Jorge Guevara

Universidad Nacional Autónoma de México

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Alfonso Díaz

Benemérita Universidad Autónoma de Puebla

Edgar Zenteno

Universidad Nacional Autónoma de México

Blanca Espinosa

Instituto Nacional de Enfermedades Respiratorias

Gonzalo Flores

Benemérita Universidad Autónoma de Puebla

Samuel Treviño

Benemérita Universidad Autónoma de Puebla

Ilhuicamina Daniel Limón

Benemérita Universidad Autónoma de Puebla

Guadalupe Muñoz‐Arenas

Benemérita Universidad Autónoma de Puebla

Berenice Venegas

Benemérita Universidad Autónoma de Puebla

Rubén Antonio Vázquez‐Roque

Benemérita Universidad Autónoma de Puebla

MÁ

Miguel Ángel Mayoral

Benito Juárez Autonomous University of Oaxaca

Cooperative Institutions

University of Edinburgh

166

Universidad Nacional Autónoma de México

Benemérita Universidad Autónoma de Puebla

Instituto Nacional de Neurología y Neurocirugía

Universitat Autònoma de Barcelona

Vall d'Hebron Hospital Universitari

Center for Research and Advanced Studies of the National Polytechnic Institute

Instituto Politécnico Nacional

Instituto Nacional de Enfermedades Respiratorias

Universidad Autónoma Metropolitana

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Activation of immunological responses in Litopenaeus setiferus hemocytes by a hemocyanin like-lectin

Aquaculture (2009)

Juan Alpuche Carlos Rosas Lorena Vázquez Jorge Guevara Alí Pereyra

Hemocyanin

Prophenoloxidase

C-type lectin

Hemocyte

10.1016/j.aquaculture.2009.03.022

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Citations (15)

Aminoguanidine treatment ameliorates inflammatory responses and memory impairment induced by amyloid-beta 25–35 injection in rats

Neuropeptides (2014)

Alfonso Díaz Karla Rojas Blanca Espinosa Raúl Chávez Edgar Zenteno

Amyloid beta

Gliosis

10.1016/j.npep.2014.03.002

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Citations (53)

Identification of Galectin-3 and Mucin-Type O-Glycans in Breast Cancer and Its Metastasis to Brain

Cancer Investigation (2008)

Miguel Ángel Mayoral C. Mayoral Antônio Carlos Oliveira Meneses Leonardo Villalvazo A. Guzmán

Galectin-3 has been implicated in tumor progression. We demonstrated immunohistochemically that Galectin-3 was negative in normal breast tissue, but it was highly increased in breast cancer and in metastatic tissues to brain. Similarly, histochemistry with mucin-specific lectins showed increased recognition in breast tumor and metastasis with Machaerocereus eruca agglutinin (Fuα 1,2 (GalNAcα 1,3) Galß1,4 in complex mucin) but not for Amaranthus leucocarpus (Galß1,3-GalNAc-α 1,0-Ser/Thr) and Arachis hypogaea lectins (Galß1,3GalNAc/Galß1,4GlcNAc). Mucin-type glycans and Galectin-3 colocalized in breast cancer and metastasis, but not in normal tissue, suggesting upregulated biosynthesis of complex O-glycosidically linked glycans and Galectin-3 favor breast cancer progression and brain metastasis.

Galectin-3

Galectin

MUC1

10.1080/07357900701837051

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Citations (46)

Peer Review #2 of "Evolutionary patterns of range size, abundance and species richness in Amazonian angiosperm trees (v0.2)"

Kyle G. Dexter Jérôme Chave D. Pitman C Sabatier R Baraloto

Amazonian tree species vary enormously in their total abundance and range size, while Amazonian tree genera vary greatly in species richness.The drivers of this variation are not well understood.Here, we construct a phylogenetic hypothesis that represents half of Amazonian tree genera in order to contribute to explaining the variation.We find several clear, broad-scale patterns.Firstly, there is significant phylogenetic signal for all three characteristics; closely related genera tend to have similar numbers of species and similar mean range size and abundance.Additionally, the species richness of genera shows a significant, negative relationship with the mean range size and abundance of their constituent species.Our results suggest that phylogenetically correlated intrinsic factors, namely traits of the genera themselves, shape among lineage variation in range size, abundance and species richness.We postulate that tree stature may be one particularly relevant trait.However, other traits may also be relevant, and our study reinforces the need for ambitious compilations of trait data for Amazonian trees.In the meantime, our study shows how large-scale phylogenies can help to elucidate, and contribute to explaining, macroecological and macroevolutionary patterns in hyperdiverse, yet poorly understood regions like the Amazon Basin.

10.7287/peerj.2402v0.2/reviews/2

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Citations (0)

Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases

Neural Regeneration Research (2023)

Sonia Irais González-Cano Gonzalo Flores Jorge Guevara Julio César Morales‐Medina Samuel Treviño

Abstract Aging is a natural phenomenon characterized by a progressive decline in physiological integrity, leading to a deterioration of cognitive function and increasing the risk of suffering from chronic-degenerative diseases, including cardiovascular diseases, osteoporosis, cancer, diabetes, and neurodegeneration. Aging is considered the major risk factor for Parkinson’s and Alzheimer’s disease develops. Likewise, diabetes and insulin resistance constitute additional risk factors for developing neurodegenerative disorders. Currently, no treatment can effectively reverse these neurodegenerative pathologies. However, some antidiabetic drugs have opened the possibility of being used against neurodegenerative processes. In the previous framework, Vanadium species have demonstrated a notable antidiabetic effect. Our research group evaluated polyoxidovanadates such as decavanadate and metforminium-decavanadate with preventive and corrective activity on neurodegeneration in brain-specific areas from rats with metabolic syndrome. The results suggest that these polyoxidovanadates induce neuronal and cognitive restoration mechanisms. This review aims to describe the therapeutic potential of polyoxidovanadates as insulin-enhancer agents in the brain, constituting a therapeutic alternative for aging and neurodegenerative diseases.

Cognitive Decline

Brain Aging

10.4103/1673-5374.380877

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Citations (11)

Metabolic syndrome causes recognition impairments and reduced hippocampal neuronal plasticity in rats

Journal of Chemical Neuroanatomy (2017)

Samuel Treviño Rubén Antonio Vázquez‐Roque Gustavo López‐López Claudia Pérez-Cruz Carolina Morán

Synaptophysin

Environmental Enrichment

10.1016/j.jchemneu.2017.02.007

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Citations (31)

Copper sulfate pretreatment prevents mitochondrial electron transport chain damage and apoptosis against MPP + -induced neurotoxicity

Chemico-Biological Interactions (2017)

Moisés Rubio‐Osornio Marisol Orozco‐Ibarra Araceli Díaz-Ruìz Eduardo Brambila Marie‐Catherine Boll

Neurotoxicity

Metallothionein

Dismutase

10.1016/j.cbi.2017.04.016

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Citations (17)

Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1–42

Oxidative Medicine and Cellular Longevity (2018)

Alfonso Díaz Claudia Escobedo Samuel Treviño Raúl Chávez Gustavo López‐López

An important worldwide health problem as the result of current lifestyle is metabolic syndrome (MS). It has been shown that MS induced by a high-calorie diet (HCD) in rats produces cognitive deterioration in the novel object recognition test (NORt) and decreases synaptic connections and dendritic order in the hippocampus and temporal cortex. However, it is unknown whether MS induced by an HCD participates in the cognitive process observed with the injection of Aβ1-42 into the hippocampus of rats as a model of Alzheimer disease (AD). The induction of MS in rats produces a deterioration in NORt; however, rats with MS injected with Aβ1-42 show a major deterioration in the cognitive process. This event could be explained by the increment in the oxidative stress in both cases studied (MS and Aβ1-42): together, the hippocampus and temporal cortex produce an enhancer effect. In the same way, we observed an increment in interleukin-1β, TNF-α, and GFAP, indicative of exacerbated inflammatory processes by the combination of MS and Aβ1-42. We can conclude that MS might play a key role in the apparition and development of cognitive disorders, including AD. We propose that metabolic theory is important to explain the apparition of cognitive diseases.

Inflammatory response

BETA (programming language)

Amyloid beta

Memory Impairment

Amyloid (mycology)

10.1155/2018/1358057

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Citations (24)

Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence

Oxidative Medicine and Cellular Longevity (2014)

Daniela Silva‐Adaya María E. Gonsebatt Jorge Guevara

The reactive oxygen species produced continuously during oxidative metabolism are generated at very high rates in the brain. Therefore, defending against oxidative stress is an essential task within the brain. An important cellular system against oxidative stress is the thioredoxin system (TS). TS is composed of thioredoxin, thioredoxin reductase, and NADPH. This review focuses on the evidence gathered in recent investigations into the central nervous system, specifically the different brain regions in which the TS is expressed. Furthermore, we address the conditions that modulate the thioredoxin system in both, animal models and the postmortem brains of human patients associated with the most common neurodegenerative disorders, in which the thioredoxin system could play an important part.

10.1155/2014/590808

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Citations (66)

High-carbohydrate and fat diet consumption causes metabolic deterioration, neuronal damage, and loss of recognition memory in rats

Journal of Chemical Neuroanatomy (2023)

Estefania Fuentes Berenice Venegas Guadalupe Muñoz‐Arenas Carolina Morán Rubén Antonio Vázquez‐Roque

Chronic Stress

10.1016/j.jchemneu.2023.102237

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Citations (18)