The combination therapy of urinary bladder cancer with radiation and hyperthermia with bleomycin was investigated. Immediately following daily external irradiation (40 Gy/4 weeks), patients were irrigated with a solution of warmed saline (intravesical temperature, 42–43°C) containing 30 μg/ml bleomycin. Of a total of 56 patients, complete responses were observed in 25, and partial responses in 21. Among T2-T3 cases, an 84% response rate was noted in combination therapy, whereas a 56% response rate was observed after radiation alone (50–70 Gy). The side-effects of the combination therapy were limited to reversible bladder irritation, and bladder capacity could be maintained within normal limits. These results suggest that combination therapy represents an effective conservative therapy for the management of bladder cancer.
Two patients treated with interstitial iridium-192 irradiation are presented. A patient with stage IV A adenocarcinoma of the uterine cervix was treated with external irradiation in combination with local hyperthermia prior to the interstitial irradiation. Another patient with stage III B squamous cell carcinoma of the vagina had a hysterectomy followed by irradiation 22 years prior to the treatment. Wires of Iridium-192 were put into place in the region of the tumor to give 40 Gy to the periphery of the tumor. The patient with carcinoma of the cervix died 15 months after the treatment. The patient with carcinoma of the vagina is well and has locally controlled disease 18 months after the treatment.
Six patients with carcinoma of the vulva and 3 with carcinoma of the vagina following radiation therapy for cancer of the cervix were analyzed. The interval between irradiation and diagnosis of the second tumor varied from 5 to 23 years. Despite the lack of having detailed information on irradiation factors in all patients, circumstantial evidence from this study suggests that radiation therapy may have contributed to the development of carcinoma of the vulva and vagina in some of the patients. Close follow-up patients treated for squamous carcinoma of the genital tract must emphasize inspection for new lesions. The incidences previously reported in the literature are also reviewed for comparison.
Experience with the 22-MeV microtron is presented. The maintenance and ease of operability of the system are satisfactory. The physical characteristics showed many clinical advantages. Fundamental measurement of dose distribution and depth dose curves were performed and clinically applied. The two-gantry system is very satisfactory and effective for irradiation by photons and electrons to treat many patients per day. The facility for intraoperative radio therapy and the physical conditions for total body irradiation are also sufficient because of the well-designed building layout and the systematized facility with the microtron system.
Local control of metastatic neck nodes is important for treatment in patients with locally advanced head and neck cancer. However, managing inoperable bulky metastatic nodes with necrotic tissue is difficult using ordinary chemoradiotherapy (CRT). Since, hyperthermia (HT) offers complementary and synergistic effects with irradiation and anti-cancer agents, HT combined with CRT was used for treatment in 11 patients with locally advanced head and neck cancer displaying bulky metastatic neck nodes.The 11 cases included 8 cases with pathological Complete Response (CR), 2 with Partial Response (PR) and 1 with No Change (NC). The response rate was 90.9%. Overall survival rate (OS) at 1 and 2 years was 90.9% and 42.4%, respectively, and median survival time was 22.0 months. Local control rate (LCR) was 61.4% at both 1 and 2 years.These clinical results indicate the effectiveness of thermochemoradiotherapy in patients with head and neck cancer displaying bulky lymph node metastasis.
Journal Article A Case of Advanced Gastric Cancer With Long-Term Survival as the Results of Combined Radiation Therapy and Chemotherapy Get access IWAO TSUKIYAMA, M.D., IWAO TSUKIYAMA, M.D. 1Department of Radiation Therapy, National Cancer Center HospitalTokyo Reprint requests: Iwao Tsukiyama M.D., Department of Radiation Therapy. National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar KIICHI WATAI, M.D., KIICHI WATAI, M.D. 1Department of Radiation Therapy, National Cancer Center HospitalTokyo Search for other works by this author on: Oxford Academic PubMed Google Scholar SHIGEO YANAGAWA, M.D., SHIGEO YANAGAWA, M.D. 1Department of Radiation Therapy, National Cancer Center HospitalTokyo Search for other works by this author on: Oxford Academic PubMed Google Scholar YASUYUKI AKINE, M.D., YASUYUKI AKINE, M.D. 1Department of Radiation Therapy, National Cancer Center HospitalTokyo Search for other works by this author on: Oxford Academic PubMed Google Scholar RYOSUKE ONO, M.D., RYOSUKE ONO, M.D. 1Department of Radiation Therapy, National Cancer Center HospitalTokyo Search for other works by this author on: Oxford Academic PubMed Google Scholar SUNAO EGAWA, M.D., SUNAO EGAWA, M.D. 1Department of Radiation Therapy, National Cancer Center HospitalTokyo Search for other works by this author on: Oxford Academic PubMed Google Scholar TERUYUKI HIROTA, M.D., TERUYUKI HIROTA, M.D. 2Department of Pathology, National Cancer Center HospitalTokyo Search for other works by this author on: Oxford Academic PubMed Google Scholar SHIGEAKI YOSHIDA, M.D., SHIGEAKI YOSHIDA, M.D. 3Department of Endoscopy, National Cancer Center HospitalTokyo Search for other works by this author on: Oxford Academic PubMed Google Scholar HAJIME YAMAGUCHI, M.D., HAJIME YAMAGUCHI, M.D. 3Department of Endoscopy, National Cancer Center HospitalTokyo Search for other works by this author on: Oxford Academic PubMed Google Scholar KYOSUKE USHIO, M.D., KYOSUKE USHIO, M.D. 4Department of Radiolgical Diagnosis, National Cancer Center HospitalTokyo Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more TOSHIO KITAGAWA, M.D. TOSHIO KITAGAWA, M.D. 5Department of Radiology, University of Tsukuba School of Medicine Search for other works by this author on: Oxford Academic PubMed Google Scholar Japanese Journal of Clinical Oncology, Volume 16, Issue 2, June 1986, Pages 157–166, https://doi.org/10.1093/oxfordjournals.jjco.a039133 Published: 01 June 1986 Article history Received: 17 March 1986 Published: 01 June 1986
