José Carlos Jaime‐Pérez

Universidad Autónoma de Nuevo León

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David Gómez‐Almaguer

Hospital Universitario Dr José Eleuterio Gonzalez

221

César Homero Gutiérrez‐Aguirre

Universidad Autónoma de Nuevo León

103

Olga Graciela Cantú‐Rodríguez

Hospital Universitario Dr José Eleuterio Gonzalez

102

ÓG

Óscar González‐Llano

Hospital Universitario Dr José Eleuterio Gonzalez

Andrés Gómez‐De León

Universidad Autónoma de Nuevo León

Guillermo J. Ruíz‐Argüelles

Clínica Ruiz

Perla R. Colunga‐Pedraza

Universidad Autónoma de Nuevo León

José Luís Herrera-Garza

Universidad Autónoma de Nuevo León

Rosario Salazar‐Riojas

Universidad Autónoma de Nuevo León

Luz Tarín‐Arzaga

Universidad Autónoma de Nuevo León

Cooperative Institutions

Universidad Autónoma de Nuevo León

311

Hospital Universitario Dr José Eleuterio Gonzalez

273

Tecnológico de Monterrey

Clínica Ruiz

University of Monterrey

Hospital Oncológico Docente "Conrado Benítez García"

Mexican Social Security Institute

Universidad Popular Autónoma del Estado de Puebla

Hospital Zambrano Hellion

Weatherford College

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Graft-versus-host disease after an outpatient peripheral blood hematopoietic cell transplant using reduced-intensity conditioning: a single-center LATAM experience

Expert Review of Hematology (2024)

José Carlos Jaime‐Pérez Jesús D. Meléndez‐Flores Jorge Valdespino‐Valdes Andrés Gómez‐De León Perla R. Colunga‐Pedraza

Background HLA compatibility predicts allogeneic hematopoietic cell transplant (allo-HCT) and graft-versus-host disease (GvHD) outcomes. There is insufficient information regarding GvHD outcomes for outpatient HLA-identical and haploidentical-HCT employing reduced-intensity conditioning (RIC).

Cumulative incidence

Single Center

10.1080/17474086.2024.2305372

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Choosing the patient for ambulatory stem cell transplantation

Biology of Blood and Marrow Transplantation (2005)

Olga Graciela Cantú‐Rodríguez César Homero Gutiérrez‐Aguirre Óscar González‐Llano José Carlos Jaime‐Pérez Rosario Salazar‐Riojas

10.1016/j.bbmt.2004.12.102

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The effect of intra‐articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis

International Journal of Rheumatic Diseases (2017)

Domingo Garay‐Mendoza Laura Villarreal‐Martínez Alejandra Garza‐Bedolla Daniela Michelle Pérez‐Garza Carlos Acosta‐Olivo

Abstract Aim Management of osteoarthritis ( OA ) is basically symptomatic. Recently, stem cells ( SC ) have been used in the search for an optimum treatment. We decided to conduct a controlled clinical trial to determine if a single intra‐articular injection of in vivo stimulated bone marrow SC could lead to an improvement in pain management and quality of life in patients with knee OA . Method This was a prospective, open‐label, phase I/ II clinical trial to assess the safety and efficacy of a single intra‐articular injection of autologous stimulated bone marrow stem cells ( BM ‐ SC ) in patients with knee OA . Individuals of both genders older than 30 years with confirmed diagnosis of OA who signed informed consent were included in two groups: SC group received in vivo BM stimulation with subcutaneous administration of granulocyte colony stimulating factor (G‐ CSF ). SC were obtained by BM aspiration and administered in a single intra‐articular injection. The control group received exclusively oral acetaminophen. Visual analogue scale and Western Ontario and McMaster Universities Osteoarthritis Index scores were performed at 1 week, 1 month and 6 months in both groups. This trial was registered in ClinialTrials.gov NCT 01485198. Results A total of 61 patients were included. Socio‐demographic characteristics, OA grades and initial scores were similar in both groups. The BM ‐ SC group showed significant improvement in knee pain and quality of life during the 6‐month follow‐up. Conclusion The study demonstrates feasibility and supports efficacy of a completely ambulatory procedure in treatment of knee OA .

Knee pain

10.1111/1756-185x.13139

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Citations (78)

Low incidence and severity of graft-versus-host disease after outpatient allogeneic peripheral blood stem cell transplantation employing a reduced-intensity conditioning

European Journal Of Haematology (2011)

Olga Graciela Cantú‐Rodríguez César Homero Gutiérrez‐Aguirre José Carlos Jaime‐Pérez Oscar Rubén Treviño-Montemayor Sylvia Aidé Martínez‐Cabriales

The prevalence and features of graft-versus-host disease (GVHD) in patients receiving allografts using peripheral blood stem cells (PBSCs) after a reduced-intensity conditioning (RIC) regimen are not well known. Several features of GVHD in patients at two institutions using RIC were assessed.We analysed the overall survival (OS) and prevalence of GVHD in patients who underwent outpatient allogeneic PBSC transplantation after RIC between October 1998 and July 2008.We included 301 patients with a median age of 30 yrs (range, 1-71 yrs). In 37 cases, allogeneic peripheral blood stem cell transplantation was indicated for non-malignant disease, and in 264 for malignant disease. The median OS was 35 months. The estimated 3-yr OS was 48%. A total of 154 patients developed GVHD: there were 64 acute, 50 chronic and 40 cases that progressed from acute to chronic. Of the 104 patients with acute GVHD (aGVHD), 40% had grade I and 60% had grades II-IV. Of the 90 patients with chronic GVHD (cGVHD), 67% had limited and 33% had extensive forms. A total of 160 patients died, 40 as a result of GVHD (24 from aGVHD and 16 from cGVHD), 50 as a result of progressive disease and 70 from diverse causes.The incidence of GVHD was lower than in other series using conventional myeloablative preparative regimens. Most importantly, the severity of GVHD did not significantly affect the long-term survival.

Regimen

10.1111/j.1600-0609.2011.01702.x

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Citations (15)

Immunoreactivity of Common Red Blood Cell Antigens in Cytoskeleton-Free Red Blood Cell Microvesicles

Archives of Medical Research (2000)

José Carlos Jaime‐Pérez David Gómez‐Almaguer

Microvesicle

10.1016/s0188-4409(00)00055-2

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Citations (3)

Intrathecal delivery of bone marrow stem cells in ALS: A preliminary report

Transplantation Open (2017)

Héctor R. Martínez David Gómez‐Almaguer José Carlos Jaime‐Pérez Leticia A. Olguín‐Ramírez Rafael Naim G. Sarquis

Introduction:There is no effective therapy for amyotrophic lateral sclerosis (ALS).Safety and feasibility of intrathecal autologous stem cell injections in ALS patients is described.Methods: Fifteen ALS patients were enrolled.ALS functional rating scale revised (ALSFRS-R) was performed.They received subcutaneous filgrastim (600 µg) for 3 days.Then, CD34+ stem cells (150 ml) were bone marrow obtained and intrathechally injected.Patients were followed up for 1-year.Results: Eight females and 7 males were included (mean 47.6 years).Interval between onset and stem cell injection was 23.8 months.Mean ALSFRS-R at inclusion and six months was 33 and 32, respectively.Four patients died, mortality was associated to scores lower than 30 points at inclusion.Discussion: Intrathecal stem cell injection is safe, and well tolerated in ALS patients.Further studies with a greater number of patients are necessary to define the usefulness of intrathecal stem cell therapy in ALS patients.

Intrathecal

10.15761/jto.1000117

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Citations (1)

TNF-α increases in the CSF of children with acute lymphoblastic leukemia before CNS relapse

Blood Cells Molecules and Diseases (2016)

José Carlos Jaime‐Pérez Carmen Magdalena Gamboa-Alonso Raúl Alberto Jiménez‐Castillo Leslie López-Silva Mónica Andrea Pinzón-Uresti

10.1016/j.bcmd.2016.12.011

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Citations (6)

Sub-Optimal Fetal Iron Acquisition under a Maternal Environment

Archives of Medical Research (2005)

José Carlos Jaime‐Pérez José Luís Herrera-Garza David Gómez‐Almaguer

Cord blood

10.1016/j.arcmed.2005.03.023

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Citations (55)

Author response for "Outcomes of second hematopoietic stem cell transplantation using reduced‐intensity conditioning in an outpatient setting"

José Carlos Jaime‐Pérez Ernesto Picón‐Galindo José Luís Herrera-Garza David Gómez‐Almaguer

Intensity

10.1002/hon.2812/v2/response1

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Alternatives for managing patients with newly diagnosed immune thrombocytopenia: a narrative review

Expert Review of Hematology (2022)

David Gómez‐Almaguer Edgar A. Rojas-Guerrero Andrés Gómez‐De León Perla R. Colunga‐Pedraza José Carlos Jaime‐Pérez

Introduction Primary immune thrombocytopenia (ITP) is an acquired bleeding disorder. Conventionally, first-line ITP therapy aims to obtain a rapid response and stop or decrease the risk of bleeding by increasing the platelet count. At this point, the duration of the response, the tolerability, and the long-term safety of pharmacologic interventions are considered less of a priority. Combination treatments that simultaneously address multiple disease mechanisms are an attractive strategy to increase efficacy in acute ITP therapy. In this review, we discuss the treatment of newly diagnosed ITP patients, emphasizing the use of new combinations to benefit from their synergy.Areas covered This article summarizes conventional treatment, recent and novel combinations, and COVID-19 management recommendations of newly diagnosed ITP patients.Expert opinion The key areas for improvement consider the long-term effects of conventional first-line therapy, reducing relapse rates, and extending responses to achieve long-term remission. Although corticosteroids remain a first-line therapy, restricting their use to avoid toxicity and the increasing use of rituximab and TPO-RAs in the first three months after diagnosis open the landscape for future interventions in frontline therapy for ITP. First-line therapy intensification or synergistic drug combination offers a potential and realistic shift in future treatment guidelines.

Tolerability

Narrative review

First line therapy

10.1080/17474086.2022.2082936

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Citations (2)