Wang Ya

Westmead Institute for Medical Research

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Zhihua Ren

Shanxi University

Xiaoping Ma

Sichuan Agricultural University

Zhicai Zuo

Sichuan Agricultural University

Zhijun Zhong

Sichuan Agricultural University

Liuhong Shen

Sichuan Agricultural University

Junliang Deng

Sichuan Agricultural University

Suizhong Cao

Sichuan Agricultural University

Yanchun Hu

Sichuan Agricultural University

Guangneng Peng

Sichuan Agricultural University

Shumin Yu

Sichuan Agricultural University

Cooperative Institutions

Sichuan Agricultural University

Chinese Academy of Sciences

Zhejiang University

Huazhong University of Science and Technology

Chinese Academy of Medical Sciences & Peking Union Medical College

Sichuan University

Sun Yat-sen University

Central South University

Capital Medical University

Peking University

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Effects of Exogenous Carbon Source on Carbon and Nitrogen Metabolism of Wheat under Drought Stress

He'nan nongye kexue (2015)

Wang Ya

Hydroponics experiment was carried out to study the effects of exogenous carbon source( including fructose,glucose,sucrose,trehalose and maltoseon) on carbon and nitrogen metabolism of wheat under drought stress. The results showed that,for Jinmai 47 and Zhengyin No. 1,under drought stress,the contents of sucrose,soluble sugar,free amino acid increased by 151. 88%,259. 13%,225. 39% and90. 31%,97. 39%,163. 91%,respectively; the contents of NO-3-N and NH+4-N decreased by 20. 58%,25. 49% and 28. 01%,21. 52%,respectively. For Jinmai 47 and Zhengyin No. 1,under drought stress,exogenous carbon sources,including fructose,glucose,sucrose,trehalose and maltose,could increase the contents of sucrose,soluble sugar and free amino acid,the increasing range were 5. 52% —31. 53%,9. 44% —26. 15% 16. 69% —55. 22% and 22. 20% —79. 23%,3. 52% —22. 91%,- 5. 61% —59. 67%,significantly; exogenous carbon sources could decrease the contents of NO-3-N and NH+4-N were declined,the decreasing range were 1. 86% —25. 33%,- 9. 85% —9. 19% and 0. 92% —31%,- 5. 11% —12. 10%,meanwhile,the drought stress and the exogenous carbon source showed an additive effect which enhanced the levels of carbon and nitrogen metabolism.

Carbon fibers

Carbohydrate Metabolism

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The magnetic resonance shutter speed discriminates vascular properties of malignant and benign breast tumors in vivo

Proceedings of the National Academy of Sciences (2008)

Wei Huang Xin Li Elizabeth A. Morris Luminita A. Tudorica Venkatraman Seshan

The pharmacokinetic analysis of dynamic-contrast-enhanced (DCE) MRI data yields K trans and k ep , two parameters independently measuring the capillary wall contrast reagent transfer rate. The almost universally used standard model (SM) embeds the implicit assumption that equilibrium transcytolemmal water exchange is effectively infinitely fast. In analyses of routine DCE-MRI data from 22 patients with suspicious breast lesions initially ruled positive by institutional screening protocols, the SM K trans values for benign and malignant lesions exhibit considerable overlap. A form of the shutter-speed model (SSM), which allows for finite exchange kinetics, agrees with the SM K trans value for each of the 15 benign lesions. However, it reveals that the SM underestimates K trans for each of the seven malignant tumors in this population. The fact that this phenomenon is unique to malignant tumors allows their complete discrimination from the benign lesions, as validated by comparison with gold-standard pathology analyses of subsequent biopsy tissue samples. Likewise, the SM overestimates k ep , particularly for the benign tumors. Thus, incorporation of the SSM into the screening protocols would have precluded all 68% of the biopsy/pathology procedures that yielded benign findings. The SM/SSM difference is well understood from molecular first principles.

Gold standard (test)

10.1073/pnas.0711226105

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Effect of Bilirubin Level in Cord Blood and Defecation Intervention in the Pathological Jaundice of Newborn

Medical & Pharmaceutical Journal of Chinese People's Liberation Army (2015)

Wang Ya

Objective To explore the effect of bilirubin level detection in cord blood on the risk prediction of pathological jaundice of newborns and early defecation intervention. Methods A total of 196 full-term newborns from June 2012 to June 2014 were divided into observation group( n = 92) and control group( n = 104). The observation group was treated with defecation intervention,while the control group was left untreated. The incidence rate of pathologic jaundice and the effect of defecation intervention on pathologic jaundice were observed. Results A total of 79 newborns had pathologic jaundice( 40. 31%). The bilirubin levels in cord blood of newborns with pathologic jaundice were higher than those of newborns without pathologic jaundice. The incidence rate of pathologic jaundice in observation group was lower than that in control group( P 0. 05). Conclusion The bilirubin level in cord blood may effectively predict the risk of incidence of hyperbilirubinemia,and defecation intervention may reduce the incidence rate of pathologic jaundice.

Cord blood

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Correlation between Sex and Prognosis of Acute Aortic Dissection in the Chinese Population

Chinese Medical Journal (2018)

Yanjie Liu Xiaozeng Wang Wang Ya Rui-Xia He Yang Lin

The prevalence, presentation, management, and prognosis of coronary heart disease differ according to sex. Greater understanding on the differences between men and women with acute aortic dissection (AAD) is needed. We aimed to investigate whether sex disparities are found in patients with AAD, and to study sex differences in complications, mortality in-hospital, and long-term.

10.4103/0366-6999.233943

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Clinical efficacy of thalidomide combined VAD regimen in the treatmen of 22 cases multiple myeloma

China Practical Medicine (2010)

Wang Ya

Objective To observe the clinical curative effect of thalidomide combined VAD regimen on treating newly diagnosed multiple myeloma(MM)patiens.Methods Of 22 patients with newly diagnosed MM treated with thalidomide combined VAD regimen.Every 21 days a course of treatment,An intermittent 4 weeks after treatment,Observation of efficacy and toxicity of drugs.Results After treatment for 3 treatments,Among the 22 patients 6 achieved partial remission(27.2%),12 improved(54.5%)and the total effective rate 81.8%.Drug toxicity were bone marrow suppression,fingertip numbness and constipation etc.Conclusion Treating newly diagnosed multiple myeloma(MM)patiens with thalidomide combined VAD regimen can obtain a better efficacy,which is worth to practice in clinics.

Regimen

Clinical efficacy

Bone marrow suppression

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The relationship between sublingual venae and gastroscope expressions in patients with portal hypertension

Chinese journal of integrated traditional and Western medicine (2010)

Wang Ya Yan Xiong Zhang Tao Lingyu Liu Sun Ke-wei

Objective:To provide a way of security,reduplicate,uninvadeily,through mutuality research to the sublingual venae and the gastroscope expressions.Methods:The portal hypertension of 58 patients with clinical diagnose and microprobe diagnose were observed,and the relationship between the esophageal varices and its degree and the sublingual venae were explored.Results:It was a positive correlation between the esophageal varices and the sublingula venae(r=0.753,P0.05).Conclusion:It is a positive correlation between the esophageal varices and the sublingula venae,the more higher integration of sublingula venae the more seriously degree of esophageal vareces,during estimating and monitoring course of disease in patients with portal hypertension,we could evaluate more efficacious to oesophageal vareces combining observeing the sublingual venae.

Venae cavae

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Clinical Efficacy of Gemcitabine and Navelbine Combined with Cisplatin on the Advanced Breast Cancer

Xiandai shengwu yixue jinzhan (2015)

Wang Ya

Objective: To investigate the efficacy of Gemcitabine combined Cisplatin and Navelbine combined Cisplatin in the treatment of advanced breast cancer. Methods: 80 patients in our hospital from May 2012 to December 2013 were selected and randomly divided into the control group and the observation group with 40 cases in each group. The patients in the control group were treated with Gemcitabine combined Cisplatin. The patients in the observation group were treated with Navelbine combined Cisplatin. Then the clinical efficacy and the adverse reactions were compared between the two groups. Results: There was no statistically significant difference about the clinical efficacy between two groups(P0.05). The incidence of adverse reactions in the observation group was 50% which was significantly lower than 72.5% in the control group with statistically significant differences(P0.05). Conclusion: Gemcitabine and Navelbine combined with Cisplatin have better clinical efficacy on the treatment of advanced breast cancer with better efficacy and less adverse reactions.

Clinical efficacy

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CHK1 affects cell sensitivity to microtubule‐targeted drugs

Journal of Cellular Physiology (2004)

Qing Ren Ronghua Liu Adam P. Dicker Wang Ya

Abstract Microtubules are the target of many anticancer drugs. Understanding the mechanism by which cells respond to different microtubule‐targeted drugs is important to resolve the drug resistance and to gain better tumor control. We report here for the first time that CHK1, an essential protein in mammalian cells, affects cell sensitivity to microtubule‐targeted drugs. By using a pair of transformed rat fibroblast cell lines, we show that compared with their counterpart B4 cells, A1‐5 cells with higher CHK1 expression are more resistant to taxotere, a microtubule stabilizer, but are more sensitive to nocodazole, a microtubule destabilizer. We also show that the altered sensitivities of A1‐5 cells to either taxotere or to nocodazole are related to the lesser microtubule‐formation in the cells. In addition, we show that the altered drug sensitivities and less microtubules‐formation shown in A1‐5 cells could be efficiently reversed by Chk1 siRNA. Taken together, these results indicate that CHK1 is one of the factors affecting cell resistance to taxotere and sensitiveness to nocodazole, suggesting that CHK1 is involved in affecting microtubule dynamics and could be inhibited for taxotere sensitization in CHK1 highly expressed tumor cells. © 2004 Wiley‐Liss, Inc.

Nocodazole

Microtubule polymerization

10.1002/jcp.20222

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Dynamic NMR effects in breast cancer dynamic-contrast-enhanced MRI

Proceedings of the National Academy of Sciences (2008)

Xin Li Wei Huang Elizabeth A. Morris Luminita A. Tudorica Venkatraman Seshan

The passage of a vascular-injected paramagnetic contrast reagent (CR) bolus through a region-of-interest affects tissue (1)H(2)O relaxation and thus MR image intensity. For longitudinal relaxation [R(1) identical with (T(1))(-1)], the CR must have transient molecular interactions with water. Because the CR and water molecules are never uniformly distributed in the histological-scale tissue compartments, the kinetics of equilibrium water compartmental interchange are competitive. In particular, the condition of the equilibrium trans cytolemmal water exchange NMR system sorties through different domains as the interstitial CR concentration, [CR(o)], waxes and wanes. Before CR, the system is in the fast-exchange-limit (FXL). Very soon after CR(o) arrival, it enters the fast-exchange-regime (FXR). Near maximal [CR(o)], the system could enter even the slow-exchange-regime (SXR). These conditions are defined herein, and a comprehensive description of how they affect quantitative pharmacokinetic analyses is presented. Data are analyzed from a population of 22 patients initially screened suspicious for breast cancer. After participating in our study, the subjects underwent biopsy/pathology procedures and only 7 (32%) were found to have malignancies. The transient departure from FXL to FXR (and apparently not SXR) is significant in only the malignant tumors, presumably because of angiogenic capillary leakiness. Thus, if accepted, this analysis would have prevented the 68% of the biopsies that proved benign.

Dynamic Contrast-Enhanced MRI

10.1073/pnas.0804224105

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Re-bleeding events in patients with small intestinal vascular malformation: Risk factors and effect of treatment with thalidomide

Shijie huaren xiaohua zazhi (2017)

Wang Ya Jinping Zhang Ying Niu Jiansheng Li

Vascular malformation

10.11569/wcjd.v25.i6.552

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