrı Doğan

Namık Kemal University

Duygu Sıddıkoğlu

Çanakkale Onsekiz Mart Üniversitesi

Cooperative Institutions

Sağlık Bilimleri Üniversitesi

Namık Kemal University

Marmara University

University of Health Sciences

Istanbul University-Cerrahpaşa

Istanbul University

University of Health Science

Sivas State Hospital

State Hospital

Hacettepe University

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The Effects of Fentanyl on Testicular Ischemia-Reperfusion Injury

Turkish Journal of Anaesthesiology and Reanimation (2021)

Cengiz Mordeniz Mahluga Jafarova Demirkapu Murat Akgül Sevil Karabağ Aliye Çelikkol

Testicular torsion is a condition that often occurs as a result of the rotation of the spermatic cord in childhood and adolescence in men, manifests with acute pain and causes infertility in the future even if emergency intervention is performed. The aim of this study is to investigate the protective and preventive effects of fentanyl, a potent analgesic agent frequently used in anaesthesia practice, on testicular ischemia reperfusion injury, which manifests through acute pain.A total of 16 adult male Wistar rats, weighing 200-250 g, were used in this study. They were divided into two groups, consisting of eight animals in each group. Torsion was created in all rats by rotating left testicles 720 clockwise on the day of the experiment. 3 mM of fentanyl was applied intraperitoneally 30 minutes before detorsion to the fentanyl group. Following an hour of ischemia, the left testicle was reinstated, and tissues were repaired according to their physiology. Following 24 hours of reperfusion, the animals were euthanised after taking left testes and blood samples.Fentanyl, administered prior to testicular detorsion, significantly suppressed germ cell damage in torsioned tissue, catalase activity and malondialdehyde levels in blood samples taken from the heart. No significant differences were observed in plasma total thiol concentration, histological score, Leydig cell counts, percentage of necrosis and tubule rupture.These findings show that fentanyl administered before detortion creates a protective effect by preventing testicular ischemia reperfusion injury leading to infertility in the future.

Spermatic Cord Torsion

Testicular pain

10.5152/tjar.2021.1392

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Citations (3)

The effect of body mass index on oncological and surgical outcomes in patients undergoing radical cystectomy for bladder cancer: A multicentre study of the association of urooncology, Turkey

International Journal of Clinical Practice (2020)

Volkan İzol Mutlu Değer Sümer Baltacı Murat Akgül İsmail Selvi

Objective We aimed to evaluate the effect of body mass index (BMI) on oncological and surgical outcomes in patients who underwent radical cystectomy (RC) for bladder cancer (BC). Materials and Methods We retrospectively assessed data from patients who underwent RC with pelvic lymphadenectomy and urinary diversion for BC recorded in the bladder cancer database of the Urooncology Association, Turkey, between 2007 and 2019. Patients were stratified into three groups according to the BMI cut-off values recommended by the WHO; Group 1 (normal weight, <25 kg/m2), Group 2 (overweight, 25.0-29.9 kg/m2) and Group 3 (obese, ≥30 kg/m2). Results In all, 494 patients were included, of them 429 (86.8%) were men and 65 (13.2%) were women. The median follow-up was 24 months (12-132 months). At the time of surgery, the number of patients in groups 1, 2 and 3 were 202 (40.9%), 215 (43.5%) and 77 (15.6%), respectively. The mean operation time and time to postoperative oral feeding were longer and major complications were statistically higher in Group 3 compared to Groups 1 and 2 (P = .019, P < .001 and P = .025, respectively). Although the mean overall survival (OS), cancer-specific survival (CSS), recurrence-free survival (RFS) and metastasis-free survival (MFS) was shorter in cases with BMI ≥ 30 kg/m2 compared with other BMI groups, differences were not statistically significant (P = .532, P = .309, P = .751 and P = .213, respectively). Conclusion Our study showed that although major complications are more common in obese patients, the increase in BMI does not reveal a significant negative effect on OS, CSS, RFS and MFS.

Lymphadenectomy

10.1111/ijcp.13750

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Citations (3)

Prospective Evaluation of Ipsilateral and Contralateral Renal Blood Flow During Retrograde Intrarenal Surgery

Urology (2021)

Cenk Murat Yazıcı Murat Akgül Ömer Özçağlayan Mücahit Doğru Çağrı Doğan

10.1016/j.urology.2021.05.015

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Citations (3)

Can the Urologists Perform Stone Analysis, Metabolic Evaluation and Metaphylaxis at Urinary Tract Stone Disease in Tekirdağ?

Dicle Medical Journal / Dicle Tip Dergisi (2019)

Cenk Murat Yazıcı Murat Akgül Ersan Arda Haluk Akpınar

Objective: As the urolithiasis is an endemic situation in our country, the urologists are well-experienced about this situation.The prevention of urolithiasis recurrence is as important as the surgical treatment.For this reason metabolic evaluation and medical treatment of stone disease is extremely important.This study aimed to evaluate urological specialists' views of metabolic evaluation and medical treatment of urolithiasis.Thus, the main problems and the probable solutions about medical treatment and metabolic evaluation of urinary system stone disease can be evaluated.Methods: The urologists working at Tekirdag were invited to the study.A face-to-face questionnaire, which was composed of three parts, was performed to the participants.In the first section, the demographic characteristics of the participants were evaluated.In the second and third sections, the approach of participants to metabolic evaluation and medical treatment in urolithiasis were investigated, respectively.Results: A total of 29 urologist who routinely performed endourological surgery were included to the study.When we evaluated their endourological practice, 65.5% of the participants were performing 10-25 endourological surgery per month.When we asked the approach of participants about the metabolic evaluation, 34.5% reported that they did not perform metabolic evaluation to their adult patients and 65.5% did not perform to the children with urolithiasis.All participants believed the efficacy of medical treatment however, 66% of the participants were performing at less than half of their patients in clinical practice.Conclusions: The clinical practice about metabolic evaluation, stone analysis and metaphylaxis were lower than expected.Most of the participants were not able to make metabolic evaluation and stone analysis.Further studies are needed to resolve the problems associated with metabolic evaluation and metaphylaxis administration.

Clinical Practice

10.5798/dicletip.620323

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Citations (1)

The effect of the pandemic period on Bladder Pain Syndrome patients under amitriptyline treatment

Neurourology and Urodynamics (2023)

Mehmet Fatih Şahin Rıdvan Özcan Arzu Malak Çağrı Doğan Cenk Murat Yazıcı

COVID-19 is a disease that may cause anxiety, depression, and stress. Bladder pain syndrome (BPS) is a disease in which stress and psychological factors might negatively affect its course. In this study, we aimed to examine the possible clinical aggregation of the pandemic period on BPS patients.A total of 35 BPS patients diagnosed between 2010 and 2018 were included. All patients were using medical treatment, and the follow-up period was at least 6 months. According to our clinical follow-up protocol, the BPS patients were given the King's Health Questionnaire (KHQ), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Overactive Bladder Form V8 (OAB-V8), and Visual Analog Score (VAS) in every visit. In the sixth month of the pandemic, the clinical course of the patients was questioned by telephone or video interview, and their treatment continuities were questioned. Information was received about the delays in their follow-up and the difficulties in accessing healthcare opportunities. The same questionnaires were filled out and compared with pre-pandemic scores.The mean age of the patients included in the study was 50.2 ± 13.32 (min:20, max:74), 11 were males and 24 were females. The mean follow-up periods were 71.8 ± 35.6 months. All questionnaire scores showed an increase compared to the pre-pandemic period. A statistically significant increase was detected during the pandemic in all sub-units of the KHQ. The VAS and OAB-V8 scores of 16 patients who requested hospital admission were significantly higher than before the pandemic. However, there was no statistically significant difference in the increase in VAS and OAB-V8 scores of the 19 patients who refused to come to the hospital.BPS patients have been negatively affected by the emotional effects of the COVID-19 pandemic. Due to the fear, stress, anxiety, and depression, the symptoms of BPS patients exacerbated, and the patients could not receive the necessary support due to a lack of regular follow-ups.

Beck Anxiety Inventory

Depression

Pandemic

10.1002/nau.25199

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Citations (2)

Recent scoring systems predicting stone-free status after retrograde intrarenal surgery; a systematic review and meta-analysis

Editor-in-Chief s Voice List of Authors is an Important Element in a Scientific Publication (2022)

Oktay Özman Murat Akgül Cem Başataç Eyüp Burak Sancak Önder Çınar

Several scoring systems and nomograms have been developed to predict the success of retrograde intrarenal surgery. But no meta-analysis for the performance of scoring systems has yet been performed. The aim of this study was to compare predictive ability of recent scoring systems for stone-free rate of retrograde intrarenal surgery.

Nomogram

Study heterogeneity

Web of science

10.5173/ceju.2022.0277

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Citations (6)

The effects of etomidate on testicular ischemia reperfusion injury in ipsilateral and contralateral testes of rats.

DOAJ (DOAJ: Directory of Open Access Journals) (2022)

Mahluga Jafarova Demirkapu S Karabag Murat Akgül Cengiz Mordeniz Hasan Raci Yananlı

Testicular torsion is a condition that manifests with acute pain and can lead to infertility despite urgent surgical intervention. The aim of this study is to investigate the protective and preventive effects of etomidate, an imidazole derivative, a non-barbiturate general anesthetic agent, without analgesic effect, on testicular ischemia-reperfusion injury.Twenty-four adult male Wistar rats weighing 200-250 g were used in the study. Torsion was created in all rats by rotating left testes 720° clockwise on the day of the experiment. 30 minutes before detorsion, 4 mg/kg etomidate and 10 mg/kg propofol were administered intraperitoneally to the etomidate and propofol groups, respectively. After an hour of ischemia, the left testis was reinstated, and the tissues were repaired according to their physiology. Following 24 hours of reperfusion, the animals were euthanized after ipsilateral and contralateral testes were removed.Etomidate applied before testicular detorsion significantly suppressed germ cell damage and Leydig cell loss in ipsilateral tissue. It did not cause any significant changes in the percentage of necrosis, histological score, and tubule rupture in ipsilateral tissue. Propofol administered before testicular detorsion significantly suppressed the percentage of necrosis only in the ipsilateral tissue. In addition, no signs of damage were observed in the contralateral testis.These findings show that etomidate administered before detortion creates a protective effect by preventing testicular ischemia-reperfusion injury.

Etomidate

Sham surgery

10.26355/eurrev_202201_27770

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Citations (5)

Active Surveillance in Prostate Cancer: Can We Expand the Indications?

Bulletin of Urooncology (2016)

Murat Akgül Asgar Garayev İlker Tınay

© Üroonkoloji Bülteni, Ga le nos Ya yı ne vi ta ra fın dan ba sıl mış tır.Bu makale "Creative Commons Alıntı-Gayriticari-Türetilemez 4.0 Uluslararası Lisansı (CC BY-NC 4.0)" ile lisanslanmıştır.Common usage of prostate-specific antigen screening and prostate biopsies increases diagnosis rate of "clinically insignificant prostate cancer".Nowadays, active surveillance is an alternative approach for overtreatment of patients diagnosed with "low-risk, localized prostate cancer".Although there is no consensus on ideal active surveillance protocol for patient-inclusion and follow-up, it was reported that protocols that are in use and accepted by various centers are as successful as curative radical therapies concerning survival of cancer.New screening methods for diagnoses of prostate cancer, the followup and studies on bio-/genomic markers are promising.These positive developments bring one question on mind: "Can we expand the indications for active surveillance in prostate cancer"?

10.4274/uob.619

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Citations (1)

Multi-aspect analysis of ureteral access sheath usage in retrograde intrarenal surgery: Results of propensity score matching study

European Urology (2021)

Oktay Özman Murat Akgül Cem Başataç Önder Çınar Eyüp Burak Sancak

10.1016/s0302-2838(21)00672-2

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Citations (0)

Can we predict postoperative fever and urinary tract ınfection after retrograde ıntrarenal surgery? Results of a case control matching multicentric RIRSearch study group

World Journal of Urology (2025)

Murat Akgül Oktay Özman Cem Başataç Hakan Çakır Önder Çınar

Postoperative fever

Nephrology

10.1007/s00345-024-05413-3

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Citations (0)