Aránzazu Díaz‐Cuenca

Instituto de Ciencia de Materiales de Sevilla

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Stuart Hampshire

University of Limerick

J.A. Odriozola

Instituto de Ciencia de Materiales de Sevilla

Mario Montes

University of the Basque Country

Juan J. Segura‐Egea

Universidad de Sevilla

Sara Borrego-González

Universidad de Sevilla

Y. Laurent

Greentech (France)

José J. Benı́tez

Centro de Investigaciones Científicas Isla de la Cartuja

Ian MacLaren

University of Glasgow

Aldo Leal‐Egaña

Heidelberg University

J Turian

Rush University Medical Center

Cooperative Institutions

Syracuse University

John Wiley & Sons (United States)

Smith College

University of Memphis

Texas A&M University

Rush University Medical Center

Universidad de Sevilla

Consejo Superior de Investigaciones Científicas

Rush University

Instituto de Ciencia de Materiales de Sevilla

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MTA HP Repair stimulates in vitro an homogeneous calcium phosphate phase coating deposition

Journal of Clinical and Experimental Dentistry (2019)

M. C. Jiménez‐Sánchez Juan J. Segura‐Egea Aránzazu Díaz‐Cuenca

To study the mineralization capacity in vitro of the bioceramic endodontic material MTA HP Repair.Bioactivity evaluation in vitro was carried out, by soaking processed cement disk in simulated body fluid (SBF) during 168 h. The cement surface was studied by Fourier transform infrared spectroscopy (FT-IR), field emission gun scanning electron microscopy (FEG-SEM) and energy dispersive X-ray analysis (EDX). Release to the SBF media of ionic degradation products was monitored using inductively coupled plasma atomic emission spectroscopy (ICP-AES).FT-IR showed increasing formation of phosphate phase bands at 1097, 960, 607 and 570 cm-1 with prolonged SBF soaking. FEG-SEM analysis reveals that HP produces a effectively surface covering consisting in homogeneous spherical phosphate phase aggregates with an average diameter of 0.5-1.0 µm. EDX analysis comparing un-treated (hydrated), 24 h and 72 h SBF treated surfaces of MTA HP Repair revealed phosphate deposition after 24 h, with high phosphorous/silicon element ratio signal measured after 24 h, indicating a very high phosphate phase deposition for this material.The study shows that MTA HP Repair produces a quick and effective bioactive response in vitro in terms of crystalline calcium phosphate surface coating formation. The high bioactive response of MTA HP Repair makes it an interesting candidate for endodontic use as repair cement. Key words:Bioactive endodontic cements, bioactive response, MTA HP Repair.

Simulated body fluid

Bioceramic

10.4317/jced.55661

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Citations (17)

Effect of Composition and Processing Conditions on the Formation of Y and Er-SiAlON B and I<sub>w</sub> Phase Glass-Ceramics

Key engineering materials (2003)

Aránzazu Díaz‐Cuenca Emrah Dölekçekiç Michael J. Pomeroy Stuart Hampshire

Sialon

10.4028/www.scientific.net/kem.237.247

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Citations (2)

SU-GG-T-52: Plan Evaluation for Treatment of Malignant Gliomas Using Californium-252 Neutron Brachytherapy and Compared with SRS

Medical Physics (2010)

Y Liu Aránzazu Díaz‐Cuenca

Purpose: The objective of this study is to perform a plan evaluation using Californium-252 neutron brachytherapy for the treatment of malignant gliomas and compare the neutron brachytherapy planning with photon Stereotactic Radiosurgery (SRS) therapy planning. Materials/Methods: After a phase I trial of neutron brachytherapy (Cf-252 implant) for the treatment of malignant gliomas, there is renewed interest to evaluate the effectiveness of radiation therapy using neutron brachytherapy compared with SRS. Here we performed a dosimetric comparison of two treatment plans based on the same patient using equivalent prescribed dose. Isodose lines and dose volume histogram of brain tumor and adjacent critical structures were used for plan evaluation. Dose of neutron brachytherapy was calculated using CT-converted Monte Carlo model and simulated by Monte Carlo code (MCNPX V2.5). The tissue component of Monte Carlo model was adapted from the sectioned images of human cadavers of the Visible Human Project of NLM. Dose of SRS plan was calculated using BrainLab iPlan. A relative biological effectiveness of 6 was used to determine the neutron equivalent dose (ncGy) for central nervous system (CNS) tissues. An equivalent dose of 6000 cGy was prescribed for both plans respectively. Results: The targets were covered by the 95% prescribed dose to 95% tumor volume in both SRS and neutron brachytherapy plans. Comparing the SRS and Cf-252 neutron brachytherapy, the mean dose was 6100 cGy and 6708 ncGy for target, 312 cGy and 177 ncGy for brainstem, 732 cGy and 311 cGy for chiasm, 255 cGy and 275 ncGy for pituitary, and 504 cGy and 420 ncGy for brain, respectively. Conclusions: Cf-252 Brachytherapy provided conformai dose distribution to the brain tumor and reduced the dose to the surrounding critical organs compared to SRS. The implanted Cf-252 source provides high dose to brain tumor and reduces the radiation exposure of normal brain.

Californium

10.1118/1.3468438

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Involvement of the Neural Stem Cell Compartment By Pediatric and Adult Gliomas: A Retrospective Review of 377 Cases

International Journal of Radiation Oncology*Biology*Physics (2014)

James C. Marsh Stewart Goldman G. Ziel Corey Bregman Aránzazu Díaz‐Cuenca

Pilocytic astrocytoma

Histology

10.1016/j.ijrobp.2014.05.956

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Involvement of the Neural Stem Cell Compartment by Low and High Grade Gliomas: A Retrospective Review of 80 Low Grade and 104 High Grade Tumors

International Journal of Radiation Oncology*Biology*Physics (2010)

James C. Marsh Aránzazu Díaz‐Cuenca Richard W. Byrne Benjamin T. Gielda Arnold M. Herskovic

Histology

10.1016/j.ijrobp.2010.07.672

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Phase I/II conformal three-dimensional radiation therapy dose escalation study in patients with supratentorial glioblastoma multiforme: Report of the radiation therapy oncology group 98–03 protocol

International Journal of Radiation Oncology*Biology*Physics (2004)

Maria Werner‐Wasik Wendy Seiferheld Jeff M. Michalski Mark R. Gilbert James A. Purdy

Radiation oncology

10.1016/j.ijrobp.2004.06.084

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Light induced hydrophilicity and osteoblast adhesion promotion on amorphous TiO₂

Journal of Biomedical Materials Research Part A (2012)

Antonia Terriza Aránzazu Díaz‐Cuenca F. Yubero Ángel Barranco Agustín R. González‐Elipe

Abstract We have studied the effect of the UV induced superhydrophilic wetting of TiO 2 thin films on the osteoblasts cell adhesion and cytoskeletal organization on its surface. To assess any effect of the photo‐catalytic removal of adventitious carbon as a factor for the enhancement of the osteoblast development, 100 nm amorphous TiO 2 thin layers were deposited on polyethylene terephthalate (PET), a substrate well known for its poor adhesion and limited wettability and biocompatibility. The TiO 2 /PET materials were characterized by X‐ray photoelectron spectroscopy, and atomic force microscopy and their wetting behavior under light illumination studied by the sessile drop method. The amorphous TiO 2 thin films showed a very poor photo‐catalytic activity even if becoming superhydrophilic after illumination. The illuminated samples recovered partially its initial hydrophobic state only after their storage in the dark for more than 20 days. Osteoblasts (HOB) were seeded both on bare PET and on TiO 2 /PET samples immediately after illumination and also after four weeks storage in darkness. Cell attachment was much more efficient on the immediately illuminated TiO 2 /PET samples, with development of focal adhesions and cell traction forces. Although we cannot completely discard some photo‐catalytic carbon removal as a factor contributing to this cell enhanced attachment, our photodegradation experiments on amorphous TiO 2 are conclusive to dismiss this effect as the major cause for this behavior. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

Superhydrophilicity

Biocompatibility

10.1002/jbm.a.34405

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Citations (20)

XPS and DRIFTS Study of Cerium in Ce-Si-AI-O-N Glasses

Materials science forum (2000)

Aránzazu Díaz‐Cuenca S. Guillopé P. Verdier Y. Laurent Antonio Fernández López

10.4028/www.scientific.net/msf.325-326.283

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Citations (6)

Nanoporous silica microparticle interaction with toll-like receptor agonists in macrophages

Acta Biomaterialia (2012)

Marta Cejudo‐Guillén M. Lourdes Ramiro‐Gutiérrez Adahir Labrador‐Garrido Aránzazu Díaz‐Cuenca David Pozo

Nanoporous

Microparticle

10.1016/j.actbio.2012.07.026

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Citations (24)

New Nano-Crystalline Hydroxyapatite-Polycarboxy/Sulfo Betaine Hybrid Materials: Synthesis and Characterization

Molecules (2024)

Aránzazu Díaz‐Cuenca Kostadinka Sezanova Rumiana Gergulova D. Rabadjieva Konstans Ruseva

Hybrid materials based on calcium phosphates and synthetic polymers can potentially be used for caries protection due to their similarity to hard tissues in terms of composition, structure and a number of properties. This study is focused on the biomimetic synthesis of hybrid materials consisting of hydroxiapatite and the zwitterionic polymers polysulfobetaine (PSB) and polycarboxybetaine (PCB) using controlled media conditions with a constant pH of 8.0–8.2 and Ca/P = 1.67. The results show that pH control is a dominant factor in the crystal phase formation, so nano-crystalline hydroxyapatite with a Ca/P ratio of 1.63–1.71 was observed as the mineral phase in all the materials prepared. The final polymer content measured for the synthesized hybrid materials was 48–52%. The polymer type affects the final microstructure, and the mineral particle size is thinner and smaller in the synthesis performed using PCB than using PSB. The final intermolecular interaction of the nano-crystallized hydroxyapatite was demonstrated to be stronger with PCB than with PSB as shown by our IR and Raman spectroscopy analyses. The higher remineralization potential of the PCB-containing synthesized material was demonstrated by in vitro testing using artificial saliva.

Hybrid material

Crystal (programming language)

10.3390/molecules29050930

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