Shanshan Li

University of Science and Technology of China

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Kaiming Zhang

University of Science and Technology of China

Wah Chiu

Stanford University

Grigore Pintilie

Stanford University

Michael F. Schmid

Stanford University

Rhiju Das

Stanford University

Rong Hu

Guilin University of Electronic Technology

Liang Liu

South China University of Technology

Xiaofeng Lin

Fujian Medical University

Zhaoming Su

Sichuan University

Ivan N. Zheludev

Stanford University

Cooperative Institutions

Chinese Academy of Sciences

223

University of Chinese Academy of Sciences

102

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhejiang University

Sun Yat-sen University

Sichuan University

University of Science and Technology of China

Peking University

Fudan University

Chinese Academy of Agricultural Sciences

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Energy Management of Sowing Unit for Extended-Range Electric Tractor Based on Improved CD-CS Fuzzy Rules

Agriculture (2023)

Zhengkai Wu Jiazhong Wang Yazhou Xing Shanshan Li Yi Jinggang

In order to ensure the continuity and endurance mileage requirements during sowing operations, it is necessary to establish accurate modeling for the working condition of the electric tractor sowing unit by adopting a reasonable energy management strategy and realizing accurate energy prediction. The existing electric tractor sowing unit battery energy management strategy is not optimal since it is mostly based on extensive rules. In this paper, according to the requirements of the sowing conditions, a precise model of electric energy consumption in the sowing cycle was established and an energy management strategy of sowing unit of extended-range electric tractor with power CD-CS was proposed. Fuzzy control rules of the dynamic SOC correction factor were established in the battery maintenance stage, and the NSGA-II algorithm was used to optimize the fuzzy control rules to optimize the battery charging and discharging efficiency. A hardware-in-the-loop simulation test platform was built, and the proposed CD-CS strategy was compared with the fuzzy improvement strategy. The simulation results show that the proposed fuzzy improvement strategy extended the battery life of the power consumption stage by 2131.9 s, which is a significant improvement. The field practical results showed that the SOC decreased by 7.21% and the simulation by 4.94% in terms of power consumption in a cycle. The power consumption variance was within a reasonable range, which further verifies the feasibility of the strategy.

Tractor

10.3390/agriculture13071303

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Citations (7)

Macrophage-targeting nano-formulated bicalutamide alleviates colitis by inducing MAP3K1-mediated degradation of NLRP3

Journal of Controlled Release (2025)

Suqin Zhong Suzhen Zhong Yi Wu Zhiyuan Liu Yinyin Yang

Bicalutamide

10.1016/j.jconrel.2025.01.076

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Citations (0)

[Phenotypic and genetic analysis of a Chinese pedigree affected with Hereditary antithrombin deficiency due to a novel variant of SERPINC1 gene].

PubMed (2024)

Yingying Chen Yating Yao Ting Li Kuangyi Shu Yang Xiao

To analyze the clinical phenotype and genetic characteristics of a Chinese pedigree affected with Hereditary antithrombin deficiency.

Sanger sequencing

Proband

Prothrombin time

10.3760/cma.j.cn511374-20210407-00308

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Biogenesis of C-Glycosyl Flavones and Profiling of Flavonoid Glycosides in Lotus (Nelumbo nucifera)

PLoS ONE (2014)

Shanshan Li Jie Wu Liguang Chen Hui Du Yan-Jun Xu

Flavonoids in nine tissues of Nelumbo nucifera Gaertner were identified and quantified by high-performance liquid chromatography with diode array detector (HPLC-DAD) and HPLC-electrospray ionization-mass spectrometry (HPLC-ESI-MSn). Thirty-eight flavonoids were identified; eleven C-glycosides and five O-glycosides were discovered for the first time in N. nucifera. Most importantly, the C-glycosyl apigenin or luteolin detected in lotus plumules proved valuable for deep elucidation of flavonoid composition in lotus tissues and for further utilization as functional tea and medicine materials. Lotus leaves possessed the significantly highest amount of flavonoids (2.06E3±0.08 mg 100 g−1 FW) and separating and purifying the bioactive compound, quercetin 3-O-glucuronide, from leaves showed great potential. In contrast, flavonoids in flower stalks, seed coats and kernels were extremely low. Simultaneously, the optimal picking time was confirmed by comparing the compound contents in five developmental phases. Finally, we proposed the putative flavonoid biosynthesis pathway in N. nucifera.

Flavones

Isorhamnetin

Carthamus

Lotus effect

Phenylpropanoid

10.1371/journal.pone.0108860

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Citations (81)

Development of benzimidazole-based compounds as novel capsid assembly modulators for the treatment of HBV infection

European Journal of Medicinal Chemistry (2024)

Kaixin Du Xianyang Wang Yuxin Bai Xue Zhang Jie Xue

Benzimidazole

IC50

EC50

Lead compound

10.1016/j.ejmech.2024.116402

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Citations (2)

All-optical nonvolatile optical modulator for in-fiber operation

Nanophotonics (2023)

Zhihai Liu Xiang Li Siying Cheng Yaru Li Wei Jin

Abstract The control of information is a defining feature of the information age, and the optical modulator likewise has a crucial role in optical networks. The transmission, processing, and storage of data have demanded low energy consumption and high speed for photonic systems, promoting the development of electro-optic modulators to all-optical modulators. Although these all-optical modulation methods eliminate the photoelectric conversion, the disadvantage of volatile materials requiring continuous power supply when processing and retaining data in new materials-based devices increase energy consumption. We propose a Ge 2 Sb 2 Te 5 (GST) integrated all-optical, nonvolatile optical modulator for in-fiber operation. The pulse-induced GST phase transition changes the reflectivity of the fiber end face, and this difference affects the result of the interference, achieving a modulation of output light intensity in interference spectra. The experimental results reveal that the device has obtained 13 dB interference intensity contrast in the telecommunications bands, and its response to a pump pulse is around 100 ns. Furthermore, we demonstrated the operation of the device as a scalar multiplication unit and a logic operation unit. The signal can be transmitted, processed, and stored in the fiber without photoelectric conversion. With the benefits of the switching power consumption of less than 100 nJ and the nonvolatile nature of GST, the device will be more energy-efficient in synchronous processing and storing. This in-fiber operating modulator lays the foundation for developing all-optical devices and networks.

Modulation (music)

10.1515/nanoph-2023-0212

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Citations (2)

1384P Efficacy of cemiplimab as monotherapy or in combination with chemotherapy in Japanese patients with advanced non-small cell lung cancer (aNSCLC)

Annals of Oncology (2024)

Yuki Sato Yukako Tani Hiroo Ishii S. Katakura M. OKI

10.1016/j.annonc.2024.08.1439

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Citations (0)

Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution

Nature Communications (2019)

Kaiming Zhang Shanshan Li Kalli Kappel Grigore Pintilie Zhaoming Su

Specimens below 50 kDa have generally been considered too small to be analyzed by single-particle cryo-electron microscopy (cryo-EM). The high flexibility of pure RNAs makes it difficult to obtain high-resolution structures by cryo-EM. In bacteria, riboswitches regulate sulfur metabolism through binding to the S-adenosylmethionine (SAM) ligand and offer compelling targets for new antibiotics. SAM-I, SAM-I/IV, and SAM-IV are the three most commonly found SAM riboswitches, but the structure of SAM-IV is still unknown. Here, we report the structures of apo and SAM-bound SAM-IV riboswitches (119-nt, ~40 kDa) to 3.7 Å and 4.1 Å resolution, respectively, using cryo-EM. The structures illustrate homologies in the ligand-binding core but distinct peripheral tertiary contacts in SAM-IV compared to SAM-I and SAM-I/IV. Our results demonstrate the feasibility of resolving small RNAs with enough detail to enable detection of their ligand-binding pockets and suggest that cryo-EM could play a role in structure-assisted drug design for RNA.

Riboswitch

Nucleic acid structure

10.1038/s41467-019-13494-7

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Citations (114)

Peptides in Brewed Wines: Formation, Structure, and Function

Journal of Agricultural and Food Chemistry (2021)

Mengjie Zhou Tingting Bu Jiexia Zheng Ling Liu Songfeng Yu

The traditional low-alcoholic beverages, such as grape wine, sake, and rice wine, have been consumed all over the world for thousands of years, each with their unique methods of production that have been practiced for centuries. Moderate consumption of wine is generally touted as beneficial for health, although there is ongoing debate for the responsible components in wine. In this review, the structural and functional characteristics, the formation mechanisms, and their health-promoting activities of peptides in three brewed wines, grape wine, Chinese rice wine (also called Chinese Huangjiu or Chinese yellow wine), and Japanese sake, are discussed. The formation of peptides in wine imparts sensorial, technological, and biological attributes. Prospects on future research, with an emphasis on the peptide characterization, formation mechanism, physiological activity, and molecular mechanisms of action, are presented.

Health Benefits

Aging of wine

10.1021/acs.jafc.1c00452

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Citations (33)

Endogenous MicroRNA-Triggered and Real-Time Monitored Drug Release via Cascaded Energy Transfer Payloads

Analytical Chemistry (2017)

Fan Yang Tingting Zhang Shanshan Li Pei Song Kai Zhang

It is a great challenge to design a drug delivery system with a controlled manner, especially one triggered by an exclusive endogenous disease marker and with an easily tracked release process. Herein, we developed a drug delivery platform of carbon dots which were connected to a stem-loop molecular beacon loaded with doxorubicin and polyethylene glycol modified folic acid. Such a platform enables one to release drugs on demand under the stimuli of endogenous microRNA-21, and turn on the fluorescence of carbon dots and doxorubicin, which allows one to monitor the drug release process. The intracellular experiment indicated that folic acid could mediate endocytosis of the nanocarrier, and the overexpressed endogenous microRNA-21 served as a unique key to unlock the drug nanocarrier by competitive hybridization with the molecular beacon, which finally resulted in fluorescence recovery and realized a chemotherapeutic effect within human breast cancer cells. The nanocarrier may have potential application in personalized treatment of different cancer subtypes in which the corresponding miRNAs are overexpressed.

Nanocarriers

Molecular beacon

10.1021/acs.analchem.7b01582

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Citations (21)