Chengbiao Ding

Anhui Medical University

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Zhengwei Wu

University of Science and Technology of China

Wenchong Ouyang

University of Science and Technology of China

Qi Liu

Taiyuan University of Technology

Runhuai Yang

Anhui Medical University

Tingting Luo

Anhui Medical University

Guangli Liu

Anhui Medical University

Quanming Lu

University of Science and Technology of China

Tao Jin

Sichuan University of Science and Engineering

Jiwen Zhu

University of Science and Technology of China

Zhenyu Liu

Shanxi Agricultural University

Cooperative Institutions

Anhui Medical University

University of Science and Technology of China

Second Hospital of Anhui Medical University

Chinese Academy of Sciences

First Affiliated Hospital of Anhui Medical University

University of Chinese Academy of Sciences

Sichuan University

Universidade Estadual de Campinas (UNICAMP)

Chinese Academy of Medical Sciences & Peking Union Medical College

Sun Yat-sen University

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Cold air plasma improving rheumatoid arthritis via mitochondrial apoptosis pathway

Bioengineering & Translational Medicine (2022)

Chengbiao Ding Leying Ni Qi Liu Chenxu Zhou Guomin Wang

Abstract Rheumatoid arthritis (RA) has plagued physicians and patients for years due to the lack of targeted treatment. In this study, inspired by the commonality between rheumatoid arthritis fibroblast‐like synoviocytes (RA‐FLS) and cancer cells, the therapeutic effects of cold air plasma (CAP) on RA are studied systematically and thoroughly. In/ex vivo results show that CAP with the proper dosage significantly relieves symptoms including synovial hyperplasia, inflammatory infiltration, and angiogenesis and eliminates the root cause by triggering the self‐antioxidant capability of the surrounding tissue. The mechanism on the molecular and cellular level is also revealed that the spontaneous reactive oxygen species (ROS) cascade induces the mitochondrial apoptosis pathway on RA‐FLS. This study reveals a new strategy for targeted treatment of RA and the mechanistic study provides the theoretical foundation for future development of plasma medicine.

Ex vivo

Infiltration (HVAC)

Mitochondrial ROS

10.1002/btm2.10366

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Citations (9)

Broadband microwave absorption effects in 2D nitrogen capacitively coupled plasma under different operating conditions

Physics of Plasmas (2023)

Wenchong Ouyang Qi Liu Chengbiao Ding Zhengwei Wu

In recent years, the interaction of electromagnetic waves (EM) with plasma sources under argon and helium discharges has been extensively studied due to its potential applications in plasma stealth. However, nitrogen, as a more economical discharge gas, has been ignored in terms of its absorption of EM waves and stealth effect. In this work, a numerical calculation model combining two-dimensional capacitively coupled plasma (CCP) fluid model and EM wave model was developed to investigate the plasma uniformity degree and broadband microwave absorption effects in helium and nitrogen CCP. It is concluded that the two-dimensional model in this paper has more accurate and reasonable through comparison with the one-dimensional and experimental results in helium CCP. Nitrogen CCP shows better broadband absorption effects than that of helium, and helium plasma has better uniformity than nitrogen under the same discharge parameters. But the uniformity degree of nitrogen plasma is not much different from that of helium under the same electron density, which means that nitrogen can significantly improve its broadband wave absorption properties to some extent without loss of uniformity degree. Based on the above conclusions, the absorption characteristics of nitrogen CCP under different radio frequency (RF) power and pressure are analyzed. The attenuation effect of nitrogen CCP increases with the increasing RF power, and it is interesting that the influence of pressure on the attenuation of EM waves is not monotonically increasing, and the related mechanism is discussed. Finally, discussion of skin depth under different RF power and pressure validates the above conclusions. The absorption band of nitrogen CCP under the best parameters in this work can reach the X-band, which shows great application potential in plasma stealth.

10.1063/5.0128430

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Oil-Free Alginate/Gelma Microsphere for Untethered Magnetic Microbot

Guangli Liu Shiyu Wu Zhou Yang Juan Wei Tingting Luo

Download This Paper Open PDF in Browser Add Paper to My Library Share: Permalink Using these links will ensure access to this page indefinitely Copy URL Copy DOI

10.2139/ssrn.4797988

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Enhanced neural recovery and reduction of secondary damage in spinal cord injury through modulation of oxidative stress and neural response

Scientific Reports (2024)

Jiwen Zhu Zhenyu Liu Qi Liu Qing‐Hua Xu Chengbiao Ding

Spinal cord injury (SCI) presents a critical medical challenge, marked by substantial neural damage and persistent functional deficits. This study investigates the therapeutic potential of cold atmospheric plasma (CAP) for SCI, utilizing a tailored dielectric barrier discharge (DBD) device to conduct comprehensive in vivo and in vitro analyses. The findings show that CAP treatment significantly improves functional recovery after SCI, reduces neuronal apoptosis, lowers inflammation, and increases axonal regeneration. These findings illustrate the efficacy of CAP in fostering a conducive environment for recovery by modulating inflammatory responses, enhancing neuronal survival, and encouraging regenerative processes. The underlying mechanism involves CAP's reactive oxygen species (ROS) reduction, followed by activating antioxidant enzymes. These findings position CAP as a pioneering approach for spinal cord injury (SCI) treatment, presenting opportunities for improved neural recovery and establishing a new paradigm in SCI therapy.

Modulation (music)

Neural Activity

10.1038/s41598-024-69861-y

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Effect of material properties on electron density and electron energy in helium atmospheric pressure plasma jet

Results in Physics (2022)

Wenchong Ouyang Chengbiao Ding Qi Liu Weifeng Deng Zhengwei Wu

In recent years, Atmospheric pressure plasma jet (APPJ) have been widely used in biomedicine and material modification. APPJ exhibits different discharge characteristics when processing various materials or biological tissues, which has a certain influence on the processing effect. However, the influence of the processed material properties on the plasma characteristics has been ignored. This work developed a fluid model to study the influence of material properties (material thickness and relative permittivity) on the plasma characteristics of needle-plane APPJ, and the related influence mechanism was discussed. High electric field and electron energy appear in the head of streamer, which shows the plasma bullet has a substantial contribution to high-energy electrons in plasma jet. Both material thickness and relative permittivity increase the electric field strength, which leads to a corresponding increase in the electron energy and electron density of APPJ. Through further quantitative analysis, an interesting phenomenon was found that compared with the effect of material thickness, material relative permittivity has a more significant influence on the electron energy, while material thickness has a greater influence on the electron density. The reason is that material thickness has a greater effect on the ionization rate than the relative permittivity, resulting in greater degree of increase in electron density, while the increase in electron density has a certain contribution to the reduction of electron energy. The results depicts that processing effect will be further improved by taking into account the influence of material properties on the plasma characteristics of APPJ.

10.1016/j.rinp.2022.105215

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Progress in The Application of Flexible and Wearable Electrochemical Sensors in Monitoring Biomarkers of Athletes

Advanced Materials Technologies (2024)

Yuteng Liu Tingting Luo Chengbiao Ding Lei Xuan Jian Li

Abstract Athletes continuously seek out creative methods and technologies to improve their physical fitness and overall performance. Wearable technology's progress offers a swift and eco‐conscious way to consistently observe physiological changes evidenced by biomarkers, stemming from an athlete's internal exertion or external workload. However, there is still a long distance to further understand the internal physiology of athletes which may bring hope to tailor training and recovery programs individually. The ongoing challenges faced by sports healthcare personnel are in finding biomarkers safely and continuously to control athletes' physical condition and tailor their recovery and eating patterns. The summary of this review encompasses the development of flexible and wearable electrochemical sensors. This article provides an overview of biofluids, commonly detected by wearable biochemical sensors and their mutual anatomical formations, with a focus on sweat and its associated biomarkers. Following this, its real‐world application in sports medicine becomes apparent, both theoretically and potentially. The paper ends by highlighting challenges and imagining the possible development of this exciting emerging field.

Wearable Technology

10.1002/admt.202400619

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Cold air plasma: A potential strategy for inducing apoptosis of rheumatoid arthritis fibroblast‐like synoviocytes

High Voltage (2021)

Chengbiao Ding Chao Chen Wenchong Ouyang Qi Liu Lin Lin

Rheumatoid arthritis (RA) is an autoimmune disease of the joints characterised by synovial hyperplasia and chronic inflammation. Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) cells are the dominant cell type in the hyperplastic synovial membrane, which play a key role in the pathogenesis of RA. They can invade cartilage, cause inflammation, destroy joints, and show tumour-like anti-apoptosis characteristics. Thus, the purpose of this study is to investigate the effect of cold air plasma (CAP) on RA-FLS cells. The results showed that CAP treatment for 120 s could significantly reduce the viability of RA-FLS cells, increase the content of intracellular reactive oxygen species (ROS), and significantly down-regulate the ratio of apoptosis-related protein Bcl-2 to Bax. In this study, a novel approach of inducing apoptosis in RA-FLS cells using CAP was proposed, which may provide a new choice for joint targeting therapy of RA.

Pathogenesis

10.1049/hve2.12132

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Design Strategy, On-Demand Control, and Biomedical Engineering Applications of Wet Adhesion

Langmuir (2024)

Tingting Luo Xingqi Lu Hui Ma Qilong Cheng Guangli Liu

The adhesion of tissues to external devices is fundamental to numerous critical applications in biomedical engineering, including tissue and organ repair, bioelectronic interfaces, adhesive robotics, wearable electronics, biomedical sensing and actuation, as well as medical monitoring, treatment, and healthcare. A key challenge in this context is that tissues are typically situated in aqueous and dynamic environments, which poses a bottleneck to further advancements in these fields. Wet adhesion technology (WAT) presents an effective solution to this issue. In this review, we summarize the three major design strategies and control methods of wet adhesion, comprehensively and systematically introducing the latest applications and advancements of WAT in the field of biomedical engineering. First, single adhesion mechanism under the frameworks of the three design strategies is systematically introduced. Second, control methods for adhesion are comprehensively summarized, including spatiotemporal control, detachment control, and reversible adhesion control. Third, a systematic summary and discussion of the latest applications of WAT in biomedical engineering research and education were presented, with a particular focus on innovative applications such as tissue-electronic interface devices, ingestible devices, end-effector components, in vivo medical microrobots, and medical instruments and equipment. Finally, opportunities and challenges encountered in the design and development of wet adhesives with advanced adhesive performance and application prospects are discussed.

10.1021/acs.langmuir.4c03628

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Cold atmospheric pressure plasma: A potential physical therapy for rheumatoid arthritis hyperplastic synovium

International Immunopharmacology (2023)

Chengbiao Ding Qi Liu Wenchong Ouyang Yi-Chen Sun Quan Liu

10.1016/j.intimp.2023.110732

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Citations (1)

A Wearable Augmented Reality Navigation System for Surgical Telementoring Based on Microsoft HoloLens

Annals of Biomedical Engineering (2020)

Peng Liu Chenmeng Li Changlin Xiao Zeshu Zhang Junqi Ma

Surgical procedures

Optical head-mounted display

10.1007/s10439-020-02538-5

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Citations (54)