Chunxiang Zhu

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10.1016/j.ijnurstu.2022.104387

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Peer Review #2 of "Associations between pro-inflammatory cytokines and fatigue in pregnant women (v0.1)"

Haiou Xia Xiaoxiao Zhu Chunxiang Zhu Zhu Xiaoxiao Haiou Xia

Background.Fatigue is one of the most prevalent symptoms among pregnant women.In patients with various diseases, pro-inflammatory cytokines are associated with fatigue; however, such associations are unknown in pregnant women.Objectives.The objective of this study was to examine the associations between pro-inflammatory cytokines and prenatal fatigue.Methods.A cross-sectional study was conducted on 271 pregnant Chinese women in their third trimester of pregnancy.Patient-reported Outcome Measurement Information System (PROMIS) was used to evaluate women's prenatal fatigue.Using enzyme-linked immunosorbent assay (ELISA), the serum concentrations of four pro-inflammatory cytokines, including tumor necrosis factor alpha(TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6) and interleukin 8 (IL-8), were measured.The data was analyzed by correlation analysis and general linear regression analysis.Results.In this sample, the mean (standard deviation) of fatigue scores was 51.94 (10.79).TNF-α (r=0.21,p<0.001),IL-6 (r=0.134,p=0.027) and IL-8(r=0.209,p=0.001) were positively correlated to prenatal fatigue, although IL-1β was not.TNF-α (β=0.263,p<0.001), along with sleep quality(β=0.27,p<0.001) and depression (β=0.376,p<0.001) independently predicted prenatal fatigue.Conclusions.TNF-α was identified as an independent biomarker for prenatal fatigue in our study.Reducing pro-inflammatory cytokines may be a unique method for lowering prenatal fatigue and, consequently, enhancing mother and child health.

10.7287/peerj.13965v0.1/reviews/2

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ソロスパン技術およびその製品特性 | 文献情報 | J-GLOBAL 科学技術総合リンクセンター

Fangzhi Xuebao (2007)

Huang Lixin Chunxiang Zhu

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Premature infants′ mothers′ postpartum depression and its related influence factors

The Journal of practical nursing (2017)

Chunxiang Zhu Ying Zhao

Objective To describe the depression of premature infants′ mothers and discuss the related influence factors. Methods A total of 86 premature infants′ mothers completed Edinburgh Postnatal Depression Scale at 3-days postpartum in this descriptive study during August 2014 to January 2015 in Obstetrics and Gynecology Hospital of Fudan University. Results The prevalence of postpartum depression in premature infants′ mothers was 25.6% (22/86). Educational levels, family support, character, and number of abortion of mothers, pregnancy complication, gestational age, birth weight, Apgar score, length of hospitalization, and birth with abnormalities of premature infants were found significantly associated with postpartum depression (P<0.05). By Logistic regression, family support (OR=3.253, 95% CI=1.180-8.966) and length of hospitalization (OR=2.905, 95% CI=1.418-5.952) were the risk factors of the postpartum depression at 3-days after delivery. Conclusions Premature infants′ mothers at 3-days postpartum presented with obvious postpartum depression. Psychological intervention should be focused on its influence factors. Key words: Infant, premature; Postpartum depression; Influencing factors

Depression

Apgar score

Premature birth

10.3760/cma.j.issn.1672-7088.2017.07.013

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Peer Review #1 of "Associations between pro-inflammatory cytokines and fatigue in pregnant women (v0.1)"

Haiou Xia Xiaoxiao Zhu Chunxiang Zhu Zhu Xiaoxiao Haiou Xia

Background.Fatigue is one of the most prevalent symptoms among pregnant women.In patients with various diseases, pro-inflammatory cytokines are associated with fatigue; however, such associations are unknown in pregnant women.Objectives.The objective of this study was to examine the associations between pro-inflammatory cytokines and prenatal fatigue.Methods.A cross-sectional study was conducted on 271 pregnant Chinese women in their third trimester of pregnancy.Patient-reported Outcome Measurement Information System (PROMIS) was used to evaluate women's prenatal fatigue.Using enzyme-linked immunosorbent assay (ELISA), the serum concentrations of four pro-inflammatory cytokines, including tumor necrosis factor alpha(TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6) and interleukin 8 (IL-8), were measured.The data was analyzed by correlation analysis and general linear regression analysis.Results.In this sample, the mean (standard deviation) of fatigue scores was 51.94 (10.79).TNF-α (r=0.21,p<0.001),IL-6 (r=0.134,p=0.027) and IL-8(r=0.209,p=0.001) were positively correlated to prenatal fatigue, although IL-1β was not.TNF-α (β=0.263,p<0.001), along with sleep quality(β=0.27,p<0.001) and depression (β=0.376,p<0.001) independently predicted prenatal fatigue.Conclusions.TNF-α was identified as an independent biomarker for prenatal fatigue in our study.Reducing pro-inflammatory cytokines may be a unique method for lowering prenatal fatigue and, consequently, enhancing mother and child health.

10.7287/peerj.13965v0.1/reviews/1

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Peer Review #2 of "Associations between pro-inflammatory cytokines and fatigue in pregnant women (v0.2)"

Haiou Xia Xiaoxiao Zhu Chunxiang Zhu Zhu Xiaoxiao Haiou Xia

Background.Fatigue is one of the most prevalent symptoms among pregnant women.In patients with various diseases, pro-inflammatory cytokines are associated with fatigue; however, such associations are unknown in pregnant women.Objectives.The objective of this study was to examine the associations between pro-inflammatory cytokines and prenatal fatigue.Methods.A cross-sectional study was conducted on 271 pregnant Chinese women in their third trimester of pregnancy.Patient-reported Outcome Measurement Information System (PROMIS) was used to evaluate women's prenatal fatigue.Using enzyme-linked immunosorbent assay (ELISA), the serum concentrations of four pro-inflammatory cytokines, including tumor necrosis factor alpha(TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6) and interleukin 8 (IL-8), were measured.The data was analyzed by correlation analysis and general linear regression analysis.Results.In this sample, the mean (standard deviation) of fatigue scores was 51.94 (10.79).TNF-α (r=0.21,p<0.001),IL-6 (r=0.134,p=0.027) and IL-8(r=0.209,p=0.001) were positively correlated to prenatal fatigue, although IL-1β was not.TNF-α (β=0.263,p<0.001), along with sleep quality(β=0.27,p<0.001) and depression (β=0.376,p<0.001) independently predicted prenatal fatigue.Conclusions.TNF-α was identified as an independent biomarker for prenatal fatigue in our study.Reducing pro-inflammatory cytokines may be a unique method for lowering prenatal fatigue and, consequently, enhancing mother and child health.

10.7287/peerj.13965v0.2/reviews/2

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Non-Contact Blood Pressure Estimation Based on Doppler Radar with Adaptive Filtering Technique

2021 IEEE Asia-Pacific Microwave Conference (APMC) (2024)

Zhi Zheng Haotian Shi Zhiying Zhou Bo Wang Chunxiang Zhu

10.1109/apmc60911.2024.10867523

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Assessing women's and health professionals' views on developing a midwifery‐led mobile health app intervention in pregnancy: A descriptive qualitative study

Journal of Advanced Nursing (2024)

Yaming Dai Hui Min Liping Sun Xiaojiao Wang Chunxiang Zhu

Abstract Aims To explore women's and health professionals' views on the development of a midwifery‐led mHealth app intervention in antenatal care and their demands for app functionality. Design Descriptive qualitative research was utilized. Methods In total, 15 pregnant or postpartum women were interviewed via in‐depth interviews and 10 health professionals including obstetricians, midwives and obstetric nurses were invited to participate in a focus group discussion (FGD). All interviews and the FGD were analysed using qualitative content analysis. Results Four key themes emerged from the data, including (1) limitations of current maternity care services; (2) potential benefits for mHealth app‐based midwifery care; (3) possible challenges for providing midwifery care through mHealth apps and (4) suggestions and needs for developing a midwifery‐led mHealth app. Participants agreed on the potential need of developing a midwifery‐led mHealth app in antenatal care to increase access to midwifery care services and to meet women's diverse needs. Participants preferred to develop professional, reliable, full‐featured and interactive mobile applications. The main functions of midwifery‐led mHealth apps included personalized assessment and health education, self‐monitoring and feedback, data sharing and interactive functions. Women mentioned that online communication and consultation with midwives could help them receive continuous support outside facilities. Health professionals expressed it would be of great convenience and timeliness to send personalized messages to women and to inform them of healthy lifestyles during pregnancy. The challenges included a shortage of human resources, medico‐legal risks associated with mHealth and data security risks. Conclusions This study explores the individual views and functional needs of target users and healthcare providers for developing a midwifery‐led mHealth app in antenatal care, which will serve as a reference for future application development. Impact Our study has important and practical implications for guiding the development of future midwifery‐led mHealth app interventions. Patient or Public Contribution No patient or public contribution.

mHealth

10.1111/jan.16086

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Effects of Acupoint Stimulation Combined with Low-frequency Pulsed Electrotherapy on Labor Pain in Women undergoing Trial of Labor: protocol for a stepped wedge cluster randomized controlled trial

Research Square (Research Square) (2023)

Yiyun Gu Xiaojiao Wang Chunxiang Zhu Hui Min Jilei Zhang

Abstract Background:Pain experienced during childbirth can have significant impacts on the progress of labor, as well as on the well-being of the mother and the fetus. The effective management of labor pain is a crucial aspect of childbirth management. Non-pharmacological methods of pain relief offer notable advantages compared to pharmacological approaches, including enhanced maternal and fetal safety, equitable healthcare access, and increased availability. Among the non-pharmacological options, transcutaneous electrical nerve stimulation (TENS) and acupoint stimulation are two commonly used methods for pain relief during labor. However, the clinical effects of these options are still inconsistent, inhibiting the generation of high-quality evidence for clinical practice. The purpose of this study is to determine the effect of acupoint stimulation combined with low-frequency pulsed electrotherapy on labor pain in women undergoing trial of labor.Methods:This is a 12-month stepped wedge cluster randomized trial that will be conducted in 4 labor and delivery units (LDU) at the Obstetrics and Gynecology Hospital of Fudan University. Each unit will receive four types of interventions: TENS, acupoint stimulation, TENS combined acupoint stimulation, and control. We aim to recruit approximately 588 pregnant women. The project will be evaluated using both quantitative and qualitative data. Quantitative data will include the visual analog scale (VAS) scores, non-pharmacological to pharmacological pain management interval (NPI), rate of epidural analgesia, and childbirth outcomes. Qualitative data will include interviews with the women and midwives.Discussion:We introduce a new outcome indicator called nonpharmacological to pharmacological pain management interval (NPI) in our study to monitor whether the use of non-pharmacological pain relief measures can delay or avoid the use of epidural analgesia, in order to improve women’s childbirth experience and maternal-fetal health outcomes. In addition, the combination of qualitative and quantitative methods will also enrich the research of TENS and acupoint stimulation technology in the field of non-pharmacological labor pain relief and provide high-quality evidence for the future development of industry standards and guidelines.Trial registration:The study has been registered in the Chinese Clinical Trial Registry on March 23, 2023, with registration number ChiCTR2300069705.Trial registration number ChiCTR2300069705.

Electrotherapy

Labor pain

McGill Pain Questionnaire

10.21203/rs.3.rs-3518645/v1

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The literature review of women′s decison on mode of delivery and its related factors

The Journal of practical nursing (2017)

Chunyi Gu Qiping Lin Chunxiang Zhu

Decision on mode of delivery (MOD) is a process involved by both clients and health care providers, based on specific clinical situations and women′s values. To help each woman obtain the best MOD is crucial for obstetric health professionals to provide women-centered high quality of care. There is a steep upward trend in cesarean sections in China due to the introduced advanced technologies, overused antenatal monitoring methods, flexible indications for cesarean sections, delayed childbearing ages and people′s misconceptions, etc.. Recently the conditional and comprehensive two-child policy have been implemented in China, which might initiate changes in fertility and birth intentions of many families, and in subsequent decisions on MOD. This review illustrates the pros and cons of MOD, decision process on MOD, influencing factors and strategies to promote decision on MOD, in order for the obstetric professionals to provide evidence-based best care for women and their families in the process of decision-making. Key words: Decision making; Mode of delivery; Influencing factors; Literature review

Maternity care

Decision-making

Mode (computer interface)

10.3760/cma.j.issn.1672-7088.2017.22.022

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i-10 index