Xinhai Cui

Shandong University of Traditional Chinese Medicine

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Mengkai Lu

Shandong University of Traditional Chinese Medicine

Zhiyuan Zhang

Shandong University of Traditional Chinese Medicine

Yuanlong Hu

Shandong University of Traditional Chinese Medicine

Chao Li

Second Affiliated Hospital of Zhejiang University

Aiwu Li

Qilu Hospital of Shandong University

Fengyin Sun

Qilu Hospital of Shandong University

Muxin Zhang

Shandong University of Traditional Chinese Medicine

Jiaqi Hao

Shandong University of Traditional Chinese Medicine

Qiangye Zhang

Qilu Hospital of Shandong University

Xianjun Fu

Shandong University of Traditional Chinese Medicine

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Shandong University of Traditional Chinese Medicine

Qilu Hospital of Shandong University

Nanjing Medical University

Shandong University

Chinese Academy of Sciences

Jiangsu Province Hospital

Harbin Medical University

Zhejiang University

Chinese Academy of Medical Sciences & Peking Union Medical College

Affiliated Hospital of Shandong University of Traditional Chinese Medicine

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Identification of Circulating Plasma Proteins as a Mediator of Hypertension-Driven Cardiac Remodeling: A Mediation Mendelian Randomization Study

Hypertension (2024)

Yuanlong Hu Lin Lin Lei Zhang Yuan Li Xinhai Cui

This study focused on circulating plasma protein profiles to identify mediators of hypertension-driven myocardial remodeling and heart failure.

Mendelian Randomization

Ventricular remodeling

Pulse pressure

10.1161/hypertensionaha.123.22504

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Citations (7)

Advances in the study of vascular related protective effect of garlic (Allium sativum) extract and compounds

The Journal of Nutritional Biochemistry (2023)

Mengkai Lu Jinyuan Pan Yuanlong Hu Liang Ding Yuan Li

Alliin

GARLIC POWDER

Functional food

10.1016/j.jnutbio.2023.109531

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Citations (9)

Association between estimated pulse wave velocity and in-hospital mortality of patients with acute kidney injury: a retrospective cohort analysis of the MIMIC-IV database

Renal Failure (2024)

Xinhai Cui Yuanlong Hu Dongxiao Li Mengkai Lu Zhiyuan Zhang

Background Estimated pulse wave velocity (ePWV) has been found to be an independent predictor of cardiovascular mortality and kidney injury, which can be estimated noninvasively. This study aimed to investigate the association between ePWV and in-hospital mortality in critically ill patients with acute kidney injury (AKI).

10.1080/0886022x.2024.2313172

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Citations (4)

Advances in the Global Distribution, Chemical Constituents, and Pharmacology of Hippocampus, a Traditional Marine Chinese Medicine

Frontiers in Marine Science (2021)

Xinhai Cui Xiangfeng Zhao Jintong Li Ziwei Li Xia Ren

Hippocampus is an important traditional marine Chinese medicinal resource that has been used to warm and tonify kidney yang in the clinic for a long time in China. Modern pharmacological studies show that its active ingredients display a wide range of pharmacological activities associated with the kidney, such as anti-inflammation, antioxidation, antitumor, and neuroprotective effects. Herein, we systematically summarize and analyze the research progress on the resource distribution, active ingredients, pharmacological activities, and clinical application of Hippocampus . First, the species and worldwide distribution of Hippocampus were assessed to clarify the existing resources, and the results showed that 44 species of Hippocampus have been found in 159 countries and regions worldwide. Then, based on the analysis of 16 kinds of active ingredients and extraction methods, the relationship between the ingredient extraction and pharmacological activities of Hippocampus was revealed. This review may provide a foundation for further research on the potential active ingredients and mechanisms of Hippocampus . In addition, the research status of traditional prescriptions containing Hippocampus was evaluated. The results implied that research on Hippocampus is still in its infancy, and the mechanism and material basis of its efficacy have not been clarified. This paper should provide directions for further studies on Hippocampus .

10.3389/fmars.2021.774927

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Citations (3)

The expressions of Ghrelin and its receptor in Hirschsprung' s disease

Zhonghua xiaoerwaike zazhi (2013)

Qiangye Zhang Xiang Li Aiwu Li Kelai Wang Xinhai Cui

Objective To study the expressions of Ghrelin and its receptor (GHSR) in the patients with Hirschsprungs disease (HD).Methods Eighteen patients who were diagnosed with HD and underwent transanal pull-through procedure were recruited in this study.The resected colon was collected to study the expressions of Ghrelin and GHSR by immunohistochemistry staining.Results Ghrelin and GHSR protein were consistently expressed in the glandular epithelium and villi of the ganglionic colon.In the aganglionic segment,the expressions of Ghrelin and GHSR were significantly reduced (Ghrelin:0.1460 ± 0.014,GHSR:0.1386 ± 0.016).However,the expressions of Ghrelin and GHSR were restored in the dilated segment of colon (Ghrelin..0.5103 ± 0.013,GHSR..0.5094 ±0.019).Moderate expressions of Ghrelin and GHSR were found in the transition zone.In the same tissue of colon,the expression of Ghrelin was not significantly different from that of GHSR (P＞0.05).Conclusions The expressions of Ghrelin and GHSR are reduced in the aganglionic colon of the patients with HD. Key words: Hirschsprung' s discase; Ghrelin; Receptors, Ghrelin

10.3760/cma.j.issn.0253-3006.2013.01.007

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Application of laparoscopic pyelplasty in surgical treatment of neonatal ureteropelvic junction obstruction

Zhonghua xiaoerwaike zazhi (2010)

Lei Zhang Xinhai Cui Zhi-hang Dong Guo-hua Tan

Objective To summarize the experience in laparscopic pyelplasty of neonatal ureteropelvic junction obstruction. Methods 31 patients were retrospective analyzed, which's mean age were 8.6 months. All the cases were detected at ante partum, and close inspection follows up until juvenal infant period. Every baby that had been accepted the operation was in strict accordance with the grade of SFU and the desire of the parents. The procedures of laparoscopic pyelplasty were retrospective recorded and analyzed. Results 29 of 31 cases were succeeded. But 2 cases turn to small incision operation. The procedures cost 110-230 minutes, which's mean time was 145 minutes. All the cases recoveries well. Cases were follow up the examinations of ultrasonogrophy at 3, 6 months after the operation. No disassociation between calices renales and pelvis renalis was detected. And it is proved that the operations are successful. Conclusions 1. Application of laparoscopic pyelplasty in surgical treatment of neonatal ureteropelvic junction obstruction is reliable. Compared with the traditional operation. laparoscopic pyelplasty has the advantages of smaller trauma and better recovery. And it represents development direction in the future. But it needs rich experience in this operating practice. 2.We have summarized many experiences in laparscopic pyelplasty of neonatal ureteropelvic junction obstruction. 3. But application of laparoscopic pyelplasty in too little babies still exist many disputes,and need more practice. Key words: Laparoscopes; Kidney pelvis; Infant

Ureteropelvic junction

Laparoscopes

Kidney pelvis

Renal pelvis

10.3760/cma.j.issn.0253-3006.2010.08.007

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Dietary inflammation and vascular calcification: a comprehensive review of the associations, underlying mechanisms, and prevention strategies

Critical Reviews in Food Science and Nutrition (2024)

Xinhai Cui Wendi Wei Yuanlong Hu Zhiyuan Zhang Mengkai Lu

Cardiovascular disease (CVD) is one of the leading causes of death globally, and vascular calcification (VC) has been recognized as an independent and strong predictor of global CVD and mortality. Chronic inflammation has been demonstrated to play a significant role in the progression of VC. This review aims to summarize the literature that aimed to elucidate the associations between dietary inflammation (DI) and VC as well as to explore the mechanisms underlying the association and discuss strategies (including dietary interventions) to prevent VC. Notably, diets rich in processed foods, carbohydrates with high glycemic index/load, saturated fatty acids,

10.1080/10408398.2024.2408447

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Association of a GATA Binding Protein 4 Polymorphism with the Risk of Hypospadias in the Chinese Children

Urologia Internationalis (2021)

Jiawei Chen Xinhai Cui Aiwu Li Guowei Li Fengyin Sun

GATA binding protein 4 (GATA4) has been implicated in the etiology of congenital malformation of the urogenital system. The present study investigated the influence of GATA4 polymorphisms on susceptibility to hypospadias.We genotyped 4 potentially functional polymorphisms (rs12458, rs12825, rs884662, and rs904018) in GATA4 in the hospital-based case-control study including 410 child patients and 520 nonmalformed individuals by the TaqMan MGB method. Risk associations were assessed using unconditional logistic regression, adjusted for potential confounding factors.A significant association was found between rs12458 (3'-UTR of GATA4) and susceptibility to hypospadias (p = 0.008). Compared with rs12458 AA genotype individuals, those harboring the variant allele (rs12458 AT/TT) were correlated with significantly higher risk of hypospadias (AT/TT vs. AA: OR = 1.42, 95% CI = 1.17-2.35, p = 0.036). Furthermore, the rs12458T allele showed significantly decreased activity in a luciferase reporter assay, indicating a possible role of rs12458 variant in regulating the combination of microRNAs with the GATA4 mRNA.The present results indicate that the functional GATA4 rs12458 variant confers individuals' susceptibility to hypospadias, possibly through regulating the GATA4 expression level.

TaqMan

GATA4

10.1159/000518644

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Citations (4)

Experience Summary of Laparoscopic Treatment for Pediatric Ureteral Polyps

Frontiers in Pediatrics (2021)

Hongjie Gao Jiawei Chen Guowei Li Xinhai Cui Fengyin Sun

Objective: To investigate surgical techniques and challenges of laparoscopic in treating pediatric ureteral polyps under laparoscopy. Methods: The clinical data of 7 of pediatric ureteral polyps patients who were admitted to the hospital from July 2015 to January 2020 were analyzed retrospectively. There were 6 males and 1 female from 7.7 to 13.9 years old at the mean age of 10.4. Before surgery, all children performed urinary B ultrasound, magnetic resonance urography (MRU), and renal radionuclide scanning. Six cases were observed on the left lateral and 1 on the right. The lesions of 5 cases were located at the ureteropelvic junction, 1 in the upper ureter and 1 in the middle ureter. The polyps were treated intraoperatively by the resecting of the lesion segment and simple polypectomy to retain the attached part of the original diseased segment of the ureter. All surgeries were performed under laparoscopy and B-ultrasound was performed during follow up after surgery. Results: All 7 surgeries were performed successfully under the laparoscope. The surgery time was 80–110 min, and the average surgery time was 97.5 min. The intraoperative bleeding was 10–25 ml and the average postoperative hospital stay was 6 d. Postoperative hematuria occurred in 1 case. Neither urinary leakage nor urinary tract infection was reported post surgery. Preoperative affected pyelectasis of all patients was 2.0–3.7 cm. Three months postoperatively, the affected pyelectasis was measured at 1.2–3.0 cm. No recurrence of polyps was reported after surgery. During the follow-up to April 2020, there was no significant change in the kidney size of all patients, and hydronephrosis was alleviated compared with that before surgery. Conclusions: Laparoscopy is a safe, effective and minimally invasive surgical technique for pediatric multiple ureteral polyps. The surgery plan was designed according to the location and size of polyps, including segmental ureterectomy of polyps + pyeloureterostomy, segmental ureterectomy of polyps + ureter - ureteral anastomosis.

Pyelogram

Urinary Leakage

Polypectomy

10.3389/fped.2021.689842

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Citations (5)

Effect of green tea on reward learning in healthy individuals: a randomized, double-blind, placebo-controlled pilot study

Nutrition Journal (2013)

Qiangye Zhang Hongchao Yang Jian Wang Aiwu Li Wentong Zhang

Abstract Background Both clinical and preclinical studies revealed that regular intake of green tea reduced the prevalence of depressive symptoms, as well as produced antidepressant-like effects in rodents. Evidence proposed that disturbed reward learning has been associated with the development of anhedonia, a core symptom of depression. However, the relationship between green tea and reward learning is poorly investigated. Our goal was to test whether chronic treatment with green tea in healthy subjects affects the process of reward learning and subsequently regulates the depressive symptoms. Methods Seventy-four healthy subjects participated in a double-blind, randomized placebo-controlled study with oral administration of green tea or placebo for 5weeks. We used the monetary incentive delay task to evaluate the reward learning by measurement of the response to reward trial or no-reward trial. We compared the reaction time of reward responsiveness between green tea and placebo treatment. Furthermore, we selected Montgomery-Asberg depression rating scale (MADRS) and 17-item Hamilton Rating Scale for Depression (HRSD-17) to estimate the depressive symptoms in these two groups. Results The results showed chronic treatment of green tea increased reward learning compared with placebo by decreasing the reaction time in monetary incentive delay task. Moreover, participants treated with green tea showed reduced scores measured in MADRS and HRSD-17 compared with participants treated with placebo. Conclusions Our findings reveal that chronic green tea increased the reward learning and prevented the depressive symptoms. These results also raised the possibility that supplementary administration of green tea might reverse the development of depression through normalization of the reward function.

Anhedonia

10.1186/1475-2891-12-84

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Citations (25)