Shengmin Li

National Center for Nanoscience and Technology

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Fernand Labrie

Endocyte (United States)

Qingzhen Wang

National Center for Nanoscience and Technology

Huige Zhou

National Center for Nanoscience and Technology

Qiaolin Liu

National Center for Nanoscience and Technology

Ru Bai

National Center for Nanoscience and Technology

Chunying Chen

National Center for Nanoscience and Technology

Tao Liu

University of Chinese Academy of Sciences

Lingcai Zhao

Nanjing Agricultural University

Jacques Couët

Institut Universitaire de Cardiologie et de Pneumologie de Québec

Jiakun Zhang

Jilin University

Cooperative Institutions

National Center for Nanoscience and Technology

Chinese Academy of Sciences

Université Laval

Nanjing Agricultural University

Ministry of Education of the People's Republic of China

Southern Medical University

University of Chinese Academy of Sciences

Xi'an Jiaotong University

Capital Medical University

Northwest University

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Toxoplasma gondiiROP18_Iinhibits host innate immunity through cGAS‐STING signaling

The FASEB Journal (2022)

Min Chen Lijie Yao Lijuan Zhou Pei Yang Weihao Zou

Toxoplasma gondii is an opportunistic protozoan, which widely infects humans and other warm-blooded animals. The type I interferon (IFN) such as IFN-α/β is involved in cGAS-STING signaling to resist T. gondii infection. We found in RAW264.7 cells, that T. gondii virulence factor TgROP18I, inhibited IFN-β production through interacting with interferon regulatory factor 3 (IRF3). Besides, TgROP18I interacted with p62 and Tumor Necrotic Factor Receptor Associated Factor 6 (TRAF6), which resulted in the inhibition of TRAF6-p62 interaction, and phosphorylation of p62. Furthermore, TgROP18I restricted the recruitment of ubiquitin, p62 and microtubule-associated protein light chain 3 (LC3) to the parasitophorous vacuole membrane (PVM) in IFN-γ-stimulated murine cell line L929 cells. In IFN-γ-stimulated human cells, TgROP18I restricted the decoration of PVM with ubiquitin, p62, and LC3, and bound with TRAF2, TRAF6, and p62, respectively. As a result, TgROP18I led to a successful parasitic replication in murine and human cells. Collectively, our study revealed the function of TgROP18I in suppressing host type I interferon responses in T. gondii infection for parasitic immune escape.

IRF3

Virulence factor

Sting

10.1096/fj.202101347r

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High-Accuracy Determination of Potassium and Selenium in Human Serum by Two-Step Isotope Dilution ICPMS

Journal of Analytical Methods in Chemistry (2021)

Jian Yang Lixia Chi Shengmin Li

A high-accuracy measurement technique for determining potassium and selenium in human serum was developed by using two-step Isotope Dilution Inductively Coupled Plasma-Mass Spectrometry (ICPMS) in this research. A more accessible method of the quadrupole ICPMS was employed in this research to achieve an equally high accuracy which had been achieved by a much more expensive method, namely, high-resolution sector field ICPMS (SF-ICPMS), with a comparatively easy and simple operation. In addition, we have evaluated the uncertainty of this method. The results showed that the determination limits of potassium and selenium in serum were 0.8 mg/kg and 2.7 μg/kg, respectively, and the precision for both measurements was lower than 0.2% and 0.7%. The measurement, when employed to measure potassium and selenium in standard materials NIST956D, NIST909C, and GBW09152, had caused a maximum deviation of less than 0.9%, within the stated uncertainty range of standard materials. The RELA international inter-laboratory comparisons of potassium in serum in 2018 conducted by our laboratory also yielded a satisfactory result.

Isotope dilution

Accuracy and precision

Dilution

Standard solution

Isotopes of potassium

10.1155/2021/5533631

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An Oxidative Stress Nanoamplifier to Enhance the Efficacy of Cisplatin in Head and Neck Cancer

Angewandte Chemie (2025)

Zhenzhen Li Qiaolin Liu Guorong Wang Ru Bai Shengmin Li

Cisplatin (CP) is a first‐line platinum‐based drug used for the treatment of head and neck cancer. However, tumor cells can diminish the therapeutic effects of CP through the detoxification system mediated by glutathione (GSH) and the nucleotide excision repair (NER) pathway. Herein, we present a light‐activable and pH‐responsive oxidative stress nanoamplifier (FPLC@IR OSNA), comprising an amphiphilic compound (FPLC) with Fmoc‐lysine acting as a connector between a nitroimidazole derivative and a pH‐responsive cinnamaldehyde (CA) derivative, loaded with photosensitizer IR780. The acidic microenvironment of lysosome can trigger the release of CA to produce H2O2, which breaks down into oxygen, further improving the phototherapy efficacy mediated by IR780 irradiation. The consumption of oxygen during the phototherapy process induces hypoxia, prompting the reduction of nitroimidazole to aminoimidazole and leading to reduced GSH synthesis, enhancing tumor cell death induced by CP. Meanwhile, the accumulation of intracellular reactive oxygen species (ROS) during phototherapy attenuates the nuclear NER pathway, further augmenting the therapy effect of CP. This strategy, by combining FPLC@IR OSNA with laser and CP, significantly promotes the therapeutic effect in vitro, and notably inhibits tumor growth in both Cal27 cell line‐derived xenograft models and patient‐derived xenograft models.

10.1002/ange.202421481

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Inhibitory effect of a steroidal antiestrogen (EM-170) on estrone-stimulated growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in the rat

Breast Cancer Research and Treatment (1995)

Fernand Labrie Shengmin Li Claude Labrie Charles L�vesque Yves M�rand

Antiestrogen

7,12-Dimethylbenz[a]anthracene

Mammary tumor

10.1007/bf00665948

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Citations (14)

Erratum

Endocrinology (1991)

Claude Labile Claude Trudel Shengmin Li Celine Mattel Jacques Couët

While the elimination of androgens of testicular origin can be easily achieved by orchiectomy or medical castration with LHRH agonists, the action of adrenal androgen precursors which are converted into the active androgen Sa-dihydrotestosterone (DHT) in the prostatic tissue itself can be partially neutralized by antiandrogens which compete with DHT for binding to the androgen receptor.In order to increase the efficiency of androgen blockade, we have used 4-MA, an inhibitor of 5o-reductase, the enzyme which converts testosterone into DHT, to reduce intracellular DHT concentrations and thus facilitate the action of the antiandrogen Flutamide.The present data show that the inhibitory effects of 4-MA (17fi, N,N-dte%lcarbamoyl-4-methyl-4-aza-5a-androstan-3-one) and of the antiandrogen Flutamide are additive on prostatic growth and on androgen-sensitive prostatic binding protein mRNA levels in the rat, thus clearly suggesting that such a combination could provide the basis for a further improvement in the therapy of prostate cancer.

10.1210/endo-129-1-565

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Ultra-strong penetrating and GSH-responsive oral drug delivery system improved therapeutic effect of gemcitabine for pancreatic tumors

Nano Today (2023)

Xu Zhang Kejian Shi Jiahui Mao K. Mao Yangrui Jia

10.1016/j.nantod.2023.102048

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Citations (3)

Block copolymer-based formulation of doxorubicin. From cell screen to clinical trials

Colloids and Surfaces B Biointerfaces (1999)

Valery Yu. Alakhov Evgueni Klinski Shengmin Li Grzegorz Pietrzyński Annie Venne